Leonard Wu

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)
    Jeremy P Braybrooke
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Biol Chem 278:48357-66. 2003
  2. ncbi request reprint Role of the BLM helicase in replication fork management
    Leonard Wu
    Cancer Research UK, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    DNA Repair (Amst) 6:936-44. 2007
  3. ncbi request reprint The Bloom's syndrome helicase can promote the regression of a model replication fork
    Christine Ralf
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Biol Chem 281:22839-46. 2006
  4. pmc Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing
    Ye Dee Tay
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 285:11427-32. 2010
  5. pmc BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 103:4068-73. 2006
  6. pmc The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
    Chit Fang Cheok
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS, UK
    Nucleic Acids Res 33:3932-41. 2005
  7. ncbi request reprint The Bloom's syndrome helicase suppresses crossing over during homologous recombination
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nature 426:870-4. 2003
  8. ncbi request reprint DNA helicases required for homologous recombination and repair of damaged replication forks
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Annu Rev Genet 40:279-306. 2006
  9. pmc Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures
    Agnieszka A Tafel
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Biol Chem 286:15832-40. 2011
  10. pmc The HRDC domain of BLM is required for the dissolution of double Holliday junctions
    Leonard Wu
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    EMBO J 24:2679-87. 2005

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)
    Jeremy P Braybrooke
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Biol Chem 278:48357-66. 2003
    ..We propose that BLM co-operates with RAD51 paralogs during the late stages of homologous recombination processes that serve to restore productive DNA replication at sites of damaged or stalled replication forks...
  2. ncbi request reprint Role of the BLM helicase in replication fork management
    Leonard Wu
    Cancer Research UK, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    DNA Repair (Amst) 6:936-44. 2007
    ..Here, recent findings are reviewed that further our understanding of the role that BLM plays in the management of damaged replication forks...
  3. ncbi request reprint The Bloom's syndrome helicase can promote the regression of a model replication fork
    Christine Ralf
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Biol Chem 281:22839-46. 2006
    ..These data establish the existence of a eukaryotic protein that could promote replication fork regression in vivo and suggest a novel pathway through which BLM might suppress genetic exchanges...
  4. pmc Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing
    Ye Dee Tay
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 285:11427-32. 2010
    ..Together, these results suggest a direct role for Yen1 in the response to DNA damage and implicate overlapping HJ resolution functions of Yen1 with Mus81 during replication fork repair...
  5. pmc BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 103:4068-73. 2006
    ..Implications of the conserved ability of type IA topoisomerases to catalyze dissolution and how the evolution of factors such as BLAP75/RMI1 might confer specificity on the execution of this process are discussed...
  6. pmc The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
    Chit Fang Cheok
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford OX3 9DS, UK
    Nucleic Acids Res 33:3932-41. 2005
    ..We present a model in which the ssDNA annealing activity of BLM facilitates its role in the processing of DNA intermediates that arise during repair of damaged replication forks...
  7. ncbi request reprint The Bloom's syndrome helicase suppresses crossing over during homologous recombination
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nature 426:870-4. 2003
    ..These results have wider implications for our understanding of the process of homologous recombination and the mechanisms that exist to prevent tumorigenesis...
  8. ncbi request reprint DNA helicases required for homologous recombination and repair of damaged replication forks
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Annu Rev Genet 40:279-306. 2006
    ....
  9. pmc Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures
    Agnieszka A Tafel
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Biol Chem 286:15832-40. 2011
    ..Together, our results suggest that one role for HEL308 at sites of blocked replication might be to open up the parental strands to facilitate the loading of subsequent factors required for replication restart...
  10. pmc The HRDC domain of BLM is required for the dissolution of double Holliday junctions
    Leonard Wu
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    EMBO J 24:2679-87. 2005
    ..Furthermore, we show that lysine-1270 of BLM, which resides in the HRDC domain and is predicted to play a role in mediating interactions with DNA, is required for efficient dissolution...
  11. doi request reprint Wrestling off RAD51: a novel role for RecQ helicases
    Leonard Wu
    Weatherall Institute of Molecular Medicine, University of Oxford, Department of Medical Oncology, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Bioessays 30:291-5. 2008
    ..Two papers have recently provided a mechanistic insight into how HR may be tempered by RecQ helicases to prevent genome instability and diseases that are a consequence of this, such as cancer...
  12. pmc Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair
    Ye Dee Tay
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington Oxford, OX3 9DS, UK
    Nucleic Acids Res 38:1889-901. 2010
    ..Models describing how Mph1, MutSalpha and Sgs1 act in concert to suppress genome rearrangements during ectopic HR repair are discussed...
  13. pmc The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha
    Leonard Wu
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Nucleic Acids Res 30:4823-9. 2002
    ..These results indicate that a physical association between BLM and topoisomerase IIIalpha is a prerequisite for their functional biochemical interaction...
  14. ncbi request reprint RecQ helicases and cellular responses to DNA damage
    Leonard Wu
    Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Mutat Res 509:35-47. 2002
    ..Here, we review some current models for how replication fork repair might be effected, and discuss potential roles for RecQ helicases in this process...
  15. ncbi request reprint Stimulation of flap endonuclease-1 by the Bloom's syndrome protein
    Sudha Sharma
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, DHHS, Baltimore, Maryland 21224 6825, USA
    J Biol Chem 279:9847-56. 2004
    ..We suggest that functional interactions between RecQ helicases and Rad2 family nucleases serve to process DNA substrates that are intermediates in DNA replication and repair...
  16. pmc Remodeling of DNA replication structures by the branch point translocase FANCM
    Kerstin Gari
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges s Lausanne, Switzerland
    Proc Natl Acad Sci U S A 105:16107-12. 2008
    ..These observations provide evidence that FANCM can remodel replication fork structures and suggest a mechanism by which FANCM could promote DNA damage tolerance in S phase...