J P Aggleton

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Episodic memory, amnesia, and the hippocampal-anterior thalamic axis
    J P Aggleton
    School of Psychology, Cardiff University, Cardiff, CF1 3YG, Wales
    Behav Brain Sci 22:425-44; discussion 444-89. 1999
  2. ncbi request reprint The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
    J P Aggleton
    School of Psychology, University of Wales, College of Cardiff, UK
    Behav Brain Res 81:189-98. 1996
  3. ncbi request reprint Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer
    J P Aggleton
    School of Psychology, Cardiff University, Wales, UK
    Hippocampus 10:466-74. 2000
  4. ncbi request reprint Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix
    J P Aggleton
    School of Psychology, Cardiff University, Cardiff, UK
    Brain 123:800-15. 2000
  5. ncbi request reprint The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia
    J P Aggleton
    University of Wales, College of Cardiff, UK
    Memory 5:49-71. 1997
  6. ncbi request reprint The ability of odours to serve as state-dependent cues for real-world memories: can Viking smells aid the recall of Viking experiences?
    J P Aggleton
    School of Psychology, Cardiff University, Wales
    Br J Psychol 90:1-7. 1999
  7. ncbi request reprint Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat
    T J Bussey
    School of Psychology, Cardiff University, CF1O 3YG, Cardiff, UK
    Behav Brain Res 111:187-202. 2000
  8. ncbi request reprint Changes in immediate early gene expression in the rat brain after unilateral lesions of the hippocampus
    T A Jenkins
    School of Psychology, Cardiff University, Cardiff, Wales, CF10 3YG, UK
    Neuroscience 137:747-59. 2006
  9. doi request reprint Mapping immediate-early gene activity in the rat after place learning in a water-maze: the importance of matched control conditions
    K L Shires
    School of Psychology, Cardiff University, Park Place, Cardiff, UK
    Eur J Neurosci 28:982-96. 2008
  10. doi request reprint The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies
    M D Iordanova
    School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK
    Eur J Neurosci 30:2177-89. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Episodic memory, amnesia, and the hippocampal-anterior thalamic axis
    J P Aggleton
    School of Psychology, Cardiff University, Cardiff, CF1 3YG, Wales
    Behav Brain Sci 22:425-44; discussion 444-89. 1999
    ..In the large majority of amnesic cases both the hippocampal-anterior thalamic and the perirhinal-medial dorsal thalamic systems are compromised, leading to severe deficits in both recall and recognition...
  2. ncbi request reprint The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
    J P Aggleton
    School of Psychology, University of Wales, College of Cardiff, UK
    Behav Brain Res 81:189-98. 1996
    ..The findings also help to account for other studies which have reported that anterior thalamic lesions have seemingly mild effects on tests of spatial memory...
  3. ncbi request reprint Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer
    J P Aggleton
    School of Psychology, Cardiff University, Wales, UK
    Hippocampus 10:466-74. 2000
    ..One consequence is that lesions in a single site often have surprisingly mild effects on standard spatial tests...
  4. ncbi request reprint Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix
    J P Aggleton
    School of Psychology, Cardiff University, Cardiff, UK
    Brain 123:800-15. 2000
    ..These findings not only indicate that fornix damage is sufficient to induce anterograde amnesia but also support the validity of recent animal tests that are thought to capture aspects of episodic memory...
  5. ncbi request reprint The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia
    J P Aggleton
    University of Wales, College of Cardiff, UK
    Memory 5:49-71. 1997
    ....
  6. ncbi request reprint The ability of odours to serve as state-dependent cues for real-world memories: can Viking smells aid the recall of Viking experiences?
    J P Aggleton
    School of Psychology, Cardiff University, Wales
    Br J Psychol 90:1-7. 1999
    ..Only the novel odour-Jorvik odours condition led to a highly significant improvement in performance. This interaction showed that the museum odours could act as effective retrieval cues for this incidentally acquired, real-world episode...
  7. ncbi request reprint Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat
    T J Bussey
    School of Psychology, Cardiff University, CF1O 3YG, Cardiff, UK
    Behav Brain Res 111:187-202. 2000
    ..It is suggested that the perirhinal/postrhinal cortex, rather than being specialised for a particular type of associative learning, is important for processing complex visual stimuli...
