Research Topics
| Wolfgang DrexlerSummaryAffiliation: Cardiff University Country: UK Publications
| Collaborators
|
Detail Information
Publications
Cellular and functional optical coherence tomography of the human retina: the Cogan lectureWolfgang Drexler
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
Invest Ophthalmol Vis Sci 48:5339-51. 2007- State-of-the-art retinal optical coherence tomographyWolfgang Drexler
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
Prog Retin Eye Res 27:45-88. 2008..Functional OCT promises to enable the differentiation of retinal pathologies via localized, functional retinal response or metabolic properties. These advances promise to have a powerful impact on fundamental as well as clinical studies... 
Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomographyMarieh Esmaeelpour
School of Optometry and Vision Sciences, Cardiff University, United Kingdom
Invest Ophthalmol Vis Sci 52:5311-6. 2011..To map choroidal (ChT) and retinal thickness (RT) in healthy subjects and patients with diabetes with and without maculopathy using three dimensional 1060-nm optical coherence tomography (3D-1060nm-OCT)...- Dispersion encoded full range frequency domain optical coherence tomographyBernd Hofer
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, United Kingdom
Opt Express 17:7-24. 2009..The suppression ratio of mirror signals is more than 50 dB and thus comparable to complex FD-OCT techniques which use multiple A-scans... - Three-dimensional 1060-nm OCT: choroidal thickness maps in normal subjects and improved posterior segment visualization in cataract patientsMarieh Esmaeelpour
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
Invest Ophthalmol Vis Sci 51:5260-6. 2010.... - Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retinaEnrique J Fernandez
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Wales, UK
Opt Express 16:11083-94. 2008..The presented technique has the potential to unveil photoreceptor development and pathogenesis as well as improved therapy monitoring of numerous retinal diseases... - Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickensJeremy A Guggenheim
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
Ophthalmic Physiol Opt 31:516-28. 2011..Hence, we tested whether pre-treatment choroidal thickness predicted susceptibility to myopia... - Multispectral in vivo three-dimensional optical coherence tomography of human skinAneesh Alex
Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales, United Kingdom
J Biomed Opt 15:026025. 2010..The performance at 1060 nm compromises between the other wavelengths in terms of penetration depth and image contrast... 
Adaptive optics optical coherence tomography at 120,000 depth scans/s for non-invasive cellular phenotyping of the living human retinaCristiano Torti
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4LU, Wales, UK
Opt Express 17:19382-400. 2009..This novel technique provides opportunities to enhance the understanding of retinal pathogenesis and early diagnosis of retinal diseases...- Wide-field optical coherence tomography of the choroid in vivoBoris Povazay
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
Invest Ophthalmol Vis Sci 50:1856-63. 2009..The clinical feasibility of dense, high-speed sampling for higher levels of detail at the macula and optic nerve head is explored with respect to motion artifacts... - Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomographyBoris Povazay
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff UniversityCardiff CF24 4LU, United Kingdom
Opt Express 17:4134-50. 2009.... - Heritability of ocular component dimensions in mice phenotyped using depth-enhanced swept source optical coherence tomographyLing Wang
School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, Wales, UK
Exp Eye Res 93:482-90. 2011..OCT with extended depth range scanning can be used to rapidly phenotype individual mice with sufficient accuracy and precision to permit gene mapping studies... - Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomographyAlexandre R Tumlinson
Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, Wales, UK
Jpn J Ophthalmol 53:315-26. 2009..To demonstrate acquisition and analysis methods for depth-resolved observation of slow retinal physiology induced changes in infrared backscatter in vivo... - Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysisVedran Kajic
School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4LU, UK
Opt Express 18:14730-44. 2010..6% against the inter-observer variability... - Selective breeding for susceptibility to myopia reveals a gene-environment interactionYen Po Chen
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
Invest Ophthalmol Vis Sci 52:4003-11. 2011..Additive genetic effects explained ∼50% of the interanimal variability in response to DSV. Conclusions. Genes and environment interact to shape refractive development in chicks... - Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eyeLing Wang
Cardiff University, School of Optometry and Vision Sciences, Wales, United Kingdom
