Fiona M Watt

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint HAN11 binds mDia1 and controls GLI1 transcriptional activity
    Kazumasa Morita
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, England, UK
    J Dermatol Sci 44:11-20. 2006
  2. ncbi request reprint Unexpected Hedgehog-Wnt interactions in epithelial differentiation
    Fiona M Watt
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Trends Mol Med 10:577-80. 2004
  3. ncbi request reprint The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Curr Biol 16:971-81. 2006
  4. ncbi request reprint Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    Soline Estrach
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:4427-38. 2006
  5. ncbi request reprint Stem cell depletion through epidermal deletion of Rac1
    Salvador Aznar Benitah
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 309:933-5. 2005
  6. pmc Role of LIM kinases in normal and psoriatic human epidermis
    Masaru Honma
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Mol Biol Cell 17:1888-96. 2006
  7. ncbi request reprint Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:2793-808. 2003
  8. ncbi request reprint Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt
    Sam M Janes
    Keratinocyte Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 117:4157-68. 2004
  9. ncbi request reprint Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions
    Robin M Hobbs
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Invest Dermatol 123:503-15. 2004
  10. pmc Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
    Kim B Jensen
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Proc Natl Acad Sci U S A 103:11958-63. 2006

Collaborators

Detail Information

Publications58

  1. ncbi request reprint HAN11 binds mDia1 and controls GLI1 transcriptional activity
    Kazumasa Morita
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, England, UK
    J Dermatol Sci 44:11-20. 2006
    ..GLI1-dependent transcription is positively regulated by DYRK1A, which is reported to bind HAN11. HAN11 is the human homologue of AN11, which controls flavonoid synthesis in plants...
  2. ncbi request reprint Unexpected Hedgehog-Wnt interactions in epithelial differentiation
    Fiona M Watt
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Trends Mol Med 10:577-80. 2004
    ..The work is discussed in the broader context of Ihh expression and function in epithelia and the different ways in which the Hh and Wnt pathways interact...
  3. ncbi request reprint The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Curr Biol 16:971-81. 2006
    ..In adult epidermis, Myc stimulates exit from the stem cell compartment, decreasing cell adhesion and, by an unknown mechanism, triggering proliferation of transit-amplifying cells...
  4. ncbi request reprint Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    Soline Estrach
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:4427-38. 2006
    ..beta-catenin stimulates Notch signalling by inducing Jag1 transcription. We conclude that the Notch pathway acts downstream of the Wnt/beta-catenin pathway to determine epidermal cell fate...
  5. ncbi request reprint Stem cell depletion through epidermal deletion of Rac1
    Salvador Aznar Benitah
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 309:933-5. 2005
    ..We conclude that a pleiotropic regulator of cell adhesion and the cytoskeleton plays a critical role in controlling exit from the stem cell niche and propose that Rac and Myc represent a global stem cell regulatory axis...
  6. pmc Role of LIM kinases in normal and psoriatic human epidermis
    Masaru Honma
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Mol Biol Cell 17:1888-96. 2006
    ....
  7. ncbi request reprint Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:2793-808. 2003
    ....
  8. ncbi request reprint Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt
    Sam M Janes
    Keratinocyte Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 117:4157-68. 2004
    ..These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt in subsequent events...
  9. ncbi request reprint Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions
    Robin M Hobbs
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Invest Dermatol 123:503-15. 2004
    ..These data suggest that activation of MEK1 downstream of beta1 integrins plays an important role in epidermal hyperproliferation and skin inflammation...
  10. pmc Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
    Kim B Jensen
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Proc Natl Acad Sci U S A 103:11958-63. 2006
    ..Lrig1 acted in part by negatively regulating the Myc promoter. We propose that Lrig1 maintains epidermal stem cells in a quiescent nondividing state, and that Lrig1 down-regulation triggers proliferation...
  11. ncbi request reprint Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
    Catherin Niemann
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 129:95-109. 2002
    ....
  12. ncbi request reprint Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis
    Kristin M Braun
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:5241-55. 2003
    ..We conclude that LRC are more sensitive to some proliferative stimuli than others and that changes in lineage can occur with or without recruitment of LRC into cycle...
