E J Blain

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis
    Rhian S Thomas
    Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Arthritis Res Ther 13:R203. 2011
  2. pmc Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation
    Angus K T Wann
    School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK
    Arthritis Res Ther 12:R207. 2010
  3. pmc Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study
    Sophie J Gilbert
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, UK
    Arthritis Res Ther 8:R89. 2006
  4. ncbi request reprint Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro
    E J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, CF10 3US, United Kingdom
    Arch Biochem Biophys 396:49-55. 2001
  5. doi request reprint Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, UK
    Phytother Res 24:905-12. 2010
  6. ncbi request reprint Mechanical regulation of matrix metalloproteinases
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, United Kingdom
    Front Biosci 12:507-27. 2007
  7. ncbi request reprint Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis
    Emma J Blain
    Connective Tissue Biology Laboratories, Biomedical Sciences Building, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Matrix Biol 25:398-408. 2006
  8. ncbi request reprint The effect of cyclical compressive loading on gene expression in articular cartilage
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Biorheology 40:111-7. 2003
  9. ncbi request reprint The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression
    E J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Wales, UK
    Biochem Soc Trans 30:879-82. 2002
  10. pmc Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, UK
    Int J Exp Pathol 90:1-15. 2009

Collaborators

Detail Information

Publications18

  1. pmc Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis
    Rhian S Thomas
    Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Arthritis Res Ther 13:R203. 2011
    ....
  2. pmc Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation
    Angus K T Wann
    School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK
    Arthritis Res Ther 12:R207. 2010
    ..The aim of this study was to examine the therapeutic potential of n-3 polyunsaturated fatty acids (PUFAs) in an in vitro model of cartilage inflammation...
  3. pmc Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study
    Sophie J Gilbert
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, UK
    Arthritis Res Ther 8:R89. 2006
    ..Therefore, small increments in endogenous ceramide in chondrocytes appear to push the homeostatic balance toward extracellular matrix synthesis but at the expense of the chondrocytic phenotype, which was, in part, mediated by PKR...
  4. ncbi request reprint Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro
    E J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, CF10 3US, United Kingdom
    Arch Biochem Biophys 396:49-55. 2001
    ..This shows, for the first time that mechanical loading can influence tissue homeostasis generating an imbalance of proteinases and their inhibitors inducing turnover and/or catabolic events in cartilage...
  5. doi request reprint Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, UK
    Phytother Res 24:905-12. 2010
    ..Due to its efficacy we propose that B. frereana should be examined further as a potential therapeutic agent for treating inflammatory symptoms associated with arthritis...
  6. ncbi request reprint Mechanical regulation of matrix metalloproteinases
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, United Kingdom
    Front Biosci 12:507-27. 2007
    ..Both mechanically-induced stimulation and inhibition of matrix metalloproteinases will be discussed and placed into context with their potential relevance to disease...
  7. ncbi request reprint Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis
    Emma J Blain
    Connective Tissue Biology Laboratories, Biomedical Sciences Building, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Matrix Biol 25:398-408. 2006
    ....
  8. ncbi request reprint The effect of cyclical compressive loading on gene expression in articular cartilage
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Biorheology 40:111-7. 2003
    ..The identification of mechanically regulated genes will greatly enhance our understanding of matrix turnover providing an exciting future in elucidating the role of mechanically-regulated genes in the development of OA...
  9. ncbi request reprint The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression
    E J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Wales, UK
    Biochem Soc Trans 30:879-82. 2002
    ..We postulate a functional role for load-induced thymosin beta(4) in modulating the cytoskeletal organization of articular cartilage chondrocytes to affect MMP expression...
  10. pmc Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, UK
    Int J Exp Pathol 90:1-15. 2009
    ..The implications and possible reasoning for this are more widely discussed and placed into context with their potential relevance to disease and therapeutic strategies...
  11. ncbi request reprint The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study
    S Li
    Arthritis Research UK Biomechanics and Bioengineering Centre, School of Biosciences, Cardiff University, UK
    Eur Cell Mater 21:508-22. 2011
    ..Differential mechano-regulation of anabolic and catabolic ECM components in the OAF and NP populations reflects their respective mechanical environments in situ...
  12. ncbi request reprint Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes
    S J Gilbert
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, Wales, UK
    Eur Cell Mater 23:41-57. 2012
    ..This study demonstrates, for the first time, that a number of catabolic and pro-inflammatory effects known to be important in human arthritis and induced by OSM and IL-1, are mediated by the PKR signalling pathway...
  13. doi request reprint Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    S J Gilbert
    Cardiff University, Cardiff, Wales, UK
    Arthritis Rheum 58:209-20. 2008
    ..The accumulation of ceramide is associated with arthritis in Farber's disease. The aim of this study was to investigate the mechanism of ceramide-induced down-regulation of type II collagen...
  14. doi request reprint Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes
    L C Davies
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, UK
    Osteoarthritis Cartilage 16:855-64. 2008
    ..To determine whether chondroitin sulphate (CS) impedes the migration of primary articular chondrocytes...
  15. doi request reprint The potential of IGF-1 and TGFbeta1 for promoting "adult" articular cartilage repair: an in vitro study
    Lindsay C Davies
    Department of Oral Surgery, Medicine, and Pathology, School of Dentistry, Cardiff University, Heath Park, Cardiff, United Kingdom
    Tissue Eng Part A 14:1251-61. 2008
    ..This may be mediated by regulation of receptor expression or endogenous factors; these findings offer further options for improving strategies for repair of cartilage defects...
  16. pmc Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc
    Siyuan Li
    Connective Tissue Biology Laboratories, Biomedical Sciences Building, School of Biosciences, Cardiff University, Cardiff, UK
    J Anat 213:725-32. 2008
    ....
  17. ncbi request reprint F-actin cytoskeletal organization in intervertebral disc health and disease
    S Li
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Biochem Soc Trans 35:683-5. 2007
    ....
  18. doi request reprint NCAM and PSA-NCAM dependent membrane spreading and F-actin reorganization in suspended adhering neural cells
    Despina Bazou
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Mol Membr Biol 25:102-14. 2008
    ..It is argued that NCAM induced contact is the initial requirement for membrane spreading and facilitates conditions for subsequent cytoskeletal reorganization in these neural cells...