S B Dunnett

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease
    Stephen B Dunnett
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, South Wales, UK Electronic address
    Neurobiol Dis 61:79-89. 2014
  2. doi request reprint Neural tissue transplantation, repair, and rehabilitation
    Stephen B Dunnett
    Department of Biosciences, The Brain Repair Group, Cardiff University, Cardiff, Wales, UK
    Handb Clin Neurol 110:43-59. 2013
  3. doi request reprint A novel extended sequence learning task (ESLeT) for rodents: validation and the effects of amphetamine, scopolamine and striatal lesions
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Wales, UK
    Brain Res Bull 88:237-50. 2012
  4. doi request reprint Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Wales, UK
    Brain Res Bull 88:251-60. 2012
  5. doi request reprint Clinical translation of cell transplantation in the brain
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff, South Wales, UK
    Curr Opin Organ Transplant 16:632-9. 2011
  6. doi request reprint Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff, South Wales, UK
    Prog Brain Res 184:35-51. 2010
  7. pmc Cell therapy in Huntington's disease
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom
    NeuroRx 1:394-405. 2004
  8. ncbi request reprint Cell transplantation for Huntington's disease Should we continue?
    Stephen B Dunnett
    Cardiff University, Cardiff, Wales, UK
    Brain Res Bull 72:132-47. 2007
  9. ncbi request reprint Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, Wales, UK
    Exp Neurol 199:479-89. 2006
  10. ncbi request reprint Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat
    S B Dunnett
    School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, Wales, UK
    Neuroscience 135:1055-65. 2005

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease
    Stephen B Dunnett
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, South Wales, UK Electronic address
    Neurobiol Dis 61:79-89. 2014
    ....
  2. doi request reprint Neural tissue transplantation, repair, and rehabilitation
    Stephen B Dunnett
    Department of Biosciences, The Brain Repair Group, Cardiff University, Cardiff, Wales, UK
    Handb Clin Neurol 110:43-59. 2013
    ....
  3. doi request reprint A novel extended sequence learning task (ESLeT) for rodents: validation and the effects of amphetamine, scopolamine and striatal lesions
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Wales, UK
    Brain Res Bull 88:237-50. 2012
    ..The ESLeT task provides a new test with distinctive advantages for the analysis of vigilance, serial responding and procedural motor learning in animal models of human neurodegenerative disease...
  4. doi request reprint Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Wales, UK
    Brain Res Bull 88:251-60. 2012
    ..This article is part of a special issue entitled 'Behavioural, Anatomical, and Genetic Characterisation of Mouse and Rat Models of Huntington's Disease.'..
  5. doi request reprint Clinical translation of cell transplantation in the brain
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff, South Wales, UK
    Curr Opin Organ Transplant 16:632-9. 2011
    ....
  6. doi request reprint Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff, South Wales, UK
    Prog Brain Res 184:35-51. 2010
    ....
  7. pmc Cell therapy in Huntington's disease
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom
    NeuroRx 1:394-405. 2004
    ..Pilot and experimental clinical trials of several approaches are now also underway, and the alternative strategies are compared...
  8. ncbi request reprint Cell transplantation for Huntington's disease Should we continue?
    Stephen B Dunnett
    Cardiff University, Cardiff, Wales, UK
    Brain Res Bull 72:132-47. 2007
    ....
  9. ncbi request reprint Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, Wales, UK
    Exp Neurol 199:479-89. 2006
    ....
  10. ncbi request reprint Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat
    S B Dunnett
    School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, Wales, UK
    Neuroscience 135:1055-65. 2005
    ....
  11. ncbi request reprint Stem cell transplantation for Huntington's disease
    Stephen B Dunnett
    The Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Exp Neurol 203:279-92. 2007
    ....
  12. ncbi request reprint Reverse transcription of inserted DNA in a monkey gives us ANDi
    S B Dunnett
    School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff, UK CF10 3US
    Trends Pharmacol Sci 22:211-5. 2001
    ..The opportunities and benefits offered by this technology are significant but must be carefully balanced against the particular practical, ethical and financial costs involving the use of primates in experimental medicine...
