Timothy J Key

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint EPIC-Oxford: lifestyle characteristics and nutrient intakes in a cohort of 33 883 meat-eaters and 31 546 non meat-eaters in the UK
    Gwyneth K Davey
    Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Public Health Nutr 6:259-69. 2003
  2. ncbi request reprint Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Timothy J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 109:119-24. 2004
  3. ncbi request reprint Nutrition and breast cancer
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, UK
    Breast 12:412-6. 2003
  4. ncbi request reprint Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
  5. doi request reprint Endogenous oestrogens and breast cancer risk in premenopausal and postmenopausal women
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX37LF, UK
    Steroids 76:812-5. 2011
  6. ncbi request reprint Diet, nutrition and the prevention of cancer
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK
    Public Health Nutr 7:187-200. 2004
  7. ncbi request reprint The effect of diet on risk of cancer
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:861-8. 2002
  8. pmc Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Ruth C Travis
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Am J Epidemiol 169:1223-32. 2009
  9. doi request reprint The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition
    Francesca L Crowe
    Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK
    Cancer Epidemiol Biomarkers Prev 18:1333-40. 2009
  10. doi request reprint Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Reiko Suzuki
    Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Cancer Causes Control 20:811-21. 2009

Detail Information

Publications95

  1. ncbi request reprint EPIC-Oxford: lifestyle characteristics and nutrient intakes in a cohort of 33 883 meat-eaters and 31 546 non meat-eaters in the UK
    Gwyneth K Davey
    Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Public Health Nutr 6:259-69. 2003
    ..To describe the lifestyle characteristics and nutrient intakes of the Oxford cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  2. ncbi request reprint Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Timothy J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 109:119-24. 2004
    ..79-1.26) for total fruits and vegetables combined; intake of cruciferous vegetables was not associated with risk. These results suggest that total consumption of fruits and vegetables is not associated with the risk for prostate cancer...
  3. ncbi request reprint Nutrition and breast cancer
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, UK
    Breast 12:412-6. 2003
    ..Nutrition might affect breast cancer risk by altering levels of growth factors such as insulin-like growth factor-I. Current dietary advice should be to avoid obesity, limit alcohol intake, and maintain a varied diet...
  4. ncbi request reprint Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
    ..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations...
  5. doi request reprint Endogenous oestrogens and breast cancer risk in premenopausal and postmenopausal women
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX37LF, UK
    Steroids 76:812-5. 2011
    ..Further data are required, with better assays and repeat measures, to provide more accurate estimates of risk and to clarify the role of oestrogens in premenopausal women and the roles of other endogenous hormones...
  6. ncbi request reprint Diet, nutrition and the prevention of cancer
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK
    Public Health Nutr 7:187-200. 2004
    ..To assess the epidemiological evidence on diet and cancer and make public health recommendations...
  7. ncbi request reprint The effect of diet on risk of cancer
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:861-8. 2002
    ..Prudent advice is to eat a varied diet including plenty of fruit, vegetables, and cereals to maintain a healthy bodyweight with the help of regular physical activity and to restrict consumption of alcohol...
  8. pmc Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Ruth C Travis
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Am J Epidemiol 169:1223-32. 2009
    ..In summary, the results of this large nested case-control study provide no evidence in support of a protective effect of circulating concentrations of vitamin D on the risk of prostate cancer...
  9. doi request reprint The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition
    Francesca L Crowe
    Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK
    Cancer Epidemiol Biomarkers Prev 18:1333-40. 2009
    ....
  10. doi request reprint Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Reiko Suzuki
    Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Cancer Causes Control 20:811-21. 2009
    ..To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men...
  11. ncbi request reprint Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition
    Francesca L Crowe
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 88:1353-63. 2008
    ..Plausible biological mechanisms underlie possible associations between fatty acids in blood and risk of prostate cancer; epidemiologic evidence for an association, however, is inconsistent...
  12. ncbi request reprint Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
    Francesca L Crowe
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:1405-13. 2008
    ..However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear...
  13. doi request reprint Prospective study of the association between grapefruit intake and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Elizabeth A Spencer
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Cancer Causes Control 20:803-9. 2009
    ..05). There was no association between grapefruit intake and estradiol or estrone among postmenopausal women. In this study, we found no evidence of an association between grapefruit intake and risk of breast cancer...
