P D Sasieni

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc Benefit of cervical screening at different ages: evidence from the UK audit of screening histories
    P Sasieni
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 89:88-93. 2003
  2. ncbi request reprint On the expected number of cancer deaths during follow-up of an initially cancer-free cohort
    Peter Sasieni
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
    Epidemiology 14:108-10. 2003
  3. ncbi request reprint Avoidance of premature death: a new definition for the proportion cured
    P D Sasieni
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London
    J Cancer Epidemiol Prev 7:165-71. 2002
  4. ncbi request reprint Cervical cancer prevention and hormonal contraception
    Peter Sasieni
    Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Lancet 370:1591-2. 2007
  5. ncbi request reprint Evaluation of the UK breast screening programmes
    P Sasieni
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventative Medicine, London, UK
    Ann Oncol 14:1206-8. 2003
  6. ncbi request reprint Chemoprevention of cervical cancer
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Best Pract Res Clin Obstet Gynaecol 20:295-305. 2006
  7. doi request reprint How many cervical cancers are prevented by treatment of screen-detected disease in young women?
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    Int J Cancer 124:461-4. 2009
  8. pmc Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART study
    D Mesher
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Charterhouse Square, LondonEC1 M 6BQ, UK
    Br J Cancer 102:1405-10. 2010
  9. pmc What is the lifetime risk of developing cancer?: the effect of adjusting for multiple primaries
    P D Sasieni
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Br J Cancer 105:460-5. 2011
  10. doi request reprint Modelling the likely effect of the increase of the upper age limit from 70 to 73 for breast screening in the UK National Programme
    S W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Stat Methods Med Res 19:547-55. 2010

