R J Errington
Affiliation: Cardiff University
- A transfer function approach to measuring cell inheritancePaul Rees
Centre for Nanohealth, School of Engineering, Swansea University, Swansea, SA2 8PP, UK
BMC Syst Biol 5:31. 2011....
- Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cellsR J Errington
Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
Adv Drug Deliv Rev 57:153-67. 2005..Finally, we discuss the future perspectives on introducing these modular kinetic assays in the high-content screening arena and the interlinking of the consequences of drug-target interactions with cellular stress responses...
- Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channelsP E Martin
Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
J Cell Sci 114:3845-55. 2001....
- Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopyP J Smith
Department of Pathology, University of Wales College of Medicine, Cardiff, United Kingdom
Cytometry 40:280-91. 2000..We describe here the spectral characteristics and applications of this synthetic compound, particularly in relation to cytometric analysis of the cell cycle...
- Gap junction assembly: multiple connexin fluorophores identify complex trafficking pathwaysP E Martin
Wales Heart Research Institute and Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
Cell Commun Adhes 8:243-8. 2001..The results indicate that multiple intracellular connexin trafficking routes exist and provide a further mechanism for regulating the connexin composition of gap junctions and thus specificity in intercellular signalling...
- Tracking the cell cycle origins for escape from topotecan action by breast cancer cellsG P Feeney
Department of Pathalogy, University of Wales College of Medicine, Cardiff, UK
Br J Cancer 88:1310-7. 2003..31 microM). Overall, topotecan differentially targeted G1-, S- and G2-phase cells, but many G2 cells were resistant to topotecan, presenting a clear route for cell cycle-mediated drug resistance...
- Technique for measurement of fluorescence lifetime by use of stroboscopic excitation and continuous-wave detectionD R Matthews
School of Physics and Astronomy, Cardiff University, 5 The Parade, Cardiff CF24 3YB, UK
Appl Opt 45:2115-23. 2006..An experimental demonstration of the technique that uses a cuvette-based analysis of a carbocyanine dye and for which the excitation source is a 650 nm wavelength, self-pulsing AlGaInP laser diode is compared with the model...
- Cytomics and drug developmentPaul J Smith
Department of Pathology, Wales College of Medicine, Cardiff University, United Kingdom
Cytometry A 71:349-51. 2007
- A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecanM J Chappell
School of Engineering, University of Warwick, Coventry, UK
Comput Methods Programs Biomed 89:169-78. 2008..The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels...