Jeremy A Guggenheim

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Similar genetic susceptibility to form-deprivation myopia in three strains of chicken
    Jeremy A Guggenheim
    Department of Optometry and Vision Sciences, Cardiff University, CF10 3NB, Cardiff, UK
    Vision Res 42:2747-56. 2002
  2. pmc Correlations in refractive errors between siblings in the Singapore Cohort Study of Risk factors for Myopia
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales CF10 3NB, UK
    Br J Ophthalmol 91:781-4. 2007
  3. doi Axes of astigmatism in fellow eyes show mirror rather than direct symmetry
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, UK
    Ophthalmic Physiol Opt 28:327-33. 2008
  4. ncbi Postnatal refractive development in the Brown Norway rat: limitations of standard refractive and ocular component dimension measurement techniques
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, UK
    Curr Eye Res 29:369-76. 2004
  5. pmc Myopia, genetics, and ambient lighting at night in a UK sample
    J A Guggenheim
    Cardiff University, Cathays Park, Cardiff, UK
    Br J Ophthalmol 87:580-2. 2003
  6. doi Heritability of ocular component dimensions in chickens: genetic variants controlling susceptibility to experimentally induced myopia and pretreatment eye size are distinct
    Yen Po Chen
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK
    Invest Ophthalmol Vis Sci 52:4012-20. 2011
  7. doi Selective breeding for susceptibility to myopia reveals a gene-environment interaction
    Yen Po Chen
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Invest Ophthalmol Vis Sci 52:4003-11. 2011
  8. doi Sex, eye size, and the rate of myopic eye growth due to form deprivation in outbred white leghorn chickens
    Yen Po Chen
    School of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 51:651-7. 2010
  9. ncbi Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. families
    Jane E Farbrother
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 45:2879-85. 2004
  10. doi Common determinants of body size and eye size in chickens from an advanced intercross line
    Ankush Prashar
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, Wales, UK
    Exp Eye Res 89:42-8. 2009

