I A McNeish

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway
    I A McNeish
    Cancer Research UK Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, W12 ONN, London, UK
    Exp Cell Res 286:186-98. 2003
  2. ncbi Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis
    I A McNeish
    Cancer Research UK Molecular Oncology Unit, Barts and the London School of Medicine, London EC1M 6BQ, United Kingdom
    Exp Cell Res 302:69-82. 2005
  3. ncbi Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells
    I A McNeish
    ICRF Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cancer Gene Ther 8:308-19. 2001
  4. ncbi Gene transfer: Bax to the future for cancer therapy
    N R Lemoine
    Cancer Research UK Clinical Centre, Sir John Vane Science Building, Barts and the London School of Medicine and Dentistry, London, UK
    Gut 53:478-9. 2004
  5. ncbi Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer
    S K Baird
    Centre for Molecular Oncology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts and the London Queen Mary s School of Medicine, London, UK
    Oncogene 27:3081-90. 2008
  6. ncbi Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer
    C K Ingemarsdotter
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Oncogene 29:6051-63. 2010
  7. ncbi Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes
    I A McNeish
    Cancer Research UK, Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Gene Ther 11:497-503. 2004
  8. ncbi Progress and prospects: gene therapy clinical trials (part 2)
    Eric Alton
    Department of Gene Therapy, Emmanuel Kaye Building, NHLI, Imperial College, Manresa Road, London, UK
    Gene Ther 14:1555-63. 2007

Collaborators

Detail Information

Publications8

  1. ncbi Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway
    I A McNeish
    Cancer Research UK Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, W12 ONN, London, UK
    Exp Cell Res 286:186-98. 2003
    ..Ad CMV-Smac can combine with other proapoptotic factors, such as cisplatin, paclitaxel, and procaspase-3, to produce greater levels of apoptosis in transfected cells...
  2. ncbi Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis
    I A McNeish
    Cancer Research UK Molecular Oncology Unit, Barts and the London School of Medicine, London EC1M 6BQ, United Kingdom
    Exp Cell Res 302:69-82. 2005
    ..We believe that expression of Smac/DIABLO can stimulate the intrinsic pathway of apoptosis in ovarian carcinoma without damaging normal ovarian tissue and therefore has therapeutic potential...
  3. ncbi Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells
    I A McNeish
    ICRF Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cancer Gene Ther 8:308-19. 2001
    ..Our data suggest that co-expression of pro-caspase-3 may lead to a significant enhancement of the efficacy of tk/GCV therapy...
  4. ncbi Gene transfer: Bax to the future for cancer therapy
    N R Lemoine
    Cancer Research UK Clinical Centre, Sir John Vane Science Building, Barts and the London School of Medicine and Dentistry, London, UK
    Gut 53:478-9. 2004
  5. ncbi Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer
    S K Baird
    Centre for Molecular Oncology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts and the London Queen Mary s School of Medicine, London, UK
    Oncogene 27:3081-90. 2008
    ..6 does not modulate the mode or extent of cell death. Thus, E1A CR2-deleted oncolytic adenoviral cytotoxicity in ovarian cancer may define a novel mode of programmed cell death...
  6. ncbi Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer
    C K Ingemarsdotter
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Oncogene 29:6051-63. 2010
    ..In combination, dl922-947 and low-dose paclitaxel induces aberrant, multipolar mitoses, mitotic slippage and multinucleation, triggering an apoptotic cell death...
  7. ncbi Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes
    I A McNeish
    Cancer Research UK, Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Gene Ther 11:497-503. 2004
    ....
  8. ncbi Progress and prospects: gene therapy clinical trials (part 2)
    Eric Alton
    Department of Gene Therapy, Emmanuel Kaye Building, NHLI, Imperial College, Manresa Road, London, UK
    Gene Ther 14:1555-63. 2007
    ..This part includes clinical trials for skin diseases, neurological disorders, HIV/AIDS, ornithine transcarbamylase deficiency, alpha(1)-antitrypsin deficiency, haemophilia and cancer...