  13. ncbi request reprint Topo II alpha reporter mice reveal proliferative regions in the epidermis and small intestine
    Elizabeth R Li
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    FEBS Lett 579:6479-85. 2005
    ..The mice therefore provide a useful model for non-invasive imaging of regions of high proliferation in normal or damaged epidermis...
  14. ncbi request reprint Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication
    Teresa Lopez-Rovira
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London, UK
    J Invest Dermatol 125:1215-27. 2005
    ..Our results highlight the context-dependent effects of beta1 integrin deletion and suggest that inflammation may be responsible for some of the K5Cre beta1-null phenotype...
  15. ncbi request reprint Epidermal stem cells: an update
    Fiona M Watt
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Curr Opin Genet Dev 16:518-24. 2006
    ..This work has also yielded new insights into skin tumour development...
  16. ncbi request reprint New roles for integrins in squamous-cell carcinoma
    Sam M Janes
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Rev Cancer 6:175-83. 2006
    ..These findings provide a mechanistic basis for the well-established links between altered integrin expression and tumour prognosis...
  17. pmc Epidermal stem cell diversity and quiescence
    Fiona M Watt
    Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge, UK
    EMBO Mol Med 1:260-7. 2009
    ..The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection...
  18. ncbi request reprint Women in cell biology: how personal lives shape careers
    Fiona M Watt
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 7:378-80. 2006
    ..Growing up, some scientists enjoyed parental support, whereas for others low expectations or a geographical disadvantage were a spur to achievement. Partners can be good, bad or indifferent, but having children is not a bar to success...
  19. ncbi request reprint Women in cell biology: getting to the top
    Fiona M Watt
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 7:287-90. 2006
    ..By contrast, my approach has been to focus on individual women who have 'made it' in science and to ask how their careers have been affected by their sex. Some positive conclusions emerge, but the overall picture is disheartening...
  20. pmc Role of integrins in regulating epidermal adhesion, growth and differentiation
    Fiona M Watt
    Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 21:3919-26. 2002
    ..In this review I summarize what is known about the expression and function of epidermal integrins, and highlight the challenges for future research...
  21. pmc MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
    Fiona M Watt
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nat Rev Cancer 8:234-42. 2008
    ....
  22. pmc Epidermal stem cells are retained in vivo throughout skin aging
    Adam Giangreco
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Aging Cell 7:250-9. 2008
    ..These findings, coupled with observed dermal gene expression changes, suggest that epidermal stem cells themselves are intrinsically aging resistant and that local environmental or systemic factors modulate skin aging...
  23. ncbi request reprint The stem cell compartment in human interfollicular epidermis
    Fiona M Watt
    Imperial Cancer Research Fund, London, UK
    J Dermatol Sci 28:173-80. 2002
    ..beta1 integrins, Notch, c-Myc and beta-catenin all regulate the size of the stem cell compartment in vitro and recent evidence from transgenic mice suggests that they are also important in vivo...
  24. ncbi request reprint Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis
    James Legg
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Development 130:6049-63. 2003
    ..We conclude that MCSP is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering...
  25. ncbi request reprint Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
    Cristina Lo Celso
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 131:1787-99. 2004
    ..We conclude that interfollicular epidermis and sebaceous glands retain the ability to be reprogrammed in adult life and that continuous beta-catenin signalling is required to maintain hair follicle tumours...
  26. pmc Epidermal Notch signalling: differentiation, cancer and adhesion
    Fiona M Watt
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Curr Opin Cell Biol 20:171-9. 2008
    ..The effects on differentiation can be cell autonomous and non-autonomous, and Notch contributes to stem cell clustering via modulation of cell adhesion...
  27. pmc The therapeutic potential of stem cells
    Fiona M Watt
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 365:155-63. 2010
    ..What makes stem cell research so exciting is its tremendous potential to benefit human health and the opportunities for interdisciplinary research that it presents...
  28. ncbi request reprint Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling
    David M Owens
    Keratinocyte Laboratory, CR UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 116:3783-91. 2003
    ..These data suggest that suprabasal alpha6beta4 promotes tumourigenesis by preventing TGFbeta from suppressing clonal expansion of initiated cells in the epidermal basal layer...
