Ying Liu

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer
    Ying Liu
    Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    BMC Genet 3:20. 2002
  2. ncbi Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer
    Ying Liu
    ICRF Molecular Oncology Laboratories, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Oncogene 21:387-99. 2002
  3. pmc Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
    Ying Liu
    Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Proc Natl Acad Sci U S A 103:976-81. 2006
  4. pmc Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1
    Carol W M Chan
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 106:1936-41. 2009
  5. ncbi Tumour suppressor genes in sporadic epithelial ovarian cancer
    Ying Liu
    ICRF Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Reproduction 123:341-53. 2002
  6. doi Mutations in the AXIN1 gene in advanced prostate cancer
    George W Yardy
    Cancer Research UK, Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Eur Urol 56:486-94. 2009
  7. ncbi MUS81 promotes common fragile site expression
    Songmin Ying
    Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK
    Nat Cell Biol 15:1001-7. 2013
  8. pmc The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans
    Ying Liu
    Department of Biology, Syracuse University, 108 College Place, Syracuse, NY 13244, USA
    Genetics 176:2265-77. 2007
  9. ncbi Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1
    Evelyn Swain
    Department of Biochemistry, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 277:36152-60. 2002
  10. ncbi Improvement of the sensitivity and resolution of PCR-SSCP analysis with optimized primer concentrations in PCR products
    Xilin Zhu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, China
    J Genet 85:233-5. 2006

Collaborators

Detail Information

Publications65

  1. pmc The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer
    Ying Liu
    Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    BMC Genet 3:20. 2002
    ..To accelerate the identification of genes, we sequenced the entire contig of approximately 1.1 Mb. Seven genes were identified within the region of allele loss between D6S264 and D6S149...
  2. ncbi Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer
    Ying Liu
    ICRF Molecular Oncology Laboratories, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Oncogene 21:387-99. 2002
    ..Clonogenic assays were performed by transfecting the full-length gene in to ovarian cancer cell lines and no suppression of growth was observed...
  3. pmc Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
    Ying Liu
    Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Proc Natl Acad Sci U S A 103:976-81. 2006
    ....
  4. pmc Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1
    Carol W M Chan
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 106:1936-41. 2009
    ..This could, therefore, explain the relatively frequent down regulation of CDX1 in colorectal carcinomas by hypermethylation...
  5. ncbi Tumour suppressor genes in sporadic epithelial ovarian cancer
    Ying Liu
    ICRF Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Reproduction 123:341-53. 2002
    ..Further research is warranted to understand fully their contribution to the pathogenesis of sporadic ovarian cancer...
  6. doi Mutations in the AXIN1 gene in advanced prostate cancer
    George W Yardy
    Cancer Research UK, Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Eur Urol 56:486-94. 2009
    ..Such mutations are rare in hepatocellular carcinomas and medulloblastomas with Wnt pathway dysfunction, and there, mutation in genes for other Wnt molecules, such as Axin, is more frequently found...
  7. ncbi MUS81 promotes common fragile site expression
    Songmin Ying
    Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK
    Nat Cell Biol 15:1001-7. 2013
    ..Our findings challenge the prevailing view that CFS breakage is a nonspecific process that is detrimental to cells, and indicate that CFS cleavage actually promotes genome stability. ..
  8. pmc The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans
    Ying Liu
    Department of Biology, Syracuse University, 108 College Place, Syracuse, NY 13244, USA
    Genetics 176:2265-77. 2007
    ..We document a complex phenotypic interaction between ego-2 and alx-1, consistent with their relationship being antagonistic with respect to some developmental processes and agonistic with respect to others...
  9. ncbi Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1
    Evelyn Swain
    Department of Biochemistry, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 277:36152-60. 2002
    ..We hypothesize that in eukaryotic cells, Arv1p functions in the sphingolipid metabolic pathway perhaps as a transporter of ceramides between the endoplasmic reticulum and Golgi...
  10. ncbi Improvement of the sensitivity and resolution of PCR-SSCP analysis with optimized primer concentrations in PCR products
    Xilin Zhu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, China
    J Genet 85:233-5. 2006
  11. ncbi Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species
    Jian Liang Zhou
    Department of Pharmacognosy, China Pharmaceutical University, No 24, Tongjia Lane, Nanjing 210009, China
    J Chromatogr A 1177:126-37. 2008
    ..6-110.0% (average 98.5%) suggesting that it is feasible to quantify steroidal alkaloids by the proposed relative quantitative determination method within acceptable errors...