J Biomed Opt 15:046004. 2010..g., day-to-day reproducibility of axial length measurement +/-5.3 microm) that is insensitive to eye motion sufficient for long-term monitoring... - Retinal and choroidal thickness in early age-related macular degenerationAshley Wood
School of Optometry and Vision Sciences, Cardiff University, United Kingdom
Am J Ophthalmol 152:1030-1038.e2. 2011.... - Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosisBoris Povazay
Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales CF24 4LU, United Kingdom
J Biomed Opt 12:041204. 2007..For the purposes of this pilot study, we present data from a normal subject and from two patients with characteristic optic nerve and retinal nerve fiber layer changes secondary to glaucoma... - Inherent homogenous media dispersion compensation in frequency domain optical coherence tomography by accurate k-samplingAlexandre R Tumlinson
Division of Biomedical Engineering, University of Arizona, Tucson 85721, USA
Appl Opt 47:687-93. 2008.... - In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomographySion A Coulman
Gene Delivery Research Group, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3NB, UK
Pharm Res 28:66-81. 2011..This is the first study to utilise OCT to investigate the architectural changes that are induced in skin following microneedle application... - Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patientsBoris Povazay
Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales, CF24 4LU, United Kingdom
J Biomed Opt 12:041211. 2007..Results achieved with 3-D OCT at 1050 nm reveal, for the first time, decisive improvements in image quality for patients with retinal pathologies and clinically significant cataract... - Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulatorEnrique J Fernandez
Center for Biomedical Engineering and Physics, Vienna University of Medicine, Austria
Vision Res 45:3432-44. 2005..Volumetric UHR OCT of the living retina, obtained with up 25,000A-scans/s and high resolution enables visualization of retinal features that might correspond to groups of terminal bars of photoreceptors at the external limiting membrane... - Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathologyTony H Ko
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Ophthalmology 112:1922.e1-15. 2005..In addition, UHR OCT can provide additional information on macular disease morphology that promises to improve understanding of disease progression and management... - Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseasesUrsula Schmidt-Erfurth
Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Waehringer Strasse 13, A-1090 Vienna, Austria
Invest Ophthalmol Vis Sci 46:3393-402. 2005..A complete 3-D data set of the macular layers allows a comprehensive analysis of focal and diffuse diseases, as well as identification of dynamic pathomechanisms... - In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscopeAlexandre R Tumlinson
University of Arizona, Division of Biomedical Engineering, Tucson, Arizona 85721, USA
J Biomed Opt 11:064003. 2006..Resolution near the cellular level is potentially capable of identifying abnormal crypt formation and dysplastic cellular organization... - Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sectionsElisabeth M Anger
Department of Physiology, Medical University of Vienna, Vienna, Austria
Exp Eye Res 78:1117-25. 2004..Such correlation will facilitate the extraction of structural information from in vivo ultrahigh resolution OCT images in clinical and experimental applications... - Short-term effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttataMatthias G Wirtitsch
Department of Ophthalmology, University of Vienna, Austria
Arch Ophthalmol 121:621-5. 2003..3 micro m (95% CI, -0.1 to 2.6 microm), respectively. CONCLUSION: Application of dorzolamide for 1 day results in a slight but statistically significant thickening of central corneal thickness in patients with cornea guttata... - Effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttataMatthias G Wirtitsch
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
Arch Ophthalmol 125:1345-50. 2007..To investigate the effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata... - Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomographyLida P Hariri
Division of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
Cancer Biol Ther 6:1753-62. 2007.... - Imaging ex vivo healthy and pathological human brain tissue with ultra-high-resolution optical coherence tomographyKostadinka Bizheva
Medical University of Vienna and Christian Doppler Laboratory, Center for Biomedical Engineering and Physics, Vienna A-1090, Austria
J Biomed Opt 10:11006. 2005.... - Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseasesAndre J Witkin
New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts 0211, USA
Am J Ophthalmol 142:945-52. 2006..FOSPET was statistically thinner in patients with RP and related diseases than in normal eyes and showed correlation with logMAR visual acuity. FOSPET appears to be a probable predictor of visual acuity in RP... - Ultrahigh resolution optical coherence tomography of macular holesChristoph Scholda
Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
