Research Topics
| Mike BenjaminSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical loadM Benjamin
School of Biosciences, Cardiff University, UK
J Anat 208:471-90. 2006..Bony spur formation is assessed in relation to other changes at entheses which parallel those in osteoarthritic synovial joints...
The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyondDennis McGonagle
Academic Unit of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
Arthritis Rheum 56:2482-91. 2007- The enthesis organ concept and its relevance to the spondyloarthropathiesMichael Benjamin
School of Biosciences, Cardiff University, Cardiff, Wales, UK
Adv Exp Med Biol 649:57-70. 2009..In this chapter, we review the extent and types ofenthesis organs and show how a patho-anatomic appreciation of these structures leads to a new platform for understanding the pathogenesis of SpA... - The cell and developmental biology of tendons and ligamentsM Benjamin
Anatomy Unit, School of Biosciences, Cardiff University, United Kingdom
Int Rev Cytol 196:85-130. 2000..Finally, we have considered the influence of growth factors and related molecules on cell proliferation and ECM synthesis... - Adipose tissue at entheses: the rheumatological implications of its distribution. A potential site of pain and stress dissipation?M Benjamin
Cardiff School of Biosciences, University of Cardiff, Museum Avenue, Cardiff CF10 3US, UK
Ann Rheum Dis 63:1549-55. 2004..To describe the distribution of adipose tissue within and adjacent to entheses in order to assess its functional significance at attachment sites... - Microdamage and altered vascularity at the enthesis-bone interface provides an anatomic explanation for bone involvement in the HLA-B27-associated spondylarthritides and allied disordersM Benjamin
University of Cardiff, Cardiff, UK
Arthritis Rheum 56:224-33. 2007..To describe the basis for entheseal-associated bone disease in the spondylarthritides, by analyzing microanatomic and histopathologic relationships between soft tissue, bone cortex, and adjacent trabeculae... - Histopathologic changes at "synovio-entheseal complexes" suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritisMichael Benjamin
Cardiff University, Cardiff, UK
Arthritis Rheum 56:3601-9. 2007..To determine the extent to which different entheses form part of a "synovio-entheseal complex" (SEC) and whether such SECs are commonly associated with the presence of inflammatory cells and evidence of enthesis microdamage... - Structure-function relationships in tendons: a reviewM Benjamin
School of Biosciences, Cardiff University, Cardiff, UK
J Anat 212:211-28. 2008..Finally, attention is drawn to the important relationship between tendons and fascia, highlighted by Wood Jones in his concept of an 'ectoskeleton' over half a century ago - work that is often forgotten today... 
Evidence for a distinctive pattern of bone formation in enthesophytesM Benjamin
Cardiff University, UK
Ann Rheum Dis 68:1003-10. 2009..As bony spur development is also an age-related phenomenon, spurs in elderly dissecting room cadavers were studied in order to establish general principles relating to their development...- The fascia of the limbs and back--a reviewMike Benjamin
School of Biosciences, Cardiff University, Cardiff, UK
J Anat 214:1-18. 2009..Such considerations far outweigh the significance of viewing fascia in a regional context alone... - Basic concepts of enthesis biology and immunologyMichael Benjamin
School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
J Rheumatol Suppl 83:12-3. 2009.... - The "enthesis organ" concept: why enthesopathies may not present as focal insertional disordersM Benjamin
University of Cardiff, Cardiff, UK
Arthritis Rheum 50:3306-13. 2004..However, the degree to which other insertions form comparable "enthesis organs" has not been established. The aim of this study was to demonstrate the applicability of the enthesis organ concept to other insertion sites... - Entheses--the bony attachments of tendons and ligamentsM Benjamin
Anatomy Unit, School of Biosciences, University of Wales Cardiff, United Kingdom
Ital J Anat Embryol 106:151-7. 2001..A wide variety of ECM molecules has been reported in enthesis fibrocartilage, but it is best characterised by its content of type II collagen and aggrecan which account for its compression-tolerance properties... - The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sitesM Benjamin
Anatomy Unit, School of Biosciences, Cardiff University, UK
J Anat 199:503-26. 2001.... - The skeletal attachment of tendons--tendon "entheses"M Benjamin
School of Biosciences, P O Box 911, Museum Avenue, Cardiff University, Cardiff CF10 3US, Wales, UK
Comp Biochem Physiol A Mol Integr Physiol 133:931-45. 2002..They are also commonly seen as sporting injuries such as tennis elbow and jumper's knee... - New insights into the function of the vastus medialis with clinical implicationsHechmi Toumi
Cardiff School of Biosciences, University of Cardiff, Museum Avenue, Cardiff, United Kingdom
