Tim Hunt

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint The discovery of cyclin (I)
    Tim Hunt
    Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom
    Cell 116:S63-4, 1 p following S65. 2004
  2. ncbi request reprint Riding tandem: circadian clocks and the cell cycle
    Tim Hunt
    Cell Cycle Control Laboratory, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Cell 129:461-4. 2007
  3. doi request reprint On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis
    Tim Hunt
    Clare Hall Laboratories, Cancer Research UK, South Mimms, Herts EN6 3LD, UK
    Adv Biol Regul 53:173-8. 2013
  4. ncbi request reprint You never know: Cdk inhibitors as anti-cancer drugs
    Tim Hunt
    Cancer Research UK, Clare Hall Laboratories, South Mimms, UK
    Cell Cycle 7:3789-90. 2008
  5. ncbi request reprint Unmasking the S-phase-promoting potential of cyclin B1
    Jonathan D Moore
    Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Science 300:987-90. 2003
  6. pmc Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
    Alessia Errico
    Clare Hall Laboratories, Cancer Research UK, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Proc Natl Acad Sci U S A 104:14929-34. 2007
  7. doi request reprint Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Science 330:1670-3. 2010
  8. ncbi request reprint Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts
    Hiroyuki Yamano
    Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 13:137-47. 2004
  9. ncbi request reprint Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2
    Hiroyuki Yamano
    Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 279:18974-80. 2004
  10. ncbi request reprint Calcineurin is required to release Xenopus egg extracts from meiotic M phase
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 449:336-40. 2007

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The discovery of cyclin (I)
    Tim Hunt
    Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom
    Cell 116:S63-4, 1 p following S65. 2004
  2. ncbi request reprint Riding tandem: circadian clocks and the cell cycle
    Tim Hunt
    Cell Cycle Control Laboratory, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Cell 129:461-4. 2007
    ..Yet, these two oscillatory systems seem to be fully independent of each other. Recent studies now reveal that some essential regulatory elements are common to both the cell cycle and circadian clock...
  3. doi request reprint On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis
    Tim Hunt
    Clare Hall Laboratories, Cancer Research UK, South Mimms, Herts EN6 3LD, UK
    Adv Biol Regul 53:173-8. 2013
    ..Failure to inhibit PP2A-B55 causes arrest of the cell cycle in G2 phase. I will discuss the role of this control mechanism in the control of mitosis...
  4. ncbi request reprint You never know: Cdk inhibitors as anti-cancer drugs
    Tim Hunt
    Cancer Research UK, Clare Hall Laboratories, South Mimms, UK
    Cell Cycle 7:3789-90. 2008
    ..You never know...
  5. ncbi request reprint Unmasking the S-phase-promoting potential of cyclin B1
    Jonathan D Moore
    Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Science 300:987-90. 2003
    ..Subcellular localization of vertebrate CDKs and the control of their activity are thus critical factors for determining their specificity...
  6. pmc Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
    Alessia Errico
    Clare Hall Laboratories, Cancer Research UK, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Proc Natl Acad Sci U S A 104:14929-34. 2007
    ..Tipin-depleted extracts also showed defects in the activation of Chk1 in response to aphidicolin, probably because of a failure to load the checkpoint mediator protein Claspin onto chromatin...
  7. doi request reprint Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Science 330:1670-3. 2010
    ..This converts Ensa into a potent and specific inhibitor of PP2A-B55δ. This pathway represents a previously unknown element in the control of mitosis...
  8. ncbi request reprint Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts
    Hiroyuki Yamano
    Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 13:137-47. 2004
    ..Our results suggest that the APC/C forms a stable interaction with the D-box of its substrates in a cell cycle-dependent manner...
  9. ncbi request reprint Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2
    Hiroyuki Yamano
    Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 279:18974-80. 2004
    ..Our results also highlight a collaborative action of the APC/C and the SCF toward the common substrate Cig2. This type of composite degradation control may be more general as the regulatory mechanism in other complex systems...
  10. ncbi request reprint Calcineurin is required to release Xenopus egg extracts from meiotic M phase
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 449:336-40. 2007
    ....
  11. pmc Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion
    Alessia Errico
    Genome Stability and Cell Cycle Control Groups, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts, UK
    EMBO J 28:3681-92. 2009
    ..These data indicate that Tipin/Tim1/And1 form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion...
  12. pmc Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
    EMBO J 28:2777-85. 2009
    ..Increasing the concentration of PP2A-B55 delta in extracts by adding recombinant enzyme inhibited the entry into mitosis. This form of PP2A seems to be a key regulator of entry into and exit from mitosis...
  13. ncbi request reprint CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
    Fumiko Esashi
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 434:598-604. 2005
    ....
  14. ncbi request reprint Nobel Lecture. Protein synthesis, proteolysis, and cell cycle transitions
    Tim Hunt
    Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom
    Biosci Rep 22:465-86. 2002
    ..The discovery of the role(s) of protein synthesis and degradation in the operation of the cell cycle is described...
  15. pmc Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis
    Jonathan D Moore
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts, EN6 3LD, United Kingdom
    Mol Biol Cell 13:4388-400. 2002
    ..In contrast to its inability to promote DNA replication, cyclin E lacking its NLS was able to cooperate with cyclin B in promoting mitotic entry...
  16. ncbi request reprint Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
    Ralph Graeser
    ICRF Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    J Cell Sci 115:3479-90. 2002
    ....
  17. ncbi request reprint [Nobel Prize in Physiology and Medicine 2001]
    Ewa Bartnik
    Neurol Neurochir Pol 36:443-7. 2002
  18. ncbi request reprint From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?
    Marcel Doree
    CRBM, UPR 1086 CNRS, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Cell Sci 115:2461-4. 2002
    ..When this fundamental discovery was confirmed in vertebrates and mammalian members of the Cdc2 family were also shown to bind cyclins, Cdc2 became Cdk1, the first cyclin-dependent protein kinase...
  19. doi request reprint The hunt for cyclin
    Peter K Jackson
    Genentech, Inc, Department of Cell Regulation, South San Francisco, CA 94080, USA
    Cell 134:199-202. 2008
    It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
  20. ncbi request reprint Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Dorée
    Claude Prigent
    Biol Cell 96:181-5. 2004
    ....
  21. pmc Characterization of a new family of cyclin-dependent kinase activators
    Ana Dinarina
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Biochem J 386:349-55. 2005
    ..The ability of RINGO proteins to activate CDK1 and CDK2 suggest also cyclin-independent roles for these kinases...
  22. pmc An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells
    Helfrid Hochegger
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Cell Biol 178:257-68. 2007
    ..This study demonstrates essential functions of Cdk1 in the control of S phase, and exemplifies a chemical genetics approach to target cyclin-dependent kinases in vertebrate cells...
  23. ncbi request reprint The crystal structure of human cyclin B
    Edward T Petri
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Cell Cycle 6:1342-9. 2007
    ..Examination of the structure provides insight into the molecular basis for differential affinities of protein based cyclin/cdk inhibitors such as p27, substrate recognition, and cdk interaction...
  24. doi request reprint Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
    Helfrid Hochegger
    Helfrid Hochegger is at the Genome Damage and Stability Centre, University of Sussex, Falmer Brighton, BN1 9RQ, UK
    Nat Rev Mol Cell Biol 9:910-6. 2008
    ..Recent work with gene-targeted mice has led to a revision of this model. We discuss cell-cycle control in light of overlapping and essential functions of the different CDKs and cyclins...