  14. doi request reprint Dietary fat and breast cancer: comparison of results from food diaries and food-frequency questionnaires in the UK Dietary Cohort Consortium
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 94:1043-52. 2011
    ..Epidemiologic studies of dietary fat and breast cancer risk are inconsistent, and it has been suggested that a true relation may have been obscured by the imprecise measurement of fat intake...
  15. doi request reprint Mortality in British vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 89:1613S-1619S. 2009
    ..Few prospective studies have examined the mortality of vegetarians...
  16. doi request reprint A prospective analysis of the association between dietary fiber intake and prostate cancer risk in EPIC
    Reiko Suzuki
    Nuffield Department of Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 124:245-9. 2009
    ..Our results suggest that dietary fiber intake is not associated with prostate cancer risk...
  17. doi request reprint Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
    Naomi E Allen
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 132:635-44. 2013
    ..These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed...
  18. doi request reprint Risk of hospitalization or death from ischemic heart disease among British vegetarians and nonvegetarians: results from the EPIC-Oxford cohort study
    Francesca L Crowe
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Am J Clin Nutr 97:597-603. 2013
    ..Few previous prospective studies have examined differences in incident ischemic heart disease (IHD) risk between vegetarians and nonvegetarians...
  19. ncbi request reprint Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:672-81. 2007
    ..Previous studies suggest that high plasma concentrations of carotenoids, retinol, or tocopherols may reduce the risk of prostate cancer...
  20. doi request reprint Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition
    Konstantinos K Tsilidis
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Int J Cancer 128:1881-9. 2011
    ..Our results show no significant association of estrogen-only or estrogen plus progestin therapy with colorectal cancer risk...
  21. ncbi request reprint Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
    Naomi E Allen
    Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Cancer Causes Control 14:65-74. 2003
    ....
  22. doi request reprint Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Naomi E Allen
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 88:1567-75. 2008
    ..Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer...
  23. doi request reprint Association between endogenous plasma hormone concentrations and fracture risk in men and women: the EPIC-Oxford prospective cohort study
    Andrew W Roddam
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK
    J Bone Miner Metab 27:485-93. 2009
    ....
  24. pmc Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
    Konstantinos K Tsilidis
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Int J Cancer 133:495-504. 2013
    ..001); SSTR5-rs197057 (uncorrected p for interaction, 0.002)]. We found no strong evidence that the associations between 16 IGF pathway SNPs and prostate cancer differed by intakes of dietary protein...
  25. pmc Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Naomi E Allen
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK
    Endocr Relat Cancer 15:485-97. 2008
    ..In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women...
  26. doi request reprint Vitamins, minerals, essential fatty acids and colorectal cancer risk in the United Kingdom Dietary Cohort Consortium
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Int J Cancer 131:E320-5. 2012
    ..There were no statistically significant associations between colorectal cancer risk and dietary intake of any of the vitamins, minerals or essential fatty acids examined...
  27. doi request reprint Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition
    Konstantinos K Tsilidis
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK
    Cancer Causes Control 22:1075-84. 2011
    ..19; 95% CI, 1.06-4.50), but was based on small numbers. In conclusion, women who currently use HT have a moderate increased risk of ovarian cancer, and which may be stronger for estrogen-only than estrogen plus progestin preparations...
  28. doi request reprint Menopausal hormone therapy and risk of endometrial carcinoma among postmenopausal women in the European Prospective Investigation Into Cancer and Nutrition
    Naomi E Allen
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, Medical Sciences Division, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
    Am J Epidemiol 172:1394-403. 2010
    ..The increased risk associated with tibolone use requires further investigation...
  29. doi request reprint Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: results from the EPIC-Oxford study
    Francesca L Crowe
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK
    Public Health Nutr 14:340-6. 2011
    ..The objective was to investigate differences in vitamin D intake and plasma concentrations of 25(OH)D among meat eaters, fish eaters, vegetarians and vegans...
  30. ncbi request reprint Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition
    Ruth C Travis
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 121:1331-8. 2007
    ....
