Tomas Lindahl

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
    Sarah C Trewick
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 419:174-8. 2002
  2. ncbi request reprint Molecular biology: ensuring error-free DNA repair
    Tomas Lindahl
    Nature 427:598. 2004
  3. ncbi request reprint Inroads into base excision repair I. The discovery of apurinic/apyrimidinic (AP) endonuclease. "An endonuclease for depurinated DNA in Escherichia coli B," Canadian Journal of Biochemistry, 1972
    Tomas Lindahl
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    DNA Repair (Amst) 3:1522-30; discussion 1521. 2004
  4. ncbi request reprint Dale Mosbaugh
    Tomas Lindahl
    DNA Repair (Amst) 4:1346. 2005
  5. doi request reprint My journey to DNA repair
    Tomas Lindahl
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, United Kingdom
    Genomics Proteomics Bioinformatics 11:2-7. 2013
  6. doi request reprint Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease
    Tomas Lindahl
    Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Herts, UK
    Biochem Soc Trans 37:535-8. 2009
  7. ncbi request reprint Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    Yun gui Yang
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Cell 131:873-86. 2007
  8. ncbi request reprint Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases
    Pertti Koivisto
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    J Biol Chem 279:40470-4. 2004
  9. ncbi request reprint Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    Deborah E Barnes
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Annu Rev Genet 38:445-76. 2004
  10. ncbi request reprint Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase
    Pertti Koivisto
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    J Biol Chem 278:44348-54. 2003

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
    Sarah C Trewick
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 419:174-8. 2002
    ..The AlkB enzyme couples oxidative decarboxylation of alpha-ketoglutarate to the hydroxylation of these methylated bases in DNA, resulting in direct reversion to the unmodified base and the release of formaldehyde...
  2. ncbi request reprint Molecular biology: ensuring error-free DNA repair
    Tomas Lindahl
    Nature 427:598. 2004
  3. ncbi request reprint Inroads into base excision repair I. The discovery of apurinic/apyrimidinic (AP) endonuclease. "An endonuclease for depurinated DNA in Escherichia coli B," Canadian Journal of Biochemistry, 1972
    Tomas Lindahl
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    DNA Repair (Amst) 3:1522-30; discussion 1521. 2004
    ..A key component of this DNA repair function was shown by Verly and co-workers to be an endonuclease acting at secondary lesions, apurinic sites, rather than directly at alkylated nucleotide residues...
  4. ncbi request reprint Dale Mosbaugh
    Tomas Lindahl
    DNA Repair (Amst) 4:1346. 2005
  5. doi request reprint My journey to DNA repair
    Tomas Lindahl
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, United Kingdom
    Genomics Proteomics Bioinformatics 11:2-7. 2013
    ..A further novel process of DNA repair discovered by my research group is the action of AlkB as an iron-dependent enzyme carrying out oxidative demethylation...
  6. doi request reprint Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease
    Tomas Lindahl
    Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Herts, UK
    Biochem Soc Trans 37:535-8. 2009
    ....
  7. ncbi request reprint Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    Yun gui Yang
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Cell 131:873-86. 2007
    ..Our data indicate that Trex1 acts on a single-stranded DNA polynucleotide species generated from processing of aberrant replication intermediates to attenuate DNA damage checkpoint signaling and prevent pathological immune activation...
  8. ncbi request reprint Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases
    Pertti Koivisto
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    J Biol Chem 279:40470-4. 2004
    ..Our data suggest that 3-methylthymine residues in DNA will be repaired inefficiently in vivo and therefore may occur at a low steady-state level, but the residues should not gradually accumulate to high levels in long lived cells...
  9. ncbi request reprint Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    Deborah E Barnes
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Annu Rev Genet 38:445-76. 2004
    ..The genetic instability characteristic of cancer cells may be due, in part, to mutations in genes whose products normally function to ensure DNA integrity...
  10. ncbi request reprint Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase
    Pertti Koivisto
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    J Biol Chem 278:44348-54. 2003
    ..AlkB is known to repair methyl and ethyl adducts in DNA; to extend this substrate range, AlkB was shown to reduce the toxic effects of DNA damaging agents that generate hydroxyethyl, propyl, and hydroxypropyl adducts...
  11. ncbi request reprint Direct removal of alkylation damage from DNA by AlkB and related DNA dioxygenases
    Barbara Sedgwick
    London Research Institute, Cancer Research United Kingdom, Clare Hall Laboratories, South Mimms, Hertfordshire
    Methods Enzymol 408:108-20. 2006
    ..Functionality in vivo is examined by complementation of the low survival of alkylated single-stranded DNA bacteriophage in an E. coli alkB mutant...
  12. pmc Reversal of DNA alkylation damage by two human dioxygenases
    Tod Duncan
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Proc Natl Acad Sci U S A 99:16660-5. 2002
    ..AlkB, ABH2, and ABH3 can also repair 1-ethyladenine residues in DNA with the release of acetaldehyde...
  13. pmc Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
    Masashi Morita
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Mol Cell Biol 24:6719-27. 2004
    ..Unexpectedly, Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure...