  13. pmc Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age
    E M Torres
    Department of Biosciences, Cardiff University, Biomedical Sciences Building, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Brain Res Bull 68:31-41. 2005
    ....
  14. doi request reprint Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease
    R C Trueman
    School of Biosciences, Cardiff University, Museum Avenue, Box 911, Cardiff CF10 3AX, Wales, UK
    Behav Brain Res 203:215-22. 2009
    ..The present results demonstrate that Hdh(Q92/Q92) mice do exhibit clear impairments on a range of sensory, motor, motivational and cognitive tests, provided appropriate sensitive tasks are used...
  15. ncbi request reprint Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests
    S P Brooks
    School of Biosciences, Cardiff University, and UWCM, Cardiff, UK
    Genes Brain Behav 4:307-17. 2005
    ....
  16. ncbi request reprint Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease
    E M Torres
    Department of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Neuroscience 146:1606-17. 2007
    ..We consider the in vivo conditions which allow this differentiation to occur, and the implications for the future of clinical trials based on dopamine cell replacement therapy...
  17. doi request reprint Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease
    R C Trueman
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Brain Res Bull 88:163-70. 2012
    ....
  18. doi request reprint Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease
    R C Trueman
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Brain Res Bull 88:156-62. 2012
    ..This indicates that if appropriately sensitive tasks are used, the more subtle and specific Hdh(Q92) knock-in model could be of use for the examination of pathogenic mechanisms in Huntington's disease and to test potential therapeutics...
  19. ncbi request reprint Ascorbic acid increases the number of dopamine neurons in vitro and in transplants to the 6-OHDA-lesioned rat brain
    V Bagga
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Cell Transplant 17:763-73. 2008
    ....
  20. ncbi request reprint Differential effects of unilateral striatal and nigrostriatal lesions on grip strength, skilled paw reaching and drug-induced rotation in the rat
    R A Jeyasingham
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, UK
    Brain Res Bull 55:541-8. 2001
    ..The results are discussed in the context of the utility, reliability and validity of alternative tests of motor deficit in animal models of Parkinson's and Huntington's diseases...
  21. ncbi request reprint Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease
    E M Torres
    Department of Biosciences, Biomedical Sciences Building, Museum Avenue, Cardiff University, PO Box 911 Cardiff South Glamorgan, UK
    Neuroscience 154:631-40. 2008
    ....
  22. doi request reprint Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates
    E M Torres
    Department of Biosciences, Cardiff University, Biomedical Sciences Building, Museum Avenue Cardiff CF10 3AX, UK
    J Neurosci Methods 200:29-35. 2011
    ....
  23. doi request reprint Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT)
    Rebecca C Trueman
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Behav Brain Res 189:317-24. 2008
    ..The deficit previously found in accuracy and reaction time was present at all ages examined in these Hdh(Q92/Q92) mice; the deficit was not progressive, and did not correlate with the evolution of neuronal nuclear inclusions...
  24. doi request reprint Medical terminations of pregnancy: a viable source of tissue for cell replacement therapy for neurodegenerative disorders
    C M Kelly
    Brain Repair Group, School of Biosciences, Cardiff University, UK
    Cell Transplant 20:503-13. 2011
    ....
  25. ncbi request reprint Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease
    A Hodges
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Cardiff, United Kingdom
    Genes Brain Behav 7:288-99. 2008
    ..This indicates that multiple behavioral tasks assessing different behavioral domains are likely to be necessary in therapeutic trials in mouse models of HD...
  26. ncbi request reprint The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease
    Rebecca C Trueman
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, UK
    Eur J Neurosci 25:551-8. 2007
    ....
  27. ncbi request reprint An operant serial implicit learning task (SILT) in rats: task acquisition, performance and the effects of striatal lesions
    Julia R Jay
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff, Wales CF10 3US, UK
    J Neurosci Methods 163:235-44. 2007
    ..These data establish a novel and efficient operant test for implicit learning in the rat...
  28. ncbi request reprint Training specificity, graft development and graft-mediated functional recovery in a rodent model of Huntington's disease
    M D Döbrössy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    Neuroscience 132:543-52. 2005
    ..The results support the hypothesis that unilateral training sensitizes the striatum that subserves the motor learning, leading to exacerbated excitotoxic lesions and to an environment less conducive for graft development...
  29. ncbi request reprint A rat embryo staging scale for the generation of donor tissue for neural transplantation
    E M Torres
    Department of Biosciences, Cardiff University, Cardif, UK
    Cell Transplant 17:535-42. 2008
    ..We show that CRL is a highly accurate, reproducible index of donor age and we present an updated embryonic staging scale for Sprague-Dawley (CD) rats that includes donor ages younger than those previously reported...
  30. doi request reprint Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space
    M J Lelos
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
    Eur J Neurosci 36:3420-8. 2012
    ....
  31. pmc In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system
    E M Torres
    Department of Biosciences, Cardiff University Museum Avenue, PO Box 911 Cardiff CF10 3US, UK
    Brain Res Mol Brain Res 137:1-10. 2005
    ....
  32. ncbi request reprint Challenges facing quantification of rat locomotion along beams of varying widths
    J K Madete
    Research Office, School of Engineering, Cardiff University, Queens Building, Cardiff CF24 3AA, UK
    Proc Inst Mech Eng H 224:1257-65. 2010
    ..Such measurements can be compared with human motion analysis to explore correlations between the animal model and human behaviour, which is an important step for translational medicine...
  33. ncbi request reprint The Corridor Task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum
    Eilis Dowd
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, CF10 3US Wales, UK
    Brain Res Bull 68:24-30. 2005
    ..We conclude that the Corridor Task is a sensitive test of lateralised sensorimotor response selection, and is suitable for assessing deficits and recovery associated with lesions and grafts within the nigrostriatal system...
  34. ncbi request reprint Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model
    Christelle Monville
    Cardiff University, Cardiff CF10 3US, UK
    J Neurosci Methods 158:219-23. 2006
    ..We report that whereas the incremental protocol is more sensitive to detect the presence of a lesion, the accelerating protocol provides a more discriminative test to correlate motor deficits against lesion size...
  35. ncbi request reprint Optimising plasticity: environmental and training associated factors in transplant-mediated brain repair
    Màtè Dàniel Döbrössy
    The Brain Repair Group, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Rev Neurosci 16:1-21. 2005
    ..With the proof of principle beginning to emerge from clinical trials, a rich area for innovative research with profound therapeutic application, even broader than the specific context of transplantation, is now opening for investigation...
  36. ncbi request reprint Striatal neurons in striatal grafts are derived from both post-mitotic cells and dividing progenitors
    Rosemary A Fricker-Gates
    School of Biosciences, Cardiff University, Cardiff, Wales
    Eur J Neurosci 19:513-20. 2004
    ....
  37. ncbi request reprint Free operant and discrete trial performance of mice in the nine-hole box apparatus: validation using amphetamine and scopolamine
    Jean Charles Bensadoun
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Box 911, Cardiff CF10 3US, Wales, UK
    Psychopharmacology (Berl) 174:396-405. 2004
    ....
  38. ncbi request reprint The role of pretraining on skilled forelimb use in an animal model of Huntington's disease
    R A Fricker-Gates
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Cell Transplant 12:257-64. 2003
    ..These results suggest that animals should be pretrained on the staircase task prior to lesion to enable maximum sensitivity in detecting both loss and recovery of function of skilled forelimb use...
  39. ncbi request reprint The staircase test of skilled reaching in mice
    A L Baird
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Brain Res Bull 54:243-50. 2001
    ....
  40. ncbi request reprint Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's disease
    A E Rosser
    School of Biosciences, Cardiff University, PO Box 911, Museum Av, Cardiff CF10 3US, Wales, UK
    Cell Transplant 12:679-86. 2003
    ....
