Sharon A Tooze

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells
    Joelle Morvan
    London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, UK
    Histochem Cell Biol 129:243-52. 2008
  2. pmc Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells
    Malika Ahras
    Cancer Research UK, London Research Institute, London WC2A 3PX, England, UK
    J Cell Biol 173:241-51. 2006
  3. pmc Early endosomes and endosomal coatomer are required for autophagy
    Minoo Razi
    London Research Institute, Cancer Research UK, London WC2A 3PX, England, UK
    J Cell Biol 185:305-21. 2009
  4. pmc TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
    Andrea Longatti
    Cancer Research UK London Research Institute, WC2A 3PF London, England, UK
    J Cell Biol 197:659-75. 2012
  5. pmc Autophagy regulation through Atg9 traffic
    Fulvio Reggiori
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, Netherlands
    J Cell Biol 198:151-3. 2012
  6. doi request reprint The origin of the autophagosomal membrane
    Sharon A Tooze
    Secretory Pathways Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, U K
    Nat Cell Biol 12:831-5. 2010
  7. doi request reprint The role of membrane proteins in mammalian autophagy
    Sharon A Tooze
    London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Semin Cell Dev Biol 21:677-82. 2010
  8. doi request reprint Trafficking and signaling in mammalian autophagy
    Sharon A Tooze
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
    IUBMB Life 62:503-8. 2010
  9. doi request reprint Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration
    Sharon A Tooze
    Cancer Research UK, London Research Institute, London, UK
    Curr Opin Neurobiol 18:504-15. 2008
  10. pmc Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
    Anne Simonsen
    Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway
    J Cell Biol 186:773-82. 2009

