K Langley

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects
    Kate Langley
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, United Kingdom
    Am J Epidemiol 176:261-8. 2012
  2. doi Genotype link with extreme antisocial behavior: the contribution of cognitive pathways
    Kate Langley
    Department of Psychological Medicine and Neurology, Cardiff University, Wales, England
    Arch Gen Psychiatry 67:1317-23. 2010
  3. doi Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
  4. doi Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 18:26-32. 2009
  5. ncbi Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review
    K Langley
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Minerva Pediatr 57:359-71. 2005
  6. ncbi Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior
    K Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Med Genet B Neuropsychiatr Genet 147:49-53. 2008
  7. ncbi A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD)
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:64-7. 2005
  8. ncbi Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
  9. ncbi No support for association between the dopamine transporter (DAT1) gene and ADHD
    K Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:7-10. 2005
  10. pmc Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder
    E Stergiakouli
    MRC Centre for Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Genes Brain Behav 10:334-44. 2011

Collaborators

Detail Information

Publications17

  1. pmc Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects
    Kate Langley
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, United Kingdom
    Am J Epidemiol 176:261-8. 2012
    ..These findings suggest that associations between maternal smoking during pregnancy and child ADHD may be due to genetic or household-level confounding rather than to causal intrauterine effects...
  2. doi Genotype link with extreme antisocial behavior: the contribution of cognitive pathways
    Kate Langley
    Department of Psychological Medicine and Neurology, Cardiff University, Wales, England
    Arch Gen Psychiatry 67:1317-23. 2010
    ..The same genotype has also been implicated in affecting cognitive function in healthy individuals. Impaired cognitive function might therefore lie on the risk pathway from genotype to clinical outcome...
  3. doi Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 196:235-40. 2010
    ..Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK...
  4. doi Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder
    Kate Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Eur Child Adolesc Psychiatry 18:26-32. 2009
    ....
  5. ncbi Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review
    K Langley
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    Minerva Pediatr 57:359-71. 2005
    ..39, 95% confidence intervals 1.61, 3.52 P<0.001). Maternal smoking during pregnancy is a risk factor for ADHD behaviour and diagnoses, although the mechanisms through which such risks work is unknown...
  6. ncbi Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior
    K Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Med Genet B Neuropsychiatr Genet 147:49-53. 2008
    ..There may be evidence of G x E on associated antisocial behavior in ADHD, but further investigation is needed...
  7. ncbi A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD)
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:64-7. 2005
    ..No evidence for association was observed with any single marker or haplotype in a sample of 279 affected children and their parents...
  8. ncbi Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
    ..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
  9. ncbi No support for association between the dopamine transporter (DAT1) gene and ADHD
    K Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:7-10. 2005
    ..63 (df 3) P = 0.65). We conclude that the 3' VNTR and three additional promoter variants in DAT1 do not appear to be associated with ADHD, or response to stimulant mediation in our sample...
  10. pmc Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder
    E Stergiakouli
    MRC Centre for Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Genes Brain Behav 10:334-44. 2011
    ..These data suggest that genetic variants affecting STS expression and/or activity could influence the function of brain regions perturbed in ADHD...
  11. ncbi Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies
    A Thapar
    Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, Wales, UK
    Mol Psychiatry 11:714-20. 2006
    ..There is also good empirical support in favour of examining antisocial behaviour in ADHD. Genetic studies of dimensional ADHD are useful for other complementary purposes...
  12. ncbi Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios
    A West
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Mol Psychiatry 7:962-6. 2002
    ....
  13. ncbi Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Mol Psychiatry 9:169-73. 2004
    ..We conclude that replication is required and that further work examining for association of GRIN2A polymorphisms with ADHD is warranted...
  14. ncbi Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD
    L Kent
    Developmental Psychiatry, University of Cambridge, Cambridge, UK
    Mol Psychiatry 10:939-43. 2005
    ..00; P=1.00). Our findings support the hypothesis that BDNF is involved in the pathogenesis of ADHD. The transmission difference between parents raises the possibility that an epigenetic process may be involved...
  15. ncbi Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth
    K J Brookes
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:94-9. 2008
    ..We conclude that the DRD4 7-repeat allele is associated with ADHD but there is no association or interaction with SOB for increased risk for ADHD. Our findings suggest that we can refute a possible effect of SOB for ADHD...
  16. ncbi Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene
    J Stevenson
    School of Psychology, University of Southampton, UK
    J Child Psychol Psychiatry 46:1081-8. 2005
    ..This paper examines the neurobiological evidence and presents preliminary testing of the hypothesis that the ADRA2A receptor gene is contributing to ADHD and comorbid RD...
  17. ncbi Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample
    Z Hawi
    Department of Genetics and Psychiatry, Trinity College, Dublin, Ireland
    Mol Psychiatry 7:718-25. 2002
    ..9, P = 0.026). These preliminary data suggest an important role for the serotonin system in the development of ADHD. Further studies, preferentially including different ethnic groups are required to substantiate these findings...