  41. ncbi request reprint Neural transplantation: restoring complex circuitry in the striatum
    R A Fricker-Gates
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, UK
    Restor Neurol Neurosci 19:119-38. 2001
    ....
  42. ncbi request reprint Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task
    Simon P Brooks
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Brain Res 1185:179-88. 2007
    ..The present data suggest that the striatum is important for the acquisition and retention of motor learning tasks, but does not play a role in the learning of implicit information...
  43. ncbi request reprint Implicit learning in a serial choice visual discrimination task in the operant 9-hole box by intact and striatal lesioned mice
    Rebecca C Trueman
    School of Bioscience, Cardiff University, Museum Avenue Box 911, Cardiff CF103US, Wales, UK
    Behav Brain Res 159:313-22. 2005
    ....
  44. ncbi request reprint Environmental housing and duration of exposure affect striatal graft morphology in a rodent model of Huntington's disease
    Mate D Dobrossy
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Cell Transplant 17:1125-34. 2008
    ....
  45. ncbi request reprint Aberrant dopamine transmission and cognitive dysfunction in animal models of Parkinson's disease
    M J Lelos
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, UK
    J Parkinsons Dis 1:151-65. 2011
    ....
  46. doi request reprint Context-driven changes in L-DOPA-induced behaviours in the 6-OHDA lesioned rat
    E L Lane
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, CF10 3AX, UK
    Neurobiol Dis 42:99-107. 2011
    ..This has clear implications for the clinical observation and experimental measurement of drug-induced dyskinesia in Parkinson's disease patients and animal models...
  47. doi request reprint Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease
    R C Trueman
    The Brain Repair Group, Cardiff University, Wales, United Kingdom
    Brain Res Bull 88:261-75. 2012
    ..Different operant paradigms are examined in relation to their relevance to Huntington's disease symptomology, as well as summarising research to date on genetic models with these tests...
  48. doi request reprint Gene expression and behaviour in mouse models of HD
    K R Bowles
    Department of Psychological Medicine, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Wales, UK
    Brain Res Bull 88:276-84. 2012
    ....
  49. ncbi request reprint The influence of astrocytes on the development, regeneration and reconstruction of the nigrostriatal dopamine system
    M A Gates
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, UK
    Restor Neurol Neurosci 19:67-83. 2001
    ..As we obtain more information on the specific influence of these cells in various developmental, traumatic and disease events we can expect to find better ways toward combating major disorders of the human CNS...
  50. doi request reprint A simple breeding protocol for the procurement of accurately staged rat donor embryos for neural transplantation
    U M Weyrauch
    Department of Biosciences, Cardiff University, Cardiff, UK
    Cell Transplant 18:471-6. 2009
    ..Here we describe a simple, reliable in-house breeding protocol for the generation of accurately staged embryos as assessed by measurements of average crown to rump length (CRL)...
  51. doi request reprint Tests to assess motor phenotype in mice: a user's guide
    Simon P Brooks
    The Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, South Wales, UK
    Nat Rev Neurosci 10:519-29. 2009
    ..This overview of available motor tasks aims to aid researchers in making the correct choice of test when attempting to tease out a transgenic phenotype or when assessing the recovery of motor function following therapeutic intervention...
  52. ncbi request reprint The corridor task: striatal lesion effects and graft-mediated recovery in a model of Huntington's disease
    Mate D Dobrossy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    Behav Brain Res 179:326-30. 2007
    ..The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation...
  53. ncbi request reprint Striatal graft projections are influenced by donor cell type and not the immunogenic background
    Claire M Kelly
    Brain Repair Group, School of Biosciences, Museum Avenue, Cardiff, CF10 3US, UK
    Brain 130:1317-29. 2007
    ....
  54. ncbi request reprint Lesions of the premotor and supplementary motor areas fail to prevent implicit learning in the operant serial implicit learning task
    Simon P Brooks
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Brain Res 1284:116-24. 2009
    ..The presented results suggest that the premotor and SMA are not essential for implicit learning, but are important in the performance of sequenced motor tasks...
