Genomes and Genes
Affiliation: Cancer Research UK
- Polycomb CBX7 has a unifying role in cellular lifespanJesus Gil
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
Nat Cell Biol 6:67-72. 2004..Taken together, these data show that CBX7 controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways...
- Immortalization of primary human prostate epithelial cells by c-MycJesus Gil
Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, United Kingdom
Cancer Res 65:2179-85. 2005..These results give a partial explanation for the physiologic role of c-Myc overexpression in prostate cancer...
- Role of polycomb group proteins in stem cell self-renewal and cancerJesus Gil
Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
DNA Cell Biol 24:117-25. 2005..In this review, we will briefly summarize current views on PcG function and the evidence linking specific PcG proteins with the behavior of stem cells and cancer cells...
- A role for CXCR2 in senescence, but what about in cancer?Juan C Acosta
Cell Proliferation Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
Cancer Res 69:2167-70. 2009..The challenge remains in how to integrate this with the well-known tumor promoting effects of IL-8 and GROalpha...
- Glycolytic enzymes can modulate cellular life spanHiroshi Kondoh
Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
Cancer Res 65:177-85. 2005..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis...
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusGoedele N Maertens
Cancer Research UK, London Research Institute, London, United Kingdom
PLoS ONE 4:e6380. 2009..Our findings provide the first evidence that a single gene can be regulated by several distinct PRC1 complexes and raise important questions about their configuration and relative functions...
- ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotencyCarlos F Pereira
MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Cell Stem Cell 6:547-56. 2010....
- Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulationNadine Martin
Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
EMBO J 32:982-95. 2013..Our results reveal an unexpected and conserved interplay between homeodomain-containing proteins and PRCs with implications in senescence, development and cancer...
- Induced pluripotent stem cells and senescence: learning the biology to improve the technologyAna Banito
MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
EMBO Rep 11:353-9. 2010....
- Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogrammingMichelle Percharde
Institute of Reproductive and Developmental Biology, Imperial College, London, United Kingdom
Genes Dev 26:2286-98. 2012..We propose an integrated model of transcriptional and coactivator control, mediated by Ncoa3, for the maintenance of ESC self-renewal and somatic cell reprogramming...
- Control of senescence by CXCR2 and its ligandsJuan C Acosta
Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
Cell Cycle 7:2956-9. 2008..Here, we discuss our findings in the context of the emerging role for secreted factors in regulating senescence through paracrine and/or autocrine mechanisms...
- Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in healthNikolay Popov
Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
Epigenetics 5:685-90. 2010..In view of the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit...
- Myc confers androgen-independent prostate cancer cell growthDavid Bernard
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kindom
J Clin Invest 112:1724-31. 2003..Furthermore, we showed that c-myc-overexpressing cells retain a functional p53 pathway and thus respond to etoposide...