Collaborators

Detail Information

Publications43

  1. pmc Benefit of cervical screening at different ages: evidence from the UK audit of screening histories
    P Sasieni
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 89:88-93. 2003
    ..British Journal of Cancer (2003) 89, 88-93. doi:10.1038/sj.bjc.6600974 www.bjcancer.com..
  2. ncbi request reprint On the expected number of cancer deaths during follow-up of an initially cancer-free cohort
    Peter Sasieni
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
    Epidemiology 14:108-10. 2003
    ..It is more accurate to calculate the expected number of deaths by explicitly considering the probability of getting cancer in a given year and the probability of dying from it before the end of the follow-up...
  3. ncbi request reprint Avoidance of premature death: a new definition for the proportion cured
    P D Sasieni
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London
    J Cancer Epidemiol Prev 7:165-71. 2002
    ..Interpretation of differences between countries or over time is complicated and requires consideration of incidence and mortality data...
  4. ncbi request reprint Cervical cancer prevention and hormonal contraception
    Peter Sasieni
    Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Lancet 370:1591-2. 2007
  5. ncbi request reprint Evaluation of the UK breast screening programmes
    P Sasieni
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventative Medicine, London, UK
    Ann Oncol 14:1206-8. 2003
    ..A new analysis of trends in England and Wales suggests that the effect of screening has been to reduce mortality by 8% over 10 years in those eligible for screening in 1990...
  6. ncbi request reprint Chemoprevention of cervical cancer
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Best Pract Res Clin Obstet Gynaecol 20:295-305. 2006
    ..Although definitive trials need to use a robust clinical endpoint (such as histology), all future trials should include biomarkers to study the subclinical effect of the study agent...
  7. doi request reprint How many cervical cancers are prevented by treatment of screen-detected disease in young women?
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    Int J Cancer 124:461-4. 2009
    ..From this analysis, at most 1.5% of women treated (equivalent to 3% of CIN3 registrations) would have had cancer by age 25, whereas it is reasonable to assume that over half of them would have regressed by age 25...
  8. pmc Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART study
    D Mesher
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Charterhouse Square, LondonEC1 M 6BQ, UK
    Br J Cancer 102:1405-10. 2010
    ..Several studies have shown that testing for high-risk human papillomavirus (HPV) types results in an improved sensitivity for CIN2+, compared with cytology, although with a somewhat lower specificity...
  9. pmc What is the lifetime risk of developing cancer?: the effect of adjusting for multiple primaries
    P D Sasieni
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Br J Cancer 105:460-5. 2011
    ..As individuals may get more than one type of cancer, what is generally estimated is the average (mean) number of cancers over a lifetime. This is not the same as the probability of getting cancer...
  10. doi request reprint Modelling the likely effect of the increase of the upper age limit from 70 to 73 for breast screening in the UK National Programme
    S W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Stat Methods Med Res 19:547-55. 2010
    ..These results suggest that the expansion of the upper age limit will be cost-effective. They remain to be confirmed by evaluation of the age extension. They provide prior estimates that may inform the evaluation of the age extension...
  11. ncbi request reprint Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control study
    V Bataille
    Genetic Epidemiology and Twin Research Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Eur J Cancer 40:429-35. 2004
    ..However, it is possible that the mean lag time of 7 years between exposure to sunbed and melanoma in this study may have led to an under-estimation of the long-term melanoma risk...
  12. ncbi request reprint Management of women who test positive for high-risk types of human papillomavirus: the HART study
    J Cuzick
    Cancer Research UK, London, UK
    Lancet 362:1871-6. 2003
    ..We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women...
  13. pmc Should aromatase inhibitors be used as initial adjuvant treatment or sequenced after tamoxifen?
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 94:460-4. 2006
    ..A mechanism explaining why greater efficacy might be so is proposed. Further results from ongoing trials will be needed to resolve this issue...
  14. pmc A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH
    R Roylance
    Molecular and Population Genetics Laboratory, Cancer Research UK, Lincoln s Inn Fields, London, UK
    Oncogene 25:6544-53. 2006
    ..Higher-grade IDCs probably develop from low-grade lesions in most cases, but there remains evidence that some GII/GIII IDCs arise without a GI precursor...
  15. pmc The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia
    V Bataille
    Imperial Cancer Research Fund Skin Tumour Laboratory, London, UK
    Br J Cancer 77:505-10. 1998
    ....
  16. doi request reprint Predicting the impact of the screening programme for colorectal cancer in the UK
    D M Parkin
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 15:163-74. 2008
    ..We examine the likely impact of the programme, in terms of reduced mortality, lives saved and changes in incidence, over the next 20 years...
  17. ncbi request reprint Changing rates of adenocarcinoma and adenosquamous carcinoma of the cervix in England
    P Sasieni
    Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Lancet 357:1490-3. 2001
    ..We have used additional data on cancers diagnosed in 1993-94 in England and up to 1997 in five English cancer registries to investigate more recent trends...
  18. ncbi request reprint Estimating prevalence when the true disease status is incompletely ascertained
    P Sasieni
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stat Med 20:935-49. 2001
    ..Estimation of and inference about the disease prevalence and the test sensitivity when disease status is ascertained on a random sample of those negative on both screening tests is discussed...
  19. pmc A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusions
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 83:561-5. 2000
    ..A range of issues including the age to start and stop screening, the appropriate screening interval, the role of self-sampling for HPV testing and the choice of primary test (HPV and/or cytology) require further evaluation...
  20. ncbi request reprint Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin
    C A Harwood
    Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, 2 Newark Street, London, E1 2AT, UK
    Br J Dermatol 150:949-57. 2004
    ..Human papillomaviruses (HPVs) are found in normal skin and in benign and malignant skin conditions. Epidermodysplasia verruciformis (EV) HPV types are those most plausibly linked to the development of squamous cell carcinomas of the skin...
  21. pmc Estimating the efficacy of screening by auditing smear histories of women with and without cervical cancer. The National Co-ordinating Network for Cervical Screening Working Group
    P D Sasieni
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 73:1001-5. 1996
