Jesus Gil

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi Polycomb CBX7 has a unifying role in cellular lifespan
    Jesus Gil
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 6:67-72. 2004
  2. ncbi Immortalization of primary human prostate epithelial cells by c-Myc
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, United Kingdom
    Cancer Res 65:2179-85. 2005
  3. ncbi Role of polycomb group proteins in stem cell self-renewal and cancer
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    DNA Cell Biol 24:117-25. 2005
  4. ncbi A role for CXCR2 in senescence, but what about in cancer?
    Juan C Acosta
    Cell Proliferation Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
    Cancer Res 69:2167-70. 2009
  5. ncbi Glycolytic enzymes can modulate cellular life span
    Hiroshi Kondoh
    Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
    Cancer Res 65:177-85. 2005
  6. ncbi Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus
    Goedele N Maertens
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 4:e6380. 2009
  7. ncbi ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
    Carlos F Pereira
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Stem Cell 6:547-56. 2010
  8. ncbi Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation
    Nadine Martin
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    EMBO J 32:982-95. 2013
  9. ncbi Induced pluripotent stem cells and senescence: learning the biology to improve the technology
    Ana Banito
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    EMBO Rep 11:353-9. 2010
  10. ncbi Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming
    Michelle Percharde
    Institute of Reproductive and Developmental Biology, Imperial College, London, United Kingdom
    Genes Dev 26:2286-98. 2012

Collaborators

  • Vasso Episkopou
  • Veronique Azuara
  • Jing Wang
  • Matilde E Lleonart
  • Hiroshi Kondoh
  • Amanda G Fisher
  • Matthias Merkenschlager
  • A Carnero
  • Ana Banito
  • Juan C Acosta
  • Nadine Martin
  • Nikolay Popov
  • Michelle Percharde
  • Gordon Peters
  • Ana O'Loghlen
  • Selina Raguz
  • Carlos F Pereira
  • Goedele N Maertens
  • David Bernard
  • SiDe Li
  • Chi Wai Eric So
  • Efstathia Thymiakou
  • Martin J Walsh
  • Gopuraja Dharmalingam
  • Thomas Carroll
  • Francesca Aguilo
  • Ambrosius P Snijders
  • Bernd B Zeisig
  • Jia Chi Yeo
  • Shyam Prabhakar
  • Huck Hui Ng
  • Fabrice Lavial
  • Jia Hui Ng
  • Rute A Tomaz
  • Vibhor Kumar
  • Malcolm G Parker
  • Natalie K Ryan
  • Tomomi Tsubouchi
  • Francesco M Piccolo
  • Stephan Sauer
  • Joana Santos
  • Ludovica Bruno
  • David Landeira
  • Haruhiko Koseki
  • Selma El Messaoudi-Aubert
  • James Nicholls
  • Tomas Racek
  • Marc Rodriguez-Niedenführ
  • Julie K Stock
  • Albin Pourtier-Manzanedo
  • David H Beach

Detail Information

Publications13

  1. ncbi Polycomb CBX7 has a unifying role in cellular lifespan
    Jesus Gil
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Cell Biol 6:67-72. 2004
    ..Taken together, these data show that CBX7 controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways...
  2. ncbi Immortalization of primary human prostate epithelial cells by c-Myc
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, United Kingdom
    Cancer Res 65:2179-85. 2005
    ..These results give a partial explanation for the physiologic role of c-Myc overexpression in prostate cancer...
  3. ncbi Role of polycomb group proteins in stem cell self-renewal and cancer
    Jesus Gil
    Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    DNA Cell Biol 24:117-25. 2005
    ..In this review, we will briefly summarize current views on PcG function and the evidence linking specific PcG proteins with the behavior of stem cells and cancer cells...
  4. ncbi A role for CXCR2 in senescence, but what about in cancer?
    Juan C Acosta
    Cell Proliferation Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
    Cancer Res 69:2167-70. 2009
    ..The challenge remains in how to integrate this with the well-known tumor promoting effects of IL-8 and GROalpha...
  5. ncbi Glycolytic enzymes can modulate cellular life span
    Hiroshi Kondoh
    Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
    Cancer Res 65:177-85. 2005
    ..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis...
  6. ncbi Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus
    Goedele N Maertens
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 4:e6380. 2009
    ..Our findings provide the first evidence that a single gene can be regulated by several distinct PRC1 complexes and raise important questions about their configuration and relative functions...
  7. ncbi ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
    Carlos F Pereira
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Stem Cell 6:547-56. 2010
    ....
  8. ncbi Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation
    Nadine Martin
    Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    EMBO J 32:982-95. 2013
    ..Our results reveal an unexpected and conserved interplay between homeodomain-containing proteins and PRCs with implications in senescence, development and cancer...
  9. ncbi Induced pluripotent stem cells and senescence: learning the biology to improve the technology
    Ana Banito
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    EMBO Rep 11:353-9. 2010
    ....
  10. ncbi Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming
    Michelle Percharde
    Institute of Reproductive and Developmental Biology, Imperial College, London, United Kingdom
    Genes Dev 26:2286-98. 2012
    ..We propose an integrated model of transcriptional and coactivator control, mediated by Ncoa3, for the maintenance of ESC self-renewal and somatic cell reprogramming...
  11. ncbi Control of senescence by CXCR2 and its ligands
    Juan C Acosta
    Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    Cell Cycle 7:2956-9. 2008
    ..Here, we discuss our findings in the context of the emerging role for secreted factors in regulating senescence through paracrine and/or autocrine mechanisms...
  12. ncbi Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health
    Nikolay Popov
    Cell Proliferation Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Epigenetics 5:685-90. 2010
    ..In view of the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit...
  13. ncbi Myc confers androgen-independent prostate cancer cell growth
    David Bernard
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kindom
    J Clin Invest 112:1724-31. 2003
    ..Furthermore, we showed that c-myc-overexpressing cells retain a functional p53 pathway and thus respond to etoposide...