Research Topics
| Ruth DuncanSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Dendrimer biocompatibility and toxicityRuth Duncan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK
Adv Drug Deliv Rev 57:2215-37. 2005....- Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinicR Duncan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, Wales, UK
J Control Release 74:135-46. 2001..Moreover, bioresponsive polymer-based constructs able to promote endosomal escape and thus intracytoplasmic delivery of macromolecular drugs (peptides, proteins and oligonucleotides) are also under study... - Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancerR Duncan
Centre for Polymer Therapeutics, Cardiff University, Cardiff, UK
Endocr Relat Cancer 12:S189-99. 2005.... - Polymer conjugates for drug targeting. From inspired to inspiration!Ruth Duncan
Welsh School of Pharmacy, Centre for Polymer Therapeutics, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
J Drug Target 14:333-5. 2006 
Polymer masked-unmasked protein therapy. 1. Bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for alpha-amylase activationRuth Duncan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Biomacromolecules 9:1146-54. 2008..The choice of masking polymer, activation mechanism, and the rate of unmasking can be tailored to therapeutic application...- Polymer conjugates as anticancer nanomedicinesRuth Duncan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Nat Rev Cancer 6:688-701. 2006..There is growing optimism that ever more sophisticated polymer-based vectors will be a significant addition to the armoury currently used for cancer therapy... - Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunitiesRuth Duncan
Welsh School of Pharmacy, Centre for Polymer Therapeutics, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
J Drug Target 14:337-41. 2006 - Designing polymer conjugates as lysosomotropic nanomedicinesR Duncan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, Wales, UK
Biochem Soc Trans 35:56-60. 2007..The present paper reviews the clinical status of polymeric anticancer agents, the rationale for the design of polymer therapeutics and discusses the benefits and challenges of lysosomotropic delivery... - Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learntRuth Duncan
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
Adv Drug Deliv Rev 61:1131-48. 2009..The preclinical and clinical observations made in these, and clinical studies with other polymer conjugates, should shape the development of next generation anticancer polymer therapeutics... - The dawning era of polymer therapeuticsRuth Duncan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
Nat Rev Drug Discov 2:347-60. 2003.... - Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cellsF Philipp Seib
Centre for Polymer Therapeutics, Welsh School of Pharmacy, King Edward VII Avenue, Cardiff University, Cardiff CF10 3XF, UK
J Control Release 117:291-300. 2007..A perception of the rate and mechanisms of cellular uptake of these vectors will be important in the context of their proposed use as drug delivery systems... - Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cellsFrancesca Greco
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Ave, Cardiff CF10 3XF, UK
J Control Release 117:28-39. 2007.... - Poly(amidoamine) conjugates containing doxorubicin bound via an acid-sensitive linkerNathalie Lavignac
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, UK
Macromol Biosci 9:480-7. 2009..These results suggest that ISA23Dox is able to release biologically active Dox in vitro and that this conjugate might be suitable for further development... - Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imagMaria Manunta
Welsh School of Pharmacy, Centre for Polymer Therapeutics, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
J Drug Target 15:37-50. 2007.... - Studies on the mechanism of interaction of a bioresponsive endosomolytic polyamidoamine with interfaces. 1. Micelles as model surfacesPeter C Griffiths
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U K
Biomacromolecules 8:1004-12. 2007..5... - Polymer therapeutics designed for a combination therapy of hormone-dependent cancerMaria J Vicent
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Redwood Building, CF10 3XF Cardiff, UK
Angew Chem Int Ed Engl 44:4061-6. 2005 - The use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug deliverySimon C W Richardson
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Av, Cardiff, Wales CF10 3XF, UK
J Control Release 127:1-11. 2008..The technique described here is a particularly powerful tool as it circumvents fixation artefacts ensuring the retention of water-soluble polymers within the vesicles they occupy... - Synthesis and preliminary evaluation of poly(amidoamine)-melittin conjugates as endosomolytic polymers and/or potential anticancer therapeuticsNathalie Lavignac
Centre for Polymer Therapeutics, Welsh, School of Pharmacy Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
Int J Pharm 300:102-12. 2005..However, this conjugate could have potential as a novel polymeric anticancer conjugate due to its lack of haemolytic activity at pH 7.4 and retention of cytotoxicity... - Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic woundsJoseph Hardwicke
Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UK
Mol Pharm 7:699-707. 2010..These results suggest further preclinical in vivo evaluation of dextrin-rhEGF is warranted to determine whether conjugate pharmacokinetics and rhEGF liberation into such a complex and aggressive environment can still lead to bioactivity... - Synthesis and endosomolytic properties of poly(amidoamine) block copolymersNathalie Lavignac
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Macromol Biosci 4:922-9. 2004..It would be interesting to study the body distribution of B2 and determine whether this toxin-delivering PAA is able to escape liver capture... - Studies on the mechanism of action of dextrin-phospholipase A2 and its suitability for use in combination therapyElaine L Ferguson
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Mol Pharm 7:510-21. 2010..However, the enhanced cytotoxicity seen in the presence of doxorubicin suggested potential for development of a dextrin-PLA2/doxorubicin combination therapy... - Polymer conjugates: nanosized medicines for treating cancerMaria J Vicent
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, UK
Trends Biotechnol 24:39-47. 2006..g. modulators of the cell cycle, signal transduction inhibitors and antiangiogenic drugs) in addition to polymer-drug combinations (e.g. endocrine- and chemo-therapy)... - HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell linesFrancesca Greco
Welsh School of Pharmacy, Redwood Building, Cardiff University, Tenovus Centre for Cancer Research, King Edward VII Avenue, UK
J Drug Target 13:459-70. 2005.... - Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repairJoseph Hardwicke
Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Tissue Engineering and Reparative Dentistry, School of Dentistry, Heath Park Campus, Cardiff University, Cardiff, UK
J Control Release 130:275-83. 2008..These observations suggest that this dextrin-rhEGF, and other dextrin-growth factor conjugates have potential for further development as bioresponsive nanomedicines for tissue repair... - Using small-angle neutron scattering to study the solution conformation of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugatesAlison Paul
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom
Biomacromolecules 8:1573-9. 2007..5 nm) compared to FCE28068. In conclusion, we have shown that SANS will be a valuable tool to elucidate conformation-performance relationships for polymer-drug conjugates... - Interaction of an endosomolytic polyamidoamine ISA23 with vesicles mimicking intracellular membranes: A SANS/EPR studyPeter C Griffiths
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
Macromol Biosci 10:963-73. 2010..The vesicle-mimetic models used here provide a new and useful tool for studying endosomolytic polymer/membrane interactions... - HPMA copolymer-1,5-diazaanthraquinone conjugates as novel anticancer therapeuticsMaria J Vicent
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, Cardiff, UK
J Drug Target 12:503-15. 2004..Nonetheless, the observed lysosomal activation of the HPMA copolymer-GFLG-amino-DAQ conjugates, suggests that evaluation of the antitumour potential in vivo is warranted... - The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouseJoseph T Hardwicke
Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair CITER, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, UK
J Control Release 152:411-7. 2011..05), relative to untreated, succinoylated dextrin and rhEGF alone controls. Overall, these findings support the further development of bioresponsive polymer conjugates, for tissue repair... - Dextrin-phospholipase A2: synthesis and evaluation as a bioresponsive anticancer conjugateElaine L Ferguson
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, United Kingdom
