Kerstin B Meyer
Affiliation: Cancer Research UK
- Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancerKerstin B Meyer
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
PLoS Biol 6:e108. 2008..We propose a model in which the Oct-1/Runx2 and C/EBPbeta binding sites in the disease-associated allele are able to lead to an increase in FGFR2 gene expression, thereby increasing the propensity for tumour formation...
- RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associationsMauro A A Castro
Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
Genome Biol 13:R29. 2012..Our results demonstrate RedeR as a new framework to deal with the multiple network levels that are inherent to complex biological systems. RedeR is available from http://bioconductor.org/packages/release/bioc/html/RedeR.html...
- A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expressionKerstin B Meyer
Cancer Research UK Cambridge Research Institute, United Kingdom
PLoS Genet 7:e1002165. 2011..In conclusion, we identified a new functional prostate cancer risk variant at the 8q24 locus, rs378854 allele G, that reduces binding of the YY1 protein and is associated with increased expression of PVT1 located 0.5 Mb downstream...
- Genome-wide association study identifies novel breast cancer susceptibility lociDouglas F Easton
CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Nature 447:1087-93. 2007..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...