W Howard Evans

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Lighting up gap junction channels in a flash
    W Howard Evans
    Department of Medical Biochemistry and Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Bioessays 24:876-80. 2002
  2. ncbi Gap junctions: structure and function (Review)
    W Howard Evans
    Department of Medical Biochemistry and Diagnostic Radiology, University of Wales College of Medicine, Cardiff, UK
    Mol Membr Biol 19:121-36. 2002
  3. ncbi Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins
    Vandana Verma
    Department of Medical Biochemistry and Immunology, Cardiff University Medical School, Heath Park, Cardiff, Wales, UK
    Eur J Cell Biol 88:79-90. 2009
  4. ncbi Manipulating connexin communication channels: use of peptidomimetics and the translational outputs
    W Howard Evans
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    J Membr Biol 245:437-49. 2012
  5. ncbi Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size
    Rodney S Berman
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, Wales, United Kingdom
    Microvasc Res 63:115-28. 2002
  6. ncbi Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy
    Jian Yang
    Department of Medical Biochemistry and Immunology, Cardiff University Medical School, Cardiff, Wales, UK
    Cell Commun Adhes 16:138-45. 2009
  7. ncbi ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide
    Thomas C Clarke
    Department of Medical Biochemistry and Immunology and Wales Heart Research Institute, Cardiff University, Cardiff, Wales, UK
    Eur J Pharmacol 605:9-14. 2009
  8. ncbi The gap junction cellular internet: connexin hemichannels enter the signalling limelight
    W Howard Evans
    Department of Medical Biochemistry and Immunology and the Wales Heart Research Institute, Cardiff University Medical School, Cardiff CF14 4XN, Wales, UK
    Biochem J 397:1-14. 2006
  9. ncbi Mimetic peptides as blockers of connexin channel-facilitated intercellular communication
    W Howard Evans
    Department of Medical Biochemistry and Immunology, Wales Heart Research Institute Cardiff University Medical School, Heath Park, Cardiff, UK
    Cell Commun Adhes 14:265-73. 2007
  10. ncbi Incorporation of connexins into plasma membranes and gap junctions
    Patricia E M Martin
    Department of Medical Biochemistry and Immunology and Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Cardiovasc Res 62:378-87. 2004