Collaborators

Detail Information

Publications29

  1. ncbi Similar genetic susceptibility to form-deprivation myopia in three strains of chicken
    Jeremy A Guggenheim
    Department of Optometry and Vision Sciences, Cardiff University, CF10 3NB, Cardiff, UK
    Vision Res 42:2747-56. 2002
    ..In contrast, the strains used here would be ideal for use in mapping QTL controlling normal ocular component dimensions...
  2. pmc Correlations in refractive errors between siblings in the Singapore Cohort Study of Risk factors for Myopia
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales CF10 3NB, UK
    Br J Ophthalmol 91:781-4. 2007
    ..The prevalence of myopia in parts of South East Asia has risen dramatically over the past 1-2 generations, suggesting that environmental factors may be particularly important determinants of refractive development in these populations...
  3. doi Axes of astigmatism in fellow eyes show mirror rather than direct symmetry
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, UK
    Ophthalmic Physiol Opt 28:327-33. 2008
    ..However, there is controversy over whether the astigmatic axes in fellow eyes typically show direct or mirror symmetry. We carried out a statistical analysis designed to address this issue...
  4. ncbi Postnatal refractive development in the Brown Norway rat: limitations of standard refractive and ocular component dimension measurement techniques
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, UK
    Curr Eye Res 29:369-76. 2004
    ..This study aimed to provide normative data in the strain of rat being used for the rat genome sequencing project whilst also evaluating standard measurement techniques...
  5. pmc Myopia, genetics, and ambient lighting at night in a UK sample
    J A Guggenheim
    Cardiff University, Cathays Park, Cardiff, UK
    Br J Ophthalmol 87:580-2. 2003
    ..It has been reported that exposure to artificial lighting at night during the first 2 years of life was very strongly associated with subsequent myopia development...
  6. doi Heritability of ocular component dimensions in chickens: genetic variants controlling susceptibility to experimentally induced myopia and pretreatment eye size are distinct
    Yen Po Chen
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK
    Invest Ophthalmol Vis Sci 52:4012-20. 2011
    ..The genetic variants controlling susceptibility to visually induced myopia in chicks are different from those controlling normal eye size...
  7. doi Selective breeding for susceptibility to myopia reveals a gene-environment interaction
    Yen Po Chen
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Invest Ophthalmol Vis Sci 52:4003-11. 2011
    ..Additive genetic effects explained ∼50% of the interanimal variability in response to DSV. Conclusions. Genes and environment interact to shape refractive development in chicks...
  8. doi Sex, eye size, and the rate of myopic eye growth due to form deprivation in outbred white leghorn chickens
    Yen Po Chen
    School of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 51:651-7. 2010
    ..Therefore, this study was undertaken to test whether the greater rate of myopic eye growth in males is a consequence of their larger eyes or of some other aspect of their sex...
  9. ncbi Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. families
    Jane E Farbrother
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 45:2879-85. 2004
    ..To determine the extent to which high myopia in a cohort of 51 U.K. families can be attributed to currently identified genetic loci...
  10. doi Common determinants of body size and eye size in chickens from an advanced intercross line
    Ankush Prashar
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, Wales, UK
    Exp Eye Res 89:42-8. 2009
    ..Furthermore, adjusting for body size will be essential in mapping pure eye size QTL in this chicken population, and may also have value in mapping eye size QTL in humans...
  11. doi Heritability of ocular component dimensions in mice phenotyped using depth-enhanced swept source optical coherence tomography
    Ling Wang
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, Wales, UK
    Exp Eye Res 93:482-90. 2011
    ..OCT with extended depth range scanning can be used to rapidly phenotype individual mice with sufficient accuracy and precision to permit gene mapping studies...
  12. pmc Ex vivo magnetic resonance imaging of crystalline lens dimensions in chicken
    Rebecca J Tattersall
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Mol Vis 16:144-53. 2010
    ....
  13. doi Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickens
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Ophthalmic Physiol Opt 31:516-28. 2011
    ..Hence, we tested whether pre-treatment choroidal thickness predicted susceptibility to myopia...
  14. pmc Myocilin polymorphisms and high myopia in subjects of European origin
    Tetyana Zayats
    1School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK
    Mol Vis 15:213-22. 2009
    ..In two of the studies, a significant association was found while in the third, there was no association. We sought to investigate the association between high myopia and polymorphisms in MYOC in subjects of European ethnicity...
  15. doi Season of birth, daylight hours at birth, and high myopia
    George McMahon
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Ophthalmology 116:468-73. 2009
    ..We sought to investigate whether these associations were evident in subjects from the United Kingdom (UK)...
  16. ncbi Family aggregation of high myopia: estimation of the sibling recurrence risk ratio
    Jane E Farbrother
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 45:2873-8. 2004
    ..To estimate the sibling recurrence risk (KS) and the sibling recurrence risk ratio (lambda(S)) for high myopia in a cohort in the United Kingdom...
  17. ncbi Graphics processing unit-based dispersion encoded full-range frequency-domain optical coherence tomography
    Ling Wang
    Cardiff University, School of Optometry and Vision Sciences, Maindy Road, Cardiff, CF24 4LU, United Kingdom
    J Biomed Opt 17:077007. 2012
    ..Implemented on a commercial low-cost GPU, a display line rate of ∼21,000 depth scans/s for 2048 samples/depth scan using 10 iterations of the fast DEFR algorithm has been achieved, sufficient for real-time visualization in situ...
  18. ncbi Anisometropia is independently associated with both spherical and cylindrical ametropia
    Xue Jiao Qin
    School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    Invest Ophthalmol Vis Sci 46:4024-31. 2005
    ..To explore the associations between anisometropia and spherical ametropia, astigmatism, age, and sex...
  19. doi Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye
    Ling Wang
    Cardiff University, School of Optometry and Vision Sciences, Wales, United Kingdom
    J Biomed Opt 15:046004. 2010
    ..g., day-to-day reproducibility of axial length measurement +/-5.3 microm) that is insensitive to eye motion sufficient for long-term monitoring...
  20. pmc Time outdoors and physical activity as predictors of incident myopia in childhood: a prospective cohort study
    Jeremy A Guggenheim
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 53:2856-65. 2012
    ..Time spent in "sports/outdoor activity" has shown a negative association with incident myopia during childhood. We investigated the association of incident myopia with time spent outdoors and physical activity separately...
  21. ncbi The association between spherical and cylindrical component powers
    Jeremy A Guggenheim
    Department of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
    Optom Vis Sci 81:62-3. 2004
  22. pmc Quality of DNA extracted from mouthwashes
    Tetyana Zayats
    School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    PLoS ONE 4:e6165. 2009
    ..Buccal cells are an attractive source of DNA, as their collection is non-invasive and can be carried out by mail. However, little attention has been given to the quality of DNA extracted from mouthwashes...
  23. ncbi Chloride channel gene expression in the rabbit cornea
    Natalie Davies
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Mol Vis 10:1028-37. 2004
    ..However, the ion transport pathways that operate to maintain stromal hydration have yet to be fully elucidated...
  24. ncbi Is active glucose transport present in bovine ciliary body epithelium?
    Chu Yan Chan
    School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    Am J Physiol Cell Physiol 292:C1087-93. 2007
    ..The elucidation of the exact function of SGLT2 in the bovine CBE may shed important light on the glucose transport and physiology of the BAB and inform future studies of glycemic control in relation to diabetic cataract formation...
  25. ncbi Astigmatic axis is related to the level of spherical ametropia
    Jane E Farbrother
    Department of Optometry and Vision Sciences, Cardiff University, United Kingdom
    Optom Vis Sci 81:18-26. 2004
    ..In this study, we evaluated the relationship between astigmatic axis and the level of spherical ametropia in both myopes and hypermetropes...
  26. ncbi Proteases in eye development and disease
    Michael A Wride
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Birth Defects Res C Embryo Today 78:90-105. 2006
    ..It is clear that proteases have diverse and important roles in ocular development and disease, and represent, in many cases, useful therapeutic targets for treating ocular conditions, which would otherwise lead to visual impairment...
  27. ncbi A chick retinal proteome database and differential retinal protein expressions during early ocular development
    Thomas C Lam
    Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
    J Proteome Res 5:771-84. 2006
    ..Proteomic technology may provide a high throughput platform for advancing eye research in the feasible future...
  28. ncbi Simultaneous defocus integration during refractive development
    Dennis Y Tse
    Center for Myopia Research, School of Optometry, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 48:5352-9. 2007
    ..To determine the effects of simultaneously presented myopic and hyperopic defocus on the refractive development of chicks...
  29. ncbi Application of fluorescence difference gel electrophoresis technology in searching for protein biomarkers in chick myopia
    Thomas C Lam
    Laboratory of Experimental Optometry, Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon
    J Proteome Res 6:4135-49. 2007
    ..We have optimized a workable protocol for the study of the differential retinal protein expressions in the LIM using 2D-DIGE approach which was shown to have a number of advantages over the traditional 2D electrophoresis technique...