  55. ncbi request reprint Human stem cells for CNS repair
    Rike Zietlow
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
    Cell Tissue Res 331:301-22. 2008
    ..Success will depend on careful investigation in experimental models to enable us to understand not just the practicalities of stem cell use, but also the underlying biological principles...
  56. ncbi request reprint Stem cell transplantation for neurodegenerative diseases
    Anne E Rosser
    Department of Neurology, School of Medicine, Cardiff University, Heath Park, UK
    Curr Opin Neurol 20:688-92. 2007
    ..To review recent developments in the application of stem cells for transplantation therapies in neurodegenerative diseases...
  57. doi request reprint Chapter 55: neural transplantation
    Stephen B Dunnett
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Handb Clin Neurol 95:885-912. 2010
    ..The final section reviews recent progress in translating cell transplantation to the clinic for application in Parkinson's and other central nervous system diseases...
  58. ncbi request reprint Pre-treatment with dopamine agonists influence L-dopa mediated rotations without affecting abnormal involuntary movements in the 6-OHDA lesioned rat
    Emma L Lane
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Behav Brain Res 213:66-72. 2010
    ..Therefore, while locomotor sensitivity is altered by the pre-treatment with dopamine agonists, there appears to be no increased risk of developing AIMs...
  59. ncbi request reprint HSV vector-delivery of GDNF in a rat model of PD: partial efficacy obscured by vector toxicity
    Christelle Monville
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Brain Res 1024:1-15. 2004
    ..This was found to be due to the way the vector was purified. The issue of toxicity, which might account for the variable functional effects, needs resolving prior to therapeutic application of these vectors...
  60. doi request reprint Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression
    Claire M Kelly
    Cardiff University, UK
    Nat Methods 6:271-3. 2009
    ....
  61. ncbi request reprint Neural transplantation in patients with Huntington's disease
    Anne E Rosser
    School of Biosciences, Cardiff University, Cardiff, UK
    CNS Drugs 17:853-67. 2003
    ..To date, these clinical studies have demonstrated the feasibility and safety of transplantation in this condition, but it will require several more years yet before the efficacy of the procedure can be confidently established...
  62. ncbi request reprint Pharmaceutical, cellular and genetic therapies for Huntington's disease
    Olivia J Handley
    The Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Clin Sci (Lond) 110:73-88. 2006
    ..These new prospects offer hope for delaying and possibly halting this debilitating disease...
  63. ncbi request reprint EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS
    Claire M Kelly
    School of Biosciences, Brain Repair Group, Cardiff University, Biomedical Science Building, Museum Avenue, P O Box 911, Cardiff CF1 3US, UK
    Brain Res Bull 68:83-94. 2005
    ..The effect of varying the concentration of EGF was assessed using mouse ENPs...
  64. ncbi request reprint Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model
    Eilis Dowd
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Eur J Neurosci 22:2587-95. 2005
    ..This study confirms that GDNF can protect against 6-OHDA-induced impairments in complex as well as simple behaviours, and reinforces the use of EIAV-based vectors for the treatment of PD...
  65. pmc The survival of neural precursor cell grafts is influenced by in vitro expansion
    Rike Zietlow
    School of Biosciences, Cardiff University, UK
    J Anat 207:227-40. 2005
    ..This has implications for the potential use of these cells for neural transplantation strategies...
  66. ncbi request reprint Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility
    Eilis Dowd
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Behav Brain Res 165:181-6. 2005
    ....
  67. ncbi request reprint Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in a lateralised nose-poking task in rats
    Eilis Dowd
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, Cardiff CF10 3US, UK
    Behav Brain Res 159:153-61. 2005
    ..This experiment confirms that the lateralised nose-poking task may be a powerful tool for assessment of the nature of deficit and recovery in rats with complete but not partial unilateral dopamine lesions...
