N Craddock

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Familiality of postpartum depression in unipolar disorder: results of a family study
    Liz Forty
    Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 163:1549-53. 2006
  2. pmc 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care
    Angus J Clarke
    Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, Wales CF14 4XN, UK
    Hum Genomics 6:11. 2012
  3. doi request reprint Genetics of bipolar disorder
    Nick Craddock
    Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK
    Lancet 381:1654-62. 2013
  4. pmc The health informatics cohort enhancement project (HICE): using routinely collected primary care data to identify people with a lifetime diagnosis of psychotic disorder
    Alexis Economou
    Centre for Health Information Research and Evaluation, ILS2, College of Medicine, Swansea University, Swansea, SA2 8PP, UK
    BMC Res Notes 5:95. 2012
  5. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
  6. pmc Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis
    Zainab Samaan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    BMC Neurol 11:66. 2011
  7. doi request reprint Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype
    N Craddock
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:146-53. 2010
  8. pmc The Bipolar Affective Disorder Dimension Scale (BADDS)--a dimensional scale for rating lifetime psychopathology in bipolar spectrum disorders
    Nick Craddock
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 4:19. 2004
  9. doi request reprint Wake-up call for British psychiatry
    Nick Craddock
    Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 193:6-9. 2008
  10. ncbi request reprint Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles
    Nick Craddock
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 190:200-3. 2007

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Familiality of postpartum depression in unipolar disorder: results of a family study
    Liz Forty
    Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 163:1549-53. 2006
    ..The authors here examine whether vulnerability to postpartum triggering of depressive episodes aggregates in families and assess how this aggregation varies with the definition of postpartum onset...
  2. pmc 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care
    Angus J Clarke
    Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, Wales CF14 4XN, UK
    Hum Genomics 6:11. 2012
    ....
  3. doi request reprint Genetics of bipolar disorder
    Nick Craddock
    Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK
    Lancet 381:1654-62. 2013
    ....
  4. pmc The health informatics cohort enhancement project (HICE): using routinely collected primary care data to identify people with a lifetime diagnosis of psychotic disorder
    Alexis Economou
    Centre for Health Information Research and Evaluation, ILS2, College of Medicine, Swansea University, Swansea, SA2 8PP, UK
    BMC Res Notes 5:95. 2012
    ..abstract:..
  5. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
    ..This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America...
  6. pmc Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis
    Zainab Samaan
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    BMC Neurol 11:66. 2011
    ..We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date...
  7. doi request reprint Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype
    N Craddock
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:146-53. 2010
    ..Our method of phenotype refinement may be useful in studies of other complex psychiatric and non-psychiatric disorders...
  8. pmc The Bipolar Affective Disorder Dimension Scale (BADDS)--a dimensional scale for rating lifetime psychopathology in bipolar spectrum disorders
    Nick Craddock
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Psychiatry 4:19. 2004
    ..This latter limitation is particularly pertinent in the context of the increasing evidence for the existence of a broader bipolar spectrum than has been acknowledged within existing classifications...
  9. doi request reprint Wake-up call for British psychiatry
    Nick Craddock
    Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 193:6-9. 2008
    ..On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients...
  10. ncbi request reprint Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles
    Nick Craddock
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 190:200-3. 2007
    ....
  11. pmc Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology
    Nick Craddock
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Bull 32:9-16. 2006
    ....
  12. ncbi request reprint The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons
    N Craddock
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 11:446-58. 2006
    ..In this review, we consider the current state of evidence and the implications both for further studies of COMT and more generally for studies of other genes...
  13. pmc The Kraepelinian dichotomy - going, going... but still not gone
    Nick Craddock
    MRC Centre for Neuropsychiatric Genetics and Genomics, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 196:92-5. 2010
    ....
  14. ncbi request reprint Genetics of affective (mood) disorders
    Nick Craddock
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Eur J Hum Genet 14:660-8. 2006
    ....
  15. doi request reprint Genetics of bipolar disorder: successful start to a long journey
    Nick Craddock
    Department of Psychological Medicine, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Trends Genet 25:99-105. 2009
    ....
  16. pmc The genetics of schizophrenia and bipolar disorder: dissecting psychosis
    N Craddock
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    J Med Genet 42:193-204. 2005
    ..Future identification of psychosis susceptibility genes will have a major impact on our understanding of disease pathophysiology and will lead to changes in classification and the clinical practice of psychiatry...