Biomacromolecules 10:1358-64. 2009..The reduced toxicity and alpha-amylase triggered activity of the dextrin-PLA(2) conjugate confirmed the potential of this approach for further development as a novel anticancer treatment... - Characterising the size and shape of polyamidoamines in solution as a function of pH using neutron scattering and pulsed-gradient spin-echo NMRZeena Khayat
Centre for Polymer Therapeutics, Welsh School of Pharmacy, King Edward's VII Avenue, Cardiff CF10 3XF, UK
Int J Pharm 317:175-86. 2006.... - Polyacetal-diethylstilboestrol: a polymeric drug designed for pH-triggered activationMaria J Vicent
Centre for Polymer Therapeutics, Welsh School of Pharmacy, University of Wales, Cardiff, UK
J Drug Target 12:491-501. 2004..Their in vitro characteristics suggest further in vivo evaluation is warranted... - Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer - doxorubicinF Philipp Seib
Welsh School of Pharmacy, Centre for Polymer Therapeutics, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
J Drug Target 14:375-90. 2006..In conclusion, the B16F10 subcellular fractionation method developed here provides a useful tool to allow comparison of the intracellular trafficking of other polymer conjugates... - Polymer coiled-coil conjugates: potential for development as a new class of therapeutic "molecular switch"Samuel P E Deacon
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom
Biomacromolecules 12:19-27. 2011..Observation that heterodimerization was achieved and that the polymer did not sterically disadvantage hybridization suggests an important future for this new family of polymer therapeutics... - Polymer-protein and polymer-drug conjugates in cancer therapyMaya Thanou
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Curr Opin Investig Drugs 4:701-9. 2003..Eleven polymer-drug conjugates have entered clinical development and activity has already been observed in chemotherapy refractory patients. Certain compounds have also demonstrated a marked reduction in drug toxicity... - Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systemsArwyn T Jones
Center for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, South Wales CF10 3XF, UK
Adv Drug Deliv Rev 55:1353-7. 2003 - N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluationF Searle
Centre for Polymer Therapeutics, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK
Bioconjug Chem 12:711-8. 2001..p. was somewhat more active (highest T/C value of 143%) than free APE (1 mg/kg) (T/C =127%). HPMA copolymer-APE conjugates warrant further evaluation as potential anticancer agents... - Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunitiesRuth Duncan
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
Adv Drug Deliv Rev 62:272-82. 2010.... - Hiroshi Maeda--defining the pathway to targeted cancer therapyRuth Duncan
Centre for Polymer Therapeutics Welsh School of Pharmacy Cardiff University, Cardiff, UK
J Drug Target 15:456. 2007 - Dextrins as potential carriers for drug targeting: tailored rates of dextrin degradation by introduction of pendant groupsD Hreczuk-Hirst
Centre for Polymer Therapeutics, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK
Int J Pharm 230:57-66. 2001.... - Poly(amidoamine) salt form: effect on pH-dependent membrane activity and polymer conformation in solutionKa-Wai Wan
Centre for Polymer Therapeutics, Welsh School of Pharmacy, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom
Biomacromolecules 5:1102-9. 2004..This study clearly demonstrates the importance of optimization of the counterion form when developing endosomolytic polymers designed to mediate pH-dependent membrane permeabilization... - HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluationElisabetta Gianasi
Centre for Polymer Therapeutics, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK
J Drug Target 10:549-56. 2002..After i.v. administration, the platinum accumulation in B16F10 tumour tissue showed a 19-fold increase in Pt AUC for the malonate conjugate when compared to cisplatin administered equi-dose at its maximum tolerated dose (MTD) (1 mg/kg)... - Understanding the mechanism of action of poly(amidoamine)s as endosomolytic polymers: correlation of physicochemical and biological propertiesP C Griffiths
School of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, United Kingdom
Biomacromolecules 5:1422-7. 2004..The results do, however, suggest that the charge on the polymer shows a closer correlation with the haemolysis activity rather than the polymer conformation... 
