Research Topics
| R EcclesSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Efficacy of inferior turbinate coblation for treatment of nasal obstructionS E J Farmer
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
J Laryngol Otol 123:309-14. 2009..To determine the efficacy of inferior turbinate coblation for the treatment of nasal obstruction...
Mechanical induction of cough in Idiopathic Pulmonary FibrosisRichard M Jones
Respiratory Unit, Morriston Hospital, Heol Maes Eglwys, Swansea, SA6 6NL, UK
Cough 7:2. 2011..abstract:..
Changes in the amplitude of the nasal cycle associated with symptoms of acute upper respiratory tract infectionR Eccles
Common Cold and Nasal Research Centre, Univeristy of Wales College of Cardiff, UK
Acta Otolaryngol 116:77-81. 1996....
Menthol: effects on nasal sensation of airflow and the drive to breatheRonald Eccles
Common Cold and Nasal Research Centre, Cardiff School of Biosciences, Biomedical Building, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
Curr Allergy Asthma Rep 3:210-4. 2003....
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and fluR Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
J Clin Pharm Ther 31:309-19. 2006..The aim of this review was to determine the safety and efficacy of the analgesics, aspirin, paracetamol and aspirin for the treatment of colds and flu...
Effects of acetylsalicylic acid on sore throat pain and other pain symptoms associated with acute upper respiratory tract infectionRon Eccles
Common Cold Centre, Cardiff University, UK
Pain Med 4:118-24. 2003..The objective of this study was to investigate the efficacy and safety of ASA for the treatment of sore throat pain associated with URTI...
Mechanisms of the placebo effect of sweet cough syrupsRonald Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Respir Physiol Neurobiol 152:340-8. 2006..The idea is developed that a sweet taste may modulate cough at the level of the nucleus tractus solitarius, possibly by influencing the production of endogenous opioids...
Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common coldRonald Eccles
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Curr Med Res Opin 26:889-99. 2010..However, most studies have investigated its clinical efficacy in healthy patients and few have included patients with common cold...
The nasal decongestant effect of xylometazoline in the common coldRonald Eccles
Common Cold Centre and Healthcare Clinical Trials, Cardiff University, Cardiff, United Kingdom
Am J Rhinol 22:491-6. 2008..The purpose of this study was to characterize objectively and subjectively the decongestant and additional effects of xylometazoline in the common cold...
Cough induced by mechanical stimulation of the upper airway in humansPatrick Lee
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff UK
Acta Otolaryngol 124:720-5. 2004..We also wished to investigate if there was any difference in cough sensitivity between healthy subjects and those with acute upper respiratory tract infection (URTI)...
Understanding the symptoms of the common cold and influenzaRon Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Lancet Infect Dis 5:718-25. 2005..The mechanisms of symptoms of sore throat, rhinorrhoea, sneezing, nasal congestion, cough, watery eyes, and sinus pain are discussed, since these mechanisms are not dealt with in any detail in standard medical textbooks...
Acute cooling of the body surface and the common coldR Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, United Kingdom
Rhinology 40:109-14. 2002....
A guide to practical aspects of measurement of human nasal airflow by rhinomanometryR Eccles
Common Cold Centre and Healthcare Clinical Trials Cardiff School of Biosciences, Cardiff University, United Kingdom
Rhinology 49:2-10. 2011....
The power of the placeboRon Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Curr Allergy Asthma Rep 7:100-4. 2007..An understanding of the placebo and nocebo effects is important for general allergy practice, and harnessing the power of the true placebo effect is a major challenge to modern medicine...
Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuseRonald Eccles
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Br J Clin Pharmacol 63:10-4. 2007..Restrictions on sales of PDE to the public may not reduce the problems associated with methamphetamine abuse...
Nasal airflow in health and diseaseR Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, UK
Acta Otolaryngol 120:580-95. 2000....
The nasal cycle in respiratory defenceR B Eccles
Common Cold and Nasal Research Centre, Cardiff School of Biosciences, Cardiff University, United Kingdom
Acta Otorhinolaryngol Belg 54:281-6. 2000....
Mechanisms of the symptoms of rhinosinusitisR Eccles
Common Cold Centre and Healthcare Clinical Trials Cardiff School of Biosciences, Cardiff University, United Kingdom
Rhinology 49:131-8. 2011..The mechanism of unilateral nasal obstruction with rhinosinusitis is discussed...
An explanation for the seasonality of acute upper respiratory tract viral infectionsR Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, UK
Acta Otolaryngol 122:183-91. 2002..A case is also made to suggest that warming of the nasal airway during fever and nasal congestion may help to resolve a current URTI...
The powerful placebo in cough studies?R Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
Pulm Pharmacol Ther 15:303-8. 2002..With active pharmacological ingredients contributing only 15% to the effects of cough treatment it seems reasonable to conduct more research on the other components of treatment such as placebo...
Importance of placebo effect in cough clinical trialsRon Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, Wales, UK
Lung 188:S53-61. 2010..The placebo effect in clinical trials may be controlled by use of a crossover design, where feasible, and the changes in the magnitude of the placebo effect in this study design are discussed...
