Research Topics
Genomes and Genes
Species | G KirovSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophreniaDetelina Grozeva
MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Schizophr Res 135:1-7. 2012..Several large, rare chromosomal copy number variants (CNVs) have recently been shown to increase risk for schizophrenia and other neuropsychiatric disorders including autism, ADHD, learning difficulties and epilepsy...
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophreniaG Kirov
Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
Mol Psychiatry 17:142-53. 2012..14). Our data indicate that defects in NMDAR postsynaptic signalling and, possibly, ARC complexes, which are known to be important in synaptic plasticity and cognition, play a significant role in the pathogenesis of schizophrenia...
The Bipolar Affective Disorder Dimension Scale (BADDS)--a dimensional scale for rating lifetime psychopathology in bipolar spectrum disordersNick Craddock
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
BMC Psychiatry 4:19. 2004..This latter limitation is particularly pertinent in the context of the increasing evidence for the existence of a broader bipolar spectrum than has been acknowledged within existing classifications...- Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotypingIrina Zaharieva
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
BMC Psychiatry 8:11. 2008..Several linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibility genes for schizophrenia within this region... - The role of copy number variation in schizophreniaGeorge Kirov
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
Expert Rev Neurother 10:25-32. 2010..They are found collectively in up to 3% of patients; therefore, they account for only a small proportion of the genetic causes of schizophrenia. In this paper I will review the evidence for these findings... 
Variation in the protocadherin gamma A gene clusterGeorge Kirov
Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
Genomics 82:433-40. 2003..It will be important to identify the phenotype associated with the loss of the PCDHGA8 gene...- Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorderG Kirov
Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
Mol Psychiatry 6:671-7. 2001..The polymorphisms identified in this study will be useful in examining the role of this gene in other neuropsychiatric disorders and behavioural traits... - Pooled genotyping of microsatellite markers in parent-offspring triosG Kirov
Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
Genome Res 10:105-15. 2000..The use of trios will confirm or reject any suggested differences, thus reducing the false-positive rate that can be created by hidden population stratification... - Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5G Kirov
Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK
Mol Psychiatry 4:558-65. 1999..No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied... - A genome-wide association study in 574 schizophrenia trios using DNA poolingG Kirov
Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Cardiff, UK
Mol Psychiatry 14:796-803. 2009..05, with the best result at P=1.2 x 10(-6) for rs11064768. This SNP is within the gene CCDC60, a coiled-coil domain gene. The third best SNP (P=0.00016) is rs893703, within RBP1, a candidate gene for schizophrenia... - Add-on topiramate reduces weight in overweight patients with affective disorders: a clinical case seriesGeorge Kirov
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
BMC Psychiatry 5:19. 2005..We used topiramate to treat 12 patients with affective disorders who had a body-mass index > 30 kg/m2... - Religious faith after psychotic illnessG Kirov
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
Psychopathology 31:234-45. 1998..We conclude that the experience of a psychotic illness is likely to lead to an increase in religious beliefs. Such beliefs are commonly used for coping with the illness and some patients attach a great importance to them... - Thyroid disorders in lithium-treated patientsG Kirov
Division of Psychological Medicine, Heath Park, Cardiff, UK
J Affect Disord 50:33-40. 1998..Little is known about the rate of thyroid disorders prior to lithium treatment, and which patients have a higher risk for developing such disorders during such treatment... - Pooled DNA genotyping on Affymetrix SNP genotyping arraysGeorge Kirov
Department of Psychological Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
BMC Genomics 7:27. 2006..However, thus far, this conclusion is based upon published data concerning only a small number of SNPs... - Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorderG Kirov
Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK
Mol Psychiatry 3:342-5. 1998..84, d.f. = 1, P = 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder... - A cross-sectional and a prospective study of thyroid disorders in lithium-treated patientsGeorge Kirov
Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, UK
J Affect Disord 87:313-7. 2005..The effects of lithium treatment on the thyroid gland have been demonstrated in a number of studies. Most of this research is based on cross-sectional studies and prospective studies are required to confirm these observations... - Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illnessGeorge Kirov
Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF144 4XN, Wales, UK
Am J Med Genet B Neuropsychiatr Genet 118:16-9. 2003..6%, P = 0.6. We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia... - Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapineM J Arranz
Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
Mol Psychiatry 3:61-6. 1998..These results provide further evidence suggesting that genetic variation at 5-HT2A receptors may influence clozapine response and strengthen the candidacy of these receptors as important therapeutic targets... - Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alphaL S Carroll
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
Mol Psychiatry 15:1101-11. 2010..However, the evidence across all approaches suggests that further study of this locus is warranted... - Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapineM J Arranz
Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
Neurosci Lett 217:177-8. 1996..An association was found between the allele Tyr452 and poor clinical response... - Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorderH J Williams
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 16:429-41. 2011..The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder... - Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotypeN Craddock
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 15:146-53. 2010..Our method of phenotype refinement may be useful in studies of other complex psychiatric and non-psychiatric disorders... - Screening the human protocadherin 8 (PCDH8) gene in schizophreniaN J Bray
