Philip E James

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, United Kingdom
    Nitric Oxide 6:18-28. 2002
  2. ncbi request reprint Influence of neuronally derived nitric oxide on blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry
    Matthew P Thomas
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine
    Adv Exp Med Biol 540:257-63. 2003
  3. ncbi request reprint NO metabolite flux across the human coronary circulation
    Stephen C Rogers
    Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
    Cardiovasc Res 75:434-41. 2007
  4. doi request reprint The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence
    Andrew G Pinder
    Department of Cardiology, Wales Heart Research Institute, Cardiff University Medical School, Cardiff, UK
    Methods Mol Biol 476:10-27. 2009
  5. ncbi request reprint Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, U K
    Adv Exp Med Biol 530:645-52. 2003
  6. ncbi request reprint In vivo EPR spectroscopy: biomedical and potential diagnostic applications
    Simon K Jackson
    Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK CF14 4XN
    Faraday Discuss 126:103-17; discussion 169-83. 2004
  7. ncbi request reprint The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence
    Andrew G Pinder
    Department of Cardiology, Wales Heart Research Institute, Cardiff University Medical School, Cardiff, UK
    Methods Mol Biol 476:11-28. 2008
  8. ncbi request reprint Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock
    Melanie Madhani
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Biochim Biophys Acta 1588:232-40. 2002
  9. doi request reprint Direct formation of thienopyridine-derived nitrosothiols--just add nitrite!
    Shantu S Bundhoo
    Section of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Eur J Pharmacol 670:534-40. 2011
  10. ncbi request reprint Variation in blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry
    Matthew P Thomas
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK CF14 4XN
    Adv Exp Med Biol 510:205-11. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, United Kingdom
    Nitric Oxide 6:18-28. 2002
    ..These site-specific measurements of pO2 provide in vivo evidence that the principal cause of liver hypoxia during hypodynamic sepsis is reduced oxygen supply to the sinusoid and can be alleviated by maintaining sinusoidal perfusion...
  2. ncbi request reprint Influence of neuronally derived nitric oxide on blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry
    Matthew P Thomas
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine
    Adv Exp Med Biol 540:257-63. 2003
  3. ncbi request reprint NO metabolite flux across the human coronary circulation
    Stephen C Rogers
    Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
    Cardiovasc Res 75:434-41. 2007
    ..Our objective was to identify whether oxygen drove apportion between various NO metabolite species across a single vascular bed...
  4. doi request reprint The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence
    Andrew G Pinder
    Department of Cardiology, Wales Heart Research Institute, Cardiff University Medical School, Cardiff, UK
    Methods Mol Biol 476:10-27. 2009
    ..Hopefully, this guide will allow authors to make more informed decisions regarding NO metabolite measurement methodology, without the need for each subsequent group to rediscover previously observed advantages and pitfalls...
  5. ncbi request reprint Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, U K
    Adv Exp Med Biol 530:645-52. 2003
    ..The exact mechanism is unclear, but increased NO as a result of decreased superoxide production seems to play an important role in alleviating tissue hypoxia...
  6. ncbi request reprint In vivo EPR spectroscopy: biomedical and potential diagnostic applications
    Simon K Jackson
    Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK CF14 4XN
    Faraday Discuss 126:103-17; discussion 169-83. 2004
    ..The development and applications of these in vivo EPR techniques for biomedical research and diagnostics is discussed...
  7. ncbi request reprint The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence
    Andrew G Pinder
    Department of Cardiology, Wales Heart Research Institute, Cardiff University Medical School, Cardiff, UK
    Methods Mol Biol 476:11-28. 2008
    ..Hopefully, this guide will allow authors to make more informed decisions regarding NO metabolite measurement methodology, without the need for each subsequent group to rediscover previously observed advantages and pitfalls...
  8. ncbi request reprint Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock
    Melanie Madhani
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Biochim Biophys Acta 1588:232-40. 2002
    ..We propose that the beneficial effects of PR-39 on liver in this septic model were mediated by increased levels of local NO and preservation of oxygen supply to the liver sinusoids...