  31. ncbi request reprint Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition
    Naomi E Allen
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford OX3 7LF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1121-7. 2007
    ..Some studies suggest that elevated serum insulin-like growth factor (IGF)-I concentrations are associated with an increased risk of prostate cancer and, in particular, with an increased risk of advanced-stage prostate cancer...
  32. pmc Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC
    Ruth C Travis
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Cancer Causes Control 23:1163-71. 2012
    ..We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition...
  33. doi request reprint Plasma phytanic acid concentration and risk of prostate cancer: results from the European Prospective Investigation into Cancer and Nutrition
    Alison J Price
    Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Am J Clin Nutr 91:1769-76. 2010
    ..Phytanic acid, a fatty acid predominantly obtained from foods high in ruminant fat, may have a biological role in the up-regulation of the protein alpha-methylacyl-coenzyme A racemase, which is overexpressed in prostate cancer tissue...
  34. pmc Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study
    Francesca L Crowe
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Eur Heart J 32:1235-43. 2011
    ..The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study...
  35. doi request reprint A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Francesca L Crowe
    Nuffield Department of Clinical Medicine, University of Oxford, UK
    Ann Hum Biol 38:194-202. 2011
    ..Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk...
  36. ncbi request reprint Nutrition and lifestyle in relation to bowel movement frequency: a cross-sectional study of 20630 men and women in EPIC-Oxford
    Miguel A Sanjoaquin
    Cancer Research UK, Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, Oxford OX2 6HE, UK
    Public Health Nutr 7:77-83. 2004
    ..To investigate the relationships between nutritional and lifestyle factors and bowel movement frequency...
  37. doi request reprint Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 89:1620S-1626S. 2009
    ..Few prospective studies have examined cancer incidence among vegetarians...
  38. ncbi request reprint Mortality in British vegetarians: review and preliminary results from EPIC-Oxford
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, United Kingdom
    Am J Clin Nutr 78:533S-538S. 2003
    ..Three prospective studies have examined the mortality of vegetarians in Britain...
  39. pmc Serum uric acid concentrations in meat eaters, fish eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort
    Julie A Schmidt
    Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e56339. 2013
    ..The aim of this study was to investigate differences in serum uric acid concentrations between meat eaters, fish eaters, vegetarians and vegans...
  40. doi request reprint Development and evaluation of the Oxford WebQ, a low-cost, web-based method for assessment of previous 24 h dietary intakes in large-scale prospective studies
    Bette Liu
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK
    Public Health Nutr 14:1998-2005. 2011
    ....
  41. ncbi request reprint Hypertension and blood pressure among meat eaters, fish eaters, vegetarians and vegans in EPIC-Oxford
    Paul N Appleby
    Cancer Research UK, Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
    Public Health Nutr 5:645-54. 2002
    ....
  42. ncbi request reprint Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men
    Naomi E Allen
    Cancer Research UK Epidemiology Unit, University of Oxford, UK
    Cancer Causes Control 13:353-63. 2002
    ..To investigate the lifestyle and nutritional determinants of serum bioavailable androgens and their related hormones in men...
  43. ncbi request reprint A prospective study of vegetarianism and isoflavone intake in relation to breast cancer risk in British women
    Ruth C Travis
    Cancer Research UK, Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, United Kingdom
    Int J Cancer 122:705-10. 2008
    ..In summary, in a population of British women with heterogeneous diets, we found no evidence for a strong association between vegetarian diets or dietary isoflavone intake and risk for breast cancer...
  44. doi request reprint Diet, vegetarianism, and cataract risk
    Paul N Appleby
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 93:1128-35. 2011
    ..Age-related cataract is a major cause of morbidity. Previous studies of diet and cataract risk have focused on specific nutrients or healthy eating indexes but not on identifiable dietary groups such as vegetarians...
  45. ncbi request reprint Soy intake and blood cholesterol concentrations: a cross-sectional study of 1033 pre- and postmenopausal women in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition
    Magdalena S Rosell
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 80:1391-6. 2004
    ..Clinical trials have suggested that the intake of soy protein reduces blood cholesterol. Few studies have explored this relation in subjects who consume soy as part of their regular diet...