  17. pmc Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses
    Nick Craddock
    Schizophr Bull 35:482-90. 2009
    ..We conclude that if psychiatry is to translate the opportunities offered by new research methodologies, we must finally abandon a 19th-century dichotomy and move to a classificatory approach that is worthy of the 21st century...
  18. doi request reprint Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
    H J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 16:429-41. 2011
    ..The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder...
  19. pmc Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept
    M L Hamshere
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 195:23-9. 2009
    ..Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research...
  20. doi request reprint Association at SYNE1 in both bipolar disorder and recurrent major depression
    E K Green
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 18:614-7. 2013
    ..032, OR=1.118). Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders...
  21. pmc The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
    E K Green
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:1016-22. 2010
    ....
  22. doi request reprint Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha
    L S Carroll
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 15:1101-11. 2010
    ..However, the evidence across all approaches suggests that further study of this locus is warranted...
  23. ncbi request reprint Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder
    C Guy
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Am J Psychiatry 154:1146-7. 1997
    ..The purpose of this study was to identify the specific expanded CAG/CTG trinucleotide repeat associated with bipolar disorder...
  24. pmc Polygenic dissection of the bipolar phenotype
    M L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Br J Psychiatry 198:284-8. 2011
    ..Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder...
  25. doi request reprint No evidence that rare coding variants in ZNF804A confer risk of schizophrenia
    S Dwyer
    MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1411-6. 2010
    ..Our results do not support the hypothesis that moderately rare non-synonymous variants at the ZNF804A locus are involved in schizophrenia susceptibility. © 2010 Wiley-Liss, Inc...
  26. ncbi request reprint Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:67-71. 1998
    ....
  27. doi request reprint Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC
    M L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 18:708-12. 2013
    ..We also provide strong evidence for overlap in genetic risk between schizophrenia and bipolar disorder...
  28. ncbi request reprint Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:342-5. 1998
    ..84, d.f. = 1, P = 0.014. Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder...
  29. doi request reprint Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk
    V Moskvina
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:252-60. 2009
    ..Our analyses show that association signals are enriched in and around genes, large numbers of genes contribute to both disorders and gene-wide analyses offer useful complementary approaches to more standard methods...
  30. doi request reprint Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain
    A L Richards
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 17:193-201. 2012
    ..Moreover, our data show that notwithstanding the likely developmental origin of schizophrenia, studies of adult brain tissue can, in principle, allow relevant susceptibility eQTLs to be identified...
  31. ncbi request reprint Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5
    G Kirov
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK
    Mol Psychiatry 4:558-65. 1999
    ..No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied...
  32. ncbi request reprint Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
    T Bowen
    University of Wales College of Medicine, Division of Psychological Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:266-9. 1998
    ..820, P = 0.047, 1-tail). Our data therefore provide modest support for the hypothesis that polymorphism in the hKCa3 gene may contribute to susceptibility to schizophrenia...
  33. ncbi request reprint Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior
    K Langley
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Med Genet B Neuropsychiatr Genet 147:49-53. 2008
    ..There may be evidence of G x E on associated antisocial behavior in ADHD, but further investigation is needed...
  34. pmc Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
    ..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia...
  35. doi request reprint DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls
    E K Green
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 156:490-2. 2011
    ..In sequencing exon 11 in 506 cases and 1,211 controls for variants that occurred only once, 4 additional rare variants were found in cases (P-value = 0.008, Fisher's exact trend test)...
  36. pmc Pooled genotyping of microsatellite markers in parent-offspring trios
    G Kirov
    Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Genome Res 10:105-15. 2000
    ..The use of trios will confirm or reject any suggested differences, thus reducing the false-positive rate that can be created by hidden population stratification...
  37. ncbi request reprint CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder
    N J Jacobsen
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet 105:295-300. 2001
    ..No evidence was found for the involvement of variants within the CUX2 coding, or 5' UTR sequence in producing susceptibility to bipolar disorder...
  38. doi request reprint Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample
    E K Green
    Department of Psychological Medicine, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Heath Park, Cardiff, UK
    Mol Psychiatry 18:1302-7. 2013
    ..Second, rs3818253 (P=3.88 × 10(-8), OR=1.16), an intronic SNP on chromosome 20q11.2 in the gene TRPC4AP, which lies in a high linkage disequilibrium region along with the genes GSS and MYH7B. ..
  39. ncbi request reprint Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder
    N J Jacobsen
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Mol Psychiatry 6:92-7. 2001
    ..Analysis of allele and genotype distributions for all six variations, and of haplotype frequencies showed no evidence for the involvement of ATP2A2 in producing susceptibility to bipolar disorder...