  29. ncbi request reprint Contribution of stem cells and differentiated cells to epidermal tumours
    David M Owens
    Cancer Research UK, London Research Institute, Keratinocyte Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Rev Cancer 3:444-51. 2003
    ..So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?..
  30. pmc A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control
    Richard D Evans
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    J Cell Biol 160:589-96. 2003
    ..They also provide new insights into how integrins regulate keratinocyte differentiation...
  31. pmc Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane
    Karen R Groot
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Biol 166:653-9. 2004
    ..On transfection, all three kazrin isoforms have similar subcellular distributions. We conclude that kazrin is a novel component of desmosomes that associates with periplakin...
  32. ncbi request reprint Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
    Violeta Silva-Vargas
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Dev Cell 9:121-31. 2005
    ....
  33. ncbi request reprint Human sebaceous tumors harbor inactivating mutations in LEF1
    Hikaru Takeda
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Med 12:395-7. 2006
    ..Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors...
  34. ncbi request reprint Epidermal label-retaining cells: background and recent applications
    Kristin M Braun
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London, UK
    J Investig Dermatol Symp Proc 9:196-201. 2004
    ..We describe how LRC can be visualized by whole-mount labelling of the epidermis and how purified LRC can be used to screen for markers of the epidermal stem cell compartment...
  35. ncbi request reprint Sequence variation in the I-like domain of the beta1 integrin subunit in human oral squamous cell carcinomas
    Richard D Evans
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, WC2A 3PX, UK
    Cancer Lett 213:189-94. 2004
    ..We conclude that mutations in the beta1 I-like domain are uncommon in SCCs. However, population based studies of the polymorphisms we found may reveal an association with SCC development or prognosis...
  36. doi request reprint Sic transit gloria: farewell to the epidermal transit amplifying cell?
    Philip H Jones
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 0XZ, UK
    Cell Stem Cell 1:371-81. 2007
    ..Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis...
  37. pmc Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture
    Soline Estrach
    Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge, CB2 1QR, UK
    J Cell Sci 120:2944-52. 2007
    ..We propose that syntenin binding to Delta1 plays a dual role in promoting intercellular adhesion and regulating Notch signalling...
  38. ncbi request reprint Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis
    Soline Estrach
    Wellcome Trust Centre for Stem Cell Research, Cambridge, UK
    J Invest Dermatol 128:825-32. 2008
    ..These results demonstrate that Dll1 contributes to the control of proliferation and differentiation in IFE, whereas Jagged1 regulates hair follicle differentiation...
  39. pmc Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier
    Lisa M Sevilla
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, England, UK
    J Cell Biol 179:1599-612. 2007
    ..Thus, combined loss of the cornified envelope proteins not only impairs the epidermal barrier, but also changes the composition of T cell subpopulations in the skin...
  40. ncbi request reprint Expression of Notch pathway genes in mammalian epidermis and modulation by beta-catenin
    Carrie A Ambler
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    Dev Dyn 236:1595-601. 2007
    ..beta-Catenin-induced up-regulation of Jagged1 precedes induction of other Notch target genes. The different sites of expression of Hes and Hey genes suggest input from additional signaling pathways...
  41. doi request reprint The vitamin D receptor is required for mouse hair cycle progression but not for maintenance of the epidermal stem cell compartment
    Hector G Palmer
    J Invest Dermatol 128:2113-7. 2008
  42. pmc The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis
    Hector G Palmer
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS ONE 3:e1483. 2008
    ..We conclude that VDR is a TCF/Lef-independent transcriptional effector of the Wnt pathway and that vitamin D analogues have therapeutic potential in tumors with inappropriate activation of Wnt signalling...
  43. doi request reprint KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis
    Lisa M Sevilla
    Epithelial Cell Biology Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    Dev Dyn 237:1718-25. 2008
    ..Together, our results suggest that loss of kazrinA causes defects in cell adhesion that affect axial elongation, cell differentiation, and epidermal morphogenesis...