  46. ncbi request reprint Association between two polymorphisms in the SRD5A2 gene and serum androgen concentrations in British men
    Naomi E Allen
    Cancer Research United Kingdom Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 12:578-81. 2003
    ..0003). Because of the rarity of this variant allele, larger studies are needed to additionally clarify the role of the A49T polymorphism in androgen metabolism...
  47. ncbi request reprint The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans
    Naomi E Allen
    Cancer Research United Kingdom Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:1441-8. 2002
    ..0001) and explained most of the differences in IGF-I concentration between the diet groups. These data suggest that a plant-based diet is associated with lower circulating levels of total IGF-I and higher levels of IGFBP-1 and IGFBP-2...
  48. pmc Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition
    Ruth C Travis
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Int J Cancer 132:1901-10. 2013
    ..CC homozygotes: 1.12, 0.96-1.32). These findings show that while variation in the lactase gene is associated with milk intake in men, the lactase polymorphism does not have a large effect on prostate cancer risk...
  49. ncbi request reprint Calcium, diet and fracture risk: a prospective study of 1898 incident fractures among 34 696 British women and men
    Timothy J Key
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK
    Public Health Nutr 10:1314-20. 2007
    ..The risk factors for fractures are incompletely understood. An outstanding question concerns the optimal amount of dietary calcium needed to minimise the risk of fracture...
  50. pmc Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians
    Francesca L Crowe
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK
    BMJ 343:d4131. 2011
    ..To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease...
  51. doi request reprint Physical activity and fracture risk: a prospective study of 1898 incident fractures among 34,696 British men and women
    Paul N Appleby
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, OX3 7LF, UK
    J Bone Miner Metab 26:191-8. 2008
    ..The markedly increased risk of fractures associated with bicycling, and the moderately increased risk associated with other exercise and sports, are probably the result of an increased incidence of injury...
  52. pmc Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies
    Andrew W Roddam
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
    Ann Intern Med 149:461-71, W83-8. 2008
    ..Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer...
  53. ncbi request reprint Reproducibility of a short semi-quantitative food group questionnaire and its performance in estimating nutrient intake compared with a 7-day diet diary in the Million Women Study
    Andrew W Roddam
    Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Public Health Nutr 8:201-13. 2005
    ..To assess the short- and long-term reproducibility of a short food group questionnaire, and to compare its performance for estimating nutrient intakes in comparison with a 7-day diet diary...
  54. doi request reprint Meat, poultry and fish and risk of colorectal cancer: pooled analysis of data from the UK dietary cohort consortium
    Elizabeth A Spencer
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Cancer Causes Control 21:1417-25. 2010
    ..In the UK Dietary Cohort Consortium, we examined associations of meat, poultry and fish intakes with colorectal cancer risk using standardised individual dietary data pooled from seven UK prospective studies...
  55. ncbi request reprint Health effects of vegetarian and vegan diets
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Richard Doll Building
    Proc Nutr Soc 65:35-41. 2006
    ..Overall, the data suggest that the health of Western vegetarians is good and similar to that of comparable non-vegetarians...
  56. ncbi request reprint No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women
    Ruth C Travis
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:2282-4. 2004
  57. pmc Pooling biomarker data from different studies of disease risk, with a focus on endogenous hormones
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, Oxford University, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:960-5. 2010
    ....
  58. doi request reprint Symposium 1: Overnutrition: consequences and solutions. Obesity and cancer risk
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK
    Proc Nutr Soc 69:86-90. 2010
    ..Estimates of the percentage of cancers that can be attributed to excess body weight suggest that in the UK and similar countries approximately 5% of all cancers are attributable to overweight and obesity...
  59. ncbi request reprint Melatonin and breast cancer: a prospective study
    Ruth C Travis
    Cancer Research UK, Epidemiology Unit, University of Oxford, Oxford, UK
    J Natl Cancer Inst 96:475-82. 2004
    ..To determine whether low levels of endogenous melatonin are associated with an increased risk for developing breast cancer, we conducted a prospective nested case-control study among British women...
