Research Topics
| Philip E JamesSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumptionPhilip E James
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, United Kingdom
Nitric Oxide 6:18-28. 2002..These site-specific measurements of pO2 provide in vivo evidence that the principal cause of liver hypoxia during hypodynamic sepsis is reduced oxygen supply to the sinusoid and can be alleviated by maintaining sinusoidal perfusion...- Influence of neuronally derived nitric oxide on blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometryMatthew P Thomas
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine
Adv Exp Med Biol 540:257-63. 2003 - NO metabolite flux across the human coronary circulationStephen C Rogers
Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
Cardiovasc Res 75:434-41. 2007..Our objective was to identify whether oxygen drove apportion between various NO metabolite species across a single vascular bed... 
The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescenceAndrew G Pinder
Department of Cardiology, Wales Heart Research Institute, Cardiff University Medical School, Cardiff, UK
Methods Mol Biol 476:10-27. 2009..Hopefully, this guide will allow authors to make more informed decisions regarding NO metabolite measurement methodology, without the need for each subsequent group to rediscover previously observed advantages and pitfalls...- Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptidePhilip E James
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, U.K
Adv Exp Med Biol 530:645-52. 2003..The exact mechanism is unclear, but increased NO as a result of decreased superoxide production seems to play an important role in alleviating tissue hypoxia... - In vivo EPR spectroscopy: biomedical and potential diagnostic applicationsSimon K Jackson
Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK CF14 4XN
Faraday Discuss 126:103-17; discussion 169-83. 2004..The development and applications of these in vivo EPR techniques for biomedical research and diagnostics is discussed... - The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescenceAndrew G Pinder
Department of Cardiology, Wales Heart Research Institute, Cardiff University Medical School, Cardiff, UK
Methods Mol Biol 476:11-28. 2008..Hopefully, this guide will allow authors to make more informed decisions regarding NO metabolite measurement methodology, without the need for each subsequent group to rediscover previously observed advantages and pitfalls... - Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shockMelanie Madhani
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
Biochim Biophys Acta 1588:232-40. 2002..We propose that the beneficial effects of PR-39 on liver in this septic model were mediated by increased levels of local NO and preservation of oxygen supply to the liver sinusoids... - Direct formation of thienopyridine-derived nitrosothiols--just add nitrite!Shantu S Bundhoo
Section of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
Eur J Pharmacol 670:534-40. 2011.... - Variation in blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometryMatthew P Thomas
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK CF14 4XN
Adv Exp Med Biol 510:205-11. 2003 - Tissue oxygenation in sepsis; new insights from in vivo EPRPhilip E James
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
NMR Biomed 17:319-26. 2004..Repeat measures of these parameters can be made directly from a defined tissue site, allowing development of new models and experiments to study the defects in tissue and organ function seen in sepsis... - Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditionsThomas E Ingram
Department of Cardiology, Wales Heart Research Institute, University of Cardiff, Heath Park, Cardiff, CF14 4XN, United Kingdom
Adv Exp Med Biol 645:21-5. 2009..55% +/- 0.93%) relaxing less than Ao (42.20% +/- 5.21%). These results suggest that relatively low concentrations of sodium nitrite can vasodilate blood vessels. This effect is independent of haemoglobin and tissue specific... - Detection of human red blood cell-bound nitric oxideStephen C Rogers
Department of Cardiology, Wales Heart Research Institute, School of Medicine Cardiff University, Cardiff CF14 4XN
J Biol Chem 280:26720-8. 2005.... - Direct vasoactive properties of thienopyridine-derived nitrosothiolsShantu S Bundhoo
Department of Cardiology and Department of Pharmacology and Toxicology D L, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom
J Cardiovasc Pharmacol 58:550-8. 2011..Differences in SNO yield and vasoactivity exist between thienopyridine preparations that might be important to our understanding of the direct pharmacological effectiveness of thienopyridines on vascular and platelet function... - Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobinPhilip E James
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
Circ Res 94:976-83. 2004..These findings may represent an important contribution to reduced NO bioavailability in the microvasculature in diabetes... - Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxationAndrew G Pinder
Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
Adv Exp Med Biol 645:13-20. 2009..This data provides further evidence that the conformational switch of haemoglobin from the R-state (oxygenated) to the T-state (deoxygenated) is essential for the release of the vasoactive moiety contained within red blood cells... - Simultaneous detection of pO2 and NO by electron paramagnetic resonancePhilip E James
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
Methods Enzymol 359:52-66. 2002 
Oxygen mediates vascular smooth muscle relaxation in hypoxiaJessica Dada
Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
PLoS ONE 8:e57162. 2013..In the wider context, these observations are key to understanding the relative roles of O2 versus NO-induced sGC activation...- Oxygen indirectly regulates nitric oxide availabilityPhilip E James
Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff, Wales, UK
Adv Exp Med Biol 510:139-43. 2003 - Red blood cell-mediated hypoxic vasodilatation: a balanced physiological viewpointPhilip E James
Circ Res 95:e8-9. 2004 - Hypoxic modulation of exogenous nitrite-induced vasodilation in humansAbdul R Maher
Birmingham University, Birmingham, B15 2TT, United Kingdom
Circulation 117:670-7. 2008..The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia... - Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscleDamian M Bailey
Department of Physiology, Faculty of Life Sciences, University of Glamorgan, Pontypridd, UK
Free Radic Res 41:182-90. 2007..These findings provide the first direct evidence for intramuscular free radical accumulation and lipid peroxidation following acute exercise in humans...