  12. ncbi Creation of engineered human embryonic stem cell lines using phiC31 integrase
    Bhaskar Thyagarajan
    Invitrogen Corporation, Carlsbad, California 92008, USA
    Stem Cells 26:119-26. 2008
    ..Our results demonstrate the utility of phiC31 integrase to target pseudo-attP sites in hESC and show that integrase-mediated site-specific integration can efficiently create stably expressing engineered human embryonic stem cell clones...
  13. ncbi Investigate the role of PTEN in chemotaxis of human breast cancer cells
    Wuzhou Wan
    Beijing National Laboratory for Molecular Sciences BNLMS, Department of Chemical Biology, and State Key Laboratory of Molecular Dynamic and Stable Structures, College of Chemistry, Peking University, Beijing, China
    Cell Signal 19:2227-36. 2007
    ..Taken together, our data show that PTEN plays a non-redundant role in EGF-induced chemotaxis of human breast cancer cells, and an optimal level of PTEN is required in these responses...
  14. ncbi KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages
    Junwen Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410008, People s Republic of China
    Biochem Biophys Res Commun 362:575-81. 2007
    ..The overexpression of KLF4 promoted the transcription and DNA binding activities of KLF4 to the IL-10 promoter. These results indicate that KLF4 plays an important role in regulating the expression of IL-10...
  15. ncbi Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus
    Jiang Yin
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    J Gen Virol 88:2259-67. 2007
    ..The possible biological implication of the interactions observed in the yeast two-hybrid system will be discussed...
  16. ncbi Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate
    Ying Liu
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    Cancer Res 67:2685-92. 2007
    ..Our results underscore the importance of H2AX as a human tumor suppressor protein, provide mechanistic insights into imatinib-induced tumor cell apoptosis and establish H2AX as a novel target in cancer therapy...
  17. ncbi The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cells
    Ying Liu
    Beijing National Laboratory for Molecular Sciences BNLMS and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
    Mol Membr Biol 24:91-101. 2007
    ..Taken together, our study indicated that integrity of lipid rafts was critical in EGF-induced chemotaxis of human breast cancer cells...
  18. ncbi Expression and antibody preparation of POU transcription factor qBrn-1
    Lei Lan
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Protein Pept Lett 14:7-11. 2007
    ....
  19. pmc Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery
    Ying Liu
    The Skaggs Institute for Chemical Biology and Departments of Chemistry and Immunology, Worm Institute of Research and Medicine, and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Pharm 4:435-47. 2007
    ....
  20. ncbi Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research
    Richard Josephson
    GlobalStem, Inc, 6 Taft Court, Rockville, Maryland 20850, USA
    Stem Cells 25:437-46. 2007
    ..On the basis of global gene and microRNA expression, 2102Ep is somewhat less similar to hESC than the alternatives; however, 2102Ep expresses more hESC-associated microRNAs than NTERA-2 does, and fewer markers of differentiated fates...
  21. pmc A large-scale proteomic analysis of human embryonic stem cells
    Thomas C Schulz
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA, USA
    BMC Genomics 8:478. 2007
    ..These analyses are only partly predictive of protein expression however, and do not shed light on post-translational regulation, leaving a large gap in our knowledge of the biology of pluripotent stem cells...
  22. ncbi Comparative pharmacokinetics and distribution kinetics in brain of phencynonate enantiomers in rats
    Yuying Kou
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Youanmen, Beijing, China
    Int J Pharm 353:88-94. 2008
    ..Therefore, stereoselective disposition of phencynonate isomers was not obviously observed in rat...
  23. doi A cryptographic approach to securely share and query genomic sequences
    Murat Kantarcioglu
    Department of Computer Science, University of Texas, Dallas, TX 75080 3021 USA
    IEEE Trans Inf Technol Biomed 12:606-17. 2008
    ..The framework can be implemented on top of existing information and network technologies in biomedical environments...
  24. ncbi Azithromycin quantitation in human plasma by high-performance liquid chromatography coupled to electrospray mass spectrometry: application to bioequivalence study
    Fengguo Xu
    Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University, Ministry of Education, Nanjing, 210009, PR China
    J Chromatogr Sci 46:479-84. 2008
    ..The limit of detection and quantitation are 2 ng/mL and 5 ng/mL, respectively. The proposed method enables the unambiguous identification and quantitation of azithromycin for pharmacokinetic, bioavailability, or bioequivalence studies...