  60. ncbi request reprint Validity of self-reported height and weight in 4808 EPIC-Oxford participants
    Elizabeth A Spencer
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
    Public Health Nutr 5:561-5. 2002
    ....
  61. ncbi request reprint Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men
    Magdalena S Rosell
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 82:327-34. 2005
    ..Plasma concentrations of long-chain n-3 polyunsaturated fatty acids are lower in vegetarians and in vegans than in omnivores. No data are available on whether these concentrations differ between long- and short-term vegetarians and vegans...
  62. ncbi request reprint A prospective study of diet and prostate cancer in Japanese men
    Naomi E Allen
    Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Cancer Causes Control 15:911-20. 2004
    ..This study aimed to examine the association between dietary intake and prostate cancer risk among 18,115 men in Hiroshima and Nagasaki, Japan, using prospective data from the Life Span Study...
  63. ncbi request reprint Association between plasma 25-hydroxyvitamin D levels and fracture risk: the EPIC-Oxford study
    Andrew W Roddam
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Epidemiol 166:1327-36. 2007
    ..15 (95% confidence interval: 0.82, 1.61) and 0.95 (95% confidence interval: 0.80, 1.13), respectively. These results were not affected by adjustment for potential confounders and were consistent across a number of subgroups...
  64. pmc Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to prostate cancer risk in the National Cancer Institute Breast and Prostate Cance
    Konstantinos K Tsilidis
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Am J Epidemiol 175:926-35. 2012
    ..005)). The authors found no strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of IGF-1, sex hormones, or their major binding proteins...
  65. ncbi request reprint Folate intake and colorectal cancer risk: a meta-analytical approach
    Miguel A Sanjoaquin
    Cancer Research U K, Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 113:825-8. 2005
    ..These results offer some support for the hypothesis that folate has a small protective effect against colorectal cancer but confounding by other dietary factors cannot be ruled out...
  66. ncbi request reprint Accuracy of self-reported waist and hip measurements in 4492 EPIC-Oxford participants
    Elizabeth A Spencer
    Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Public Health Nutr 7:723-7. 2004
    ..To assess the accuracy of self-reported waist and hip circumferences and the waist-to-hip ratio (WHR) by comparison with measured waist and hip circumferences and WHR in a sample of middle-aged men and women...
  67. ncbi request reprint Reproducibility over 5 years of measurements of 6-sulphatoxymelatonin in urine samples from postmenopausal women
    Ruth C Travis
    Cancer Research UK, Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 12:806-8. 2003
    ..39-0.73). The classification of aMT6S concentrations in first morning voids from postmenopausal women appears to be sufficiently reproducible to justify its use as a marker for long-term exposure to melatonin in epidemiological studies...
  68. pmc Oestrogen exposure and breast cancer risk
    Ruth C Travis
    Cancer Research UK, Epidemiology Unit, University of Oxford, Oxford, UK
    Breast Cancer Res 5:239-47. 2003
    ..Finally, we discuss how these advances might influence strategies for reducing the incidence of breast cancer...
  69. ncbi request reprint Mortality in British vegetarians
    Paul N Appleby
    Imperial Cancer Research Fund, Cancer Epidemiology Unit, The Radcliffe Infirmary, Oxford, UK
    Public Health Nutr 5:29-36. 2002
    ..To compare the mortality of British vegetarians and non-vegetarians...
  70. ncbi request reprint Serum insulin-like growth factor I (IGF-I) concentration in men is not associated with the cytosine-adenosine repeat polymorphism of the IGF-I gene
    Naomi E Allen
    Cancer Research United Kingdom Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:319-20. 2002
  71. ncbi request reprint Eating out of home and its correlates in 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Philippos Orfanos
    Department of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, Athens 11527, Greece
    Public Health Nutr 10:1515-25. 2007
    ....
  72. ncbi request reprint Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)
    Carlos A Gonzalez
    Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain
    J Natl Cancer Inst 98:345-54. 2006
    ..We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort...
  73. ncbi request reprint Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Carlos A Gonzalez
    Department of Epidemiology, Catalan Institute of Oncology, Barcelona ICO IDIBELL, Spain
    Int J Cancer 118:2559-66. 2006
    ..Our study supports a possible protective role of vegetable intake in the intestinal type of GC and the ACO. Citrus fruit consumption may have a role in the protection against cardia GC and ACO...