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
Genes Brain Behav 1:187-91. 2002..These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded... - Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic studyD Ivanov
Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
Br J Psychiatry 183:409-13. 2003..None of the controls showed a pattern of genotypes consistent with hemizygosity. CONCLUSIONS: VCFS may be less frequent among patients with psychosis than previously suggested; this rate is not increased among early-onset patients... - Detailed analysis of PRODH and PsPRODH reveals no association with schizophreniaH J Williams
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003..05 level. These results do not suggest that PRODH or PsPRODH contribute to the aetiology of schizophrenia, and that the putative schizophrenia susceptibility gene in 22q11 remains unknown... - Polygenic dissection of the bipolar phenotypeM L Hamshere
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
Br J Psychiatry 198:284-8. 2011..Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder... - Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2M C O'Donovan
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 14:30-6. 2009..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia... - Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brainA L Richards
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 17:193-201. 2012..Moreover, our data show that notwithstanding the likely developmental origin of schizophrenia, studies of adult brain tissue can, in principle, allow relevant susceptibility eQTLs to be identified... - Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHDD Turic
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD... - The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophreniaE K Green
Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 15:1016-22. 2010.... - Association analysis between dopamine receptor genes and bipolar affective disorderT Li
Department of Psychological Medicine, The Institute of Psychiatry, London, UK
Psychiatry Res 86:193-201. 1999..We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease... - Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)N M Williams
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
Arch Gen Psychiatry 61:336-44. 2004..Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been identified in more than 1 study... - Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic conceptM L Hamshere
Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Br J Psychiatry 195:23-9. 2009..Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research... - Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approachN M Williams
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
Mol Psychiatry 7:1092-100. 2002..35, P = 0.006, P = 0.078 corrected for 13 alleles)... - DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controlsE K Green
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 156:490-2. 2011..In sequencing exon 11 in 506 cases and 1,211 controls for variants that occurred only once, 4 additional rare variants were found in cases (P-value = 0.008, Fisher's exact trend test)... - Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4B Glaser
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, UK
Mol Psychiatry 10:920-7. 2005..001), where some of the variance was accounted for by the genotype at ss24735177. Our findings thus indicate the potential functional relevance of the associated haplotype and now require replication in independent samples... - Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine responseM J Arranz
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Schizophr Res 32:93-9. 1998..Statistical analysis of extreme responders showed a clearer association of the 102-T/C with clozapine response. These results reinforce the hypothesis and strengthen the candidacy of these receptors as important therapeutic targets... - Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophreniaL S Carroll
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
Am J Med Genet B Neuropsychiatr Genet 156:844-9. 2011..Therefore very rare, low-to-moderate penetrance protein coding mutations or non-coding mutations at DLG1 and/or PAK2, or a nearby gene, may reproduce the behavioral characteristics of the 3q29 microdeletion... - 5-HT2A receptor and bipolar affective disorder: association studies in affected patientsM J Arranz
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Neurosci Lett 224:95-8. 1997..No strong associations were found between any of these polymorphisms and bipolar affective disorder. Genetic variation at the 5-HT2A receptor gene does not play a major role in the pathogenesis of the disorder... - Linkage analysis between bipolar affective disorder and markers on chromosome XH P Vallada
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Psychiatr Genet 8:183-6. 1998..We conclude that there is no evidence of a common major gene for bipolar affective disorder at Xq25-q27 in our set of families... - The molecular genetics of schizophrenia: progress so farG Kirov
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff
Mol Med Today 3:124-30. 1997..Here, we review the evidence for these linkages, as well as findings from association studies that have not yet received as much independent confirmation... - A new form of familial multi-nodular goitre with progression to differentiated thyroid cancerA Bakhsh
Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Endocr Relat Cancer 13:475-83. 2006..From these findings and from the absence of any linkage to any of the known loci associated with MNG or FNMTC, we suggest that this represents a new form of inherited MNG with a significant risk of progression to papillary carcinoma... - Support for RGS4 as a susceptibility gene for schizophreniaNigel M Williams
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
Biol Psychiatry 55:192-5. 2004..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples... - Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008.... - A network of dopaminergic gene variations implicated as risk factors for schizophreniaMichael E Talkowski
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Hum Mol Genet 17:747-58. 2008..Our data suggest that a network of dopaminergic polymorphisms increase risk for SZ... - Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophreniaLyudmila Georgieva
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
Biol Psychiatry 64:419-27. 2008..We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder... - Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophreniaLyudmila Georgieva
Department of Medical Genetics, Medical University Sofia, Sofia, Bulgaria
