Kate Langley

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 7:26. 2007
  2. pmc Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
    Marian L Hamshere
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Br J Psychiatry 203:107-11. 2013
  3. ncbi request reprint Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Br J Psychiatry 194:62-7. 2009
  4. pmc Autistic traits in children with ADHD index clinical and cognitive problems
    Miriam Cooper
    Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 23:23-34. 2014
  5. ncbi request reprint Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity
    Tom Fowler
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Psychiatr Genet 19:312-9. 2009
  6. ncbi request reprint Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
  7. ncbi request reprint Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, College of Medicine, School of Psychology, Cardiff University, Heath Park, Cardiff, Wales
    Arch Gen Psychiatry 62:1275-8. 2005
  8. pmc High loading of polygenic risk for ADHD in children with comorbid aggression
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Am J Psychiatry 170:909-16. 2013
  9. pmc Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 66:722-7. 2009
  10. ncbi request reprint Advances in genetic findings on attention deficit hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Psychol Med 37:1681-92. 2007

Detail Information

Publications30

  1. pmc Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    BMC Psychiatry 7:26. 2007
    ..It is possible that these different clinical manifestations of the disorder may arise because of the differing effects of the environmental indicators of environmental risk. We set out to test this hypothesis...
  2. pmc Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
    Marian L Hamshere
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Br J Psychiatry 203:107-11. 2013
    ..There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants...
  3. ncbi request reprint Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Br J Psychiatry 194:62-7. 2009
    ..Children with attention-deficit hyperactivity disorder (ADHD) are thought to be at higher risk of psychopathy. Early biological and social adversity may contribute to this risk...
  4. pmc Autistic traits in children with ADHD index clinical and cognitive problems
    Miriam Cooper
    Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 23:23-34. 2014
    ....
  5. ncbi request reprint Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity
    Tom Fowler
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Psychiatr Genet 19:312-9. 2009
    ..The aims of this study were to test whether these gene variants are linked to psychopathy traits in attention-deficit hyperactivity disorder (ADHD)...
  6. ncbi request reprint Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
    ..Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK...
  7. ncbi request reprint Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, College of Medicine, School of Psychology, Cardiff University, Heath Park, Cardiff, Wales
    Arch Gen Psychiatry 62:1275-8. 2005
    ..Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene...
  8. pmc High loading of polygenic risk for ADHD in children with comorbid aggression
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Am J Psychiatry 170:909-16. 2013
    ..The findings also highlight the fact that aggression in ADHD indexes genetic as well as clinical severity. ..
  9. pmc Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 66:722-7. 2009
    ..It is, however, impossible to be certain of adequate control for confounding factors with observational designs. We use a novel "natural experiment" design that separates prenatal environmental from alternative inherited effects...
  10. ncbi request reprint Advances in genetic findings on attention deficit hyperactivity disorder
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Psychol Med 37:1681-92. 2007
    ....
  11. ncbi request reprint Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 18:26-32. 2009
    ....
  12. ncbi request reprint The contribution of gene-environment interaction to psychopathology
    Anita Thapar
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Dev Psychopathol 19:989-1004. 2007
    ..Finally, current and anticipated methodological challenges and implications for future research in this area are considered...
  13. pmc What have we learnt about the causes of ADHD?
    Anita Thapar
    Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK
    J Child Psychol Psychiatry 54:3-16. 2013
    ..Attention deficit hyperactivity disorder (ADHD) and its possible causes still attract controversy. Genes, pre and perinatal risks, psychosocial factors and environmental toxins have all been considered as potential risk factors...
  14. pmc Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects
    Kate Langley
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, United Kingdom
    Am J Epidemiol 176:261-8. 2012
    ..These findings suggest that associations between maternal smoking during pregnancy and child ADHD may be due to genetic or household-level confounding rather than to causal intrauterine effects...
  15. pmc Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3
    Nigel M Williams
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, and School of Medicine, Cardiff University, Cardiff, UK
    Am J Psychiatry 169:195-204. 2012
    ..Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology...