  74. ncbi request reprint Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nu
    Federico Canzian
    Hormones and Cancer Team, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:2316-25. 2005
    ....
  75. pmc Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition
    Teresa Norat
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69 372 Lyon cedex 08, France
    J Natl Cancer Inst 97:906-16. 2005
    ..Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing...
  76. ncbi request reprint Is the association with fiber from foods in colorectal cancer confounded by folate intake?
    Sheila A Bingham
    Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1552-6. 2005
    ..The association with fiber from different food sources was analyzed, but again, there were no significance trends after maximum adjustment...
  77. ncbi request reprint Consumption of vegetables and fruits and risk of breast cancer
    Carla H van Gils
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA 293:183-93. 2005
    ..Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption...
  78. ncbi request reprint Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Int J Cancer 111:762-71. 2004
    ..Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer...
  79. ncbi request reprint Amount of DNA in plasma and cancer risk: a prospective study
    Emmanuelle Gormally
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:746-9. 2004
    ..e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67)...
  80. ncbi request reprint Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
    Sheila A Bingham
    MRC Dunn Human Nutrition Unit, Cambridge, UK
    Lancet 361:1496-501. 2003
    ..Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect...
  81. ncbi request reprint The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:449-55. 2006
    ....
  82. ncbi request reprint Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study
    Paula Jakszyn
    Department of Epidemiology, Catalan Institute of Oncology, ICO IDIBELL Barcelona, Spain
    Carcinogenesis 27:1497-501. 2006
    ..09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk...
  83. ncbi request reprint Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort
    Karen Steindorf
    Unit of Environmental Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 119:2389-97. 2006
    ..It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors...
  84. ncbi request reprint Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC)
    Dagrun Engeset
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    Int J Cancer 119:175-82. 2006
    ..Although the period of follow-up is relatively short, the results provide no evidence for an association between fish intake and breast cancer risk...
  85. doi request reprint Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition study
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, 901 85 Umea, Sweden
    Cancer Epidemiol Biomarkers Prev 17:279-85. 2008
    ..The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B(12) in a large prospective cohort...
  86. doi request reprint Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies
    Andrew W Roddam
    J Natl Cancer Inst 100:170-83. 2008
    ..We performed a collaborative analysis of the existing worldwide epidemiologic data to examine these associations in a uniform manner and to provide more precise estimates of risks...
  87. ncbi request reprint The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition
    Stein Emil Vollset
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 16:2416-24. 2007
    ..However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer...
  88. ncbi request reprint Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  89. ncbi request reprint Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort
    Anne E Cust
    Nutrition and Hormones Unit, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 166:912-23. 2007
    ....
  90. ncbi request reprint Cereal fiber intake may reduce risk of gastric adenocarcinomas: the EPIC-EURGAST study
    Mendez M A
    Department of Epidemiology, Catalan Institute of Oncology, Barcelona ICO IDIBELL, Spain
    Int J Cancer 121:1618-23. 2007
    ..Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships...
  91. ncbi request reprint Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Jakob Linseisen
    Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Int J Cancer 121:1103-14. 2007
    ..In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers...
  92. ncbi request reprint Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Sabine Rohrmann
    Division of Clinical Epidemiology C020, German Cancer Research Centre, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
    Cancer Causes Control 18:537-49. 2007
    ..The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology...
  93. ncbi request reprint Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Gabriele Nagel
    Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Epidemiol 36:66-76. 2007
    ..To evaluate the association of socioeconomic position with adenocarcinoma of the oesophagus and stomach...
  94. doi request reprint Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition
    Sabine Rohrmann
    Division of Cancer Epidemiology C020, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1282-7. 2008
    ..No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men...
  95. ncbi request reprint The prevalence and features of the polycystic ovary syndrome in an unselected population
    Ricardo Azziz
    Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233, USA
    J Clin Endocrinol Metab 89:2745-9. 2004
    ..0 and 4.8%, respectively, not significantly different. These data from a large representative unselected population support the concept that PCOS is the most common endocrine abnormality of reproductive-aged women in the United States...