Psychiatr Genet 13:103-6. 2003..31, a region in which evidence for linkage to schizophrenia has been reported. The gene has an unusually large first exon of 3544 nucleotides, which encodes the signal peptide and all nine ectodomains in the protein... - Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorderElaine K Green
Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
Arch Gen Psychiatry 62:642-8. 2005..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects... - Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studiesAlbena Dimitrova
Department of Medical Genetics, Medical University Sofia, University Hospital Maichin Dom, Sofia, Bulgaria
Psychiatr Genet 12:137-41. 2002..2). The VNTR polymorphism in the 5-HTT gene does not appear to be a major risk factor for increasing susceptibility to major psychiatric disorders... - Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasisNadine Norton
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
Am J Med Genet 114:491-6. 2002..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia... - Universal, robust, highly quantitative SNP allele frequency measurement in DNA poolsNadine Norton
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
Hum Genet 110:471-8. 2002..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost... - Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13Marian L Hamshere
Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
Arch Gen Psychiatry 62:1081-8. 2005..Follow-up of this region should use samples enriched for cases of schizoaffective disorder. Our findings have similar implications for the search for genetic variation on chromosome 22q11 that influences susceptibility to psychosis... - Strong evidence that GNB1L is associated with schizophreniaNigel M Williams
Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Hum Mol Genet 17:555-66. 2008..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism... - Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophreniaGeorge Kirov
Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
Hum Mol Genet 17:458-65. 2008..Both genes have been affected by CNVs in patients with autism and mental retardation, but neither has been previously implicated in SZ... - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variantsPaul R Burton
Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
Nat Genet 39:1329-37. 2007.... - Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's diseaseElaine Green
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
Am J Psychiatry 162:35-42. 2005..Further molecular genetic analysis of this region is required to identify the gene(s)... - Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)Rachel Raybould
Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
Biol Psychiatry 57:696-701. 2005..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample... - No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samplesBeate Glaser
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
Biol Psychiatry 58:78-80. 2005..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()... - Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samplesMichael E Talkowski
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 60:152-62. 2006..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles... - Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophreniaNadine Norton
Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006.... - Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UKElaine K Green
Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
Br J Psychiatry 188:21-5. 2006..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder... - Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from BulgariaGeorge Kirov
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
Biol Psychiatry 55:971-5. 2004..We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47)... - Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorderNigel M Williams
Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
Arch Gen Psychiatry 63:366-73. 2006..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association... - Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356Beate Glaser
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples... - Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibilityBeate Glaser
Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
Schizophr Res 87:21-7. 2006..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia... - Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophreniaLyudmila Georgieva
Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
Proc Natl Acad Sci U S A 103:12469-74. 2006..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function... - Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesEleftheria Zeggini
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
Science 316:1336-41. 2007..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes... - Genetics of epilepsy: epilepsy research foundation workshop reportSanjay Sisodiya
Epilepsy Research Foundation, United Kingdom
Epileptic Disord 9:194-236. 2007..Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy... - Underpowered repetitive transcranial magnetic stimulation might not be an effective antidepressant treatmentGeorge Kirov
J Clin Psychiatry 66:543; author reply 543-4. 2005 - Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. familiesJane E Farbrother
School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
Invest Ophthalmol Vis Sci 45:2879-85. 2004..Thus, additional loci for high myopia are likely to be the cause of the majority of cases of high myopia in the United Kingdom... - Family aggregation of high myopia: estimation of the sibling recurrence risk ratioJane E Farbrother
School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
Invest Ophthalmol Vis Sci 45:2873-8. 2004..Instead, it may be necessary to consider high myopia as a "complex disease" resulting from the influence of either alleles of reduced penetrance ("susceptibility genes"), environmental factors, or both... - Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseSheila A Fisher
Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Nat Genet 40:710-2. 2008..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases... - Finding schizophrenia genesGeorge Kirov
Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
J Clin Invest 115:1440-8. 2005..These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it... - Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European originSven Cichon
Nat Genet 36:783-4; author reply 784-5. 2004 - The effectiveness of electroconvulsive therapy in treatment-resistant depression: a naturalistic studyNajeeb Khalid
North Glamorgan NHS Trust, Merthyr Tydfil, Cardiff, UK
J ECT 24:141-5. 2008..We wanted to assess whether ECT is still highly effective in such a severely treatment-resistant population...