  14. ncbi request reprint Repair of alkylated DNA: recent advances
    Barbara Sedgwick
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    DNA Repair (Amst) 6:429-42. 2007
    ..We provide a more detailed description of the structures and biochemical properties of the recently discovered DNA dioxygenases...
  15. ncbi request reprint Recent progress on the Ada response for inducible repair of DNA alkylation damage
    Barbara Sedgwick
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Oncogene 21:8886-94. 2002
  16. ncbi request reprint 5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity
    Qian An
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, UK
    Cancer Res 67:940-5. 2007
    ..The data provides a clearer understanding of the action of FU, suggesting predictive biomarkers of drug response and a mechanism for acquired resistance in tumors...
  17. pmc C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases
    Qian An
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK
    EMBO J 24:2205-13. 2005
    ..Such cells are also hypersensitive to ionizing radiation, and reveal a role of Smug1 in the repair of lesions generated by oxidation of cytosine...
  18. ncbi request reprint Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase
    Johanna Paik
    Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Hertfordshire, United Kingdom
    Cancer Res 65:10472-7. 2005
    ..Our data support the hypothesis that ablation of AAG activity in human tumor cells may provide a useful strategy to enhance the efficacy of current chemotherapeutic regimens that include alkylating agents...
  19. ncbi request reprint Down-regulation of DNA repair synthesis at DNA single-strand interruptions in poly(ADP-ribose) polymerase-1 deficient murine cell extracts
    Russell J Sanderson
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    DNA Repair (Amst) 1:547-58. 2002
    ..Decreased DNA repair synthesis observed in PARP-1 deficient cell extracts is associated with reduced cellular expression of several factors required for long-patch base excision repair (BER), including FEN-1 and DNA ligase I...
  20. pmc DNA base excision repair of uracil residues in reconstituted nucleosome core particles
    Hilde Nilsen
    Mutagenesis and Chromosome Dynamics Laboratories, Clare Hall Laboratories, Cancer Research UK
    EMBO J 21:5943-52. 2002
    ..Thus, base excision repair can proceed in nucleosome core particles in vitro, but the repair efficiency is limited by the reduced activity of the uracil-DNA glycosylases and DNA polymerase beta on nucleosome cores...
  21. ncbi request reprint Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice
    Hilde Nilsen
    Clare Hall Laboratories, CR UK London Research Institute, South Mimms, Hertfordshire EN6 3LD, UK
    Oncogene 24:3063-6. 2005
    ..Other B-cell lymphomas from Ung(-/-) mice exhibited a modest increase in mutation frequency...
  22. ncbi request reprint Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
    Hilde Nilsen
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Oncogene 22:5381-6. 2003
    ..Furthermore, they support a specific role for Ung in the immune system, with lymphomagenesis being related to perturbed processing of antibody genes in germinal centre B cells...
  23. pmc Celebrating 40 years of biochemistry in Europe
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genome Biol 5:344. 2004
  24. ncbi request reprint Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    Cristina Rada
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Curr Biol 12:1748-55. 2002
    ..A major resolution mode involves excising the uracil, an activity that at least four different enzymes can accomplish in the mouse...
  25. ncbi request reprint Inroads into base excision repair II. The discovery of DNA glycosylases. "An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues," Proc. Nat. Acad. Sci. USA, 1974
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    DNA Repair (Amst) 3:1532-6; discussion 1531-2. 2004
    ..The discovery of a DNA glycosylase that specifically removes uracil from DNA, opened the door for uncovering a large class of such enzymes that are fundamental to the process of base excision repair of DNA...
  26. ncbi request reprint Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors
    Yali Xie
    Department of Microbiology, Immunology, and Molecular Genetics and The Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
    Cancer Res 64:3096-102. 2004
    ..The mice described here provide a valuable model for studying the mechanisms of oxidative DNA damage in tumorigenesis and investigating preventive or therapeutic approaches...
  27. ncbi request reprint Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases
    Maria Teresa Russo
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Rome, Italy
    Cancer Res 64:4411-4. 2004
    ..Because there is an increased incidence of lung and small intestine cancer in Myh(-/-)/Ogg1(-/-) mice, these findings support a causal role for unrepaired oxidized DNA bases in cancer development...
  28. ncbi request reprint DNA repair: from molecular mechanism to human disease
    Errol C Friedberg
    Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA
    DNA Repair (Amst) 5:986-96. 2006
  29. ncbi request reprint Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase
    David B Winter
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 170:5558-62. 2003
    ..These findings show that hypermutation is unaffected in the absence of Ogg1 activity and indicate that 8-hydroxyguanine lesions most likely do not cause V gene mutations...
  30. ncbi request reprint Human DNA repair genes, 2005
    Richard D Wood
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion, Suite 2 6, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Mutat Res 577:275-83. 2005
    ..This article discusses the approximately 25 genes added, since the original version of the table was first produced in 2001, and some other revisions...
  31. pmc The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
    ..Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid methylation status is linked to increased fat mass...
  32. ncbi request reprint Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus
    Yanick J Crow
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Nat Genet 38:917-20. 2006
    ..Our findings suggest an unanticipated role for TREX1 in processing or clearing anomalous DNA structures, failure of which results in the triggering of an abnormal innate immune response...