Affiliation: Cardiff University
Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed publisher
..Targeting of γδ T-APC functions may lead to the development of novel gut-directed immunotherapies and vaccines. ..
Bonneville M, Chen Z, DÃ©chanet Merville J, Eberl M, FourniÃ© J, Jameson J, et al
. Chicago 2014--30 years of Î³Î´ T cells. Cell Immunol. 2015;296:3-9 pubmed publisher
..This conference was organized by Zheng Chen from 16 to 18 May 2014 at his home institution, the University of Illinois College of Medicine, and boasted 180 attendants from all over the world and almost 100 submitted abstracts. ..
Tyler C, Doherty D, Moser B, Eberl M. Human VÎ³9/VÎ´2 T cells: Innate adaptors of the immune system. Cell Immunol. 2015;296:10-21 pubmed publisher
..Although the direct physiological relevance for most of these mechanisms still needs to be demonstrated in vivo, these findings may have implications for novel therapies, diagnostic tests and vaccines. ..
Liuzzi A, McLaren J, Price D, Eberl M. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Curr Opin Immunol. 2015;36:31-7 pubmed publisher
Liuzzi A, Kift Morgan A, Lopez Anton M, Friberg I, Zhang J, Brook A, et al
. Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling. J Immunol. 2016;197:2195-207 pubmed publisher
..These findings are likely to be applicable to other acute infections where local activation of unconventional T cells contributes to the antimicrobial inflammatory response. ..
Vermijlen D, Gatti D, Kouzeli A, Rus T, Eberl M. γδ T cell responses: How many ligands will it take till we know?. Semin Cell Dev Biol. 2018;84:75-86 pubmed publisher
..We here review the latest progress in the identification and validation of putative γδ T cell ligands and discuss the implications of such findings for γδ T cell responses in health and disease. ..
Zhang J, Friberg I, Kift Morgan A, Parekh G, Morgan M, Liuzzi A, et al
. Machine-learning algorithms define pathogen-specific local immune fingerprints inÂ peritoneal dialysis patients with bacterial infections. Kidney Int. 2017;92:179-191 pubmed publisher
..Thus, our data establish the power of non-linear mathematical models to analyze complex biomedical datasets and highlight key pathways involved in pathogen-specific immune responses. ..
Eberl M, Roberts G, Meuter S, Williams J, Topley N, Moser B. A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog. 2009;5:e1000308 pubmed publisher
Eberl M, Moser B. Monocytes and gammadelta T cells: close encounters in microbial infection. Trends Immunol. 2009;30:562-8 pubmed publisher
..Vgamma9/Vdelta2 T cells act thus as a cellular switch between innate and adaptive defence mechanisms...