Retina 26:1034-41. 2006..Hence, UHR OCT could lead to better understanding of macular hole pathogenesis and to more accurate disease prognosis... - Comparison of partial coherence interferometers: Acmaster versus laboratory prototypeKatharina Kriechbaum
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Refract Surg 22:811-6. 2006..CONCLUSIONS: The ACMaster is a user-friendly device that enables axial anterior segment biometry using the partial coherence interferometry technique with a reproducibility similar to that of the original laboratory prototype... - Local corneal thickness changes after small-incision cataract surgeryMatthias Bolz
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 32:1667-71. 2006..The prolonged corneal thickening at 3.0 mm eccentricity temporally could be a result of the proximity to the incision site... - Influence of severity of nuclear cataract on optical biometryAna Prinz
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 32:1161-5. 2006..Furthermore, it was found that AL in the phakic eye was overestimated by about 0.07 mm because of a slightly too low value of the group refractive index used for the crystalline lens... - Effect of accommodation and pupil size on the movement of a posterior chamber lens in the phakic eyeVanessa Petternel
Department of Ophthalmology, University of Vienna, Vienna, Austria
Ophthalmology 111:325-31. 2004..This mechanism might cause inadequate aqueous circulation in the prelenticular space and might be one of the causes of subcapsular opacification in some of the eyes after ICL implantation... - Ultrahigh-resolution optical coherence tomographyWolfgang Drexler
Department of Medical Physics, Christian Doppler Laboratory, University of Vienna, Vienna, Austria
J Biomed Opt 9:47-74. 2004.... - Determining postoperative anterior chamber depthKatharina Kriechbaum
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:2122-6. 2003..The refractive outcome of cataract surgery can be improved by combining preoperative high-precision PCI biometry and numerical ray tracing for IOL power calculations... - Postoperative change in effective lens position of a 3-piece acrylic intraocular lensChristina Koeppl
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:1974-9. 2003..Although the change in refraction was small, there was variability among patients. The sharp posterior optic edge design did not affect the IOL's movement in the capsular bag... - Influence of operator experience on the performance of ultrasound biometry compared to optical biometry before cataract surgeryOliver Findl
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:1950-5. 2003..The noncontact optical method, which is essentially operator independent, gave significantly more reliable biometry before cataract surgery, especially in the case of less experienced operators... - Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomographyWolfgang Drexler
Department of Medical Physics, University of Vienna, Christian Doppler Laboratory, Austria
Arch Ophthalmol 121:695-706. 2003.... - Intraocular lens movement caused by ciliary muscle contractionOliver Findl
Department of Ophthalmology, University of Vienna, Austria
J Cataract Refract Surg 29:669-76. 2003..To investigate intraocular lens (IOL) movement, measured as a change in anterior chamber depth (ACD) caused by pilocarpine-induced ciliary muscle contraction... - Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomographyMartin Gloesmann
Institutes of Physiology, University of Vienna, Vienna, Austria
Invest Ophthalmol Vis Sci 44:1696-703. 2003..The specific assignment of OCT signal patterns to retinal substructures provides a basis for improved interpretation of in vivo ophthalmic OCT tomograms of high clinical relevance... - Comparison of anterior chamber depth measurement methods in phakic and pseudophakic eyesKatharina Kriechbaum
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:89-94. 2003..21; P >.2). CONCLUSIONS: In phakic eyes, the difference between IOLMaster and PCI measurements was small and not statistically significant. In pseudophakic eyes, the difference was larger and the methods did not correlate... - Optical biometry in cataract surgeryOliver Findl
, Allgemeines Krankenhaus Wien, Austria
Dev Ophthalmol 34:131-40. 2002 - Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thicknessGeorg Rainer
Department of Ophthalmology, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Cataract Refract Surg 28:2142-5. 2002..To compare central corneal thickness (CCT) measurements obtained with 3 ultrasound pachymeters and with partial coherence interferometry (PCI) and evaluate the effect of repeated contact by a pachymetry probe on corneal thickness... - Refractive outcome of cataract surgery using partial coherence interferometry and ultrasound biometry: clinical feasibility study of a commercial prototype IIBarabara Kiss
, Allegemeines Krankenhaus Wien, Vienna, Austria
J Cataract Refract Surg 28:230-4. 2002..However, the difference in axial length measured by the ALM compared to that measured by IUS must be considered when using the IOL A-constants supplied by the manufacturers... - Analysis of nonlinear systems to estimate intraocular lens position after cataract surgeryOliver Findl