PDEPT: polymer-directed enzyme prodrug therapy. I. HPMA copolymer-cathepsin B and PK1 as a model combinationR Satchi
Centre for Polymer Therapeutics, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WCIN IAX, UK
Br J Cancer 85:1070-6. 2001..This study proves the concept of PDEPT and further optimisation is warranted...- Poly(amidoamine)-mediated intracytoplasmic delivery of ricin A-chain and geloninN G Pattrick
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, CF10 3XF, Cardiff, UK
J Control Release 77:225-32. 2001..26 mg/ml, respectively. In contrast, the neutral polymer dextran and the PAA ISA 22 were unable to mediate this effect. These observations suggest that specific PAA-toxin combinations warrant further development as novel therapeutics... - Poly(amidoamine)s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitroS C Richardson
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF
Biomacromolecules 2:1023-8. 2001..These properties suggest that PAAs warrant further development as endosomolytic vectors... - Poly(ethylene glycol)-poly(ester-carbonate) block copolymers carrying PEG-peptidyl-doxorubicin pendant side chains: synthesis and evaluation as anticancer conjugatesLars Andersson
PolyPeptide Laboratories (Sweden) AB, PO Box 30089, SE 20061 Limhamn, Sweden
Biomacromolecules 6:914-26. 2005..However, the successful scale-up synthesis of DBM2-PEG4000-S-PEG3000 constructs suggest that they are worthy of further investigation as carriers for controlled release and targeting of less hydrophobic agents... - Novel monodisperse PEG-dendrons as new tools for targeted drug delivery: synthesis, characterization and cellular uptakeManuela Berna
Department of Pharmaceutical Science, University of Padua, Via Marzolo 5, 35100 Padua, Italy
Biomacromolecules 7:146-53. 2006..These well-defined novel architectures have potential for further development as targetable drug delivery systems or tools for construction of structurally defined modified surfaces... - PEG-doxorubicin conjugates: influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activityFrancesco M Veronese
Department of Pharmaceutical Science, University of Padua, Via F Marzolo 5, 35100 Padua, Italy
Bioconjug Chem 16:775-84. 2005..Further studies are warranted with PEG5000(L)-GFLG-Dox to determine its spectrum of antitumor activity and also the optimum dosing schedule before clinical testing... - Polyacetal-doxorubicin conjugates designed for pH-dependent degradationRyan Tomlinson
Biomedical Polymers Group, Department of Pharmaceutics, The School of Pharmacy, University of London, UK
Bioconjug Chem 14:1096-106. 2003..2 wt % DOX content. Moreover, APEG-DOX exhibited lower uptake by liver and spleen. These observations suggest that APEG anticancer conjugates warrant further development as novel polymer therapeutics for improved tumor targeting... - Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsinBenjaporn Treetharnmathurot
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand
Int J Pharm 357:252-9. 2008..PEG-trypsin conjugates containing the higher molecular weight of mPEG (5000 g/mol) were more stable than free trypsin, and the conjugate containing CC-mPEG 5000 g/mol had the best thermal stability... - Total synthesis and preliminary biological evaluation of cis-solamin isomersAlex R L Cecil
Department of Chemistry, The University of Southampton, Highfield, UK
J Org Chem 69:3368-74. 2004..The methodology was also applied to the synthesis of three further cis-solamin isomers 2, ent-1, and ent-2. Cytotoxicity and hemolytic properties of cis-solamin isomers and synthetic intermediates are reported... - Polyvalent dendrimer glucosamine conjugates prevent scar tissue formationSunil Shaunak
Faculty of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
Nat Biotechnol 22:977-84. 2004.... - LEAPT: lectin-directed enzyme-activated prodrug therapyMark A Robinson
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom
Proc Natl Acad Sci U S A 101:14527-32. 2004.... - PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combinationRonit Satchi-Fainaro
Department of Cell Research and Immunology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Bioconjug Chem 14:797-804. 2003..The PDEPT combination displayed no toxicity at the doses used, so further evaluation of this approach to establish the maximum tolerated dose (MTD) is recommended...