G Kirov

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
    Elliott Rees
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK
    Hum Mol Genet 23:1669-76. 2014
  2. ncbi request reprint The penetrance of copy number variations for schizophrenia and developmental delay
    George Kirov
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom Electronic address
    Biol Psychiatry 75:378-85. 2014
  3. pmc Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia
    Detelina Grozeva
    MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 135:1-7. 2012
  4. pmc De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
    G Kirov
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    Mol Psychiatry 17:142-53. 2012
  5. pmc The Bipolar Affective Disorder Dimension Scale (BADDS)--a dimensional scale for rating lifetime psychopathology in bipolar spectrum disorders
    Nick Craddock
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 4:19. 2004
  6. pmc Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping
    Irina Zaharieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 8:11. 2008
  7. doi request reprint The role of copy number variation in schizophrenia
    George Kirov
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Expert Rev Neurother 10:25-32. 2010
  8. ncbi request reprint Variation in the protocadherin gamma A gene cluster
    George Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genomics 82:433-40. 2003
  9. pmc Add-on topiramate reduces weight in overweight patients with affective disorders: a clinical case series
    George Kirov
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    BMC Psychiatry 5:19. 2005
  10. ncbi request reprint A cross-sectional and a prospective study of thyroid disorders in lithium-treated patients
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, UK
    J Affect Disord 87:313-7. 2005

Collaborators

Detail Information

Publications79

  1. ncbi request reprint CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
    Elliott Rees
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK
    Hum Mol Genet 23:1669-76. 2014
    ..2% excess in cases after excluding known schizophrenia-associated loci, suggesting that additional susceptibility loci exist. However, even larger samples are required for their discovery. ..
  2. ncbi request reprint The penetrance of copy number variations for schizophrenia and developmental delay
    George Kirov
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom Electronic address
    Biol Psychiatry 75:378-85. 2014
    ..Their penetrance for SCZ has been estimated to be modest. However, comparisons between their penetrance for SCZ or DD/ASD/CM, or estimates of the total penetrance for any of these disorders have not yet been made...
  3. pmc Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia
    Detelina Grozeva
    MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 135:1-7. 2012
    ..Several large, rare chromosomal copy number variants (CNVs) have recently been shown to increase risk for schizophrenia and other neuropsychiatric disorders including autism, ADHD, learning difficulties and epilepsy...
  4. pmc De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
    G Kirov
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    Mol Psychiatry 17:142-53. 2012
    ..14). Our data indicate that defects in NMDAR postsynaptic signalling and, possibly, ARC complexes, which are known to be important in synaptic plasticity and cognition, play a significant role in the pathogenesis of schizophrenia...
  5. pmc The Bipolar Affective Disorder Dimension Scale (BADDS)--a dimensional scale for rating lifetime psychopathology in bipolar spectrum disorders
    Nick Craddock
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 4:19. 2004
    ..This latter limitation is particularly pertinent in the context of the increasing evidence for the existence of a broader bipolar spectrum than has been acknowledged within existing classifications...
  6. pmc Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping
    Irina Zaharieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 8:11. 2008
    ..Several linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibility genes for schizophrenia within this region...
  7. doi request reprint The role of copy number variation in schizophrenia
    George Kirov
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Expert Rev Neurother 10:25-32. 2010
    ..They are found collectively in up to 3% of patients; therefore, they account for only a small proportion of the genetic causes of schizophrenia. In this paper I will review the evidence for these findings...
  8. ncbi request reprint Variation in the protocadherin gamma A gene cluster
    George Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genomics 82:433-40. 2003
    ..It will be important to identify the phenotype associated with the loss of the PCDHGA8 gene...
  9. pmc Add-on topiramate reduces weight in overweight patients with affective disorders: a clinical case series
    George Kirov
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    BMC Psychiatry 5:19. 2005
    ..We used topiramate to treat 12 patients with affective disorders who had a body-mass index > 30 kg/m2...