  25. pmc Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells
    Ying Liu
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:947-56. 2008
    ..To optimize culture and transduction conditions, we compared various lengths of time for prestimulation before transduction, transduction duration, and posttransduction cell culture...
  26. ncbi An HPLC method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles
    Yinghao Mei
    Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    J Chromatogr B Analyt Technol Biomed Life Sci 869:138-41. 2008
    ....
  27. pmc Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila hox protein ultrabithorax
    Ying Liu
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
    J Biol Chem 283:20874-87. 2008
    ..The amino acid sequences of I2 and much of the I1 and R regions vary significantly among Ultrabithorax orthologues, potentially diversifying Hox-DNA interactions...
  28. doi Bioequivalence assessment of two formulations of spironolactone in Chinese healthy male volunteers
    Feng Guo Xu
    Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, PR China
    Arzneimittelforschung 58:117-21. 2008
    ..This study shows that the test formulation is bioequivalent to the reference formulation for spironolactone and its main active metabolite canrenone...
  29. doi Quantitative determination of nitrendipine in human plasma using high-performance liquid chromatography-mass spectrometry
    Ying Liu
    Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University, Ministry of Education, Nanjing, PR China
    Arzneimittelforschung 58:111-6. 2008
    ..This validated method was successfully applied to the evaluation of the pharmacokinetic profiles of nitrendipine tablets administered to 8 Chinese healthy volunteers...
  30. pmc Analysis of correlated mutations in HIV-1 protease using spectral clustering
    Ying Liu
    Department of Computational Biology, School of Medicine, University of Pittsburgh, PA 15232, USA
    Bioinformatics 24:1243-50. 2008
    ..Resistance is usually imparted by a cooperative mechanism that can be elucidated by a covariance analysis of sequence data. Identification of such correlated substitutions of amino acids may be obscured by evolutionary noise...
  31. pmc Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription
    Ying Liu
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Endocrinology 149:3512-20. 2008
    ..In addition, the data indicate that phosphorylated CREB is essential but not sufficient for activation of CRH transcription, suggesting that full promoter stimulation requires the interaction of phosphorylated CREB with a coactivator...
  32. doi Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction
    Fengguo Xu
    Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University, Ministry of Education, Nanjing 210009, China
    J Pharm Biomed Anal 47:586-95. 2008
    ....
  33. pmc The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover
    Guangzuo Luo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 283:10433-44. 2008
    ..Eisosomes then control endocytosis to align the composition and function of the plasma membrane to match demand...
  34. doi Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
    Ping Zhang
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
    Int J Pharm 355:269-76. 2008
    ..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
  35. ncbi Development of a microscopy-based assay for protein kinase Czeta activation in human breast cancer cells
    Caijie Zhao
    Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology and State Key Laboratory of Molecular Dynamic and Stable Structures, College of Chemistry, Peking University, Beijing 100871, China
    Anal Biochem 362:8-15. 2007
    ..This assay can be used in screening for inhibitors of PKCzeta activation, which is critically required for cancer cell chemotaxis...
  36. ncbi Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells
    De Sheng Xiao
    Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 38:883-92. 2006
    ..DPC4 may inhibit the proliferation of colon cancer cell by restraining growth and inducing apoptosis, and the invasion and metastasis of colorectal carcinoma cells. MMP-9 may be one of the downstream target genes regulated by DPC4...
  37. ncbi Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions
    Shr Jeng Leu
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 60607 7170, USA
    J Biol Chem 279:44177-87. 2004
    ....
  38. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
    ..To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival...
  39. ncbi Recursion equations in predicting band width under gradient elution
    Heng Liang
    The Key Laboratory of Biomedical Information Engineering of Education Ministry, Separation Science Institute, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    J Chromatogr A 1040:19-31. 2004
    ..Recursion equations and literature equations were used in dealing with same experimental data in RP-HPLC, and the comparison results show that the recursion equations can accurately predict band width under gradient elution...
  40. ncbi Ecotoxicological evaluation of 4-aminobiphenyl using a test battery
    Jiangning Chen
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, Nanjing University, Nanjing 210093, China
    Ecotoxicol Environ Saf 58:104-9. 2004
    ....
