Ian R Jones

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
  2. pmc The effectiveness of exercise as a treatment for postnatal depression: study protocol
    Amanda J Daley
    Primary Care Clinical Sciences, School of Health and Population Sciences, University of Birmingham, Birmingham, UK
    BMC Pregnancy Childbirth 12:45. 2012
  3. pmc The Bipolar Interactive Psychoeducation (BIPED) study: trial design and protocol
    Sharon Simpson
    South East Wales Trials Unit, Department of Primary Care and Public Health, 7thfloor Neuadd Merionnydd, School of Medicine, Cardiff University, Heath Park, Cardiff, UK, CF14 4XN
    BMC Psychiatry 9:50. 2009
  4. ncbi request reprint Searching for the puerperal trigger: molecular genetic studies of bipolar affective puerperal psychosis
    Ian Jones
    Perinatal Psychiatry, Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Neuropsychiatric Genetics Group, Cardiff University, Cardiff, United Kingdom
    Psychopharmacol Bull 40:115-28. 2007
  5. ncbi request reprint Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16
    Ian Jones
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK
    Am J Psychiatry 164:1099-104. 2007
  6. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
  7. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
  8. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
  9. ncbi request reprint Anticipation and repeat expansion in bipolar disorder
    MICHAEL O'DONOVAN
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Am J Med Genet C Semin Med Genet 123:10-7. 2003
  10. doi request reprint P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
    Elaine K Green
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1063-9. 2009