  10. ncbi request reprint A cross-sectional and a prospective study of thyroid disorders in lithium-treated patients
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, Wales, UK
    J Affect Disord 87:313-7. 2005
    ..The effects of lithium treatment on the thyroid gland have been demonstrated in a number of studies. Most of this research is based on cross-sectional studies and prospective studies are required to confirm these observations...
  11. ncbi request reprint A genome-wide association study in 574 schizophrenia trios using DNA pooling
    G Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Cardiff, UK
    Mol Psychiatry 14:796-803. 2009
    ..05, with the best result at P=1.2 x 10(-6) for rs11064768. This SNP is within the gene CCDC60, a coiled-coil domain gene. The third best SNP (P=0.00016) is rs893703, within RBP1, a candidate gene for schizophrenia...
  12. ncbi request reprint Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness
    George Kirov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF144 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 118:16-9. 2003
    ..6%, P = 0.6. We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia...
  13. ncbi request reprint Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 6:671-7. 2001
    ..The polymorphisms identified in this study will be useful in examining the role of this gene in other neuropsychiatric disorders and behavioural traits...
  14. pmc Pooled genotyping of microsatellite markers in parent-offspring trios
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Genome Res 10:105-15. 2000
    ..The use of trios will confirm or reject any suggested differences, thus reducing the false-positive rate that can be created by hidden population stratification...
  15. ncbi request reprint Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:342-5. 1998
    ..84, d.f. = 1, P = 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder...
  16. pmc Pooled DNA genotyping on Affymetrix SNP genotyping arrays
    George Kirov
    Department of Psychological Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    BMC Genomics 7:27. 2006
    ..However, thus far, this conclusion is based upon published data concerning only a small number of SNPs...
  17. ncbi request reprint Thyroid disorders in lithium-treated patients
    G Kirov
    Division of Psychological Medicine, Heath Park, Cardiff, UK
    J Affect Disord 50:33-40. 1998
    ..Little is known about the rate of thyroid disorders prior to lithium treatment, and which patients have a higher risk for developing such disorders during such treatment...
  18. ncbi request reprint Religious faith after psychotic illness
    G Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychopathology 31:234-45. 1998
    ..We conclude that the experience of a psychotic illness is likely to lead to an increase in religious beliefs. Such beliefs are commonly used for coping with the illness and some patients attach a great importance to them...
  19. ncbi request reprint Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5
    G Kirov
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK
    Mol Psychiatry 4:558-65. 1999
    ..No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied...
  20. ncbi request reprint Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
    Mol Psychiatry 3:61-6. 1998
    ..These results provide further evidence suggesting that genetic variation at 5-HT2A receptors may influence clozapine response and strengthen the candidacy of these receptors as important therapeutic targets...
  21. doi request reprint Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha
    L S Carroll
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 15:1101-11. 2010
    ..However, the evidence across all approaches suggests that further study of this locus is warranted...
  22. ncbi request reprint Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
    H J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 16:429-41. 2011
    ..The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder...
  23. ncbi request reprint Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
    Neurosci Lett 217:177-8. 1996
    ..An association was found between the allele Tyr452 and poor clinical response...
  24. ncbi request reprint Screening the human protocadherin 8 (PCDH8) gene in schizophrenia
    N J Bray
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Genes Brain Behav 1:187-91. 2002
    ..These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded...
  25. ncbi request reprint Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype
    N Craddock
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:146-53. 2010
    ..Our method of phenotype refinement may be useful in studies of other complex psychiatric and non-psychiatric disorders...
  26. pmc Polygenic dissection of the bipolar phenotype
    M L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Br J Psychiatry 198:284-8. 2011
    ..Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder...
  27. ncbi request reprint Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
    ..05 level. These results do not suggest that PRODH or PsPRODH contribute to the aetiology of schizophrenia, and that the putative schizophrenia susceptibility gene in 22q11 remains unknown...
  28. ncbi request reprint Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study
    D Ivanov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 183:409-13. 2003
    ..About 30% of patients with VCFS have psychosis, and the rate of these deletions in schizophrenia has been reported to be about 1%. Even higher rates of VCFS deletions have been reported for childhood-onset schizophrenia...