  41. ncbi Attenuation of zinc-induced neuronal death by the interaction of growth inhibitory factor with Rab3A in rat hippocampal neurons
    Ying Liu
    National Key Laboratory of Protein Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Neurosci Lett 358:149-52. 2004
    ..This result was supported by both Annexin -V FITC/propidium dual staining and chromosomal DNA analysis. These findings suggest that GIF may inhibit Zn(2+)-induced neuronal death via its interaction with Rab3A...
  42. pmc Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution
    Krishnamurthy Malathi
    Institute of Human Nutrition, Columbia University Medical Center, 630 W 168 St, New York, NY 10032, USA
    J Cell Biol 164:547-56. 2004
    ..We propose that the primordial function of these proteins is to recycle sphingolipids and that defects in this process in higher eukaryotes secondarily result in cholesterol accumulation...
  43. ncbi The effects of a growth-inhibiting tripeptide, acetylGlu-Ser-GlyNH2 (Ac-ESG), on gene expression and cell cycle progression of two lymphoma cell lines
    Ying Liu
    Institute of Pediatric Research, National Hospital, University of Oslo, N 0027 Oslo, Norway
    Anticancer Res 23:3159-65. 2003
    ..In this paper we describe the effects of Ac-ESG on growth-related gene expression and cell cycle progression in two lymphoma cell lines, Ramos and Molt, representing B and T lymphocytes, respectively...
  44. ncbi Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61)
    Shr Jeng Leu
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 278:33801-8. 2003
    ....
  45. ncbi [Study on mechanisms of human gastric carcinoma cells apoptosis induced by genistein]
    Danfeng Song
    Public Health School, Harbin Medical University, Harbin 150001, China
    Wei Sheng Yan Jiu 32:128-30. 2003
    ..These indicated that genistein could induce the apoptosis of gastric carcinoma cells. The inhibition of the expression of mutant p53 and enhance of the protein expression of Caspase-3 would be possible mechanism...
  46. ncbi Enhancement of antitumor effect of cisplatin against human ovarian carcinoma cells by mifepristone in vivo
    Ying Liu
    Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China
    Di Yi Jun Yi Da Xue Xue Bao 23:242-4. 2003
    ..To investigate in vivo the enhancement by mifepristone (RU486) of the antitumor effect of cisplatin (DDP) on human ovarian carcinoma...
  47. ncbi [Effect of isoflavone on human breast cancer cell line MCF-7 and its probable mechanism]
    Qingwei Fang
    Department of Public Health, Harbin Medical University, Harbin 150001, China
    Wei Sheng Yan Jiu 31:367-9. 2002
    ..Western Blotting showed that isoflavone increased iNOS protein expression. These results suggested that isoflavone significantly inhibited the MCF-7 growth and induced cell apoptosis by regulating iNOS gene expression...
  48. ncbi [Inhibitory effects of genistein on the synthesis of DNA and the protein expression of cyclin D1 in human gastric carcinoma cell-line]
    Danfeng Song
    Public Health School, Harbin Medical University, Harbin 150001, China
    Wei Sheng Yan Jiu 31:106-8. 2002
    ....
  49. ncbi Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues
    Wei Shuo Fang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China
    Bioorg Med Chem Lett 12:1543-6. 2002
    ..Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines...
  50. ncbi Effects of protein kinase C on M-phase promoting factor in early development of fertilized mouse eggs
    Bing Zhi Yu
    Department of Biochemistry, China Medical University, Shenyang, 110001, People s Republic of China
    Cell Biochem Funct 22:291-8. 2004
    ..These results clearly indicate that PKC may affect the progression of the cell cycle through post-translational modification of MPF activity...
  51. ncbi The acidic C-terminal domain stabilizes the chaperone function of protein disulfide isomerase
    Rui Tian
    Laboratory of Visual Information Processing, Chinese Academy of Sciences, Beijing, China
    J Biol Chem 279:48830-5. 2004
    ..This suggests that domain c is required for the stabilization and maintenance of the chaperone function of PDI under extreme conditions...
  52. pmc The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A
    Haekyung Lee
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    J Virol 80:11343-54. 2006
    ..This suggests that specific interactions between the NS5B hydrophobic domain and other membrane-bound factors may not play a decisive role in HCV replication...
