Erik Sahai

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Mechanisms of cancer cell invasion
    Erik Sahai
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Curr Opin Genet Dev 15:87-96. 2005
  2. ncbi request reprint Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
  3. pmc Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]
    Felix A Grusche
    European Molecular Biology Laboratory, Heidelberg, Germany
    BMC Dev Biol 9:14. 2009
  4. pmc Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy
    Erik Sahai
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    BMC Biotechnol 5:14. 2005
  5. ncbi request reprint Illuminating the metastatic process
    Erik Sahai
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Rev Cancer 7:737-49. 2007
  6. doi request reprint PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
    Sophie Pinner
    Tumour Cell Biology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 10:127-37. 2008
  7. doi request reprint Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
    Fernando Calvo
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London, UK
    Nat Cell Biol 15:637-46. 2013
  8. doi request reprint Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
    Souhila Medjkane
    Transcription Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 11:257-68. 2009
  9. pmc Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
    Cristina Hidalgo-Carcedo
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 13:49-58. 2011
  10. doi request reprint Cancer dissemination--lessons from leukocytes
    Chris D Madsen
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 19:13-26. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Mechanisms of cancer cell invasion
    Erik Sahai
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Curr Opin Genet Dev 15:87-96. 2005
    ..This work has challenged our views about what causes cancer cells to become motile in the first place, and has demonstrated that cancer cells can move in many different ways...
  2. ncbi request reprint Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
    ..Instead, carcinoma cells use Cdc42 and MRCK (myotonic dystrophy kinase-related CDC42-binding protein kinases) mediated regulation of MLC to follow the tracks generated by fibroblasts...
  3. pmc Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]
    Felix A Grusche
    European Molecular Biology Laboratory, Heidelberg, Germany
    BMC Dev Biol 9:14. 2009
    ..How epithelial cells adopt their particular polarised forms is poorly understood. In a screen for genes regulating epithelial morphology in Drosophila, we identified sds22, a conserved gene previously characterised in yeast...
  4. pmc Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy
    Erik Sahai
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    BMC Biotechnol 5:14. 2005
    ..However, the use of genetically encoded fluorescent proteins to distinguish different cell types in living animals has not been described at single cell resolution using multiphoton microscopy...
  5. ncbi request reprint Illuminating the metastatic process
    Erik Sahai
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Rev Cancer 7:737-49. 2007
    ..This Review will describe recent advances in our understanding of the different steps of metastasis gained from cellular resolution imaging, and how these techniques can be used in preclinical drug evaluation...
  6. doi request reprint PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
    Sophie Pinner
    Tumour Cell Biology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 10:127-37. 2008
    ..In the absence of PDK1, negative regulation by RhoE predominates, causing reduced acto-myosin contractility and motility. This work uncovers a novel non-catalytic role for PDK1 in regulating cortical acto-myosin and cell motility...
  7. doi request reprint Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
    Fernando Calvo
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London, UK
    Nat Cell Biol 15:637-46. 2013
    ..Actomyosin contractility and Src function are required for YAP activation by stiff matrices. Further, transient ROCK inhibition is able to disrupt the feed-forward loop, leading to a long-lasting reversion of the CAF phenotype...
  8. doi request reprint Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
    Souhila Medjkane
    Transcription Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 11:257-68. 2009
    ..Actin-based cell behaviour and experimental metastasis thus require Rho-dependent nuclear signalling through the MRTF-SRF network...
  9. pmc Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
    Cristina Hidalgo-Carcedo
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 13:49-58. 2011
    ..Depletion of DDR1, Par3, Par6 or RhoE leads to increased actomyosin contactility at cell-cell contacts, a loss of cell-cell cohesion and defective collective cell invasion...
  10. doi request reprint Cancer dissemination--lessons from leukocytes
    Chris D Madsen
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 19:13-26. 2010
    ..Further, we propose that the ability to switch between different migratory mechanisms is critical for cells to relocate from one tissue to another...
  11. pmc Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination
    Sophie Pinner
    Tumour Cell Biology Laboratory, Institute of Cancer Research, London, United Kingdom
    Cancer Res 69:7969-77. 2009
    ..These data show reversible phenotype switching during melanoma metastasis...
  12. pmc Arkadia regulates tumor metastasis by modulation of the TGF-β pathway
    Marco A Briones-Orta
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    Cancer Res 73:1800-10. 2013
    ..Our findings indicate that Arkadia is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis...
