C R Flannery

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage
    C R Flannery
    Connective Tissue Biology Research Group, Cardiff School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, UK
    Matrix Biol 19:549-53. 2000
  2. ncbi Expression and activity of articular cartilage hyaluronidases
    C R Flannery
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PreClinical Buildings, Cardiff, Wales, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 251:824-9. 1998
  3. ncbi Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism
    C R Flannery
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PreClinical Buildings, Cardiff, Wales, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 254:535-41. 1999
  4. ncbi Expression of ADAMTS homologues in articular cartilage
    C R Flannery
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PreClinical Buildings, Cardiff, Wales, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 260:318-22. 1999
  5. ncbi Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
    C R Flannery
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Wales, UK
    Matrix Biol 18:225-37. 1999
  6. pmc Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
    C B Little
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF1 3US, Wales, U K
    Biochem J 344:61-8. 1999
  7. ncbi n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation
    C L Curtis
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, United Kingdom
    J Biol Chem 275:721-4. 2000
  8. pmc Catabolism of aggrecan, decorin and biglycan in tendon
    S G Rees
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, U K
    Biochem J 350:181-8. 2000
  9. ncbi Molecular cloning and sequence analysis of the aggrecan interglobular domain from porcine, equine, bovine and ovine cartilage: comparison of proteinase-susceptible regions and sites of keratan sulfate substitution
    C R Flannery
    Connective Tissue Biology Laboratories, School of Molecular and Medical Biosciences, University of Wales, Cardiff, UK
    Matrix Biol 16:507-11. 1998
  10. ncbi Mechanisms involved in cartilage proteoglycan catabolism
    B Caterson
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Wales, Cardiff, UK
    Matrix Biol 19:333-44. 2000

Collaborators

Detail Information

Publications16

  1. ncbi IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage
    C R Flannery
    Connective Tissue Biology Research Group, Cardiff School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, UK
    Matrix Biol 19:549-53. 2000
    ..This catabolism was associated with aggrecanase (but not MMP) activity, with correlative mRNA expression for aggrecanase-2...
  2. ncbi Expression and activity of articular cartilage hyaluronidases
    C R Flannery
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PreClinical Buildings, Cardiff, Wales, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 251:824-9. 1998
    ....
  3. ncbi Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism
    C R Flannery
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PreClinical Buildings, Cardiff, Wales, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 254:535-41. 1999
    ..Modifications to the structure of SZP, coupled with inhibition of SZP synthesis during inflammation, may account for the attachment and invasion of pannus observed in inflammatory joint diseases...
  4. ncbi Expression of ADAMTS homologues in articular cartilage
    C R Flannery
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, PreClinical Buildings, Cardiff, Wales, CF1 3US, United Kingdom
    Biochem Biophys Res Commun 260:318-22. 1999
    ..quot;..
  5. ncbi Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
    C R Flannery
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Wales, UK
    Matrix Biol 18:225-37. 1999
    ....
  6. pmc Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
    C B Little
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF1 3US, Wales, U K
    Biochem J 344:61-8. 1999
    ..This study demonstrates that the release of aggrecan from both normal and OA cartilage in response to catabolic stimulation in vitro involves a primary cleavage by aggrecanase and not MMPs...
  7. ncbi n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation
    C L Curtis
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, United Kingdom
    J Biol Chem 275:721-4. 2000
    ....
  8. pmc Catabolism of aggrecan, decorin and biglycan in tendon
    S G Rees
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, U K
    Biochem J 350:181-8. 2000
    ....
  9. ncbi Molecular cloning and sequence analysis of the aggrecan interglobular domain from porcine, equine, bovine and ovine cartilage: comparison of proteinase-susceptible regions and sites of keratan sulfate substitution
    C R Flannery
    Connective Tissue Biology Laboratories, School of Molecular and Medical Biosciences, University of Wales, Cardiff, UK
    Matrix Biol 16:507-11. 1998
    ..Similarly, known sites of keratan sulfate attachment in the IGD are highly conserved in all species. The results provide essential amino acid sequence data for species commonly used in model systems of cartilage degeneration...
  10. ncbi Mechanisms involved in cartilage proteoglycan catabolism
    B Caterson
    Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Wales, Cardiff, UK
    Matrix Biol 19:333-44. 2000
    ..Furthermore, the catabolism of link proteins by MMPs is also initiated when overt collagen degradation is evident...
  11. ncbi A mechanism underlying the movement requirement for synovial joint cavitation
    G P Dowthwaite
    School of Biosciences and Cardiff Institute of Tissue Engineering and Repair, University of Wales Cardiff, PO Box 900, Museum Avenue, Cardiff CF10 3US, UK
    Matrix Biol 22:311-22. 2003
    ..These results show that cell-matrix interactions modify the response of embryonic cells to mechanical strain and provide further insight into the mechano-dependent mechanism of joint cavity morphogenesis...
  12. ncbi Bioregulation of lubricin expression by growth factors and cytokines
    A R C Jones
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, MA 02140, USA
    Eur Cell Mater 13:40-5; discussion 45. 2007
    ..Collectively, the results of studies on cytokine and growth factor regulation of lubricin biosynthesis and biodistribution may help provide new insights and therapeutic perspectives for promoting joint function...
  13. ncbi Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains
    J D Sandy
    Shriners Hospital for Crippled Children, Tampa Unit, Florida 33612
    J Biol Chem 266:8198-205. 1991
    ....
  14. ncbi Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration
    C B Little
    Raymond Purves Bone and Joint Research Laboratories, University of Sydney at the Royal North Shore Hospital, St Leonards 2065, NSW, Australia
    Osteoarthritis Cartilage 13:162-70. 2005
    ..To determine whether the focal susceptibility to cartilage degeneration in joints is related to a differential response to cytokine stimulation...
  15. pmc The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain
    J D Sandy
    Shriners Hospital for Crippled Children, Tampa, Florida 33612
    J Clin Invest 89:1512-6. 1992
    ..S. 1991. Acta Orthop. Scand. 62:623-632) is promoted by the action of a normal cartilage proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain...
  16. ncbi Boundary mode frictional properties of engineered cartilaginous tissues
    J P Gleghorn
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Eur Cell Mater 14:20-8; discussion 28-9. 2007
    ....