Barry J Thompson

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. doi request reprint Sticking together the Crumbs - an unexpected function for an old friend
    Barry J Thompson
    Cancer Research UK, London Research Institute, 44 Lincolns Inn Fields, London, WC2A 3LY, UK
    Nat Rev Mol Cell Biol 14:307-14. 2013
  2. doi request reprint Cell polarity: models and mechanisms from yeast, worms and flies
    Barry J Thompson
    Cancer Research UK, London Research Institute, Lincoln s Inn Fields, London WC2A 3LY, UK
    Development 140:13-21. 2013
  3. pmc Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]
    Felix A Grusche
    European Molecular Biology Laboratory, Heidelberg, Germany
    BMC Dev Biol 9:14. 2009
  4. pmc Mal/SRF is dispensable for cell proliferation in Drosophila
    Barry J Thompson
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 5:e10077. 2010
  5. doi request reprint Developmental control of cell growth and division in Drosophila
    Barry J Thompson
    Cancer Research UK, London Research Institute, Lincoln s Inn Fields, WC2A 3PX, London, UK
    Curr Opin Cell Biol 22:788-94. 2010
  6. pmc The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells
    Eliana P Lucas
    Epithelial Biology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, England, UK
    J Cell Biol 201:875-85. 2013
  7. pmc Differential proliferation rates generate patterns of mechanical tension that orient tissue growth
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London, UK
    EMBO J 32:2790-803. 2013
  8. doi request reprint Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium
    Georgina C Fletcher
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 22:1116-22. 2012
  9. doi request reprint Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway
    Clara M Sidor
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 23:223-8. 2013
  10. pmc Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 25:131-6. 2011

Collaborators

Detail Information

Publications16

  1. doi request reprint Sticking together the Crumbs - an unexpected function for an old friend
    Barry J Thompson
    Cancer Research UK, London Research Institute, 44 Lincolns Inn Fields, London, WC2A 3LY, UK
    Nat Rev Mol Cell Biol 14:307-14. 2013
    ..Recent evidence now points to a conserved and fundamental role for the extracellular domain of Crumbs in mediating homophilic Crumbs-Crumbs interactions at cell-cell junctions...
  2. doi request reprint Cell polarity: models and mechanisms from yeast, worms and flies
    Barry J Thompson
    Cancer Research UK, London Research Institute, Lincoln s Inn Fields, London WC2A 3LY, UK
    Development 140:13-21. 2013
    ....
  3. pmc Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]
    Felix A Grusche
    European Molecular Biology Laboratory, Heidelberg, Germany
    BMC Dev Biol 9:14. 2009
    ..How epithelial cells adopt their particular polarised forms is poorly understood. In a screen for genes regulating epithelial morphology in Drosophila, we identified sds22, a conserved gene previously characterised in yeast...
  4. pmc Mal/SRF is dispensable for cell proliferation in Drosophila
    Barry J Thompson
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 5:e10077. 2010
    ..My results indicate that Mal/SRF can promote tissue growth when abnormally active, but is not normally required for tissue growth during development...
  5. doi request reprint Developmental control of cell growth and division in Drosophila
    Barry J Thompson
    Cancer Research UK, London Research Institute, Lincoln s Inn Fields, WC2A 3PX, London, UK
    Curr Opin Cell Biol 22:788-94. 2010
    ....
  6. pmc The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells
    Eliana P Lucas
    Epithelial Biology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, England, UK
    J Cell Biol 201:875-85. 2013
    ..Instead, Warts phosphorylates and inhibits the actin regulator Ena to activate F-actin Capping protein activity on inner membranes and thereby restricts F-actin polymerization mainly to the outer rim of the migrating cluster...
  7. pmc Differential proliferation rates generate patterns of mechanical tension that orient tissue growth
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London, UK
    EMBO J 32:2790-803. 2013
    ..Our results suggest that patterned rates of cell proliferation can influence tissue mechanics and thus determine the orientation of cell divisions and tissue shape. ..
  8. doi request reprint Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium
    Georgina C Fletcher
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 22:1116-22. 2012
    ..Once Crb is removed from the plasma membrane, it undergoes recycling via Rab11 endosomes. Our results provide a dynamic model for understanding how epithelial polarity is maintained in Drosophila follicle cells...
  9. doi request reprint Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway
    Clara M Sidor
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 23:223-8. 2013
    ..Finally, Mask proteins are functionally conserved between Drosophila and humans and are coexpressed with YAP in a wide variety of human stem/progenitor cells and tumors...
  10. pmc Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 25:131-6. 2011
    ..Planar polarization of Dachs is ultimately oriented by long-range gradients emanating from compartment boundaries, and is therefore a mechanism linking these gradients with the control of tissue shape...
  11. pmc The young and happy marriage of membrane traffic and cell polarity
    Barry J Thompson
    London Research Institute, UK
    EMBO Rep 13:670-2. 2012
    ..It brought together scientists from two once separate fields and highlighted their emerging interdependence. The wealth of scientific insights and discoveries presented laid a path for future research...
  12. pmc Kibra is a regulator of the Salvador/Warts/Hippo signaling network
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 18:300-8. 2010
    ..We suggest that Kibra is part of an apical scaffold that promotes SWH pathway activity...
  13. pmc The ubiquitin ligase FbxL7 regulates the Dachsous-Fat-Dachs system in Drosophila
    Mariana Rodrigues-Campos
    Cancer Research UK London Research Institute, Lincoln s Inn Fields, London WC2A 3LY, UK GABBA, ICBAS, Universidade do Porto, 4050 313 Porto, Portugal
    Development 141:4098-103. 2014
    ..GFP-tagged FbxL7 localises to the plasma membrane in a Ft-dependent manner and is planar polarised. We propose that Ft recruits FbxL7 to the proximal side of the cell to help restrict Ds and Dachs to the distal side of the cell...
  14. pmc Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia
    Graham P Bell
    Epithelial Biology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 25:61-8. 2015
    ..Our findings suggest a revised model for Lgl regulation and function in both symmetric and asymmetric cell divisions...
  15. pmc The Spectrin cytoskeleton regulates the Hippo signalling pathway
    Georgina C Fletcher
    Epithelial Biology Laboratory, Cancer Research UK London Research Institute, London, UK
    EMBO J 34:940-54. 2015
    ..Our findings identify both apical and basolateral Spectrins as regulators of Hippo signalling and suggest Spectrins as potential mechanosensors. ..
  16. pmc Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove
    Marina E Ivanova
    Structural Biology Laboratories, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3LY, England
    Acta Crystallogr D Biol Crystallogr 71:555-64. 2015
    ..Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 may be regulated by intradomain contacts or by protein-protein interaction. ..