  16. pmc Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants
    Kate Langley
    Department of Psychological Medicine and Neurology, and MRC Centre for Neuropsychiatric Genetics, Cardiff University, Cardiff, UK
    Br J Psychiatry 199:398-403. 2011
    ..Submicroscopic, rare chromosomal copy number variants (CNVs) contribute to neurodevelopmental disorders but it is not known whether they define atypical clinical cases...
  17. ncbi request reprint Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder
    Anita Thapar
    Dept of Psychological Medicine, Wales College of Medicine Cardiff University, Heath Park, Cardiff, Wales, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 15:118-25. 2006
    ..Antisocial behaviour is an important adverse outcome of ADHD. The aim of this review is to examine what is known about the clinical, genetic and environmental factors that contribute to the link between ADHD and antisocial behaviour...
  18. ncbi request reprint A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder
    Darko Turic
    Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, United Kingdom
    Biol Psychiatry 57:1461-6. 2005
    ..SLC1A3 is thus both a functional and positional candidate gene for ADHD...
  19. pmc Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder
    Amani Hassan
    Child and Adolescent Mental Health Services Network, Medical Research Council Centre for Neuropsychiatric Genetics, Department of Psychological Medicine and Neurology, Cardiff University, UK
    Br J Psychiatry 198:195-8. 2011
    ..No study has examined the prevalence of bipolar disorder in a UK sample of children with ADHD...
  20. pmc Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
    Nigel M Williams
    MRC Centre in Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, UK
    Lancet 376:1401-8. 2010
    ..We aimed to establish whether burden of CNVs was increased in ADHD, and to investigate whether identified CNVs were enriched for loci previously identified in autism and schizophrenia...
  21. ncbi request reprint No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 13:107-10. 2003
    ..In an attempt to replicate these findings, we examined this polymorphism and a variable number tandem repeat in the second intron of 5-HTT for association with ADHD...
  22. pmc Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?
    Sharifah Shameem Agha
    Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK
    Eur Child Adolesc Psychiatry 22:369-77. 2013
    ..This study highlights that children with more severe behavioural symptoms are more likely to have a parent with persistent ADHD which has important implications when considering treatment and intervention strategies...
  23. pmc No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study
    Sophie Mills
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    BMC Psychiatry 4:15. 2004
    ..Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention...
  24. ncbi request reprint Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorder
    Naureen S Whittinger
    Department of Psychological Medicine, Cardiff University, Cardiff, Wales, UK
    J Am Acad Child Adolesc Psychiatry 46:179-87. 2007
    ..To examine precursors of adolescent conduct disorder (CD) in children with attention-deficit/hyperactivity disorder (ADHD), investigating the significance of childhood oppositional defiant disorder (ODD) and ADHD...
  25. ncbi request reprint The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity
    Jane Holmes
    Section of Child and Adolescent Psychiatry, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 184:74-8. 2004
    ..Thus, information on children's symptoms in school is usually required. This paper presents the Child ADHD Teacher Telephone Interview (CHATTI), an instrument aimed at systematically obtaining this information...
  26. ncbi request reprint A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder
    Avshalom Caspi
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 65:203-10. 2008
    ..Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior...
  27. ncbi request reprint Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective
    Anita Thapar
    Br J Psychiatry 190:1-3. 2007
    ..Genes and environmental factors that influence the origins of disorder are not necessarily the same as those that contribute to its course and outcome...
  28. ncbi request reprint Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder
    Deborah C Lawson
    Department of Psychologycal Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:84-9. 2003
    ..0, 95% CI = 1.09, 3.5), and TDT analysis indicated a statistical trend toward association. Our findings highlight the importance of phenotype definition and the need for the MAOA VNTR to be further examined...
  29. ncbi request reprint Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD
    Kate Langley
    Department of Psychological Medicine, University of Wales College of Medicine
    Am J Psychiatry 161:133-8. 2004
    ..In this article the authors examine whether the DRD4 7-repeat allele is associated with performance on a variety of neuropsychological tasks in children with ADHD...
  30. ncbi request reprint No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder
    Antony Payton
    Centre for Integrated Genomic Medical Research, Stopford Building, Manchester University, Manchester, UK
    Psychiatr Genet 13:183-5. 2003
    ..We attempted to replicate these findings...