A G Cardno

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi Heritability estimates for psychotic disorders: the Maudsley twin psychosis series
    A G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Arch Gen Psychiatry 56:162-8. 1999
  2. ncbi Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics
    A G Cardno
    University of Wales College of Medicine, Cardiff, UK
    Am J Med Genet 97:12-7. 2000
  3. ncbi Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes
    M L Hamshere
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Med Genet 43:563-7. 2006
  4. ncbi Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
    T Bowen
    University of Wales College of Medicine, Division of Psychological Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:266-9. 1998
  5. ncbi A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs
    N M Williams
    Neuropsychiatric Genetics Unit, Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 8:1729-39. 1999
  6. ncbi Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:67-71. 1998
  7. ncbi The kings schizotypy questionnaire as a quantitative measure of schizophrenia liability
    L A Jones
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF14 4XN, Cardiff, UK
    Schizophr Res 45:213-21. 2000
  8. ncbi A genomewide linkage study of age at onset in schizophrenia
    A G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet 105:439-45. 2001
  9. ncbi Dimensions of psychosis in affected sibling pairs
    A G Cardno
    Medical Research Council, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Schizophr Bull 25:841-50. 1999
  10. ncbi Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 10:33-7. 2000

Collaborators

Detail Information

Publications17

  1. ncbi Heritability estimates for psychotic disorders: the Maudsley twin psychosis series
    A G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Arch Gen Psychiatry 56:162-8. 1999
    ....
  2. ncbi Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics
    A G Cardno
    University of Wales College of Medicine, Cardiff, UK
    Am J Med Genet 97:12-7. 2000
    ..More recently, twin studies have begun to be used to directly investigate molecular genetic and epigenetic processes underlying schizophrenia...
  3. ncbi Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes
    M L Hamshere
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK
    J Med Genet 43:563-7. 2006
    ..093 times per genome scan, ILOD = 2.83). CONCLUSIONS: Our findings identify loci that may harbour genes that play a role in susceptibility to, or modify the risk of, episodes of major depression in people with schizophrenia...
  4. ncbi Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
    T Bowen
    University of Wales College of Medicine, Division of Psychological Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:266-9. 1998
    ..820, P = 0.047, 1-tail). Our data therefore provide modest support for the hypothesis that polymorphism in the hKCa3 gene may contribute to susceptibility to schizophrenia...
  5. ncbi A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs
    N M Williams
    Neuropsychiatric Genetics Unit, Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 8:1729-39. 1999
    ..05, but only 0.70 to detect a locus of lambda(s)= 2. Our results suggest that common genes of major effect (lambda(s)> 3) are unlikely to exist for schizophrenia...
  6. ncbi Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:67-71. 1998
    ....
  7. ncbi The kings schizotypy questionnaire as a quantitative measure of schizophrenia liability
    L A Jones
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF14 4XN, Cardiff, UK
    Schizophr Res 45:213-21. 2000
    ....
  8. ncbi A genomewide linkage study of age at onset in schizophrenia
    A G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet 105:439-45. 2001
    ..68) coincided with the region showing maximum evidence for linkage in the study by Blouin et al. [1998: Nat Genet 20:70-73] of categorical schizophrenia...
  9. ncbi Dimensions of psychosis in affected sibling pairs
    A G Cardno
    Medical Research Council, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Schizophr Bull 25:841-50. 1999
    ..They may be weakly associated with such factors and with factors that do not contribute liability to schizophrenia but do influence the form taken by the illness...
  10. ncbi Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia
    T Bowen
    Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Psychiatr Genet 10:33-7. 2000
    ..No evidence for association of CTG18.1, ERDA1 and/or TGC13-7a with schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis...
  11. ncbi Twin study of symptom dimensions in psychoses
    A G Cardno
    Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Cardiff, UK
    Br J Psychiatry 179:39-45. 2001
    ..CONCLUSIONS: The disorganised dimension, and possibly other symptom dimensions, may be useful phenotypes for molecular genetic studies of psychoses...
  12. ncbi Sustained and selective attention as measures of genetic liability to schizophrenia
    L A Jones
    Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Res 48:263-72. 2001
    ..However, our results may have been affected by self-selection bias in probands and relatives and clinical heterogeneity among probands, which could have reduced our power to detect effects...
  13. ncbi A systematic genomewide linkage study in 353 sib pairs with schizophrenia
    N M Williams
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Hum Genet 73:1355-67. 2003
    ..02) to 17p11.2-q25.1 in a single pedigree with schizophrenia. In our view, the evidence is now sufficiently compelling to undertake detailed mapping studies of these three regions...
  14. ncbi Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 7:1092-100. 2002
    ..35, P = 0.006, P = 0.078 corrected for 13 alleles)...
  15. ncbi Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype
    G Jones
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, UK
    Br J Psychiatry 179:351-5. 2001
    ..Although the aetiology of aggression is multifactorial, three studies have reported associations between polymorphisms of the catechol-O-methyltransferase (COMT) gene and aggression in schizophrenia...
  16. ncbi No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH)
    H J Williams
    Neuropsychiatric Genetics Department, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Med Genet 88:557-9. 1999
    ..08 in the control group, with no significant allelic or genotypic association observed. Therefore, we were unable to obtain evidence that this polymorphism contributes directly to susceptibility to schizophrenia...
  17. ncbi Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls
    P Sklar
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 28:126-8. 2001
    ..These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia...