M Boulton

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint The role of the retinal pigment epithelium: topographical variation and ageing changes
    M Boulton
    Department of Optometry and Vision Sciences, Cardiff University, UK
    Eye (Lond) 15:384-9. 2001
  2. ncbi request reprint Stem cells in the eye
    Mike Boulton
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, Wales, UK
    Int J Biochem Cell Biol 36:643-57. 2004
  3. ncbi request reprint Retinal photodamage
    M Boulton
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK
    J Photochem Photobiol B 64:144-61. 2001
  4. ncbi request reprint Ageing of the retinal pigment epithelium: implications for transplantation
    Mike Boulton
    School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    Graefes Arch Clin Exp Ophthalmol 242:76-84. 2004
  5. ncbi request reprint Oxygen modulates the release of urokinase and plasminogen activator inhibitor-1 by retinal pigment epithelial cells
    J T Erichsen
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, Wales, UK
    Int J Biochem Cell Biol 33:237-47. 2001
  6. ncbi request reprint Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin
    F A Shamsi
    Cell and Molecular Biology Unit, Department of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 42:3041-6. 2001
  7. ncbi request reprint The pathogenesis of diabetic retinopathy: old concepts and new questions
    J Cai
    Department of Optometry and Vision Sciences, Cardiff University, UK
    Eye (Lond) 16:242-60. 2002
  8. pmc VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells
    B Zhao
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Br J Ophthalmol 90:1052-9. 2006
  9. ncbi request reprint Decreased pigment epithelium-derived factor expression in human breast cancer progression
    Jun Cai
    Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Wales College of Medicine, Cardiff University, United Kingdom
    Clin Cancer Res 12:3510-7. 2006
  10. ncbi request reprint RPE lipofuscin and its role in retinal pathobiology
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Exp Eye Res 80:595-606. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The role of the retinal pigment epithelium: topographical variation and ageing changes
    M Boulton
    Department of Optometry and Vision Sciences, Cardiff University, UK
    Eye (Lond) 15:384-9. 2001
    ..While the aetiology of age-related macular degeneration is complex and is as yet unresolved, it is likely that accelerated ageing-like changes in the RPE play a fundamental role in the development of this condition...
  2. ncbi request reprint Stem cells in the eye
    Mike Boulton
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, Wales, UK
    Int J Biochem Cell Biol 36:643-57. 2004
    ..It will further discuss their role in pathology and their potential for therapeutic intervention...
  3. ncbi request reprint Retinal photodamage
    M Boulton
    Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK
    J Photochem Photobiol B 64:144-61. 2001
    ..The aim of this article is to provide a detailed review of our current understanding of the photochemistry and photobiology of these chromophores and to consider how they may contribute to retinal ageing and pathology...
  4. ncbi request reprint Ageing of the retinal pigment epithelium: implications for transplantation
    Mike Boulton
    School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    Graefes Arch Clin Exp Ophthalmol 242:76-84. 2004
    ..The article concludes by considering the suitability of senescent RPE cells for transplantation and whether such cells can be rejuvenated...
  5. ncbi request reprint Oxygen modulates the release of urokinase and plasminogen activator inhibitor-1 by retinal pigment epithelial cells
    J T Erichsen
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, Wales, UK
    Int J Biochem Cell Biol 33:237-47. 2001
    ..These results suggest that both oxygen tension and growth factors may interact to modulate the proteolytic properties of the human retinal pigment epithelium...
  6. ncbi request reprint Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin
    F A Shamsi
    Cell and Molecular Biology Unit, Department of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 42:3041-6. 2001
    ..CONCLUSIONS: Lipofuscin has the capacity to reduce the efficacy of the lysosomal and antioxidant systems in RPE cells that may play an important role in retinal ageing and the development of age-related macular degeneration...
  7. ncbi request reprint The pathogenesis of diabetic retinopathy: old concepts and new questions
    J Cai
    Department of Optometry and Vision Sciences, Cardiff University, UK
    Eye (Lond) 16:242-60. 2002
    ....
  8. pmc VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells
    B Zhao
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Br J Ophthalmol 90:1052-9. 2006
    ....
  9. ncbi request reprint Decreased pigment epithelium-derived factor expression in human breast cancer progression
    Jun Cai
    Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Wales College of Medicine, Cardiff University, United Kingdom
    Clin Cancer Res 12:3510-7. 2006
    ..The aim of this study was to correlate the expression of pigment epithelium-derived factor (PEDF), a potent endogenous antiangiogenic molecule, with severity and prognosis in breast cancer...
  10. ncbi request reprint RPE lipofuscin and its role in retinal pathobiology
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Exp Eye Res 80:595-606. 2005
    ..Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues...
  11. ncbi request reprint Placenta growth factor is over-expressed and has prognostic value in human breast cancer
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Eur J Cancer 41:2819-27. 2005
    ..017) with recurrence, metastasis and patient mortality. Our study has shown that PlGF is over-expressed in breast cancer tissues and correlates with patient prognosis, and is likely to play a major role in the pathogenesis of tumours...
  12. pmc Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2
    Bojun Zhao
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff University, UK
    Br J Ophthalmol 91:538-45. 2007
    ..To determine vascular endothelial growth factor C (VEGF-C) expression in retinal endothelial cells, its antiapoptotic potential and its putative role in diabetic retinopathy...
  13. ncbi request reprint Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors
    Louise M Carrington
    Cell and Molecular Unit, School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Invest Ophthalmol Vis Sci 47:1886-94. 2006
    ..Determining the actions of distinct TGF-beta isoforms and their inhibitors during early corneal wound healing is an essential step in guiding therapeutic intervention...
  14. ncbi request reprint Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
    Jun Cai
    School of Optometry and Vision Sciences, Cardiff University, UK
    J Biol Chem 281:3604-13. 2006
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
  15. ncbi request reprint Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS
    Jun Cai
    Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, UK
    Microvasc Res 71:20-31. 2006
    ....
  16. ncbi request reprint Blue light induces mitochondrial DNA damage and free radical production in epithelial cells
    Bernard F Godley
    Retina Foundation of the Southwest, Dallas, Texas 75231, USA
    J Biol Chem 280:21061-6. 2005
    ..We conclude that visible light can cause cell dysfunction through the action of reactive oxygen species on DNA and that this may contribute to cellular aging, age-related pathologies, and tumorigenesis...
  17. ncbi request reprint Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing
    Louise M Carrington
    Cell and Molecular Biology Unit, Department of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    J Cataract Refract Surg 31:412-23. 2005
    ..To investigate the effects of hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) on early wound healing in the corneal epithelium and stroma...
  18. ncbi request reprint Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2
    Bojun Zhao
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences and Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff CF10 3NB, UK
    Microvasc Res 68:239-46. 2004
    ....
  19. ncbi request reprint The photoreactivity of ocular lipofuscin
    Mike Boulton
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Photochem Photobiol Sci 3:759-64. 2004
    ..Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss...
  20. ncbi request reprint Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells
    Jun Cai
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Diabetes 52:2959-68. 2003
    ..Together, these findings indicate that PlGF-containing ligands contribute to pathological angiogenesis by prolonging cell survival signals and maintaining vascular networks...
  21. ncbi request reprint A role for notch signaling in human corneal epithelial cell differentiation and proliferation
    Aihua Ma
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 48:3576-85. 2007
    ..To identify the role of Notch signaling in the human corneal epithelium...