Research Topics
| P D SasieniSummaryAffiliation: Cancer Research UK Country: UK Publications
| Collaborators
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Detail Information
Publications
Benefit of cervical screening at different ages: evidence from the UK audit of screening historiesP Sasieni
Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
Br J Cancer 89:88-93. 2003..British Journal of Cancer (2003) 89, 88-93. doi:10.1038/sj.bjc.6600974 www.bjcancer.com..
On the expected number of cancer deaths during follow-up of an initially cancer-free cohortPeter Sasieni
Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
Epidemiology 14:108-10. 2003..It is more accurate to calculate the expected number of deaths by explicitly considering the probability of getting cancer in a given year and the probability of dying from it before the end of the follow-up...- Avoidance of premature death: a new definition for the proportion curedP D Sasieni
Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London
J Cancer Epidemiol Prev 7:165-71. 2002..Interpretation of differences between countries or over time is complicated and requires consideration of incidence and mortality data... - Cervical cancer prevention and hormonal contraceptionPeter Sasieni
Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
Lancet 370:1591-2. 2007 - Evaluation of the UK breast screening programmesP Sasieni
Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventative Medicine, London, UK
Ann Oncol 14:1206-8. 2003..A new analysis of trends in England and Wales suggests that the effect of screening has been to reduce mortality by 8% over 10 years in those eligible for screening in 1990... - Chemoprevention of cervical cancerPeter Sasieni
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
Best Pract Res Clin Obstet Gynaecol 20:295-305. 2006..Although definitive trials need to use a robust clinical endpoint (such as histology), all future trials should include biomarkers to study the subclinical effect of the study agent... 
How many cervical cancers are prevented by treatment of screen-detected disease in young women?Peter Sasieni
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London, United Kingdom
Int J Cancer 124:461-4. 2009..From this analysis, at most 1.5% of women treated (equivalent to 3% of CIN3 registrations) would have had cancer by age 25, whereas it is reasonable to assume that over half of them would have regressed by age 25...- Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART studyD Mesher
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Charterhouse Square, LondonEC1 M 6BQ, UK
Br J Cancer 102:1405-10. 2010..Several studies have shown that testing for high-risk human papillomavirus (HPV) types results in an improved sensitivity for CIN2+, compared with cytology, although with a somewhat lower specificity... - What is the lifetime risk of developing cancer?: the effect of adjusting for multiple primariesP D Sasieni
Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK
Br J Cancer 105:460-5. 2011..As individuals may get more than one type of cancer, what is generally estimated is the average (mean) number of cancers over a lifetime. This is not the same as the probability of getting cancer... - Modelling the likely effect of the increase of the upper age limit from 70 to 73 for breast screening in the UK National ProgrammeS W Duffy
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
Stat Methods Med Res 19:547-55. 2010..These results suggest that the expansion of the upper age limit will be cost-effective. They remain to be confirmed by evaluation of the age extension. They provide prior estimates that may inform the evaluation of the age extension... - Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control studyV Bataille
Genetic Epidemiology and Twin Research Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Eur J Cancer 40:429-35. 2004..However, it is possible that the mean lag time of 7 years between exposure to sunbed and melanoma in this study may have led to an under-estimation of the long-term melanoma risk... - Management of women who test positive for high-risk types of human papillomavirus: the HART studyJ Cuzick
Cancer Research UK, London, UK
Lancet 362:1871-6. 2003..We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women... - Should aromatase inhibitors be used as initial adjuvant treatment or sequenced after tamoxifen?J Cuzick
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Br J Cancer 94:460-4. 2006..A mechanism explaining why greater efficacy might be so is proposed. Further results from ongoing trials will be needed to resolve this issue... - A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGHR Roylance
Molecular and Population Genetics Laboratory, Cancer Research UK, Lincoln s Inn Fields, London, UK