  53. ncbi Determination of thiencynonate by liquid chromatographic-mass spectrometry and its application to pharmacokinetics in rats
    Yanxia Xu
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100069, PR China
    J Pharm Biomed Anal 42:149-54. 2006
    ..47 to 9.28% in rat plasma. Extraction recoveries were in the range of 67.63-76.76% in plasma. This method was successfully applied to the identification and quantification of thiencynonate in pharmacokinetic studies...
  54. ncbi Massively parallel signature sequencing profiling of fetal human neural precursor cells
    Jingli Cai
    Stem Cell Biology Unit Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Stem Cells Dev 15:232-44. 2006
    ..In addition, our results allow us to identify novel genes expressed in fNPCs and provide a detailed profile of fNPCs...
  55. ncbi Expression of qBrn-1, a new member of the POU gene family, in the early developing nervous system and embryonic kidney
    Lei Lan
    The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Dev Dyn 235:1107-14. 2006
    ..The distinct dynamic expression patterns of qBrn-1 and qBrn-2 indicate multiple roles of the class III POU genes in quail neurogenesis and organogenesis...
  56. pmc Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania School of Medicine, 816 Biomedical Research Building II III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 26:831-42. 2006
    ....
  57. ncbi Serum proteomic pattern analysis for early cancer detection
    Ying Liu
    Laboratory for Bioinformatics and Medical Informatics, Department of Computer Science, Erik Jonsson School of Engineering and Computer Science, University of Texas at Dallas, Richardson, 75083, USA
    Technol Cancer Res Treat 5:61-6. 2006
    ..82. When redial kernel was applied to either of the two data sets, all the samples were predicted as cancer samples, with a sensitivity of 1 and a specificity of 0. Furthermore, feature selection did not improve SVM performance...
  58. ncbi [Identification of drought tolerant germplasm and inheritance and QTL mapping of related root traits in soybean (Glycine max (L.) Merr.)]
    Ying Liu
    National Center for Soybean Improvement, National Key Laboratory for Crop Genetics and Germplasm Enhancement, Soybean Research Institute of Nanjing Agricultural University, Nanjing 210095, China
    Yi Chuan Xue Bao 32:855-63. 2005
    ..The results of segregation analysis and QTL mapping appeared pretty consistent with each other, which could be used as a demonstration of each other...
  59. ncbi Genetic variant characterization in intron 4 of the surfactant protein B gene
    Aaron Hamvas
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Hum Mutat 26:494-5. 2005
    ..7, 95% CI 1.0-7.2). Reliable characterization of genetic variants in intron 4 requires both a high fidelity polymerase and sequencing of variant alleles...
  60. ncbi Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE
    Ying Liu
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 280:38976-81. 2005
    ..Expression of PKCbetaII/T500V was found not to affect the antigen-induced responses. These results suggest that PKCbetaII plays a critical role in monomeric IgE responses, but not in antigen responses...
  61. pmc Saturated fat-rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall
    Toru Seo
    Department of Pediatrics, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 115:2214-22. 2005
    ..These studies suggest that arterial LDL-CE delivery via SU can be an important mechanism in vivo and that dietary influences on arterial LPL levels and atherogenesis modulate arterial LDL-CE delivery, cholesterol deposition, and SU...
  62. ncbi Establishment of a new embryonic stem cell line derived from C57BL/6 mouse expressing EGFP ubiquitously
    Rie Shimizukawa
    Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Genesis 42:47-52. 2005
    ..The B6G-2 cell line is freely available from the BioResource Center, RIKEN Tsukuba Institute (http://www.brc.riken.jp/lab/cell/english/)...
  63. ncbi [Chiral separation of beta-receptor blockers and analogs on novel norvancomycin-bonded chiral stationary phase]
    Guosheng Ding
    Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116012, China
    Se Pu 22:386-9. 2004
    ....
  64. ncbi Active learning with support vector machine applied to gene expression data for cancer classification
    Ying Liu
    Georgia Institute of Technology, College of Computing, Atlanta, Georgia 30322, USA
    J Chem Inf Comput Sci 44:1936-41. 2004
    ..In active learning the areas under the receiver operating characteristic (ROC) curves were over 0.81, while in passive learning the areas under the ROC curves were below 0.50...
  65. ncbi HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110
    Ying Liu
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:23854-63. 2002
    ..Taken together, these data demonstrate that Tip110 regulates Tat transactivation activity through direct interaction, and suggest that Tip110 is an important cellular factor for HIV-1 gene expression and viral replication...