Caryn S Ross-Innes

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc A co-ordinated interaction between CTCF and ER in breast cancer cells
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB20RE, UK
    BMC Genomics 12:593. 2011
  2. pmc Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
    Kelly A Holmes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom
    Proc Natl Acad Sci U S A 109:2748-53. 2012
  3. pmc FOXA1 is a key determinant of estrogen receptor function and endocrine response
    Antoni Hurtado
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Nat Genet 43:27-33. 2011
  4. pmc Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nature 481:389-93. 2012
  5. doi request reprint Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor
    Hisham Mohammed
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cell Rep 3:342-9. 2013
  6. pmc A CTCF-independent role for cohesin in tissue-specific transcription
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genome Res 20:578-88. 2010
  7. pmc Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
    Jessica L L Robinson
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    EMBO J 30:3019-27. 2011
  8. pmc Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genes Dev 24:171-82. 2010
  9. pmc Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells
    Deborah A Sanders
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    Genome Biol 14:R6. 2013

Collaborators

Detail Information

Publications9

  1. pmc A co-ordinated interaction between CTCF and ER in breast cancer cells
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB20RE, UK
    BMC Genomics 12:593. 2011
    ..Recent research has shown a role for CTCF in estrogen receptor (ER) biology, at some individual loci, but a multi-context global analysis of CTCF binding and transcription activity is lacking...
  2. pmc Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
    Kelly A Holmes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom
    Proc Natl Acad Sci U S A 109:2748-53. 2012
    ..Furthermore, TLE1 is essential for effective ER-mediated cell division. We have discovered a distinct role for TLE1, as a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions...
  3. pmc FOXA1 is a key determinant of estrogen receptor function and endocrine response
    Antoni Hurtado
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Nat Genet 43:27-33. 2011
    ..Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells...
  4. pmc Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nature 481:389-93. 2012
    ..By establishing transcription-factor mapping in primary tumour material, we show that there is plasticity in ER-binding capacity, with distinct combinations of cis-regulatory elements linked with the different clinical outcomes...
  5. doi request reprint Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor
    Hisham Mohammed
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cell Rep 3:342-9. 2013
    ..These findings reveal an unexpected role for GREB1 as an estrogen-specific ER cofactor that is expressed in drug-sensitive contexts...
  6. pmc A CTCF-independent role for cohesin in tissue-specific transcription
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genome Res 20:578-88. 2010
    ....
  7. pmc Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
    Jessica L L Robinson
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    EMBO J 30:3019-27. 2011
    ..These findings show that AR binds and regulates ER cis-regulatory elements in molecular apocrine tumours, resulting in a transcriptional programme reminiscent of ER-mediated transcription in luminal breast cancers...
  8. pmc Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genes Dev 24:171-82. 2010
    ....
  9. pmc Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells
    Deborah A Sanders
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    Genome Biol 14:R6. 2013
    ..CONCLUSIONS: These findings reveal a novel role for FOXM1 in ERα transcriptional activity in breast cancer and uncover a FOXM1-regulated gene signature associated with ER-positive breast cancer patient prognosis...