    ..These data suggest that full adherence to current guidelines could perhaps have prevented another 1250 cases, but additional steps would have been required to prevent some of the 2300 remaining cases in women under the age of 70...
  22. ncbi request reprint Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic
    L R Lipton
    Molecular and Population Genetics Laboratory, London Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Clin Oncol 22:4934-43. 2004
    ....
  23. pmc Predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20-29 in the UK
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK
    Br J Cancer 102:933-9. 2010
    ..In the UK, vaccination for girls aged 12-13 with catch-up for girls up to age 18 was introduced in 2008, using the bivalent GSK vaccine (Cervarix)...
  24. ncbi request reprint Cancer screening for medical oncologists: importance of quality control and audit
    P Sasieni
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
    Ann Oncol 13:199-204. 2002
  25. pmc Cancer mortality in the United Kingdom: projections to the year 2025
    A H Olsen
    Department of Mathematics and Statistics, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 99:1549-54. 2008
    ..Actual numbers of deaths will increase for most cancers...
  26. ncbi request reprint The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women
    V Bataille
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    J Invest Dermatol 119:1317-22. 2002
    ..The evidence of a major genetic influence on acne should stimulate the search for potential genes that may lead to new therapeutic approaches...
  27. ncbi request reprint Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)
    Johanne Geary
    Department of Medical Genetics, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Fam Cancer 7:163-72. 2008
    ..Breast cancer RR was 1.7 overall. The type of mutation (truncating or other type, and site of mutation) showed no obvious correlation with the presence or absence of extra-colonic cancers in families...
  28. ncbi request reprint Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women
    Henry Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Int J Cancer 121:2484-91. 2007
    ..Cytology appears to be sufficient for cervical surveillance, with HPV testing being less specific with poor positive predictive value. There appears to be no additional benefit from routine colposcopy...
  29. doi request reprint Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith study
    Jack Cuzick
    Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Int J Cancer 122:2294-300. 2008
    ..52, p = 0.001), whereas there was little difference according to initial cytology (HR = 1.64, p = 0.51)...
  30. ncbi request reprint Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses
    Marc Arbyn
    Unit of Cancer Epidemiology, Scientific Institute of Public Health, J Wytsmanstreet 14, Brussels, Belgium
    Vaccine 24:S3/78-89. 2006
    ..More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods...
  31. ncbi request reprint Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome
    Isis Dove-Edwin
    Family Cancer Group, Cancer Research, UK Colorectal Cancer Unit, St Mark s Hospital, Watford Road, Harrow, Middlesex, United Kingdom
    Gastroenterology 130:1995-2000. 2006
    ..We sought to establish whether these individuals are also at increased risk by examining the incidence of advanced neoplasia during surveillance...
  32. ncbi request reprint The UK breast-screening programme should start at age 47 years
    Peter Sasieni
    Lancet 362:246-7. 2003
  33. ncbi request reprint Cervical screening in adolescents--at least do no harm
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London EC1M 6BQ, UK
    Lancet 364:1642-4. 2004
  34. ncbi request reprint A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe
    Veronique Bataille
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, London, UK
    Eur J Cancer 41:2141-9. 2005
    ..Sunbed exposure has become increasingly prevalent over the last 20 years, especially in Northern Europe but the full impact of this exposure on skin cancers may not become apparent for many years...
  35. ncbi request reprint Overview of the European and North American studies on HPV testing in primary cervical cancer screening
    Jack Cuzick
    Cancer Research UK, Wolfson Institute of Preventive Medicine, London
    Int J Cancer 119:1095-101. 2006
    ..These results support the use of HPV testing as the sole primary screening test, with cytology reserved for women who test HPV positive. Large demonstration projects are needed to fully evaluate this strategy...
  36. ncbi request reprint Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia
    William Patrick Soutter
    Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    Int J Cancer 118:2048-55. 2006
    ..Women should be encouraged to persevere with annual smears for at least 10 years after their treatment as this may offer them the best chance of detecting recurrence at a treatable stage...
  37. ncbi request reprint Methodological issues in international comparison of interval breast cancers
    Jean Luc Bulliard
    Cancer Epidemiology Unit, University Institute of Social and Preventive Medicine, Lausanne, Switzerland
    Int J Cancer 119:1158-63. 2006
    ..Valid comparisons of IC are possible with careful attention to the definition but true differences in IC frequency across screening programmes should exceed 10% to be possibly indicative of real differences between programmes...
  38. ncbi request reprint Liquid-based versus conventional cervical cytology
    Peter Sasieni
    Lancet 367:1481; author reply 1482-3. 2006
  39. pmc How many mutations in a cancer?
    Ian Tomlinson
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 160:755-8. 2002
  40. pmc Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study
    Isis Dove-Edwin
    Family Cancer Group, Cancer Research UK Colorectal Cancer Unit, St Mark s Hospital, Harrow, Middlesex HA1 3UJ
    BMJ 331:1047. 2005
    ..To determine to what extent individuals with various family histories of colorectal cancer (from one to three or more affected first degree relatives) benefit from colonoscopic surveillance...
  41. ncbi request reprint Cervical screening by visual inspection, HPV testing, liquid-based and conventional cytology in Amazonian Peru
    Maribel Almonte
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Int J Cancer 121:796-802. 2007
    ..VIA gives immediate results, but will require investment in regular training and supervision. Further work is needed to determine whether screened-positive women should all be treated or triaged with a more specific test...
  42. pmc X-inactivation patch size in human female tissue confounds the assessment of tumor clonality
    Marco Novelli
    Department of Histopathology, Rockefeller Building, University Street, University College London Hospitals, London WC1E 6JJ, United Kingdom
    Proc Natl Acad Sci U S A 100:3311-4. 2003
    ..Results show that the patch size is relatively large in both the human colon and breast, confounding assessment of tumor clonality with traditional X-inactivation studies...
  43. ncbi request reprint A weighted Kaplan-Meier estimator for matched data with application to the comparison of chemotherapy and bone-marrow transplant in leukaemia
    Stefania Galimberti
    Department of Clinical Medicine, Prevention and Biotechnology, Section of Medical Statistics, University of Milano Bicocca, Monza, Italy
    Stat Med 21:3847-64. 2002
    ..The procedures proposed here are applied to data collected from an Italian study whose aim was the evaluation of bone marrow transplant, as compared to intensive chemotherapy, in the cure of paediatric acute lymphoblastic leukaemia...