Research Topics
| A K CampbellSummaryAffiliation: Cardiff University Country: UK Publications
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Publications
Darwin's illness revealedAnthony K Campbell
The Darwin Centre for Biology and Medicine, Milton, Pembrokeshire, UK
Postgrad Med J 81:248-51. 2005..Darwin only got better when, by chance, he stopped taking milk and cream. Darwin's illness highlights something else he missed--the importance of lactose in mammalian and human evolution...- Lactose causes heart arrhythmia in the water flea Daphnia pulexAnthony K Campbell
Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
Comp Biochem Physiol B Biochem Mol Biol 139:225-34. 2004..The results show that D. pulex is a novel model system for studying effects of agonists and toxins on cell signalling and ion channels in situ... - The molecular basis of lactose intoleranceAnthony K Campbell
Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Cardiff CF14 XN, UK
Sci Prog 88:157-202. 2005..Darwin missed something else--the key to our own evolution--the Rubicon some 300 million years ago that produced lactose and lactase in sufficient amounts to be susceptible to natural selection... - Fermentation product butane 2,3-diol induces Ca2+ transients in E. coli through activation of lanthanum-sensitive Ca2+ channelsAnthony K Campbell
Department of Medical Biochemistry and Immunology, School of Medicine, Tenovus Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Cell Calcium 41:97-106. 2007..These results were consistent with butane 2,3-diol activating a novel La3+-sensitive Ca2+ channel. They have important implications for the role of butane 2,3-diol and Ca2+ in bacterial-host cell signalling... - Methylglyoxal and other carbohydrate metabolites induce lanthanum-sensitive Ca2+ transients and inhibit growth in E. coliAnthony K Campbell
Department of Medical Biochemistry and Immunology, Cardiff University, Tenovus Building, Health Park, Cardiff CF14 XN, UK
Arch Biochem Biophys 468:107-13. 2007..They have important implications in bacterial-host cell signalling, and where numbers of different bacteria compete for the same substrates, e.g., the gut in lactose and food intolerance... - Jean-Marie Bassot (1933-2007): a life of unquenched curiosityAnthony K Campbell
Darwin Centre, Department of Medical Biochemistry and Immunology, Cardiff University, Tenovus Building, Heath Park, Cardiff CF14 4XN, UK
Luminescence 23:187-90. 2008 - The molecular basis of lactose intoleranceAnthony K Campbell
Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Cardiff, CF14 XN, UK
Sci Prog 92:241-87. 2009..Darwin missed something else--the key to our own evolution--the Rubicon some 300 million years ago that produced lactose and lactase in sufficient amounts to be susceptible to natural selection... - Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndromeA K Campbell
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK
Toxicology 278:268-76. 2010..We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers... - Slow changes in cytosolic free Ca2+ in Escherichia coli highlight two putative influx mechanisms in response to changes in extracellular calciumH E Jones
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
Cell Calcium 25:265-74. 1999..This suggested the presence of at least two Ca2+ influx processes, one inhibited by La3+ and the other not... - Current evidence suggests independent regulation of nuclear calciumM N Badminton
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
Cell Calcium 23:79-86. 1998..In addition, they highlight the advantages of using targeted aequorin in intact cells to monitor changes in organelle [Ca2+]... - Systemic lactose intolerance: a new perspective on an old problemS B Matthews
Department of Medical Biochemistry and Immunology, Llandough Hospital, Cardiff and Vale NHS Trust, Penarth Vale of Glamorgan, UK
Postgrad Med J 81:167-73. 2005..This review highlights the wide range of systemic symptoms caused by lactose intolerance. This has important implications for the management of irritable bowel syndrome, and for doctors of many specialties... - Enzymatic activity of albumin shown by coelenterazine chemiluminescenceN Vassel
School of Pharmacy and Pharmaceutical Science, Cardiff University, King Edward VII Avenue, CF10 3NB Cardiff, UK
Luminescence 27:234-41. 2012..They also have important consequences in diseases such as diabetes, gut disorders and food intolerance where a mono-oxygenase could affect cell surface proteins... - DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cellsPaul J Smith
Department of Pathology, University of Wales, College of Medicine, Health Park, Cardiff, United Kingdom
Am J Physiol Cell Physiol 283:C609-22. 2002..Early stress responses in p53(wt) cells take place in an environment of enhanced Zn(2+) availability... - Direct measurement of free Ca(2+) shows different regulation of Ca(2+) between the periplasm and the cytosol of Escherichia coliH E Jones
Department of Medical Biochemistry, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
Cell Calcium 32:183-92. 2002.... - Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivityJonathan P Waud
Department of Medical Biochemistry and Immunology, Llandough Hospital, Cardiff and Vale NHS Trust, Llandough, Vale of Glamorgan, South Wales, Cardiff, UK
Ann Clin Biochem 45:50-8. 2008..Breath methane and symptoms are not recorded as standard practice. The clinical value of analysing C/T(13910) and G/A(22018) polymorphisms, strongly associated with lactose sensitivity, has not been established... - A mathematical model predicts that calreticulin interacts with the endoplasmic reticulum Ca(2+)-ATPaseHelen L Baker
Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
Biophys J 82:582-90. 2002.... - Reversible injury of cultured rat oligodendrocytes by complementN J Scolding
Section of Neurology, University of Wales College of Medicine, Heath Park, Cardiff
Immunology 67:441-6. 1989..Reversible and/or lytic complement-mediated oligodendrocyte injury has implications for the pathogenesis of human and experimental demyelinating diseases... - Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cellsC H George
Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF4 4XN, United Kingdom
J Biol Chem 273:29822-9. 1998..The implications of the subplasma-membrane Ca2+ levels on the gating of gap junctions are discussed... - Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptorsH L Roderick
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
FEBS Lett 405:181-5. 1997..Thus, despite ER targeting and retention signals, calreticulin is also located within the nucleus where its presence increases due to its interaction with glucocorticoid receptors... - Escherichia coli lacking the AcrAB multidrug efflux pump also lacks nonproteinaceous, PHB-polyphosphate Ca2+ channels in the membraneHelen E Jones
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
Biochim Biophys Acta 1612:90-7. 2003..In other experiments, we showed that the particular defective calcium handling detected in N43 was not due to the absence of AcrA but to other unknown factors in this strain... - Cytosolic Ca2+ regulates protein expression in E. coli through release from inclusion bodiesRiffat Naseem
Department of Medical Biochemistry and Immunology, Tenovus Building, Cardiff University, Heath Park, Cardiff CF14 XN, UK
Biochem Biophys Res Commun 360:33-9. 2007..These results have important implications for unravelling the physiological role of cytosolic Ca(2+) in bacteria, particularly where several species are competing for the same nutrients, such as in the gut... - ATP regulates calcium efflux and growth in E. coliRiffat Naseem
Department of Medical Biochemistry and Immunology, Cardiff University, Tenovus Building, Heath Park, Cardiff, Wales, UK
J Mol Biol 391:42-56. 2009..We therefore propose that ATP is most likely to regulate Ca(2+) efflux in E. coli through an ATPase... - pH and monovalent cations regulate cytosolic free Ca(2+) in E. coliRiffat Naseem
Department of Medical Biochemistry and Immunology, Tenovus Building, Cardiff University, Heath Park, Cardiff, UK
Biochim Biophys Acta 1778:1415-22. 2008..The results have important significance in the adaptation of E. coli to different ionic environments such as the gut, fresh water and in sea water near sewage effluents...