John D Hayes

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity
    Philip J Sherratt
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, United Kingdom
    Toxicol Appl Pharmacol 179:89-97. 2002
  2. ncbi request reprint Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element
    Ian R Jowsey
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Mol Pharmacol 64:1018-28. 2003
  3. ncbi request reprint Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    Gail K McWalter
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Nutr 134:3499S-3506S. 2004
  4. ncbi request reprint Glutathione transferases
    John D Hayes
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Annu Rev Pharmacol Toxicol 45:51-88. 2005
  5. ncbi request reprint Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways
    Anneke C Blackburn
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra
    Mol Pharmacol 69:650-7. 2006
  6. pmc Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
    Xiu Jun Wang
    Cancer Research U K Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 104:19589-94. 2007
  7. doi request reprint 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein
    Michael O Kelleher
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Carcinogenesis 30:1754-62. 2009
  8. pmc Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum
    Yiguo Zhang
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 399:373-85. 2006
  9. ncbi request reprint Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
    Larry G Higgins
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 226:328-37. 2008
  10. doi request reprint The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence
    Yiguo Zhang
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    J Biol Chem 284:3195-210. 2009

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity
    Philip J Sherratt
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, United Kingdom
    Toxicol Appl Pharmacol 179:89-97. 2002
    ..Taking this information into account, it is unlikely that humans have a sufficiently high capacity to activate DCM for this compound to be considered to represent a carcinogenic risk...
  2. ncbi request reprint Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element
    Ian R Jowsey
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Mol Pharmacol 64:1018-28. 2003
    ..Collectively, these data demonstrate a role for Nrf2 and the ARE in regulating transcription of mGSTA3...
  3. ncbi request reprint Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    Gail K McWalter
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Nutr 134:3499S-3506S. 2004
    ..These experiments show that broccoli seeds are effective at inducing antioxidant and detoxication proteins, both in vivo and ex vivo, in an Nrf2-dependent manner...
  4. ncbi request reprint Glutathione transferases
    John D Hayes
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Annu Rev Pharmacol Toxicol 45:51-88. 2005
    ..Consistent with this hypothesis, the promoters of cytosolic GST and MAPEG genes contain antioxidant response elements through which they are transcriptionally activated during exposure to Michael reaction acceptors and oxidative stress...
  5. ncbi request reprint Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways
    Anneke C Blackburn
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra
    Mol Pharmacol 69:650-7. 2006
    ..Patients with acquired deficiency of GSTZ1-1 caused by therapeutic exposure to dichloroacetic acid for the clinical treatment of lactic acidosis may be at increased risk of drug- and chemical-induced toxicity...
  6. pmc Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
    Xiu Jun Wang
    Cancer Research U K Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 104:19589-94. 2007
    ..These data suggest that cross-talk between Nrf2 and RARalpha could markedly influence the sensitivity of cells to electrophiles and oxidative stressors and, as a consequence, to carcinogenesis...
  7. doi request reprint 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein
    Michael O Kelleher
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Carcinogenesis 30:1754-62. 2009
    ..4-fold resistance against subsequent exposure to the alpha,beta-unsaturated aldehyde acrolein, indicating that the phytochemical exerts chemopreventive properties against genotoxic xenobiotics...
  8. pmc Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum
    Yiguo Zhang
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 399:373-85. 2006
    ..Thus Nrf1 and Nrf2 are targeted to different subcellular compartments and are negatively regulated by distinct mechanisms...
  9. ncbi request reprint Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
    Larry G Higgins
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 226:328-37. 2008
    ..Priming of nrf2(+/+) MEFs, but not nrf2(-/-) MEFs, with C+K conferred 2-fold resistance towards acrolein...
  10. doi request reprint The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence
    Yiguo Zhang
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    J Biol Chem 284:3195-210. 2009
    ..Lastly, data are presented suggesting that the NHB2 sequence in mouse Nrf3 may regulate the topology of the transcription factor within the ER membrane...
  11. doi request reprint Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    Larry G Higgins
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 237:267-80. 2009
    ..Thus Nrf2-dependent up-regulation of GSH is the principal mechanism by which sulforaphane pre-treatment induced resistance to acrolein, CuOOH and chlorambucil, but not menadione...