Do chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic reviewJ Boyce
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol 31:15-9. 2006..Such studies provide evidence that reduced nasal airflow causes no significant nasal disease. . There is no convincing evidence that a reduction in nasal airflow is a causative factor for rhinitis or sinusitis...
Normal nasal patency: problems in obtaining standard reference values for the surgeonM Moore
Common Cold Centre, Cardiff University, Wales, UK
J Laryngol Otol 126:563-9. 2012..Rather than classify populations according to unscientific categories such as race, anthropometric measures such as the nasal index are proposed...
Effect of submucosal diathermy to the inferior turbinates on unilateral and total nasal airflow in patients with rhinitisS M Quine
Department of Otolaryngology, University Hospital of Wales, Cardiff, UK
Acta Otolaryngol 119:911-5. 1999..The importance of considering the nose as two separate airways in the evaluation of nasal treatments is emphasized...
Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infectionR Eccles
Common Cold Centre, Cardiff University, Cardiff, UK
Curr Med Res Opin 22:2411-8. 2006..The additive effect of the combination was apparent for both single and multiple doses...
Nasal congestion: mechanisms, measurement and medications. Core information for the clinicianS S Davis
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol Allied Sci 29:659-66. 2004....
The relationship between nasal index and nasal airway resistance, and response to a topical decongestantN M Doddi
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Rhinology 49:583-6. 2011..02). The absence of any physiological differences between the different nose types may be due to acclimatisation of participants to the area of recruitment...
Chronic inferior turbinate enlargement and the implications for surgical interventionS E J Farmer
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
Rhinology 44:234-8. 2006..The underlying pathology of turbinate enlargement has important implications for the surgical management of nasal obstruction...
Coblation® inferior turbinate reduction: a long-term follow-up with subjective and objective assessmentS C Leong
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, and Deaprtment of Otolaryngology Head and Neck Surgery, University Hospital of Wales, Cardiff, Wales, UK
Rhinology 48:108-12. 2010..Although there was improvement in the subjective assessment of nasal obstruction, this did not achieve statistical significance...
Assessment of subjective scales for selection of patients for nasal septal surgeryJ M Boyce
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol 31:297-302. 2006....
Evidence for correlation of objective and subjective measures of nasal airflow in patients with common coldJ D Clarke
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol 30:35-8. 2005..To utilize posterior rhinomanometry and conductance, as units of measurement, to further investigate the relationship between subjective and objective measures of nasal airflow...
The use of nasal spirometry as an objective measure of nasal septal deviation and the effectiveness of septal surgeryP J Cuddihy
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol Allied Sci 28:325-30. 2003..01), and with patient subjective symptom assessment r= 0.94 (P < 0.01) preoperatively and r= 0.51 (P < 0.01) postoperatively. The findings indicate that nasal spirometry may be useful in patient selection for septal surgery...
Postnasal drip syndrome. Two hundred years of controversy between UK and USAA Sanu
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Rhinology 46:86-91. 2008..Current research on treating excessive airway mucus in the lower airways may be applicable to PNDS...
[Cough induction by high-frequency chest percussion in healthy volunteers and patients with common cold]P C L Lee
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Respir Med 98:771-6. 2004..This method of inducing cough in subjects with URTI may be useful for studies on the mechanism of cough and for studies on antitussive medicines...
Objective evidence for the efficacy of surgical management of the deviated septum as a treatment for chronic nasal obstruction: a systematic reviewM Moore
Common Cold Centre, Cardiff University, Cardiff, UK
Clin Otolaryngol 36:106-13. 2011..Nasal septal surgery is a common procedure, but there are concerns that the benefits of this surgery are mainly cosmetic...
The effects of a hot drink on nasal airflow and symptoms of common cold and fluA Sanu
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
Rhinology 46:271-5. 2008..In conclusion the results support the folklore that a hot tasty drink is a beneficial treatment for relief of most symptoms of common cold and flu...
A clinical study to evaluate the efficacy of the antihistamine doxylamine succinate in the relief of runny nose and sneezing associated with upper respiratory tract infectionR Eccles
Common Cold and Nasal Research Centre, University of Wales, Cardiff, UK
J Pharm Pharmacol 47:990-3. 1995..Of the expected side-effects, 13.3% of doxylamine-treated patients reported drowsiness. The incidence of sedative effects was lower than has been reported for other commonly used first-generation antihistamines...
Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infectionR Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Pulm Pharmacol Ther 17:337-42. 2004..The airway vibration model of cough may have some advantages over inhaled tussigens as the stimulus is easily controlled and the method is safe for use in children...
The use of nasal spirometry for the assessment of unilateral nasal obstruction associated with changes in posture in healthy subjects and subjects with upper respiratory tract infectionP J Cuddihy
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol Allied Sci 28:108-11. 2003..The results illustrate the incidence of complete unilateral nasal obstruction associated with URTI when lying flat and demonstrate the usefulness of nasal spirometry in studying nasal airflow partitioning in health and disease...