Oncogene 25:6544-53. 2006..Higher-grade IDCs probably develop from low-grade lesions in most cases, but there remains evidence that some GII/GIII IDCs arise without a GI precursor... - The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and AustraliaV Bataille
Imperial Cancer Research Fund Skin Tumour Laboratory, London, UK
Br J Cancer 77:505-10. 1998.... - Predicting the impact of the screening programme for colorectal cancer in the UKD M Parkin
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
J Med Screen 15:163-74. 2008..We examine the likely impact of the programme, in terms of reduced mortality, lives saved and changes in incidence, over the next 20 years... - Changing rates of adenocarcinoma and adenosquamous carcinoma of the cervix in EnglandP Sasieni
Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, WC2A 3PX, London, UK
Lancet 357:1490-3. 2001..We have used additional data on cancers diagnosed in 1993-94 in England and up to 1997 in five English cancer registries to investigate more recent trends... - Estimating prevalence when the true disease status is incompletely ascertainedP Sasieni
Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
Stat Med 20:935-49. 2001..Estimation of and inference about the disease prevalence and the test sensitivity when disease status is ascertained on a random sample of those negative on both screening tests is discussed... - A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusionsJ Cuzick
Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
Br J Cancer 83:561-5. 2000..A range of issues including the age to start and stop screening, the appropriate screening interval, the role of self-sampling for HPV testing and the choice of primary test (HPV and/or cytology) require further evaluation... - Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skinC A Harwood
Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, 2 Newark Street, London, E1 2AT, UK
Br J Dermatol 150:949-57. 2004..Human papillomaviruses (HPVs) are found in normal skin and in benign and malignant skin conditions. Epidermodysplasia verruciformis (EV) HPV types are those most plausibly linked to the development of squamous cell carcinomas of the skin... - Estimating the efficacy of screening by auditing smear histories of women with and without cervical cancer. The National Co-ordinating Network for Cervical Screening Working GroupP D Sasieni
Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
Br J Cancer 73:1001-5. 1996..These data suggest that full adherence to current guidelines could perhaps have prevented another 1250 cases, but additional steps would have been required to prevent some of the 2300 remaining cases in women under the age of 70... - Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinicL R Lipton
Molecular and Population Genetics Laboratory, London Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom
J Clin Oncol 22:4934-43. 2004..CONCLUSION: We believe that a quantitative model, such as the Amsterdam-plus model, should be the first choice for selecting families or patients for evaluation of HNPCC using molecular tests. We present an algorithm for this process... - Predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20-29 in the UKJ Cuzick
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK
Br J Cancer 102:933-9. 2010..In the UK, vaccination for girls aged 12-13 with catch-up for girls up to age 18 was introduced in 2008, using the bivalent GSK vaccine (Cervarix)... - Cancer screening for medical oncologists: importance of quality control and auditP Sasieni
Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
Ann Oncol 13:199-204. 2002 - Cancer mortality in the United Kingdom: projections to the year 2025A H Olsen
Department of Mathematics and Statistics, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
Br J Cancer 99:1549-54. 2008..Actual numbers of deaths will increase for most cancers... - The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in womenV Bataille
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
J Invest Dermatol 119:1317-22. 2002..The evidence of a major genetic influence on acne should stimulate the search for potential genes that may lead to new therapeutic approaches... - Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)Johanne Geary
Department of Medical Genetics, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
Fam Cancer 7:163-72. 2008..Breast cancer RR was 1.7 overall. The type of mutation (truncating or other type, and site of mutation) showed no obvious correlation with the presence or absence of extra-colonic cancers in families... - Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive womenHenry Kitchener
Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
Int J Cancer 121:2484-91. 2007..Cytology appears to be sufficient for cervical surveillance, with HPV testing being less specific with poor positive predictive value. There appears to be no additional benefit from routine colposcopy... - Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith studyJack Cuzick
Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
Int J Cancer 122:2294-300. 2008..52, p = 0.001), whereas there was little difference according to initial cytology (HR = 1.64, p = 0.51)... - Chapter 9: Clinical applications of HPV testing: a summary of meta-analysesMarc Arbyn
Unit of Cancer Epidemiology, Scientific Institute of Public Health, J Wytsmanstreet 14, Brussels, Belgium
Vaccine 24:S3/78-89. 2006..More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods... - Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndromeIsis Dove-Edwin
Family Cancer Group, Cancer Research, UK Colorectal Cancer Unit, St. Mark's Hospital, Watford Road, Harrow, Middlesex, United Kingdom
Gastroenterology 130:1995-2000. 2006..Lynch syndrome individuals require short surveillance intervals as is the recommended practice... - The UK breast-screening programme should start at age 47 yearsPeter Sasieni
Lancet 362:246-7. 2003 - Cervical screening in adolescents--at least do no harmAnne Szarewski
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London EC1M 6BQ, UK
Lancet 364:1642-4. 2004 - A multicentre epidemiological study on sunbed use and cutaneous melanoma in EuropeVeronique Bataille
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, London, UK
Eur J Cancer 41:2141-9. 2005..Sunbed exposure has become increasingly prevalent over the last 20 years, especially in Northern Europe but the full impact of this exposure on skin cancers may not become apparent for many years... - Overview of the European and North American studies on HPV testing in primary cervical cancer screeningJack Cuzick
Cancer Research UK, Wolfson Institute of Preventive Medicine, London
Int J Cancer 119:1095-101. 2006..These results support the use of HPV testing as the sole primary screening test, with cytology reserved for women who test HPV positive. Large demonstration projects are needed to fully evaluate this strategy... - Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasiaWilliam Patrick Soutter
Imperial College, Hammersmith Hospital Campus, London, United Kingdom
Int J Cancer 118:2048-55. 2006..Women should be encouraged to persevere with annual smears for at least 10 years after their treatment as this may offer them the best chance of detecting recurrence at a treatable stage... - Methodological issues in international comparison of interval breast cancersJean Luc Bulliard
Cancer Epidemiology Unit, University Institute of Social and Preventive Medicine, Lausanne, Switzerland
Int J Cancer 119:1158-63. 2006..Valid comparisons of IC are possible with careful attention to the definition but true differences in IC frequency across screening programmes should exceed 10% to be possibly indicative of real differences between programmes... - Liquid-based versus conventional cervical cytologyPeter Sasieni
Lancet 367:1481; author reply 1482-3. 2006 - How many mutations in a cancer?Ian Tomlinson
Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
Am J Pathol 160:755-8. 2002 - Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up studyIsis Dove-Edwin
Family Cancer Group, Cancer Research UK Colorectal Cancer Unit, St Mark's Hospital, Harrow, Middlesex HA1 3UJ
BMJ 331:1047. 2005..This would reduce the demand for colonoscopic surveillance... - Cervical screening by visual inspection, HPV testing, liquid-based and conventional cytology in Amazonian PeruMaribel Almonte
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
Int J Cancer 121:796-802. 2007..VIA gives immediate results, but will require investment in regular training and supervision. Further work is needed to determine whether screened-positive women should all be treated or triaged with a more specific test... - X-inactivation patch size in human female tissue confounds the assessment of tumor clonalityMarco Novelli
Department of Histopathology, Rockefeller Building, University Street, University College London Hospitals, London WC1E 6JJ, United Kingdom
Proc Natl Acad Sci U S A 100:3311-4. 2003..Results show that the patch size is relatively large in both the human colon and breast, confounding assessment of tumor clonality with traditional X-inactivation studies... - A weighted Kaplan-Meier estimator for matched data with application to the comparison of chemotherapy and bone-marrow transplant in leukaemiaStefania Galimberti
Department of Clinical Medicine, Prevention and Biotechnology, Section of Medical Statistics, University of Milano Bicocca, Monza, Italy
Stat Med 21:3847-64. 2002..The procedures proposed here are applied to data collected from an Italian study whose aim was the evaluation of bone marrow transplant, as compared to intensive chemotherapy, in the cure of paediatric acute lymphoblastic leukaemia...