  40. ncbi request reprint Design of case-controls studies with unscreened controls
    V Moskvina
    Bioinformatics and Biostatistics Unit, Cardiff University, College of Medicine, CF14 4XN, UK
    Ann Hum Genet 69:566-76. 2005
    ..2. With the steady reduction in genotyping costs and the availability of common sets of "population controls" this design is likely to become increasingly cost effective...
  41. ncbi request reprint Schizophrenia: genes at last?
    M J Owen
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Trends Genet 21:518-25. 2005
    ..The identification of these, and other susceptibility genes, will open up new avenues for research aimed at understanding the pathogenesis of schizophrenia, and will catalyse a re-appraisal of the classification of psychiatric disorders...
  42. pmc Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes
    M L Hamshere
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Med Genet 43:563-7. 2006
    ..Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression...
  43. ncbi request reprint Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4
    B Glaser
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, UK
    Mol Psychiatry 10:920-7. 2005
    ..001), where some of the variance was accounted for by the genotype at ss24735177. Our findings thus indicate the potential functional relevance of the associated haplotype and now require replication in independent samples...
  44. ncbi request reprint Linkage analysis between bipolar affective disorder and markers on chromosome X
    H P Vallada
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatr Genet 8:183-6. 1998
    ..We conclude that there is no evidence of a common major gene for bipolar affective disorder at Xq25-q27 in our set of families...
  45. doi request reprint The neuropsychiatric phenotype in Darier disease
    K Gordon-Smith
    Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, U K
    Br J Dermatol 163:515-22. 2010
    ..It is caused by mutations in a single gene, ATP2A2, which is expressed in the skin and brain...
  46. ncbi request reprint Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios
    A West
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Mol Psychiatry 7:962-6. 2002
    ....
  47. ncbi request reprint Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Mol Psychiatry 9:169-73. 2004
    ..We conclude that replication is required and that further work examining for association of GRIN2A polymorphisms with ADHD is warranted...
  48. doi request reprint Sub-threshold manic symptoms in recurrent major depressive disorder are a marker for poor outcome
    D J Smith
    Department of Psychological Medicine, School of Medicine, Cardiff University, University Hospital of Wales, Cardiff, UK
    Acta Psychiatr Scand 119:325-9. 2009
    ..A small but significant proportion of patients with major depressive disorder (MDD) report mild manic symptoms which are below the diagnostic threshold for a hypomanic episode...
  49. pmc Evidence that duplications of 22q11.2 protect against schizophrenia
    E Rees
    MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
    Mol Psychiatry 19:37-40. 2014
    ..014% vs 0.085%, OR=0.17, P=0.00086). 22q11.2 duplications represent the first putative protective mutation for schizophrenia...
  50. ncbi request reprint ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes
    N J Jacobsen
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 8:1631-6. 1999
    ..This supports the hypothesis that the DD gene has pleiotropic effects in brain and that mutations in SERCA2 are implicated in the pathogenesis of neuropsychiatric disorders...
  51. pmc The genetic deconstruction of psychosis
    Michael J Owen
    Department of Psychological Medicine, The School of Medicine, Cardiff University, Cardiff, UK
    Schizophr Bull 33:905-11. 2007
    ....
  52. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  53. ncbi request reprint Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16
    Ian Jones
    Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK
    Am J Psychiatry 164:1099-104. 2007
    ..The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis...
  54. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  55. ncbi request reprint Differences in depressive symptom profile between males and females
    Daniel J Smith
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, CF10 3XQ, UK
    J Affect Disord 108:279-84. 2008
    ..Here we compare the clinical profile of major depression for men and women from a sample of almost 600 well-characterized individuals with recurrent major depressive disorder (MDD)...
  56. doi request reprint Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:1169-74. 2008
    ..Our data provide complementary evidence for chromosome 8p as a susceptibility locus for schizophrenia, and suggest that genetic variation within this region may influence risk, at least in part, through effects on DTNBP1 expression...
  57. doi request reprint Incidence of hospitalization for postpartum psychotic and bipolar episodes
    Ian Jones
    Arch Gen Psychiatry 65:356. 2008
  58. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  59. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  60. doi request reprint Clinical differences between bipolar and unipolar depression
    Liz Forty
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Br J Psychiatry 192:388-9. 2008
    ..Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression...
  61. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  62. ncbi request reprint Whole genome linkage scan of recurrent depressive disorder from the depression network study
    Peter McGuffin
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Hum Mol Genet 14:3337-45. 2005
    ..Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined...