  44. doi request reprint Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin
    Cristina Lo Celso
    Massachusetts General Hospital, Center for Regenerative Medicine, Boston, Massachusetts, USA
    Stem Cells 26:1241-52. 2008
    ..Our studies provide evidence for a bipotential epidermal stem cell population in an in vitro model of human epidermal lineage selection and highlight the importance of Myc as a regulator of sebocyte differentiation...
  45. ncbi request reprint Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type
    Catherin Niemann
    Cancer Research UK London Research Institute, London, United Kingdom
    Cancer Res 67:2916-21. 2007
    ..We propose that LEF1 NH(2)-terminal mutations play a dual role in skin cancer, specifying tumor type by inhibiting Wnt signaling and acting as a tumor promoter by preventing induction of p53...
  46. pmc Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis
    Sam M Janes
    Keratinocyte Laboratory, CR UK London Research Institute, 44 Lincoln s Inn Fields, WC2A 3PX, England
    J Cell Biol 166:419-31. 2004
    ..These results suggest that down-regulation of alphavbeta5 through up-regulation of alphavbeta6 may protect SCCs from anoikis by activating an Akt survival signal...
  47. ncbi request reprint Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors
    David M Owens
    Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Mol Carcinog 44:60-6. 2005
    ....
  48. ncbi request reprint Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease
    Robin M Hobbs
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, United Kingdom
    J Biol Chem 278:19798-807. 2003
    ..These results provide a mechanism by which aberrant integrin expression triggers epidermal hyperproliferation and inflammation...
  49. pmc Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1
    Anneli Gebhardt
    Institute for Cell Biology, University of Marburg, 35033 Marburg, Germany
    J Cell Biol 172:139-49. 2006
    ..Our data show that regulation of cell adhesion is a major function of the Myc-Miz1 complex and suggest that it may contribute to Myc-induced exit from the epidermal stem cell compartment...
  50. ncbi request reprint The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells
    Joanne G W Nijhof
    Department of Dermatology, Leiden University Medical Center LUMC The Netherlands
    Development 133:3027-37. 2006
    ..Taken together, these data suggest that the cell-surface marker MTS24 identifies a new reservoir of hair follicle keratinocytes with a proliferative capacity and gene expression profile suggestive of progenitor or stem cells...
  51. ncbi request reprint Designer skin: lineage commitment in postnatal epidermis
    Catherin Niemann
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Trends Cell Biol 12:185-92. 2002
    ..We also present evidence that postnatal epidermis can be reprogrammed, altering the number and location of cells that differentiate along specific epidermal lineages...
  52. ncbi request reprint A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair
    Richard Grose
    Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
    Development 129:2303-15. 2002
    ..These findings demonstrate a crucial role of beta 1 integrins in keratinocyte migration and wound re-epithelialisation. Movies available on-line..
  53. ncbi request reprint Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening
    Masaru Honma
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London
    J Biomol Screen 11:977-84. 2006
    ..Because the compound affected the tumor cells at a lower concentration than primary keratinocytes, it may have potential as an antitumor therapy...
  54. ncbi request reprint Epidermal deletion of Rac1 causes stem cell depletion, irrespective of whether deletion occurs during embryogenesis or adulthood
    Salvador A Benitah
    J Invest Dermatol 127:1555-7. 2007
  55. ncbi request reprint Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway
    Rachel McMullan
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Curr Biol 13:2185-9. 2003
    ..Thus, these results indicate that ROCK plays a critical role in regulating the balance between proliferation and differentiation in human keratinocytes...
  56. doi request reprint Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3
    Josema Torres
    Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 10:194-201. 2008
    ..We conclude that Nanog represses the pro-differentiation activities of NFkappaB and cooperates with Stat3 to maintain pluripotency...
  57. ncbi request reprint Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways
    Ingo Haase
    Department of Dermatology and Center for Molecular Medicine, University of Cologne CMMC, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Cell Sci 116:3227-38. 2003
    ..Our results show that IGF-1 and EGF can influence different components of the keratinocyte migration machinery that determines the speed of wound epithelialization...
  58. ncbi request reprint Amparo Cano
    Fiona M Watt
    J Cell Sci 117:3075-6. 2004