Collaborators

Detail Information

Publications37

  1. pmc Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells
    Joelle Morvan
    London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, UK
    Histochem Cell Biol 129:243-52. 2008
    ....
  2. pmc Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells
    Malika Ahras
    Cancer Research UK, London Research Institute, London WC2A 3PX, England, UK
    J Cell Biol 173:241-51. 2006
    ..Granule formation, and the sorting of SgII and PC2 from the trans-Golgi network into ISGs and MSGs, however, is not affected. We conclude that Syt IV is an essential component for secretory granule maturation...
  3. pmc Early endosomes and endosomal coatomer are required for autophagy
    Minoo Razi
    London Research Institute, Cancer Research UK, London WC2A 3PX, England, UK
    J Cell Biol 185:305-21. 2009
    ....
  4. pmc TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
    Andrea Longatti
    Cancer Research UK London Research Institute, WC2A 3PF London, England, UK
    J Cell Biol 197:659-75. 2012
    ..Thus, TBC1D14- and Rab11-dependent vesicular transport from REs contributes to and regulates starvation-induced autophagy...
  5. pmc Autophagy regulation through Atg9 traffic
    Fulvio Reggiori
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, Netherlands
    J Cell Biol 198:151-3. 2012
    ..These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation...
  6. doi request reprint The origin of the autophagosomal membrane
    Sharon A Tooze
    Secretory Pathways Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, U K
    Nat Cell Biol 12:831-5. 2010
    ..In recent months, new information has emerged that both the ER and mitochondria may provide a membrane source, enlightening some older findings and revealing how complex the initiation of autophagy may be in mammalian cells...
  7. doi request reprint The role of membrane proteins in mammalian autophagy
    Sharon A Tooze
    London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Semin Cell Dev Biol 21:677-82. 2010
    ..In addition, the identification of so far uncharacterized transmembrane proteins which are involved in autophagy will also help to address the important questions of where, how, and why autophagosomes form...
  8. doi request reprint Trafficking and signaling in mammalian autophagy
    Sharon A Tooze
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
    IUBMB Life 62:503-8. 2010
    ..Here, we will review the recent progress made in understanding the induction of autophagy, with emphasis on the contributions from our laboratory...
  9. doi request reprint Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration
    Sharon A Tooze
    Cancer Research UK, London Research Institute, London, UK
    Curr Opin Neurobiol 18:504-15. 2008
    ..Although recent evidence supports this assumption, how autophagy protects cells from damage leading to neurodegeneration is not yet clear...
  10. pmc Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
    Anne Simonsen
    Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway
    J Cell Biol 186:773-82. 2009
    ..Here we discuss the cross talk between autophagy and intracellular compartments, highlighting recent exciting data about the role and regulation of the Vps34 class III phosphatidylinositol (PI) 3-kinase in autophagy...
  11. doi request reprint Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
    Hannah E J Polson
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
    Autophagy 6:506-22. 2010
    ..In view of our data we propose a role for WIPI2 in the progression of omegasomes into autophagosomes...
  12. pmc Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
    Edmond Y W Chan
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell Biol 29:157-71. 2009
    ....
  13. ncbi request reprint Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
    Andrew R J Young
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    J Cell Sci 119:3888-900. 2006
    ..We speculate that starvation-induced autophagy, which requires mAtg9, may rely on an alteration of the steady-state trafficking of mAtg9, in a Atg1-dependent manner...
  14. ncbi request reprint In vitro reconstitution of fusion between immature autophagosomes and endosomes
    Joelle Morvan
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
    Autophagy 5:676-89. 2009
    ..We also demonstrate that the lipidated form of the autophagosomal protein LC3 is dispensable for this fusion event...
  15. doi request reprint A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes
    Grant P Otto
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, UK
    Traffic 11:688-705. 2010
    ..Thus,we propose that SHIP164 functions in trafficking through the early/recycling endosomal system...
  16. pmc Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP
    Jemma L Webber
    London Research Institute, Secretory Pathways Laboratory, Cancer Research UK, London, UK
    EMBO J 29:27-40. 2010
    ..Our results provide evidence for a link between the MAPK pathway and the control of autophagy through mAtg9 and p38IP...
  17. pmc GGA function is required for maturation of neuroendocrine secretory granules
    Or Kakhlon
    Secretory Pathway Laboratories, Cancer Research UK, London Research Institute, London, UK
    EMBO J 25:1590-602. 2006
    ..Our results suggest that inhibition of CCV budding from ISGs downregulates the sorting from the ISGs and perturbs the intragranular activity of PC2...
  18. pmc PIKfyve regulation of endosome-linked pathways
    Jane de Lartigue
    Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Traffic 10:883-93. 2009
    ..We suggest that PIKfyve inhibition may render the late endosome/lysosome compartment refractory to fusion with both autophagosomes and with EGFR-containing multivesicular bodies...
  19. ncbi request reprint siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
    Edmond Y W Chan
    Secretory Pathways Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    J Biol Chem 282:25464-74. 2007