  9. doi request reprint Direct formation of thienopyridine-derived nitrosothiols--just add nitrite!
    Shantu S Bundhoo
    Section of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Eur J Pharmacol 670:534-40. 2011
    ....
  10. ncbi request reprint Variation in blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry
    Matthew P Thomas
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK CF14 4XN
    Adv Exp Med Biol 510:205-11. 2003
  11. ncbi request reprint Tissue oxygenation in sepsis; new insights from in vivo EPR
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    NMR Biomed 17:319-26. 2004
    ..Repeat measures of these parameters can be made directly from a defined tissue site, allowing development of new models and experiments to study the defects in tissue and organ function seen in sepsis...
  12. doi request reprint Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions
    Thomas E Ingram
    Department of Cardiology, Wales Heart Research Institute, University of Cardiff, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Adv Exp Med Biol 645:21-5. 2009
    ..55% +/- 0.93%) relaxing less than Ao (42.20% +/- 5.21%). These results suggest that relatively low concentrations of sodium nitrite can vasodilate blood vessels. This effect is independent of haemoglobin and tissue specific...
  13. ncbi request reprint Detection of human red blood cell-bound nitric oxide
    Stephen C Rogers
    Department of Cardiology, Wales Heart Research Institute, School of Medicine Cardiff University, Cardiff CF14 4XN
    J Biol Chem 280:26720-8. 2005
    ....
  14. doi request reprint Direct vasoactive properties of thienopyridine-derived nitrosothiols
    Shantu S Bundhoo
    Department of Cardiology and Department of Pharmacology and Toxicology D L, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Cardiovasc Pharmacol 58:550-8. 2011
    ..Differences in SNO yield and vasoactivity exist between thienopyridine preparations that might be important to our understanding of the direct pharmacological effectiveness of thienopyridines on vascular and platelet function...
  15. ncbi request reprint Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Circ Res 94:976-83. 2004
    ..These findings may represent an important contribution to reduced NO bioavailability in the microvasculature in diabetes...
  16. doi request reprint Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation
    Andrew G Pinder
    Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
    Adv Exp Med Biol 645:13-20. 2009
    ..This data provides further evidence that the conformational switch of haemoglobin from the R-state (oxygenated) to the T-state (deoxygenated) is essential for the release of the vasoactive moiety contained within red blood cells...
  17. ncbi request reprint Simultaneous detection of pO2 and NO by electron paramagnetic resonance
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Methods Enzymol 359:52-66. 2002
  18. doi request reprint Low-dose sodium nitrite attenuates myocardial ischemia and vascular ischemia-reperfusion injury in human models
    Thomas E Ingram
    Wales Heart Research Institute, Cardiff University Medical School, Cardiff, United Kingdom
    J Am Coll Cardiol 61:2534-41. 2013
    ..The aim of this study was to assess the potential benefits of inorganic nitrite in 2 clinical models: stress-induced myocardial ischemia and whole-arm ischemia-reperfusion...
  19. pmc Oxygen mediates vascular smooth muscle relaxation in hypoxia
    Jessica Dada
    Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    PLoS ONE 8:e57162. 2013
    ..In the wider context, these observations are key to understanding the relative roles of O2 versus NO-induced sGC activation...
  20. ncbi request reprint Oxygen indirectly regulates nitric oxide availability
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff, Wales, UK
    Adv Exp Med Biol 510:139-43. 2003
  21. ncbi request reprint Red blood cell-mediated hypoxic vasodilatation: a balanced physiological viewpoint
    Philip E James
    Circ Res 95:e8-9. 2004
  22. doi request reprint Hypoxic modulation of exogenous nitrite-induced vasodilation in humans
    Abdul R Maher
    Birmingham University, Birmingham, B15 2TT, United Kingdom
    Circulation 117:670-7. 2008
    ..The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia...
  23. ncbi request reprint Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle
    Damian M Bailey
    Department of Physiology, Faculty of Life Sciences, University of Glamorgan, Pontypridd, UK
    Free Radic Res 41:182-90. 2007
    ..These findings provide the first direct evidence for intramuscular free radical accumulation and lipid peroxidation following acute exercise in humans...