Research Topics
Genomes and Genes
| Sharon A ToozeSummaryAffiliation: Cancer Research UK Country: UK Publications
| Collaborators
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Detail Information
Publications
The role of membrane proteins in mammalian autophagySharon A Tooze
London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Semin Cell Dev Biol 21:677-82. 2010..In addition, the identification of so far uncharacterized transmembrane proteins which are involved in autophagy will also help to address the important questions of where, how, and why autophagosomes form...
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexesAnne Simonsen
Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway
J Cell Biol 186:773-82. 2009..Here we discuss the cross talk between autophagy and intracellular compartments, highlighting recent exciting data about the role and regulation of the Vps34 class III phosphatidylinositol (PI) 3-kinase in autophagy...- Liaisons dangereuses: autophagy, neuronal survival and neurodegenerationSharon A Tooze
Cancer Research UK, London Research Institute, London, UK
Curr Opin Neurobiol 18:504-15. 2008..Although recent evidence supports this assumption, how autophagy protects cells from damage leading to neurodegeneration is not yet clear... - The origin of the autophagosomal membraneSharon A Tooze
Secretory Pathways Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, U K
Nat Cell Biol 12:831-5. 2010..In recent months, new information has emerged that both the ER and mitochondria may provide a membrane source, enlightening some older findings and revealing how complex the initiation of autophagy may be in mammalian cells... - Trafficking and signaling in mammalian autophagySharon A Tooze
Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
IUBMB Life 62:503-8. 2010..Here, we will review the recent progress made in understanding the induction of autophagy, with emphasis on the contributions from our laboratory... - Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanismEdmond Y W Chan
Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Mol Cell Biol 29:157-71. 2009.... 
In vitro reconstitution of fusion between immature autophagosomes and endosomesJoelle Morvan
Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
Autophagy 5:676-89. 2009..We also demonstrate that the lipidated form of the autophagosomal protein LC3 is dispensable for this fusion event...- Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomesAndrew R J Young
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
J Cell Sci 119:3888-900. 2006..We speculate that starvation-induced autophagy, which requires mAtg9, may rely on an alteration of the steady-state trafficking of mAtg9, in a Atg1-dependent manner... - Early endosomes and endosomal coatomer are required for autophagyMinoo Razi
London Research Institute, Cancer Research UK, London WC2A 3PX, England, UK
J Cell Biol 185:305-21. 2009.... - A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomesGrant P Otto
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, UK
Traffic 11:688-705. 2010..Thus,we propose that SHIP164 functions in trafficking through the early/recycling endosomal system... - Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IPJemma L Webber
London Research Institute, Secretory Pathways Laboratory, Cancer Research UK, London, UK
EMBO J 29:27-40. 2010..Our results provide evidence for a link between the MAPK pathway and the control of autophagy through mAtg9 and p38IP... - GGA function is required for maturation of neuroendocrine secretory granulesOr Kakhlon
Secretory Pathway Laboratories, Cancer Research UK, London Research Institute, London, UK
EMBO J 25:1590-602. 2006..Our results suggest that inhibition of CCV budding from ISGs downregulates the sorting from the ISGs and perturbs the intragranular activity of PC2... - AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1Ina Hinners
Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO Rep 4:1182-9. 2003.... - Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WACNicole C McKnight
Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, London, UK
EMBO J 31:1931-46. 2012..The identification of these novel regulatory proteins with diverse functions in autophagy contributes towards a fuller understanding of autophagosome formation... - siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagyEdmond Y W Chan
Secretory Pathways Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
J Biol Chem 282:25464-74. 2007..In contrast, ULK1-(1-351) was diffuse in the cytoplasm. These experiments reveal at least two domains in ULK1 which likely function via unique sets of effectors to regulate autophagy... - New insights into the function of Atg9Jemma L Webber
London Research Institute, Cancer Research UK, London, United Kingdom
FEBS Lett 584:1319-26. 2010..We summarise recent data on the role of Atg9 trafficking in yeast and mammalian autophagy and discuss the role of p38IP and p38 MAPK in regulation of mAtg9 trafficking and autophagy... - Changing directions: clathrin-mediated transport between the Golgi and endosomesIna Hinners
Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
J Cell Sci 116:763-71. 2003..Recent data have shed light on the locations, functions and interactions of AP-1 and GGA proteins. These data provide support for the role of both in anterograde transport from the Golgi complex... - PIKfyve regulation of endosome-linked pathwaysJane de Lartigue
Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Traffic 10:883-93. 2009..We suggest that PIKfyve inhibition may render the late endosome/lysosome compartment refractory to fusion with both autophagosomes and with EGFR-containing multivesicular bodies... - Membrane trafficking events that partake in autophagyAndrea Orsi
Secretory Pathways Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Curr Opin Cell Biol 22:150-6. 2010..Recent studies have shed light on the machinery required for both these early and late events to occur... - Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagyJustin Joachim
London Research Institute, Cancer Research UK, London, UK
Autophagy 8:1397-400. 2012.... - Atg9 trafficking in Mammalian cellsJemma L Webber
Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, United Kingdom
Autophagy 3:54-6. 2007..3) Here we address the implications of our model with regard to membrane trafficking events in mammalian cells after starvation... - Tales of the autophagy crusadersEyal Kalie
London Research Institute, Cancer Research UK, London, UK
EMBO Rep 13:175-7. 2012..It brought together researchers from around the globe to cover the biogenesis of the autophagosome, as well as related topics including the regulation of autophagy, selective autophagy and the role of autophagy in disease and cell death... - Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cellsMalika Ahras
Cancer Research UK, London Research Institute, London WC2A 3PX, England, UK
J Cell Biol 173:241-51. 2006..Granule formation, and the sorting of SgII and PC2 from the trans-Golgi network into ISGs and MSGs, however, is not affected. We conclude that Syt IV is an essential component for secretory granule maturation... - Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomesRobert Köchl
Cancer Research UK, London Research Institute, Secretory Pathways Laboratory, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
Traffic 7:129-45. 2006..Stimulation of autophagosome formation by vinblastine was independent of nutrients and mTOR activity but was inhibited by depletion of the Autophagy proteins Atg5 and Atg6, known to be required for autophagy... - Correlative light and electron microscopyMinoo Razi
London Research Institute, Cancer Research UK, London, UK
Methods Enzymol 452:261-75. 2009..CLEM gives a broad low magnification overview of the cell, allowing an assessment of both spatial and temporal events, as well as providing high-resolution information about individual autophagosomes or single compartments... - Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cellsJoelle Morvan
London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, UK
Histochem Cell Biol 129:243-52. 2008.... - Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3Carol Austin
Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, England
Biochemistry 41:4669-77. 2002.... - Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2Fiona McAlpine
London Research Institute, Cancer Research UK, Secretory Pathways Laboratory, London, UK
Autophagy 9:361-73. 2013..Our findings support functional redundancy between ULK1 and ULK2 for nutrient-dependent activation of autophagy and furthermore highlight the differential pathways that respond to amino acid and glucose deprivation... - Regulation and recruitment of phosphatidylinositol 4-kinase on immature secretory granules is independent of ADP-ribosylation factor 1Christina Panaretou
The Secretory Pathways Laboratory, Cancer Research UK London Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, U K
Biochem J 363:289-95. 2002..Our results suggest that the regulation of PtdIns 4-kinase on the ISGs differs in comparison with that on the TGN, and might be related to a specific requirement of ISG maturation...