  8. ncbi request reprint Changes in immediate early gene expression in the rat brain after unilateral lesions of the hippocampus
    T A Jenkins
    School of Psychology, Cardiff University, Cardiff, Wales, CF10 3YG, UK
    Neuroscience 137:747-59. 2006
    ..The findings support the notion that the anterior thalamic nuclei, hippocampus, and parahippocampal cortices form the key components of an interdependent neuronal network involved in spatial mnemonic processing...
  9. doi request reprint Mapping immediate-early gene activity in the rat after place learning in a water-maze: the importance of matched control conditions
    K L Shires
    School of Psychology, Cardiff University, Park Place, Cardiff, UK
    Eur J Neurosci 28:982-96. 2008
    ..Rather, the activity in combinations of regions, including prefrontal cortex, provides a stronger correlate of water-maze learning...
  10. doi request reprint The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies
    M D Iordanova
    School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK
    Eur J Neurosci 30:2177-89. 2009
    ....
  11. ncbi request reprint Perirhinal cortex and place-object conditional learning in the rat
    T J Bussey
    School of Psychology, Cardiff University, United Kingdom
    Behav Neurosci 115:776-85. 2001
    ..The results suggest that, although the perirhinal cortex and hippocampus can be functionally dissociated, their normal mode of operation includes the integration of object and spatial information...
  12. ncbi request reprint Disconnecting hippocampal projections to the anterior thalamus produces deficits on tests of spatial memory in rats
    E C Warburton
    School of Psychology, University of Cardiff, Wales CF10 3YG, UK
    Eur J Neurosci 12:1714-26. 2000
    ....
  13. ncbi request reprint Effects of selective excitotoxic prefrontal lesions on acquisition of nonmatching- and matching-to-place in the T-maze in the rat: differential involvement of the prelimbic-infralimbic and anterior cingulate cortices in providing behavioural flexibility
    R Dias
    School of Psychology, Cardiff University, PO Box 901, Cardiff CF10 3YG, UK
    Eur J Neurosci 12:4457-66. 2000
    ....
  14. ncbi request reprint The conjoint importance of the hippocampus and anterior thalamic nuclei for allocentric spatial learning: evidence from a disconnection study in the rat
    E C Warburton
    School of Psychology, University of Cardiff, Wales CF10 3YG, United Kingdom
    J Neurosci 21:7323-30. 2001
    ..These results provide direct support for the notion that the performance of tasks that require spatial memory rely on the operation of the anterior thalamus and hippocampus within an integrated neural network...
  15. ncbi request reprint Differential deficits in the Morris water maze following cytotoxic lesions of the anterior thalamus and fornix transection
    E C Warburton
    School of Psychology, University of Wales, College of Cardiff, UK
    Behav Brain Res 98:27-38. 1999
    ....
  16. ncbi request reprint Comparing the effects of selective cingulate cortex lesions and cingulum bundle lesions on water maze performance by rats
    E C Warburton
    School of Psychology, University of Wales Cardiff, UK
    Eur J Neurosci 10:622-34. 1998
    ..The results of the excitotoxic lesions suggest that previous studies examining conventional cingulate lesions may have been influenced by damage to adjacent fibre tracts, such as the cingulum bundle...
  17. ncbi request reprint Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats?
    E C Warburton
    School of Psychology, University of Cardiff, Wales, United Kingdom
    Behav Neurosci 113:956-67. 1999
    ..The rats with more extensive thalamic lesions were more impaired in both tasks and did show a loss of procedural information...
  18. doi request reprint Selective lamina dysregulation in granular retrosplenial cortex (area 29) after anterior thalamic lesions: an in situ hybridization and trans-neuronal tracing study in rats
    E Amin
    School of Psychology, Cardiff University, Wales CF10 3AT, UK
    Neuroscience 169:1255-67. 2010
    ..These layer II Rgb cells are likely to have been trans-neuronally labeled, revealing a pathway from lamina II of Rgb to those deeper retrosplenial cells that project directly to the anterior thalamic nuclei...
  19. doi request reprint Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice
    G L Poirier
    School of Psychology, Cardiff University, 70 Park Place, Cardiff, Wales, CF10 3AT, UK
    Neuroscience 174:71-83. 2011
    ..These findings indicate that retrosplenial cortex dysfunction occurs during early stages of amyloid production in Tg2576 mice and may contribute to cognitive dysfunction...
  20. ncbi request reprint On the transience of egocentric working memory: evidence from testing the contribution of limbic brain regions
    A L Baird
    School of Psychology, Cardiff University, Cardiff, United Kingdom
    Behav Neurosci 118:785-97. 2004
    ..Fornix lesions transiently disrupted performance of the J-maze task (Experiments 3 and 4), but neither fornix (Experiment 1) nor retrosplenial (Experiment 2) lesions impaired the plus-maze tasks...