  29. ncbi request reprint Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample
    E K Green
    Department of Psychological Medicine, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 18:1302-7. 2013
    ..Second, rs3818253 (P=3.88 × 10(-8), OR=1.16), an intronic SNP on chromosome 20q11.2 in the gene TRPC4AP, which lies in a high linkage disequilibrium region along with the genes GSS and MYH7B. ..
  30. pmc Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
    ..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia...
  31. ncbi request reprint Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain
    A L Richards
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 17:193-201. 2012
    ..Moreover, our data show that notwithstanding the likely developmental origin of schizophrenia, studies of adult brain tissue can, in principle, allow relevant susceptibility eQTLs to be identified...
  32. ncbi request reprint Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
    ..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
  33. pmc The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
    E K Green
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:1016-22. 2010
    ....
  34. ncbi request reprint Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
    ..35, P = 0.006, P = 0.078 corrected for 13 alleles)...
  35. ncbi request reprint Association analysis between dopamine receptor genes and bipolar affective disorder
    T Li
    Department of Psychological Medicine, The Institute of Psychiatry, London, UK
    Psychiatry Res 86:193-201. 1999
    ..We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease...
  36. ncbi request reprint Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:336-44. 2004
    ..Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been identified in more than 1 study...
  37. pmc Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept
    M L Hamshere
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 195:23-9. 2009
    ..Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research...
  38. doi request reprint DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls
    E K Green
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 156:490-2. 2011
    ..In sequencing exon 11 in 506 cases and 1,211 controls for variants that occurred only once, 4 additional rare variants were found in cases (P-value = 0.008, Fisher's exact trend test)...
  39. ncbi request reprint Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4
    B Glaser
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, UK
    Mol Psychiatry 10:920-7. 2005
    ..001), where some of the variance was accounted for by the genotype at ss24735177. Our findings thus indicate the potential functional relevance of the associated haplotype and now require replication in independent samples...
  40. doi request reprint Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia
    L S Carroll
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
    Am J Med Genet B Neuropsychiatr Genet 156:844-9. 2011
    ..Therefore very rare, low-to-moderate penetrance protein coding mutations or non-coding mutations at DLG1 and/or PAK2, or a nearby gene, may reproduce the behavioral characteristics of the 3q29 microdeletion...
  41. ncbi request reprint 5-HT2A receptor and bipolar affective disorder: association studies in affected patients
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Neurosci Lett 224:95-8. 1997
    ..No strong associations were found between any of these polymorphisms and bipolar affective disorder. Genetic variation at the 5-HT2A receptor gene does not play a major role in the pathogenesis of the disorder...
  42. ncbi request reprint Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Schizophr Res 32:93-9. 1998
    ..Statistical analysis of extreme responders showed a clearer association of the 102-T/C with clozapine response. These results reinforce the hypothesis and strengthen the candidacy of these receptors as important therapeutic targets...
  43. ncbi request reprint Linkage analysis between bipolar affective disorder and markers on chromosome X
    H P Vallada
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatr Genet 8:183-6. 1998
    ..We conclude that there is no evidence of a common major gene for bipolar affective disorder at Xq25-q27 in our set of families...
  44. ncbi request reprint The molecular genetics of schizophrenia: progress so far
    G Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff
    Mol Med Today 3:124-30. 1997
    ..Here, we review the evidence for these linkages, as well as findings from association studies that have not yet received as much independent confirmation...
  45. ncbi request reprint A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer
    A Bakhsh
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Endocr Relat Cancer 13:475-83. 2006
    ..From these findings and from the absence of any linkage to any of the known loci associated with MNG or FNMTC, we suggest that this represents a new form of inherited MNG with a significant risk of progression to papillary carcinoma...
  46. pmc Evidence that duplications of 22q11.2 protect against schizophrenia
    E Rees
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
    Mol Psychiatry 19:37-40. 2014
    ..014% vs 0.085%, OR=0.17, P=0.00086). 22q11.2 duplications represent the first putative protective mutation for schizophrenia...