  13. pmc Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility
    Silvia Giampieri
    Tumour Cell Biology Laboratory, CR UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 11:1287-96. 2009
    ..Constitutive TGFbeta signalling promoted single cell motility and intravasation but reduced subsequent growth in the lungs. Thus, transient TGFbeta signalling is essential for blood-borne metastasis...
  14. doi request reprint Cell communication networks in cancer invasion
    Fernando Calvo
    Tumour Cell Biology Laboratory, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Curr Opin Cell Biol 23:621-9. 2011
    ..Here we summarise the key components of the network and their mechanisms of communication. Finally, we discuss the difficulties and opportunities that this complex network of interactions presents during cancer therapy...
  15. ncbi request reprint Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Nat Cell Biol 5:711-9. 2003
    ..Combined blockade of extracellular proteases and ROCK negates the ability of tumour cells to switch between modes of motility and synergises to prevent tumour cell invasion...
  16. ncbi request reprint Melanoma invasion - current knowledge and future directions
    Cedric Gaggioli
    Tumour Cell Biology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Pigment Cell Res 20:161-72. 2007
    ..This review will summarise our current understanding of melanoma invasion and focus on the new model systems that can be used to study melanoma...
  17. doi request reprint Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions
    Melda Tozluoğlu
    Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Nat Cell Biol 15:751-62. 2013
    ..Intravital imaging is used to verify bleb-driven migration at tumour margins, and the predicted response to single and combinatorial manipulations. ..
  18. ncbi request reprint Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
    Charles Swanton
    Signal Transduction, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cancer Cell 11:498-512. 2007
    ..COL4A3BP expression is increased in drug-resistant cell lines and in residual tumor following paclitaxel treatment of ovarian cancer, suggesting that it could be a target for chemotherapy-resistant cancers...
  19. ncbi request reprint RHO-GTPases and cancer
    Erik Sahai
    Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Rev Cancer 2:133-42. 2002
    ..A branch of the RAS family--the RHO proteins--is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets?..
  20. ncbi request reprint ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
    Emmanuel Vial
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom
    Cancer Cell 4:67-79. 2003
    ....
  21. ncbi request reprint p53 moves into control of cell morphology
    Erik Sahai
    Institute of Cancer Research, London SW3 6JB, United Kingdom
    Mol Interv 2:286-9. 2002
  22. ncbi request reprint Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
    ..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1...
  23. ncbi request reprint Tumor cells caught in the act of invading: their strategy for enhanced cell motility
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Cell Biol 15:138-45. 2005
    ..These results support a "tumor microenvironment invasion model" and provide new target opportunities for cancer therapy...
  24. ncbi request reprint Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 65:5278-83. 2005
    ..Disruption of this loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both macrophage and tumor cell migration and invasion...
  25. ncbi request reprint Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
    Chengsen Xue
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:192-7. 2006
    ....
  26. ncbi request reprint Tumor cell migration in three dimensions
    Steven Hooper
    Tumour Cell Biology Laboratory, Cancer Research United Kingdom London Research Institute
    Methods Enzymol 406:625-43. 2006
    ....
  27. ncbi request reprint Imaging tumor cell movement in vivo
    Dmitriy Kedrin
    Albert Einstein College of Medicine, Bronx, New York, USA
    Curr Protoc Cell Biol . 2007
    ..The Basic Protocol describes the standard methods used for generation of mammary tumors and imaging them. Additional protocols for labeling macrophages, blood vessel imaging, and image analysis are also included...
  28. ncbi request reprint ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo
    Jeffrey B Wyckoff
    Analytical Imaging Facility, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 16:1515-23. 2006
    ..Imaging of live tumors shows that MLC is organized in a similar ROCK-dependent fashion in vivo and that inhibition of ROCK but not matrix-metalloproteases reduces cancer cell motility in vivo...
  29. pmc Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility
    Erik Sahai
    Centre National de la Recherche Scientifique, UMR 6543, Centre Antoine Lacassagne, Nice 06189, France
    J Cell Biol 176:35-42. 2007
    ..Our results suggest that Smurf1 is a pivotal regulator of tumor cell movement through its regulation of RhoA signaling...
  30. ncbi request reprint ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 4:408-15. 2002
    ..The ability of Dia1 to regulate the actin network is crucial for the localization of adherens junction components to the cell periphery...
  31. ncbi request reprint Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis
    Daniel R Croft
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 64:8994-9001. 2004
    ..These results suggest that ROCK inhibitors would be useful antimetastatic and antiangiogenic chemotherapeutic agents in tumors associated with elevated RhoA, RhoC, ROCK I, or ROCK II expression...