Jeremy A Guggenheim

..In contrast, the strains used here would be ideal for use in mapping QTL controlling normal ocular component dimensions...

..The prevalence of myopia in parts of South East Asia has risen dramatically over the past 1-2 generations, suggesting that environmental factors may be particularly important determinants of refractive development in these populations...

..However, there is controversy over whether the astigmatic axes in fellow eyes typically show direct or mirror symmetry. We carried out a statistical analysis designed to address this issue...

..This study aimed to provide normative data in the strain of rat being used for the rat genome sequencing project whilst also evaluating standard measurement techniques...

..It has been reported that exposure to artificial lighting at night during the first 2 years of life was very strongly associated with subsequent myopia development...

..The genetic variants controlling susceptibility to visually induced myopia in chicks are different from those controlling normal eye size...

..Additive genetic effects explained ∼50% of the interanimal variability in response to DSV. Conclusions. Genes and environment interact to shape refractive development in chicks...

..Therefore, this study was undertaken to test whether the greater rate of myopic eye growth in males is a consequence of their larger eyes or of some other aspect of their sex...

..Thus, additional loci for high myopia are likely to be the cause of the majority of cases of high myopia in the United Kingdom...

..Furthermore, adjusting for body size will be essential in mapping pure eye size QTL in this chicken population, and may also have value in mapping eye size QTL in humans...

..OCT with extended depth range scanning can be used to rapidly phenotype individual mice with sufficient accuracy and precision to permit gene mapping studies...

....

..Hence, we tested whether pre-treatment choroidal thickness predicted susceptibility to myopia...

..In two of the studies, a significant association was found while in the third, there was no association. We sought to investigate the association between high myopia and polymorphisms in MYOC in subjects of European ethnicity...

..We sought to investigate whether these associations were evident in subjects from the United Kingdom (UK)...

..Instead, it may be necessary to consider high myopia as a "complex disease" resulting from the influence of either alleles of reduced penetrance ("susceptibility genes"), environmental factors, or both...

..Implemented on a commercial low-cost GPU, a display line rate of ∼21,000 depth scans/s for 2048 samples/depth scan using 10 iterations of the fast DEFR algorithm has been achieved, sufficient for real-time visualization in situ...

....

..g., day-to-day reproducibility of axial length measurement +/-5.3 microm) that is insensitive to eye motion sufficient for long-term monitoring...

..Time spent in "sports/outdoor activity" has shown a negative association with incident myopia during childhood. We investigated the association of incident myopia with time spent outdoors and physical activity separately...

..Buccal cells are an attractive source of DNA, as their collection is non-invasive and can be carried out by mail. However, little attention has been given to the quality of DNA extracted from mouthwashes...

..These channels are likely to be important for the maintenance of corneal transparency...

..The elucidation of the exact function of SGLT2 in the bovine CBE may shed important light on the glucose transport and physiology of the BAB and inform future studies of glycemic control in relation to diabetic cataract formation...

..Low ametropes, particularly myopes, were more likely to have axes ATR...

..It is clear that proteases have diverse and important roles in ocular development and disease, and represent, in many cases, useful therapeutic targets for treating ocular conditions, which would otherwise lead to visual impairment...

..Proteomic technology may provide a high throughput platform for advancing eye research in the feasible future...

..To determine the effects of simultaneously presented myopic and hyperopic defocus on the refractive development of chicks...

..We have optimized a workable protocol for the study of the differential retinal protein expressions in the LIM using 2D-DIGE approach which was shown to have a number of advantages over the traditional 2D electrophoresis technique...