  68. ncbi request reprint Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants
    Eilis Dowd
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Eur J Neurosci 20:1953-9. 2004
    ..This data suggests that this operant task may be a powerful tool for validating and elucidating the mechanism of action of experimental brain repair therapies prior to entering the clinic...
  69. ncbi request reprint Transplanted hNT cells ("LBS neurons") in a rat model of huntington's disease: good survival, incomplete differentiation, and limited functional recovery
    Rosemary A Fricker-Gates
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Cell Transplant 13:123-36. 2004
    ....
  70. ncbi request reprint Spatially and temporally restricted chemoattractive and chemorepulsive cues direct the formation of the nigro-striatal circuit
    Monte A Gates
    Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, CF10 3US, UK
    Eur J Neurosci 19:831-44. 2004
    ....
  71. ncbi request reprint Environmental enrichment affects striatal graft morphology and functional recovery
    Mate D Dobrossy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    Eur J Neurosci 19:159-68. 2004
    ..The results indicate that an enriched environment can affect both graft function and graft morphology through as yet unknown mechanisms...
  72. ncbi request reprint The release of excitatory amino acids, dopamine, and potassium following transplantation of embryonic mesencephalic dopaminergic grafts to the rat striatum, and their effects on dopaminergic neuronal survival in vitro
    Rike Zietlow
    Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, UK
    Cell Transplant 11:637-52. 2002
    ....
  73. ncbi request reprint Motor training effects on recovery of function after striatal lesions and striatal grafts
    Mate D Dobrossy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, Wales, UK
    Exp Neurol 184:274-84. 2003
    ....
  74. ncbi request reprint The effects of lateralized training on spontaneous forelimb preference, lesion deficits, and graft-mediated functional recovery after unilateral striatal lesions in rats
    Mate D Dobrossy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    Exp Neurol 199:373-83. 2006
    ....
  75. ncbi request reprint Fronto-striatal disconnection disrupts operant delayed alternation performance in the rat
    Anna White
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Neuroreport 17:435-41. 2006
    ....
  76. ncbi request reprint Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease
    Eduardo M Torres
    Department of Biosciences, Cardiff University, UK
    Eur Neuropsychopharmacol 17:206-14. 2007
    ....
  77. ncbi request reprint An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections
    Eduardo M Torres
    Cardiff University, School of Biosciences, Museum Avenue, Cardiff CF10 3US, United Kingdom
    J Neurosci Methods 158:64-74. 2006
    ..The present investigation contributes to the development of new fixation protocols, optimised for use in both immunohistochemical methods and morphometric analyses...
  78. ncbi request reprint Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise
    Mate D Dobrossy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    Eur J Neurosci 24:3223-33. 2006
    ..Appropriately exploiting the underlying, and yet unknown, mechanisms could lead the way to improved anatomical and potentially functional integration of the graft...
  79. pmc Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data
    Lesley Jones
    Depts of Psychological Medicine and Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK
    BMC Bioinformatics 7:211. 2006
    ..We conducted an experiment hybridising RNA from human brain to 117 U133A Affymetrix GeneChips and used these data to explore the relationship between 4 pre-chip variables and 22 post-chip outcomes and quality control measures...
  80. ncbi request reprint Validation of the l-dopa-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists
    Christelle Monville
    Cardiff University, School of Biosciences, Museum Avenue, Cardiff CF10 3US, UK
    Brain Res Bull 68:16-23. 2005
    ..g. using grafts while blocking the unwanted adverse effects of the drugs...
  81. doi request reprint The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats
    M J Lelos
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK Electronic address
    Appetite 71:287-94. 2013
    ..Loss of these cells in neurodegenerative disorders, such Huntington's disease, may contribute to regulatory changes evident in the course of the disease. ..
  82. pmc Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475
    A E Rosser
    School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    J Neurol Neurosurg Psychiatry 73:678-85. 2002
    ....
  83. ncbi request reprint Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease
    S P Brooks
    Cardiff University, Schools of Biological Sciences, Museum Avenue, PO Box 911, Cardiff CF10 3US, Wales, UK
    Brain Res Bull 69:452-7. 2006
    ....