Med Sci Sports Exerc 39:1153-9. 2007..To investigate the gross anatomy of the distal portion of the quadriceps, and to compare the relative contributions of the vastus medialis oblique (VMO) and vastus lateralis (VL) during dynamic weight-bearing conditions... - Fatigue and muscle-tendon stiffness after stretch-shortening cycle and isometric exerciseHechmi Toumi
ERIM EA 3295, University of Auvergne Medical School, 63000 Clermont Ferrand, France
Appl Physiol Nutr Metab 31:565-72. 2006..Both fatigue protocols induced muscle fatigue, and the decrease in jump performance was linked to a decrease in the strength and stiffness of the knee extensor muscles... - Is iliotibial band syndrome really a friction syndrome?John Fairclough
School of Sport and Physical Recreation, University of Wales Institute, Cardiff, UK
J Sci Med Sport 10:74-6; discussion 77-8. 2007..Our view is that ITB syndrome is related to impaired function of the hip musculature and that its resolution can only be properly achieved when the biomechanics of hip muscle function are properly addressed... - Magnetic resonance imaging of entheses using ultrashort TE (UTE) pulse sequencesMichael Benjamin
School of Biosciences, Cardiff University, Cardiff, UK
J Magn Reson Imaging 25:381-9. 2007..Entheses are involved in overuse syndromes and seronegative spondyloarthropathies (SpA) and there are important issues related to tissue repair and healing following surgery... - Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical loadAndrew D Waggett
Connective Tissue Biology Laboratory, School of Biosciences, Cardiff University, Biomedical Sciences Building, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
Eur J Cell Biol 85:1145-54. 2006..Cells coordinate and control their response to mechanical signals at least in part by differential actions of these two types of gap junction... - The structure and histopathology of the "enthesis organ" at the navicular insertion of the tendon of tibialis posteriorBernhard Moriggl
Institute of Anatomy and Histology, University of Innsbruck, Innsbruck, Austria
J Rheumatol 30:508-17. 2003..g., in patients with spondyloarthropathy. The prominence of fibrocartilage in the enthesis organ, and the degenerative changes to which it is subject, support the view that spondyloarthropathy has an underlying biomechanical basis... - An immunohistochemical study of the tissue bridging adult spondylolytic defects--the presence and significance of fibrocartilaginous enthesesBronek M Boszczyk
Neurosurgery, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany
Eur Spine J 15:965-71. 2006.... - Expression of a wide range of fibrocartilage molecules at the entheses of the alar ligaments - possible antigenic targets for rheumatoid arthritis?Alexandra A Boszczyk
Anatomische Anstalt, Ludwig Maximilians Universitat, Munchen, Germany
J Rheumatol 30:1420-5. 2003..The alar ligaments provide the mechanical restraint for head rotation and their integrity can be compromised in patients with RA and occasionally in those with spondyloarthropathy... - Advances in the understanding of entheseal inflammationDennis McGonagle
Rheumatology and Rehabilitation Research Unit, The University of Leeds and Halifax General Hospital, 36 Clarendon Road, Halifax HX3 0PW, UK
Curr Rheumatol Rep 4:500-6. 2002..Unraveling the pathogenic basis of enthesitis will have important implications for understanding and defining therapies in SpA... - Tendons are dynamic structures that respond to changes in exercise levelsMichael Benjamin
Scand J Med Sci Sports 12:63-4. 2002 - Report on the Second international Enthesitis WorkshopDennis McGonagle
University of Leeds, UK
Arthritis Rheum 48:896-905. 2003 - Expression of a wide range of extracellular matrix molecules in the tendon and trochlea of the human superior oblique muscleStefan Milz
Department of Anatomy, Ludwig Maximilians University, Pettenkoferstrasse 11, D 80336 Munich, Germany
Invest Ophthalmol Vis Sci 43:1330-4. 2002..To show that the molecular composition of the extracellular matrix of the trochlea and its associated tendon may explain the link between some cases of acquired Brown syndrome and rheumatoid arthritis... - The biomechanical link between skin and joint disease in psoriasis and psoriatic arthritis: what every dermatologist needs to knowDennis McGonagle
Ann Rheum Dis 67:1-4. 2008 - An immunohistochemical study of the extracellular matrix of the tarsal plate in the upper eyelid in human beingsStefan Milz
Anatomische Anstalt, Ludwig Maximilians Universitat, Munich, Germany
J Anat 206:37-45. 2005..An immune reaction directed against these molecules could alter tarsal gland function by interfering with the interaction between the glands and their territorial matrix... - Immunohistochemical analysis of the extracellular matrix in the posterior capsule of the zygapophysial joints in patients with degenerative L4-5 motion segment instabilityBronek M Boszczyk
Department of Neurosurgery, Berufsgenossenschaftliche Unfallklinik Murnau, Germany
J Neurosurg 99:27-33. 2003....