  12. ncbi request reprint Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones
    Xiu Jun Wang
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chem Biol 17:75-85. 2010
    ..Thus, the oxidation of para- and ortho-hydroquinones to quinones represents the rate-limiting step in the activation of Nrf2...
  13. doi request reprint Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
    John D Hayes
    Biomedical Research Institute, Ninewells Hospital, University of Dundee, Scotland, United Kingdom
    Antioxid Redox Signal 13:1713-48. 2010
    ....
  14. ncbi request reprint Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa
    Rachel E Thomson
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    J Histochem Cytochem 52:653-62. 2004
    ..These results are consistent with a role for mGST K1-1 in detoxification, and the confirmation of the intramitochondrial localization of this enzyme implies a unique role for GST class kappa as an antioxidant enzyme...
  15. pmc Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
    A Kenneth MacLeod
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Carcinogenesis 30:1571-80. 2009
    ..This study also shows that AKR1B10, AKR1C1 and AKR1C2 proteins have potential utility as biomarkers for NRF2 activation in the human...
  16. doi request reprint Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane
    Yiguo Zhang
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 430:497-510. 2010
    ..Thus Nrf1 can adopt several topologies within membranes that are determined by its NTD...
  17. ncbi request reprint Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants
    A Kenneth MacLeod
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Drug Metab Dispos 38:341-6. 2010
    ..Here we identify AKR1B13 and AKR1D2 as further inducible members of the rat AKR superfamily...
  18. doi request reprint The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors
    Yiguo Zhang
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD19SY, Scotland, UK
    Biochem J 418:293-310. 2009
    ..Collectively, these results suggest that the activity of Nrf1 critically depends on its topology within the ER, and that this is modulated by redox stressors, as well as by its glycosylation status...
  19. ncbi request reprint Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 281:24756-68. 2006
    ..We show that self-association is a general feature of Cul3 substrate adaptors and propose that the fixed-ends mechanism is commonly utilized to recruit, orientate, and ubiquitylate substrates upon this family of ubiquitin ligases...
  20. ncbi request reprint The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer
    John D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell 21:732-4. 2006
    ..Surprisingly, Padmanabhan et al. (2006) provide evidence in a recent issue of Molecular Cell to support the notion that elevated Nrf2 activity may also play a role in the evolution of cancer...
  21. pmc Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
    Tim W P Devling
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 102:7280-7285A. 2005
    ..75-fold increase in intracellular glutathione 48 h after transfection. Thus, antagonism of Keap1 by siRNA can be used to preadapt human cells to oxidative stress without the need to expose them to redox stressors...
  22. ncbi request reprint The cancer chemopreventive actions of phytochemicals derived from glucosinolates
    John D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Eur J Nutr 47:73-88. 2008
    ..Certain indoles act as ligands for AhR. Isothiocyanates and indoles are also capable of affecting cell cycle arrest and stimulating apoptosis. The mechanisms responsible for these anti-proliferative responses are discussed...
  23. pmc The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
    Yiguo Zhang
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 408:161-72. 2007
    ..Wild-type Nrf1 is glycosylated through its Asn/Ser/Thr-rich domain, between amino acids 296 and 403, and this modification was not observed in an Nrf1(Delta299-400) mutant. Glycosylation of Nrf1 was not necessary to retain it in the ER...
  24. ncbi request reprint Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 279:31556-67. 2004
    ..A model can now be proposed to explain how the turnover of this protein adapts in response to alterations in cellular redox state...
  25. ncbi request reprint Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors
    Paul Nioi
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Mutat Res 555:149-71. 2004
    ..The XRE recruits the arylhydrocarbon receptor (AhR) and AhR nuclear translocator. Cross-talk may occur between Nrf2 and AhR, but the details of this process remain to be elucidated...
  26. ncbi request reprint Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with I
    Paul J Meakin
    Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Mol Cell Biol 34:3305-20. 2014
    ..Therefore, Nrf2 protects against NASH by suppressing lipogenesis, supporting mitochondrial function, increasing the threshold for the UPR and inflammation, and enabling adaptation to HF-diet-induced oxidative stress. ..
  27. pmc Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    Michael McMahon
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland
    Proc Natl Acad Sci U S A 107:18838-43. 2010
    ....