Department of Ophthalmology, Medical University of Vienna, , 1090 Vienna, Austria
J Cataract Refract Surg 30:863-6. 2004..68 for the MLP; however, this difference was not statistically significant. CONCLUSION: The prediction of postoperative ACD with the MLP was not significantly better than the prediction using linear regression... - Central corneal thickness measurements with partial coherence interferometry, ultrasound, and the Orbscan systemGeorg Rainer
Department of Ophthalmology, University of Vienna, Vienna, Austria
Ophthalmology 111:875-9. 2004..To compare the reliability of central corneal thickness measurements (CCT) obtained with partial coherence interferometry (PCI), ultrasound pachymetry, and the Orbscan system... - Ultrahigh-resolution optical coherence tomography of surgically closed macular holesTony H Ko
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Mass, USA
Arch Ophthalmol 124:827-36. 2006..Thin epiretinal membranes do not seem to decrease visual acuity and may play a role in reestablishing foveal anatomy after surgery... - Optical biometry of the anterior eye segment: interexaminer and intraexaminer reliability of ACMasterStefan Sacu
Department of Ophthalmology, Section of Clinical Biometrics, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 31:2334-9. 2005..However, lens thickness measurements in cataract eyes were often difficult... - Ultrahigh resolution optical coherence tomography in macular dystrophyMatthias G Wirtitsch
Department of Ophthalmology, Medical University of Vienna, , 1090 Vienna, Austria
Am J Ophthalmol 140:976-983. 2005.... - Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomographyLelia A Paunescu
New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
Ophthalmology 113:48-57. 2006.... - Intraocular lens-capsular bag imaging with ultrahigh-resolution optical coherence tomography Pseudophakic human autopsy eyesReijo J Linnola
PlusHealth-Doctors Ltd, Vaasa, Finland
J Cataract Refract Surg 31:818-23. 2005..Ultrahigh-resolution OCT may also help in determining the area of origin of PCO after cataract surgery... - Change in IOL position and capsular bag size with an angulated intraocular lens early after cataract surgeryChristina Koeppl
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 31:348-53. 2005..Loss of haptic memory seemed to be the most likely cause. Myopic eyes with large capsular bags showed less IOL shift in the early postoperative period than hyperopic eyes with smaller capsular bags... - Ultrahigh-resolution optical coherence tomography in glaucomaGadi Wollstein
New England Eye Center, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Ophthalmology 112:229-37. 2005..CONCLUSIONS: Ultrahigh-resolution OCT provides high-resolution images of the ocular posterior segment, which improves the ability to detect retinal abnormalities due to glaucoma... - Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomographyErdem Ergun
Department of Ophthalmology, General Hospital of Vienna, Vienna, Austria
Invest Ophthalmol Vis Sci 46:310-6. 2005..Therefore, UHR-OCT could be of future use in judging patients' prognoses in Stargardt's disease... - Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repairTony H Ko
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Ophthalmology 111:2033-43. 2004..The ability to visualize photoreceptors and their integrity or impairment is an indicator of macular hole progression and surgical outcome... - Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65Birgit Lorenz
Department of Paediatric Ophthalmology and Ophthalmogenetics, University of Regensburg, Germany
Ophthalmology 111:1585-94. 2004..This study was conducted to evaluate fundus autofluorescence in patients with early-onset severe retinal dystrophy (EOSRD, or early-onset rod-cone dystrophy) associated with mutations on both alleles of RPE65... - Laserinterferometric assessment of pilocarpine-induced movement of an accommodating intraocular lens: a randomized trialOliver Findl
Department of Ophthalmology, University of Vienna, Austria
Ophthalmology 111:1515-21. 2004..To measure the axial movement of an accommodating intraocular lens (IOL) induced by ciliary muscle contraction after application of pilocarpine... - Imaging ex vivo and in vitro brain morphology in animal models with ultrahigh resolution optical coherence tomographyKostadinka Bizheva
Department of Medical Physics, Medical University of Vienna and Christian Doppler Laboratory, Vienna A-1090, Austria
J Biomed Opt 9:719-24. 2004..In addition, the OCT image penetration depth and the scattering properties of gray and white brain matter were evaluated in tissue samples from the visual cortex of a fixed monkey brain... - Biometry of cataractous eyes using partial coherence interferometry: clinical feasibility study of a commercial prototype IBarbara Kiss
, Allgemeines Krankenhaus Wien, Vienna, Austria
J Cataract Refract Surg 28:224-9. 2002..However, the difference between the PCI and IUS in axial length measurement must be considered when using the constants supplied by intraocular lens (IOL) manufacturers for IOL power calculations...