  84. doi request reprint Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant
    S J Paynter
    Dept Obs and Gyn, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Cryobiology 58:308-14. 2009
    ..The present results provide key parameters for optimisation of freezing protocols for cryopreservation of primary foetal brain tissues for application in neural cell transplantation...
  85. doi request reprint Medium spiny neurons for transplantation in Huntington's disease
    Claire M Kelly
    Brain Repair Group, School of Biosciences, Museum Avenue, Cardiff University, Cardiff CF10 3AX, Wales, UK
    Biochem Soc Trans 37:323-8. 2009
    ....
  86. pmc Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3
    Jason Peter Twohig
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    J Neurosci 30:3782-92. 2010
    ..These studies indicate that DR3 plays a key nonredundant role in the retention of normal motor control function during aging in mice and implicate DR3 in progressive neurological disease...
  87. ncbi request reprint Hippocampal lesions impair performance on a conditional delayed matching and non-matching to position task in the rat
    Hazel L Sloan
    Brain Repair Group, School of Biosciences, Cardiff University, Museum, Wales, UK
    Behav Brain Res 171:240-50. 2006
    ..This task may prove useful in determining the cognitive roles of a range of brain areas...
  88. ncbi request reprint Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests
    S P Brooks
    School of Biosciences, Cardiff University, Cardiff, UK
    Genes Brain Behav 3:206-15. 2004
    ..These data taken together suggest that choice of background strain is a crucial consideration for the repeated behavioural assessment of motor deficits in transgenic mouse models of disease...
  89. ncbi request reprint Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task
    Hazel L Sloan
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Behav Brain Res 171:116-26. 2006
    ....
  90. ncbi request reprint Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's disease
    Richard J E Armstrong
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, CB2 2PY, Cambridge, UK
    Exp Brain Res 151:204-17. 2003
    ..Furthermore, derivation of ENPs from the VM at the time of normal dopaminergic neurogenesis is inadequate to ensure functional dopaminergic grafts on transplantation...
  91. ncbi request reprint Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS
    Carrie B Hurelbrink
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Eur J Neurosci 15:1255-66. 2002
    ....
  92. ncbi request reprint Rewiring the Parkinsonian brain
    Rosemary A Fricker-Gates
    Nat Med 8:105-6. 2002
  93. ncbi request reprint The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease
    Richard J E Armstrong
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, United Kingdom
    Exp Neurol 175:98-111. 2002
    ....
  94. ncbi request reprint Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice
    Christopher Pittenger
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:2808-13. 2006
    ....
  95. ncbi request reprint Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: implications for clinical trials in Huntington's disease
    Carrie B Hurelbrink
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Cell Transplant 12:687-95. 2003
    ....
  96. ncbi request reprint Cell transplantation for Huntington's disease
    Anne E Rosser
    Lancet Neurol 5:284-5. 2006
  97. ncbi request reprint Re-examining the ontogeny of substantia nigra dopamine neurons
    Monte A Gates
    Schools of Medicine and Life Sciences, Keele University, Staffordshire, UK
    Eur J Neurosci 23:1384-90. 2006
    ....
  98. ncbi request reprint Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
    Alexandre Kuhn
    Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Hum Mol Genet 16:1845-61. 2007
    ....
  99. ncbi request reprint A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1 PD, UK
    Eur J Neurosci 21:855-70. 2005
    ..Our study shows that cognitive decline caused by a genetic mutation can be slowed by a combination drug treatment, and gives hope that cognitive symptoms in HD can be treated...
  100. ncbi request reprint Neural transplantation for the treatment of Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Sweden
    Lancet Neurol 2:437-45. 2003
  101. ncbi request reprint Selective lesioning of the cholinergic septo-hippocampal pathway does not disrupt spatial short-term memory: a comparison with the effects of fimbria-fornix lesions
    Boyer D Winters
    Medical Research Council Cambridge Centre for Brain Repair, and Departmernt of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Behav Neurosci 118:546-62. 2004
    ....