  28. doi request reprint Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
    Larry G Higgins
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Drug Metab Rev 43:92-137. 2011
    ..We discuss cross-talk between the different induction mechanisms, and have employed bioinformatics to identify cis-elements in the upstream regions of GST genes to which the various transcription factors mentioned above may be recruited...
  29. doi request reprint Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
    Sudhir Chowdhry
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Free Radic Biol Med 48:357-71. 2010
    ..Thus, impairment of Nrf2 activity may represent a major risk factor for the evolution of NAFLD to NASH...
  30. ncbi request reprint Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents
    Xiu Jun Wang
    Cancer Research UK Molecular Pharmacology Unit and Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Cancer Res 66:10983-94. 2006
    ..Our findings show that Nrf2 can be activated by certain anticancer agents, and this will influence the effectiveness of chemotherapy...
  31. doi request reprint The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613
    John M Hourihan
    Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Antioxid Redox Signal 19:465-81. 2013
    ....
  32. doi request reprint NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
    John D Hayes
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Trends Biochem Sci 34:176-88. 2009
    ..Moreover, constitutive NRF2 activation might cause drug resistance in tumours, and an understanding of how the transcription factor is regulated indicates ways in which this could be overcome...
  33. ncbi request reprint Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents
    Philip J Sherratt
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Biochem Pharmacol 66:51-61. 2003
    ..Importantly, dietary compounds can modulate PGE(2) biosynthesis, and this is likely to influence colon tumorigenesis...
  34. ncbi request reprint Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2
    Ian R Jowsey
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem Biophys Res Commun 312:1226-35. 2003
    ..These data suggest a previously unrecognised role for GSTs in mouse adipocytes...
  35. doi request reprint The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics
    Larry G Higgins
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Chem Biol Interact 192:37-45. 2011
    ..However, inducible resistance towards menadione that occurred upon pre-treatment with 3μM Sul was independent of glutathione and may be due to upregulation of Nqo1. Thus Nrf2 controls cellular resistance against electrophiles...
  36. pmc Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase
    Ian R Jowsey
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 373:559-69. 2003
    ..Furthermore, the association of these enzymes with mitochondrial fractions is consistent with them performing a specific conserved biological role within this organelle...
  37. ncbi request reprint The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    John D Hayes
    Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK Electronic address
    Trends Biochem Sci 39:199-218. 2014
    ....
  38. pmc Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains
    Yiguo Zhang
    The NSFC funded Laboratory of Cell Biochemistry and Gene Regulation, College of Medical Bioengineering and Faculty of Life Sciences, Chongqing University, Chongqing, China Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    PLoS ONE 9:e93458. 2014
    ..e. glycosylation, the putative deglycosylation and selective proteolysis), which together control its ability to transactivate target genes. ..
  39. doi request reprint Nrf2 orchestrates fuel partitioning for cell proliferation
    John D Hayes
    Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Cell Metab 16:139-41. 2012
    ..This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway...
  40. pmc Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence
    Paul Nioi
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 374:337-48. 2003
    ..Furthermore, our results indicate that distinct AREs have differential sequence requirements, and a universally applicable consensus sequence cannot be derived...
  41. pmc Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
    Simon A Chanas
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 365:405-16. 2002
    ..These data also indicate that attenuated induction of GSH-dependent enzymes in Nrf2(-/-) mice probably accounts for their failure to adapt to chronic exposure to chemical and oxidative stress...
  42. ncbi request reprint Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity
    Christophe Cavin
    Quality and Safety Department, Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    Toxicol Sci 96:30-9. 2007
    ..Our data suggest that reduction of cellular defense against oxidative stress by Nrf2 inhibition may be a plausible mechanism of OTA nephrotoxicity and carcinogenicity...
  43. ncbi request reprint Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium
    Sarah C Cobbe
    Department of Molecular and Cellular Pathology, Biomedical Research Centre, University of Dundee, UK
    Eur J Gastroenterol Hepatol 15:41-7. 2003
    ..The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma...
  44. ncbi request reprint Nomenclature for mammalian soluble glutathione transferases
    Bengt Mannervik
    Department of Biochemistry, Uppsala University Biomedical Center, Sweden
    Methods Enzymol 401:1-8. 2005
    ..Soluble GSTs from other mammalian species can be classified in the same manner as the human enzymes, and this chapter presents the application of the nomenclature to the rat and mouse GSTs...