  21. ncbi request reprint Novel spatial arrangements of familiar visual stimuli promote activity in the rat hippocampal formation but not the parahippocampal cortices: a c-fos expression study
    T A Jenkins
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales, CF10 3YG, UK
    Neuroscience 124:43-52. 2004
    ....
  22. ncbi request reprint Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition
    S L Dix
    School of Psychology, University of Cardiff Wales, Cardiff, UK
    Behav Brain Res 99:191-200. 1999
    ..In the standard condition and the context condition, the first 2 min were found to be the most sensitive period. In the two conditions involving a position change, discrimination was only evident in the first minute...
  23. ncbi request reprint Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats
    L A Wilton
    School of Psychology, Cardiff University, United Kingdom
    Behav Neurosci 115:861-9. 2001
    ..Although object recognition appeared unaffected, marked impairments were found in the ability to detect when an object was placed in a novel position (object-in-place memory)...
  24. pmc Neural systems underlying episodic memory: insights from animal research
    J P Aggleton
    School of Psychology, University of Cardiff, Cardiff CF10 3YG, UK
    Philos Trans R Soc Lond B Biol Sci 356:1467-82. 2001
    ..The validity of this convergent approach is supported by new findings showing that the same set of regions is implicated in anterograde amnesia in humans...
  25. doi request reprint Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity
    G L Poirier
    School of Psychology, Cardiff University, 70 Park Place, Cardiff, Wales CF10 3AT, UK
    Neuroscience 160:452-69. 2009
    ..These findings not only indicate that the impact of anterior thalamic lesions on cognition could be enhanced by retrosplenial cortex dysfunction but they also show that the effects could increase with longer post-insult survival...
  26. pmc Anterior thalamic nuclei lesions in rats disrupt markers of neural plasticity in distal limbic brain regions
    J R Dumont
    School of Psychology, Cardiff University, Cardiff, Wales CF10 3AT, United Kingdom
    Neuroscience 224:81-101. 2012
    ....
  27. ncbi request reprint How rats perform spatial working memory tasks: limitations in the use of egocentric and idiothetic working memory
    J E Futter
    Cardiff University, Cardiff, UK
    Q J Exp Psychol (Hove) 59:77-99. 2006
    ..Both experiments indicate that rats are very poor at using either egocentric or idiothetic information to alternate, and that retention delays as short as 10 s can eliminate the use of these forms of memory...
  28. ncbi request reprint Sensory preconditioning in rats with lesions of the anterior thalamic nuclei: evidence for intact nonspatial 'relational' processing
    J Ward-Robinson
    School of Psychology, Cardiff University, UK
    Behav Brain Res 133:125-33. 2002
    ..In contrast, the same lesions led to a severe deficit on a test of spatial memory. These results help to refine our understanding of the contribution of the anterior thalamic nuclei to spatial memory...
  29. pmc Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: implications for neuropsychological investigations
    D K Jones
    CUBRIC, School of Psychology, Cardiff University, Cardiff, CF10 3AT, United Kingdom
    Neuropsychologia 51:67-78. 2013
    ..The present study provides a new framework for subdividing the cingulum, based both on its known connectivity and MRI-based properties...
  30. doi request reprint Magnitude of the object recognition deficit associated with perirhinal cortex damage in rats: Effects of varying the lesion extent and the duration of the sample period
    M M Albasser
    School of Psychology, Cardiff University, Cardiff, Wales, UK
    Behav Neurosci 123:115-24. 2009
    ..This study highlights the critical importance of the perirhinal cortex within the temporal lobe for recognition memory and shows that the lesion-induced deficit occurs despite seemingly normal levels of close object exploration...
  31. ncbi request reprint Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory
    P Machin
    School of Psychology, Cardiff University, Wales
    Behav Neurosci 116:232-40. 2002
    ..Although interactions between the perirhinal cortex and hippocampus may be important for integrating object-place information, the perirhinal cortex is often not necessary for tasks that selectively tax allocentric spatial memory...
  32. pmc The rat retrosplenial cortex is required when visual cues are used flexibly to determine location
    E L Hindley
    School of Psychology, Cardiff University, Park Place, Cardiff, Wales CF10 3AT, UK
    Behav Brain Res 263:98-107. 2014
    ....