  63. ncbi request reprint Variation in the coding sequence and flanking splice junctions of the estrogen receptor alpha (ERalpha) gene does not play an important role in genetic susceptibility to bipolar disorder or bipolar affective puerperal psychosis
    Fiona Middle
    Division of Neuroscience, Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
    Am J Med Genet B Neuropsychiatr Genet 118:72-5. 2003
    ..We conclude that variation in the coding sequence and flanking splice junctions of the ERalpha gene does not play an important pathogenic role in the majority of cases of Bipolar Disorder or Bipolar Affective Puerperal Psychosis...
  64. ncbi request reprint Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...
  65. ncbi request reprint Searching for the puerperal trigger: molecular genetic studies of bipolar affective puerperal psychosis
    Ian Jones
    Perinatal Psychiatry, Department of Psychological Medicine, The Henry Wellcome Building for Biomedical Research in Wales, Neuropsychiatric Genetics Group, Cardiff University, Cardiff, United Kingdom
    Psychopharmacol Bull 40:115-28. 2007
    ..We are undertaking association studies in women with postpartum psychosis at a number of candidate genes of interest in BP disorder with an emphasis on those for which the expression is influenced by steroid hormones...
  66. ncbi request reprint Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases
    Jin Yan
    Department of Molecular Genetics and Molecular Diagnosis, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Neurosci Lett 380:37-41. 2005
    ..In conclusion, we describe three novel structural variants of the Vitamin D receptor. Further study is required to clarify their role, if any, in psychiatric disease...
  67. ncbi request reprint Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications
    Elaine Green
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Curr Psychiatry Rep 5:469-76. 2003
    ....
  68. ncbi request reprint Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases
    Jinong Feng
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Am J Med Genet B Neuropsychiatr Genet 133:50-3. 2005
    ..One uncommon missense variant was found in each of the RARbeta, RARgamma, and RXRgamma genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia...
  69. ncbi request reprint Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease
    Elaine Green
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK
    Am J Psychiatry 162:35-42. 2005
    ..Here molecular genetic analyses aimed at localizing and identifying the susceptibility gene in this region are reported...
  70. ncbi request reprint Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
    ..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples...
  71. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004
  72. ncbi request reprint Mutation scanning of the androgen receptor gene in patients with psychiatric disorders reveals highly conserved variants in alcoholic and phobia patients
    Jin Yan
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Psychiatr Genet 14:57-60. 2004
    ..R726L and P516S occur at highly conserved amino acids. Further study is required to assess whether these VAPSEs contribute to the risk of alcoholism or phobia or other diseases...
  73. ncbi request reprint Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13
    Marian L Hamshere
    Department of Psychological Medicine, School of Medicine, Cardiff University, Wales
    Arch Gen Psychiatry 62:1081-8. 2005
    ..However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder...
  74. ncbi request reprint Familiality of symptom dimensions in depression
    Ania Korszun
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Arch Gen Psychiatry 61:468-74. 2004
    ..A dimensional rather than a categorical approach to depressive phenotype definition may be more useful for identification of susceptibility genes...
  75. ncbi request reprint Effects of differential genotyping error rate on the type I error probability of case-control studies
    Valentina Moskvina
    Bioinformatics and Biostatistics Unit, School of Medicine, Wales College of Medicine, Cardiff University, Cardiff, UK
    Hum Hered 61:55-64. 2006
    ....
  76. ncbi request reprint Do puerperal psychotic episodes identify a more familial subtype of bipolar disorder? Results of a family history study
    Ian Jones
    Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
    Psychiatr Genet 12:177-80. 2002
    ..0077). Despite relatively small numbers, this study provides evidence to support the hypothesis that puerperal episodes identify a more familial subtype of bipolar disorder...
  77. ncbi request reprint Interrelationship of childhood trauma, neuroticism, and depressive phenotype
    Valentina Moskvina
    Department of Psychological Medicine, University of Cardiff, Cardiff, Wales, United Kingdom
    Depress Anxiety 24:163-8. 2007
    ....
  78. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  79. ncbi request reprint Use of phenotypic covariates in association analysis by sequential addition of cases
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Eur J Hum Genet 14:529-34. 2006
    ..We also illustrate the use of the method for taking account of a dimensional measure of psychosis in a study of the schizophrenia susceptibility gene, dysbindin, in bipolar disorder...