The use of race as a demographic variable in clinical researchS C Leong
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, United Kingdom
Rhinology 48:3-6. 2010..Researchers continue to categorise demograpic variables according to racial lines despite the fact that the definition of race has no scientific or anthropological validity...
Coughing and choking in motor neuron diseaseS Hadjikoutis
Department of Medicine Neurology, University of Wales College of Medicine, Cardiff, UK
J Neurol Neurosurg Psychiatry 68:601-4. 2000..To assess the frequency and severity of coughing and choking episodes, possible related factors, and their association with chest infections in patients with motor neuron disease (MND)...
The role of anthropometric measurements in nasal surgery and research: a systematic reviewN M Doddi
Common Cold Centre, Cardiff University, Cardiff, UK
Clin Otolaryngol 35:277-83. 2010..Data of average nasal anthropometric values for various ethnic groups is promoted to be of great importance in planning aesthetic nasal surgery, but there may be fundamental problems with this approach...
A systematic review of the nasal index and the significance of the shape and size of the nose in rhinologyS C Leong
Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol 34:191-8. 2009..There was great interest in the 19th and early 20th century in classifying human races as Caucasian, Asian African etc. according to nasal shape and size, and the nasal index was the most commonly used measurement to differentiate races...
Voluntary control of coughP C L Lee
Common Cold Centre, Cardiff School of Biosciences, Cardiff, CF10 3US, UK
Pulm Pharmacol Ther 15:317-20. 2002..A cough model demonstrating the voluntary and reflex control of cough in man is proposed. A hypothesis is proposed that cough associated with common cold is a mixture of both reflex and voluntary cough...
Use of a portable spirometer for studies on the nasal cycleJ Hanif
Common Cold Center, University of Cardiff, Cardiff School of Biosciences, United Kingdom
Am J Rhinol 15:303-6. 2001..Spirometry has considerable advantages over rhinomanometry for studies on the nasal cycle because of portability and ease of use...
Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled TrialM Jawad
Common Cold Centre and Healthcare, Cardiff University, Cardiff CF10 3XQ, UK
Evid Based Complement Alternat Med 2012:841315. 2012..Conclusions. Compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio...
Paradoxical increase in nasal airway resistance following a topical nasal decongestant sprayN M Doddi
Common Cold Centre, Cardiff University, Cardiff, CF10 3AX, United Kingdom
Rhinology 49:127. 2011..Nasal obstruction is a very common problem associated with common cold and topical nasal decongestant sprays are effective symptomatic treatments causing a decrease in nasal airway resistance (NAR)...
Understanding submucosal electrosurgery for the treatment of nasal turbinate enlargementS E J Farmer
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, UK
J Laryngol Otol 121:615-22. 2007....
What, if any, is the value of septal surgery?D G Roblin
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol Allied Sci 27:77-80. 2002
Efficacy and safety of topical combinations of ipratropium and xylometazoline for the treatment of symptoms of runny nose and nasal congestion associated with acute upper respiratory tract infectionRonald Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, United Kingdom
Am J Rhinol 21:40-5. 2007..This study investigated the efficacy and safety of a combination nasal spray of ipratropium and xylometazoline for simultaneous treatment of these symptoms...
Efficacy and safety of single and multiple doses of pseudoephedrine in the treatment of nasal congestion associated with common coldRonald Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, United Kingdom
Am J Rhinol 19:25-31. 2005..Support for the decongestant efficacy of multiple doses of pseudoephedrine is provided by objective measures on day 3 and subjective measures made over three days, but not by the VAS scores on day 3...
Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality?Jonathan D Clarke
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Acta Otolaryngol 125:1307-11. 2005..Improved methods for measuring nasal sensations are required to further investigate the relationship between objective and subjective measures of nasal obstruction...
How good are patients at determining which side of the nose is more obstructed? A study on the limits of discrimination of the subjective assessment of unilateral nasal obstructionJonathan D Clarke
Common Cold Center, Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
Am J Rhinol 20:20-4. 2006..The aim of this study was to measure the minimum difference in unilateral airflow that can be reliably detected by a patient...
"Drink plenty of fluids": no harm in fluids for colds and fluRonald Eccles
BMJ 328:957-8; author reply 958. 2004
Acute cooling of the feet and the onset of common cold symptomsClaire Johnson
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Fam Pract 22:608-13. 2005..CONCLUSION: Acute chilling of the feet causes the onset of common cold symptoms in around 10% of subjects who are chilled. Further studies are needed to determine the relationship of symptom generation to any respiratory infection...
Normal range for nasal partitioning of airflow determined by nasal spirometry in 100 healthy subjectsD Graham Roblin
Common Cold Center Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
Am J Rhinol 17:179-83. 2003..A case may be made that patients on the waiting list that fall within the normal range of NPR are unlikely to benefit from septal surgery because their nasal passages are not greatly asymmetrical...
Re: effects of unilateral naris closure on the nasal and maxillary sinus mucosa in rabbit by Seung-Heon Shin and Won-Wook Heo, Auris Nasus Larynx 32 (2005) 139-143Ronald Eccles
Auris Nasus Larynx 33:117; author reply 119. 2006