Research Grants

  1. Genetics of Anorexia Nervosa
    Ian Jones; Fiscal Year: 2005

Detail Information

Publications35

  1. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
    ..Here molecular genetic analyses aimed at localizing and identifying the susceptibility gene in this region are reported...
  2. pmc The effectiveness of exercise as a treatment for postnatal depression: study protocol
    Amanda J Daley
    Primary Care Clinical Sciences, School of Health and Population Sciences, University of Birmingham, Birmingham, UK
    BMC Pregnancy Childbirth 12:45. 2012
    ....
  3. pmc The Bipolar Interactive Psychoeducation (BIPED) study: trial design and protocol
    Sharon Simpson
    South East Wales Trials Unit, Department of Primary Care and Public Health, 7thfloor Neuadd Merionnydd, School of Medicine, Cardiff University, Heath Park, Cardiff, UK, CF14 4XN
    BMC Psychiatry 9:50. 2009
    ..Psychoeducational interventions have emerged as promising long-term therapeutic options for bipolar disorder...
  4. ncbi request reprint Searching for the puerperal trigger: molecular genetic studies of bipolar affective puerperal psychosis
    Ian Jones
    Perinatal Psychiatry, Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Neuropsychiatric Genetics Group, Cardiff University, Cardiff, United Kingdom
    Psychopharmacol Bull 40:115-28. 2007
    ..We are undertaking association studies in women with postpartum psychosis at a number of candidate genes of interest in BP disorder with an emphasis on those for which the expression is influenced by steroid hormones...
  5. ncbi request reprint Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16
    Ian Jones
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK
    Am J Psychiatry 164:1099-104. 2007
    ..The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis...
  6. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  7. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  8. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  9. ncbi request reprint Anticipation and repeat expansion in bipolar disorder
    MICHAEL O'DONOVAN
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Am J Med Genet C Semin Med Genet 123:10-7. 2003
    ..No pathogenic triplet repeat has yet been unambiguously implicated...
  10. doi request reprint P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
    Elaine K Green
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1063-9. 2009
    ..Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders...
  11. ncbi request reprint Familiality of postpartum depression in unipolar disorder: results of a family study
    Liz Forty
    Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 163:1549-53. 2006
    ..The authors here examine whether vulnerability to postpartum triggering of depressive episodes aggregates in families and assess how this aggregation varies with the definition of postpartum onset...
  12. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  13. doi request reprint Is depression severity the sole cause of psychotic symptoms during an episode of unipolar major depression? A study both between and within subjects
    Liz Forty
    Department of Psychological Medicine, School of Medicine, Cardiff University, University Hospital of Wales, Cardiff, CF14 4XN, UK
    J Affect Disord 114:103-9. 2009
    ..Our aim was to answer the question: Is depression severity the sole cause of psychotic symptoms during an episode of unipolar major depression?..
  14. doi request reprint Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31
    Marian L Hamshere
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff, CF14 4XN, UK
    Bipolar Disord 11:610-20. 2009
    ..Findings in recent association studies at two specific genes suggest that the occurrence of mood-incongruent psychotic features may indicate a relatively homogeneous subset of the bipolar phenotype. We examined this hypothesis...
  15. doi request reprint Clinical characteristics of unipolar disorder and bipolar disorder according to the lifetime presence of recurrent panic attacks
    Liz Forty
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Bipolar Disord 11:307-15. 2009
    ..The frequent comorbidity of panic and affective disorders has been described in previous studies. However, it is not clear how panic disorder comorbidity in unipolar disorder and bipolar disorder is related to illness course...
  16. doi request reprint Polarity at illness onset in bipolar I disorder and clinical course of illness
    Liz Forty
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Bipolar Disord 11:82-8. 2009
    ..We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder...
  17. doi request reprint Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Affect Disord 116:23-9. 2009
    ..To assess whether bipolar disorder type I segregates into three clinically distinct sub-groups defined by age-at-onset...
  18. doi request reprint Identifying hypomanic features in major depressive disorder using the hypomania checklist (HCL-32)
    Liz Forty
    Department of Psychological Medicine, School of Medicine, Cardiff University, University Hospital of Wales, Cardiff, CF14 4XN, UK
    J Affect Disord 114:68-73. 2009
    ..We here examine the occurrence of hypomanic symptoms in individuals with a history of major depression selected to exclude indicators of underlying bipolarity...
  19. doi request reprint Clinical differences between bipolar and unipolar depression
    Liz Forty
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 192:388-9. 2008
    ..Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression...
  20. ncbi request reprint Obstetric variables associated with bipolar affective puerperal psychosis
    Emma Robertson Blackmore
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Cardiff, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Psychiatry 188:32-6. 2006
    ..These include: (a) primiparity, (b) pregnancy complications, (c) delivery complications, (d) Caesarean section, (e) female baby and (f) shorter gestation period...
  21. ncbi request reprint Risk of puerperal and non-puerperal recurrence of illness following bipolar affective puerperal (post-partum) psychosis
    Emma Robertson
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Psychiatry 186:258-9. 2005
    ..A history of bipolar episodes prior to the puerperal psychosis did not predict risk following subsequent pregnancies, but positive family history of mental illness predicted shorter time to non-puerperal relapse...
  22. ncbi request reprint Differences in depressive symptom profile between males and females
    Daniel J Smith
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, CF10 3XQ, UK
    J Affect Disord 108:279-84. 2008
    ..Here we compare the clinical profile of major depression for men and women from a sample of almost 600 well-characterized individuals with recurrent major depressive disorder (MDD)...
  23. doi request reprint Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
    Elaine K Green
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010
    ..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide Pā€‰=ā€‰0.0058; experiment-wide corrected significance Pā€‰=ā€‰0.052)...
  24. doi request reprint Reducing the Hypomania Checklist (HCL-32) to a 16-item version
    Liz Forty
    Department of Psychological Medicine, School of Medicine, Cardiff University, University Hospital of Wales, Cardiff, CF14 4XN, UK
    J Affect Disord 124:351-6. 2010
    ..In this study, we assess whether it is possible to reduce the number of items on the HCL-32 without any loss in the screening tool's ability to reliably differentiate between bipolar disorder (BD) and major depressive disorder (MDD)...
  25. pmc The Bipolar Affective Disorder Dimension Scale (BADDS)--a dimensional scale for rating lifetime psychopathology in bipolar spectrum disorders
    Nick Craddock
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 4:19. 2004
    ..This latter limitation is particularly pertinent in the context of the increasing evidence for the existence of a broader bipolar spectrum than has been acknowledged within existing classifications...
  26. doi request reprint Wake-up call for British psychiatry
    Nick Craddock
    Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 193:6-9. 2008
    ..On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients...
  27. doi request reprint Clinical questions and uncertainty--prolactin measurement in patients with schizophrenia and bipolar disorder
    James Walters
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Psychopharmacol 22:82-9. 2008
    ..We will identify the areas of uncertainty that remain for clinicians and consider the practical questions that future research should address...
  28. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  29. ncbi request reprint Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases
    Jin Yan
    Department of Molecular Genetics and Molecular Diagnosis, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Neurosci Lett 380:37-41. 2005
    ..In conclusion, we describe three novel structural variants of the Vitamin D receptor. Further study is required to clarify their role, if any, in psychiatric disease...
  30. ncbi request reprint Mutation scanning of the androgen receptor gene in patients with psychiatric disorders reveals highly conserved variants in alcoholic and phobia patients
    Jin Yan
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Psychiatr Genet 14:57-60. 2004
    ..R726L and P516S occur at highly conserved amino acids. Further study is required to assess whether these VAPSEs contribute to the risk of alcoholism or phobia or other diseases...
  31. ncbi request reprint MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism
    Akane Shibayama
    Department of Molecular Genetics and Diagnosis, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Am J Med Genet B Neuropsychiatr Genet 128:50-3. 2004
    ..009). These mutations suggest that a possible association between MECP2 mutations and autism may warrant further study...
  32. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  33. ncbi request reprint Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases
    Jinong Feng
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Am J Med Genet B Neuropsychiatr Genet 133:50-3. 2005
    ..One uncommon missense variant was found in each of the RARbeta, RARgamma, and RXRgamma genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia...
  34. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  35. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....

Research Grants4

  1. Genetics of Anorexia Nervosa
    Ian Jones; Fiscal Year: 2005
    ..The diagnostic and genetic data and lymphoblastoid cell lines (derived from blood samples) will become part of a national archival resource for genetic studies of AN through the NIMH Genetics Initiative. ..