  80. ncbi request reprint MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism
    Akane Shibayama
    Department of Molecular Genetics and Diagnosis, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Am J Med Genet B Neuropsychiatr Genet 128:50-3. 2004
    ..009). These mutations suggest that a possible association between MECP2 mutations and autism may warrant further study...
  81. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  82. ncbi request reprint Cognitive style in bipolar disorder
    Lisa Jones
    Department of Psychiatry, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
    Br J Psychiatry 187:431-7. 2005
    ..Abnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance...
  83. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  84. ncbi request reprint Triplet repeats and bipolar disorder
    Ian Jones
    Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, United Kingdom
    Curr Psychiatry Rep 4:134-40. 2002
    ..It is likely that the controversy surrounding anticipation and the existence of triplet repeats will only finally be resolved with the demonstration of such a mutation in the aetiology of bipolar disorder...
  85. ncbi request reprint Anticipation and repeat expansion in bipolar disorder
    MICHAEL O'DONOVAN
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Am J Med Genet C Semin Med Genet 123:10-7. 2003
    ..No pathogenic triplet repeat has yet been unambiguously implicated...
  86. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  87. ncbi request reprint Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5
    Elaine K Green
    Molecular Psychiatry Group, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
    Psychiatr Genet 13:97-101. 2003
    ..1; pedigree 5501, maximum LOD=3.6)...
  88. ncbi request reprint Is there a relationship between attention deficit hyperactivity disorder and bipolar disorder?
    Lindsey Kent
    Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
    J Affect Disord 73:211-21. 2003
    ..However, several fundamental methodological issues require rectification in future research in order to further elucidate the relationship between these disorders...
  89. ncbi request reprint Attitudes towards future testing for bipolar disorder susceptibility genes: a preliminary investigation
    Ian Jones
    Division of Neuroscience, Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
    J Affect Disord 71:189-93. 2002
    ..Psychiatrists, who will have to administer such tests, appear significantly more cautious...
  90. ncbi request reprint Bipolar disorder and childbirth: the importance of recognising risk
    Ian Jones
    Br J Psychiatry 186:453-4. 2005
  91. ncbi request reprint Sex differences in symptom patterns of recurrent major depression in siblings
    Valentina Moskvina
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Depress Anxiety 25:527-34. 2008
    ..38, P=0.004) and appetite gain (exp(B)=2.19, P<0.001). Sex significantly modifies clinical features of depression and an earlier onset of depression and atypical depressive symptoms occur more frequently in women...
  92. doi request reprint Medical disorders in people with recurrent depression
    Anne Farmer
    Medical Research Council, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Br J Psychiatry 192:351-5. 2008
    ..Few studies have examined the rates of physical disorders in those with recurrent depression...
  93. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  94. ncbi request reprint The beginning of the end for the Kraepelinian dichotomy
    Nick Craddock
    Br J Psychiatry 186:364-6. 2005
  95. ncbi request reprint Clinical presentation of postnatal and non-postnatal depressive episodes
    Carly Cooper
    Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
    Psychol Med 37:1273-80. 2007
    ..We have undertaken within- and between-individual comparisons of the clinical presentation of postnatal (PN) and non-postnatal (NPN) depressive episodes in women with recurrent depression...
  96. ncbi request reprint Postnatal euphoria: are 'the highs' an indicator of bipolarity?
    Jessica Heron
    Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
    Bipolar Disord 7:103-10. 2005
    ..This paper critically reviews the literature on milder forms of high mood occurring in the puerperium and discusses the potential clinical and research significance of 'the highs'...
  97. ncbi request reprint Risk of puerperal and non-puerperal recurrence of illness following bipolar affective puerperal (post-partum) psychosis
    Emma Robertson
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Psychiatry 186:258-9. 2005
    ..A history of bipolar episodes prior to the puerperal psychosis did not predict risk following subsequent pregnancies, but positive family history of mental illness predicted shorter time to non-puerperal relapse...
  98. ncbi request reprint Obstetric variables associated with bipolar affective puerperal psychosis
    Emma Robertson Blackmore
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Cardiff, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Psychiatry 188:32-6. 2006
    ..These include: (a) primiparity, (b) pregnancy complications, (c) delivery complications, (d) Caesarean section, (e) female baby and (f) shorter gestation period...
  99. ncbi request reprint Association of DRD4 in children with ADHD and comorbid conduct problems
    Jane Holmes
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales, United Kingdom
    Am J Med Genet 114:150-3. 2002
    ..Further work is needed to examine these phenotype issues...