Research Topics
Genomes and GenesSpecies | K LangleySummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effectsKate Langley
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, United Kingdom
Am J Epidemiol 176:261-8. 2012..These findings suggest that associations between maternal smoking during pregnancy and child ADHD may be due to genetic or household-level confounding rather than to causal intrauterine effects...
Genotype link with extreme antisocial behavior: the contribution of cognitive pathwaysKate Langley
Department of Psychological Medicine and Neurology, Cardiff University, Wales, England
Arch Gen Psychiatry 67:1317-23. 2010..The same genotype has also been implicated in affecting cognitive function in healthy individuals. Impaired cognitive function might therefore lie on the risk pathway from genotype to clinical outcome...- Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorderKate Langley
Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
Br J Psychiatry 196:235-40. 2010..Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK... - Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorderKate Langley
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
Eur Child Adolesc Psychiatry 18:26-32. 2009.... 
Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A reviewK Langley
Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
Minerva Pediatr 57:359-71. 2005..39, 95% confidence intervals 1.61, 3.52 P<0.001). Maternal smoking during pregnancy is a risk factor for ADHD behaviour and diagnoses, although the mechanisms through which such risks work is unknown...- Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behaviorK Langley
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
Am J Med Genet B Neuropsychiatr Genet 147:49-53. 2008..There may be evidence of G x E on associated antisocial behavior in ADHD, but further investigation is needed... - A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD)D Turic
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 133:64-7. 2005..No evidence for association was observed with any single marker or haplotype in a sample of 279 affected children and their parents... - Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHDD Turic
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD... - No support for association between the dopamine transporter (DAT1) gene and ADHDK Langley
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 139:7-10. 2005..63 (df 3) P = 0.65). We conclude that the 3' VNTR and three additional promoter variants in DAT1 do not appear to be associated with ADHD, or response to stimulant mediation in our sample... - Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorderE Stergiakouli
MRC Centre for Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Genes Brain Behav 10:334-44. 2011..These data suggest that genetic variants affecting STS expression and/or activity could influence the function of brain regions perturbed in ADHD... - Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studiesA Thapar
Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, Wales, UK
Mol Psychiatry 11:714-20. 2006..There is also good empirical support in favour of examining antisocial behaviour in ADHD. Genetic studies of dimensional ADHD are useful for other complementary purposes... - Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained triosA West
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
Mol Psychiatry 7:962-6. 2002.... - Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHDD Turic
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
Mol Psychiatry 9:169-73. 2004..We conclude that replication is required and that further work examining for association of GRIN2A polymorphisms with ADHD is warranted... - Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHDL Kent
Developmental Psychiatry, University of Cambridge, Cambridge, UK
Mol Psychiatry 10:939-43. 2005..00; P=1.00). Our findings support the hypothesis that BDNF is involved in the pathogenesis of ADHD. The transmission difference between parents raises the possibility that an epigenetic process may be involved... - Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birthK J Brookes
MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 147:94-9. 2008..We conclude that the DRD4 7-repeat allele is associated with ADHD but there is no association or interaction with SOB for increased risk for ADHD. Our findings suggest that we can refute a possible effect of SOB for ADHD... - Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A geneJ Stevenson
School of Psychology, University of Southampton, UK
J Child Psychol Psychiatry 46:1081-8. 2005..This paper examines the neurobiological evidence and presents preliminary testing of the hypothesis that the ADRA2A receptor gene is contributing to ADHD and comorbid RD... - Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sampleZ Hawi
Department of Genetics and Psychiatry, Trinity College, Dublin, Ireland
Mol Psychiatry 7:718-25. 2002..9, P = 0.026). These preliminary data suggest an important role for the serotonin system in the development of ADHD. Further studies, preferentially including different ethnic groups are required to substantiate these findings...