    ..In contrast, ULK1-(1-351) was diffuse in the cytoplasm. These experiments reveal at least two domains in ULK1 which likely function via unique sets of effectors to regulate autophagy...
  20. pmc AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1
    Ina Hinners
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO Rep 4:1182-9. 2003
    ....
  21. doi request reprint Endocytosis and autophagy: Shared machinery for degradation
    Christopher A Lamb
    London Research Institute, Cancer Research UK, London, UK
    Bioessays 35:34-45. 2013
    ..Editor's suggested further reading in BioEssays The evolution of dynamin to regulate clathrin-mediated endocytosis Abstract...
  22. pmc Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC
    Nicole C McKnight
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
    EMBO J 31:1931-46. 2012
    ..The identification of these novel regulatory proteins with diverse functions in autophagy contributes towards a fuller understanding of autophagosome formation...
  23. doi request reprint New insights into the function of Atg9
    Jemma L Webber
    London Research Institute, Cancer Research UK, London, United Kingdom
    FEBS Lett 584:1319-26. 2010
    ..We summarise recent data on the role of Atg9 trafficking in yeast and mammalian autophagy and discuss the role of p38IP and p38 MAPK in regulation of mAtg9 trafficking and autophagy...
  24. pmc Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2
    Fiona McAlpine
    London Research Institute, Cancer Research UK, Secretory Pathways Laboratory, London, UK
    Autophagy 9:361-73. 2013
    ..Our findings support functional redundancy between ULK1 and ULK2 for nutrient-dependent activation of autophagy and furthermore highlight the differential pathways that respond to amino acid and glucose deprivation...
  25. doi request reprint Membrane trafficking events that partake in autophagy
    Andrea Orsi
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Curr Opin Cell Biol 22:150-6. 2010
    ..Recent studies have shed light on the machinery required for both these early and late events to occur...
  26. ncbi request reprint Changing directions: clathrin-mediated transport between the Golgi and endosomes
    Ina Hinners
    Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 116:763-71. 2003
    ..Recent data have shed light on the locations, functions and interactions of AP-1 and GGA proteins. These data provide support for the role of both in anterograde transport from the Golgi complex...
  27. ncbi request reprint Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
    Robert Köchl
    Cancer Research UK, London Research Institute, Secretory Pathways Laboratory, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Traffic 7:129-45. 2006
    ..Stimulation of autophagosome formation by vinblastine was independent of nutrients and mTOR activity but was inhibited by depletion of the Autophagy proteins Atg5 and Atg6, known to be required for autophagy...
  28. pmc Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy
    Justin Joachim
    London Research Institute, Cancer Research UK, London, UK
    Autophagy 8:1397-400. 2012
    ....
  29. ncbi request reprint Atg9 trafficking in Mammalian cells
    Jemma L Webber
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, United Kingdom
    Autophagy 3:54-6. 2007
    ..3) Here we address the implications of our model with regard to membrane trafficking events in mammalian cells after starvation...
  30. ncbi request reprint Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage
    Martina Wirth
    London Research Institute, Cancer Research UK, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Semin Cancer Biol 23:301-9. 2013
    ..In this review we discuss how the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions and we highlight data linking these complexes together. ..
  31. pmc ULK1 regulates melanin levels in MNT-1 cells independently of mTORC1
    Eyal Kalie
    Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom
    PLoS ONE 8:e75313. 2013
    ..Furthermore we show that regulation of melanogenesis by ULK1 is independent of mTORC1 inhibition. Our data thus provide intriguing insights regarding the involvement of the key regulatory autophagy machinery in melanogenesis. ..
  32. pmc Tales of the autophagy crusaders
    Eyal Kalie
    London Research Institute, Cancer Research UK, London, UK
    EMBO Rep 13:175-7. 2012
    ..It brought together researchers from around the globe to cover the biogenesis of the autophagosome, as well as related topics including the regulation of autophagy, selective autophagy and the role of autophagy in disease and cell death...
  33. ncbi request reprint Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3
    Carol Austin
    Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, England
    Biochemistry 41:4669-77. 2002
    ....
  34. pmc Regulation and recruitment of phosphatidylinositol 4-kinase on immature secretory granules is independent of ADP-ribosylation factor 1
    Christina Panaretou
    The Secretory Pathways Laboratory, Cancer Research UK London Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, U K
    Biochem J 363:289-95. 2002
    ..Our results suggest that the regulation of PtdIns 4-kinase on the ISGs differs in comparison with that on the TGN, and might be related to a specific requirement of ISG maturation...
  35. doi request reprint Current views on the source of the autophagosome membrane
    Sharon A Tooze
    London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3LY, U K
    Essays Biochem 55:29-38. 2013
    ..In the present chapter, I review the data from the pre-molecular decades, and discuss the most recent publications to give an overview of the current view of where, and how, autophagosomes form in mammalian cells. ..
  36. doi request reprint Correlative light and electron microscopy
    Minoo Razi
    London Research Institute, Cancer Research UK, London, UK
    Methods Enzymol 452:261-75. 2009
    ..CLEM gives a broad low magnification overview of the cell, allowing an assessment of both spatial and temporal events, as well as providing high-resolution information about individual autophagosomes or single compartments...