Collaborators

Detail Information

Publications25

  1. ncbi Lighting up gap junction channels in a flash
    W Howard Evans
    Department of Medical Biochemistry and Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Bioessays 24:876-80. 2002
    ....
  2. ncbi Gap junctions: structure and function (Review)
    W Howard Evans
    Department of Medical Biochemistry and Diagnostic Radiology, University of Wales College of Medicine, Cardiff, UK
    Mol Membr Biol 19:121-36. 2002
    ..Genetic ablation approaches are helping to map out a connexin code and point to specific connexins being required for cell growth and differentiation as well as underwriting basic intercellular communication...
  3. ncbi Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins
    Vandana Verma
    Department of Medical Biochemistry and Immunology, Cardiff University Medical School, Heath Park, Cardiff, Wales, UK
    Eur J Cell Biol 88:79-90. 2009
    ..Since calcium signalling is fundamental to the maintenance of cellular homeostasis, connexin hemichannels emerge as therapeutic targets open to manipulation by reagents interacting with external regions of these channels...
  4. ncbi Manipulating connexin communication channels: use of peptidomimetics and the translational outputs
    W Howard Evans
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    J Membr Biol 245:437-49. 2012
    ..Cx peptidomimetics show promise as candidates in developing new therapeutic approaches for containing and reversing damage inflicted on CxHcs, especially in hypoxia and ischemia in the heart and in brain functions...
  5. ncbi Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size
    Rodney S Berman
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, Wales, United Kingdom
    Microvasc Res 63:115-28. 2002
    ....
  6. ncbi Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy
    Jian Yang
    Department of Medical Biochemistry and Immunology, Cardiff University Medical School, Cardiff, Wales, UK
    Cell Commun Adhes 16:138-45. 2009
    ..The results concur with the hypothesis that bone marrow cells elicit improved cardiac function through release of undefined paracrine mediators...
  7. ncbi ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide
    Thomas C Clarke
    Department of Medical Biochemistry and Immunology and Wales Heart Research Institute, Cardiff University, Cardiff, Wales, UK
    Eur J Pharmacol 605:9-14. 2009
    ....
  8. ncbi The gap junction cellular internet: connexin hemichannels enter the signalling limelight
    W Howard Evans
    Department of Medical Biochemistry and Immunology and the Wales Heart Research Institute, Cardiff University Medical School, Cardiff CF14 4XN, Wales, UK
    Biochem J 397:1-14. 2006
    ....
  9. ncbi Mimetic peptides as blockers of connexin channel-facilitated intercellular communication
    W Howard Evans
    Department of Medical Biochemistry and Immunology, Wales Heart Research Institute Cardiff University Medical School, Heath Park, Cardiff, UK
    Cell Commun Adhes 14:265-73. 2007
    ..A mechanism is proposed to help explain the dual action of connexin mimetic peptides on connexin hemichannels and gap-junctional coupling...
  10. ncbi Incorporation of connexins into plasma membranes and gap junctions
    Patricia E M Martin
    Department of Medical Biochemistry and Immunology and Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    Cardiovasc Res 62:378-87. 2004
    ..This mechanism of channel assembly is highly dependent on microtubule integrity and may allow cells to rapidly modulate gap junctional cross talk...
  11. ncbi Gap junction intercellular communication during lymphocyte transendothelial migration
    Ernesto Oviedo-Orta
    Department of Medical Biochemistry, University of Wales College of Medicine, HeathPark Cardiff, CF14 4XN, UK
    Cell Biol Int 26:253-63. 2002
    ..Although gap junctional communication was inhibited by connexin mimetic peptides, they had little influence on the transmigration process...
  12. ncbi CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro
    Alexandra Bermudez Fajardo
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    J Leukoc Biol 82:608-12. 2007
    ..Therefore, a further mechanism featuring gap junction-mediated communication may be implicated in immune regulation...
  13. ncbi Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor
    Elke De Vuyst
    Department of Physiology and Pathophysiology, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
    Mol Biol Cell 18:34-46. 2007
    ....
  14. ncbi The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43
    Thomas C Clarke
    Department of Medical Biochemistry and Immunology and Wales Heart Research Institute, Cardiff University, Cardiff, Wales
    Br J Pharmacol 147:486-95. 2006
    ..We conclude that the effects of rotigaptide were confined to cells expressing Cx43...
  15. ncbi Intracellular calcium changes trigger connexin 32 hemichannel opening
    Elke De Vuyst
    Department of Physiology and Pathophysiology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    EMBO J 25:34-44. 2006
    ..Our results indicate that [Ca2+]i elevation triggers hemichannel opening, and suggest that these channels are under physiological control...
  16. ncbi Altered permeability and modulatory character of connexin channels during mammary gland development
    Darren Locke
    Department of Pharmacology and Physiology, UMDNJ, Newark, NJ 07101, USA
    Exp Cell Res 298:643-60. 2004
    ..Connexin channel stoichiometry, permeability, and chemical gating character change in precisely the desired fashion after parturition to maximize molecular and electrical coupling to support coordinated milk secretion...
  17. ncbi Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26
    Katleen Braet
    Department of Physiology and Pathophysiology, Ghent University, De Pintelaan 185, Block B, Room 306, Ghent B-9000, Belgium
    Cell Calcium 33:37-48. 2003
    ..Photoliberating calcium did not trigger intercellular calcium waves or ATP release. We conclude that InsP(3)-triggered ATP release through connexin hemichannels contributes to the intercellular propagation of calcium signals...
  18. ncbi Connexin channels, connexin mimetic peptides and ATP release
    Luc Leybaert
    Department of Physiology and Pathophysiology, Ghent University, Ghent, Belgium
    Cell Commun Adhes 10:251-7. 2003
    ..Work performed up to now with these peptides should be re-interpreted in terms of these new findings...
  19. ncbi Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells
    Katleen Braet
    Department of Physiology and Pathophysiology, Ghent University, De Pintelaan, Ghent, Belgium
    J Cell Physiol 197:205-13. 2003
    ....
  20. ncbi Gap junctions and connexins: potential contributors to the immunological synapse
    Ernesto Oviedo-Orta
    Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
    J Leukoc Biol 72:636-42. 2002
    ..The increasing structural and functional evidence points to a potential role that lymphocyte gap junctional intercellular communication may play within the complex signaling components of the immunological synapse...
  21. ncbi Epidermal stem cells do not communicate through gap junctions
    Maja Matic
    Department of Oral Biology and Pathology, SUNY at Stony Brook, New York 11794, USA
    J Invest Dermatol 118:110-6. 2002
    ..Thus, presumptive keratinocyte stem cells can be identified and separated based on connexin 43 expression...
  22. ncbi Cell-cell communication in heterocellular cultures of alveolar epithelial cells
    Brant E Isakson
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Respir Cell Mol Biol 29:552-61. 2003
    ..In conclusion, AT1 and AT2 cells have unique connexin profiles that allow for functional coupling and distinct intercellular pathways for coordination of Ca2+ signaling...
  23. ncbi Adenosine stimulates connexin 43 expression and gap junctional communication in pituitary folliculostellate cells
    B Mary Lewis
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    FASEB J 20:2585-7. 2006
    ..These data suggest that adenosine, formed locally in the anterior pituitary gland can stimulate gap junction communication in FS cells...
  24. ncbi Post-translational integration and oligomerization of connexin 26 in plasma membranes and evidence of formation of membrane pores: implications for the assembly of gap junctions
    Shoeb Ahmad
    Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, U.K
    Biochem J 365:693-9. 2002
    ....
  25. ncbi Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels
    Mark S Turner
    Department of Molecular and Cellular Pharmacology, University of Miami, Fla, USA
    Circ Res 95:726-33. 2004
    ..The role of this regulated phosphorylation in the adaptation to ischemia remains to be determined...