Marian L Hamshere

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs
    Elin S Blom
    Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    BMC Med Genet 10:122. 2009
  2. doi request reprint Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Affect Disord 116:23-9. 2009
  3. pmc Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    BMC Proc 1:S100. 2007
  4. pmc Covariate linkage analysis of GAW14 simulated data incorporating subclinical phenotype, sex, population, parent-of-origin, and interaction
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, Cardiff University, Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Genet 6:S45. 2005
  5. doi request reprint Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
    Elaine K Green
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010
  6. pmc Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
    Marian L Hamshere
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Br J Psychiatry 203:107-11. 2013
  7. doi request reprint Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
  8. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
  9. ncbi request reprint Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
  10. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011

Collaborators

Detail Information

Publications20

  1. pmc Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs
    Elin S Blom
    Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    BMC Med Genet 10:122. 2009
    ..Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes...
  2. doi request reprint Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Affect Disord 116:23-9. 2009
    ..To assess whether bipolar disorder type I segregates into three clinically distinct sub-groups defined by age-at-onset...
  3. pmc Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    BMC Proc 1:S100. 2007
    ....
  4. pmc Covariate linkage analysis of GAW14 simulated data incorporating subclinical phenotype, sex, population, parent-of-origin, and interaction
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, Cardiff University, Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Genet 6:S45. 2005
    ..Focusing on a randomly chosen replicate (42) we investigated the effect of the 12 subclinical phenotypes, sex, population, and parent-of-origin on the linkage signal from a model-free linkage analysis of Kofendrerd Personality Disorder...
  5. doi request reprint Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
    Elaine K Green
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010
    ..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052)...
  6. pmc Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
    Marian L Hamshere
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Br J Psychiatry 203:107-11. 2013
    ..There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants...
  7. doi request reprint Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 156:929-40. 2011
    ..At present there are no genome-wide significant linkage results for these phenotypes, but a number of suggestive findings warrant further investigation...
  8. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
    ..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes...
  9. ncbi request reprint Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  10. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
    ..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10))...
  11. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)...
  12. doi request reprint Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..7 × 10(-5)). Including earlier reported data for trans-disorder effects for ZNF804A and CACNA1C, six out of eight of the most robustly associated loci for either disorder show trans-disorder effects...
  13. pmc Combining linkage data sets for meta-analysis and mega-analysis: the GAW15 rheumatoid arthritis data set
    Ricardo Segurado
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Proc 1:S104. 2007
    ..The two approaches were compared, and give strong support to the HLA locus on chromosome 6 as a susceptibility locus. Other regions of interest include loci on chromosomes 11, 2, and 12...
  14. doi request reprint Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31
    Marian L Hamshere
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff, CF14 4XN, UK
    Bipolar Disord 11:610-20. 2009
    ..Findings in recent association studies at two specific genes suggest that the occurrence of mood-incongruent psychotic features may indicate a relatively homogeneous subset of the bipolar phenotype. We examined this hypothesis...
  15. doi request reprint Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia
    Detelina Grozeva
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    Arch Gen Psychiatry 67:318-27. 2010
    ..The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date...
  16. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  17. pmc Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests
    Beate Glaser
    Biostatistics and Bioinformatics Unit, and Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff, Wales, CF14 4XN, UK
    BMC Proc 1:S54. 2007
    ..Follow-up analysis, such as by LR, is required since RFs do not indicate high-risk genotype combinations...
  18. ncbi request reprint Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
    ..To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment...
  19. pmc Factor structure of autistic traits in children with ADHD
    Joanna Martin
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    J Autism Dev Disord 44:204-15. 2014
    ..Moreover, the study also finds that there is some overlap across hyperactive-impulsive symptoms and RRB traits in children with ADHD, which merits further investigation. ..
  20. pmc High loading of polygenic risk for ADHD in children with comorbid aggression
    Marian L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    Am J Psychiatry 170:909-16. 2013
    ..The findings also highlight the fact that aggression in ADHD indexes genetic as well as clinical severity. ..