  47. ncbi request reprint Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...
  48. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  49. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
    ..Here molecular genetic analyses aimed at localizing and identifying the susceptibility gene in this region are reported...
  50. ncbi request reprint Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
    ..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples...
  51. ncbi request reprint Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
    ..Our data do not support the hypothesis that an interaction between these genes influences susceptibility to schizophrenia...
  52. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  53. ncbi request reprint Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
    George Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:971-5. 2004
    ..We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47)...
  54. ncbi request reprint Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  55. ncbi request reprint Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia
    Lyudmila Georgieva
    Department of Medical Genetics, Medical University Sofia, Sofia, Bulgaria
    Psychiatr Genet 13:103-6. 2003
    ..31, a region in which evidence for linkage to schizophrenia has been reported. The gene has an unusually large first exon of 3544 nucleotides, which encodes the signal peptide and all nine ectodomains in the protein...
  56. ncbi request reprint Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies
    Albena Dimitrova
    Department of Medical Genetics, Medical University Sofia, University Hospital Maichin Dom, Sofia, Bulgaria
    Psychiatr Genet 12:137-41. 2002
    ..2). The VNTR polymorphism in the 5-HTT gene does not appear to be a major risk factor for increasing susceptibility to major psychiatric disorders...
  57. ncbi request reprint Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Am J Med Genet 114:491-6. 2002
    ..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia...
  58. ncbi request reprint Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Genet 110:471-8. 2002
    ..Our assay conditions are generalisable, universal, robust and, therefore, for the first time, permit high-throughput association analysis at a realistic cost...
  59. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  60. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  61. doi request reprint Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
    ..We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder...
  62. pmc Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:152-62. 2006
    ..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles...
  63. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  64. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  65. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  66. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  67. ncbi request reprint Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:458-65. 2008
    ..Both genes have been affected by CNVs in patients with autism and mental retardation, but neither has been previously implicated in SZ...
  68. ncbi request reprint Strong evidence that GNB1L is associated with schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:555-66. 2008
    ..However, other explanations are possible, and further analyses will be required to clarify the correct functional mechanism...
  69. pmc A network of dopaminergic gene variations implicated as risk factors for schizophrenia
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Mol Genet 17:747-58. 2008
    ..Our data suggest that a network of dopaminergic polymorphisms increase risk for SZ...
  70. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  71. ncbi request reprint Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 141:96-101. 2006
    ....
  72. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004
  73. ncbi request reprint Genetics of epilepsy: epilepsy research foundation workshop report
    Sanjay Sisodiya
    Epilepsy Research Foundation, United Kingdom
    Epileptic Disord 9:194-236. 2007
    ..Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy...
  74. ncbi request reprint Family aggregation of high myopia: estimation of the sibling recurrence risk ratio
    Jane E Farbrother
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 45:2873-8. 2004
    ..To estimate the sibling recurrence risk (KS) and the sibling recurrence risk ratio (lambda(S)) for high myopia in a cohort in the United Kingdom...
  75. pmc Finding schizophrenia genes
    George Kirov
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    J Clin Invest 115:1440-8. 2005
    ..These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it...
  76. ncbi request reprint Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. families
    Jane E Farbrother
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 45:2879-85. 2004
    ..To determine the extent to which high myopia in a cohort of 51 U.K. families can be attributed to currently identified genetic loci...
  77. ncbi request reprint Underpowered repetitive transcranial magnetic stimulation might not be an effective antidepressant treatment
    George Kirov
    J Clin Psychiatry 66:543; author reply 543-4. 2005
  78. doi request reprint The effectiveness of electroconvulsive therapy in treatment-resistant depression: a naturalistic study
    Najeeb Khalid
    North Glamorgan NHS Trust, Merthyr Tydfil, Cardiff, UK
    J ECT 24:141-5. 2008
    ..We wanted to assess whether ECT is still highly effective in such a severely treatment-resistant population...
  79. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...