Research Topics
Genomes and Genes
| Julian DownwardSummaryAffiliation: Cancer Research UK Country: UK Publications
| Collaborators
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Detail Information
Publications
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanismsRoy M Katso
Ludwig Institute for Cancer Research, Royal Free and University College Hospital Medical School, London W1W 7BS, United Kingdom
Mol Biol Cell 17:3729-44. 2006..Taken together, these findings suggest that PI3KC2beta regulates the migration and survival of human tumor cells by distinct molecular mechanisms...- Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cellsBoon Tin Chua
Singapore OncoGenome Project, Institute of Medical Biology, A STAR, 8A Biomedical Grove, 06 06 Immunos, Singapore
Mol Cancer 8:131. 2009..Here, we transfected the MDA-MB 468 breast cell line with the human kinome siRNA library and measured Akt activation using an antibody specific for phosphoserine 473 of Akt... 
Targeting RAS signalling pathways in cancer therapyJulian Downward
Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Rev Cancer 3:11-22. 2003..Rational therapies that target the RAS pathways might inhibit tumour growth, survival and spread. Several of these new therapeutic agents are showing promise in the clinic and many more are being developed...- Signal transduction. Prelude to an anniversary for the RAS oncogeneJulian Downward
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Science 314:433-4. 2006 - Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?Julian Downward
Signal Transduction Laboratory, Cancer Research UK London Research Institute, UK
Biochem J 376:e9-10. 2003..Epidermal growth factor receptor function is needed for basal nucleotide exchange on Ras, whereas the LPA receptor controls an inducible exchange activity... 
YAP and p73: a complex affairJulian Downward
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Mol Cell 32:749-50. 2008..2008) demonstrate that YAP binds p73 to activate PML transcription, which in turn mediates YAP sumoylation and stabilization, increases p73 activity, and thereby generates a DNA-damage-induced feedback loop...- Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategiesMichael Steckel
Signal Transduction, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
Cell Res 22:1227-45. 2012..These observations suggest novel targets and new ways of combining existing therapies for optimal effect in RAS mutant cancers, which are traditionally seen as being highly refractory to therapy... - Initiation of high frequency multi-drug resistance following kinase targeting by siRNAsCharles Swanton
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
Cell Cycle 6:2001-4. 2007..Furthermore, this work supports efforts to identify common pathways of drug response for future drug discovery programmes... - CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motilityPatrick Michl
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
J Biol Chem 281:15138-44. 2006..These data identify CUTL1 as a novel target of PKA through which this protein kinase can modulate tumor cell motility and tumor progression... - CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy inductionAlvin J X Lee
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
J Pathol 226:482-94. 2012.... - Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expressionOona Delpuech
Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Mol Cell Biol 27:4917-30. 2007..Our results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function... - Unraveling the complexity of endocrine resistance in breast cancer by functional genomicsCharles Swanton
Cancer Research UK London Research Institute, Signal Transduction Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Cancer Cell 13:83-5. 2008..CDK10 is thus a potential biomarker for sensitivity in prospective clinical trials of patients treated with endocrine therapies... - Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cellsBarbara Nicke
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom
Mol Cell 20:673-85. 2005..MINK is thus a distal target of Ras signaling in the induction of a growth-arrested, senescent-like phenotype that may act to oppose oncogenic transformation in HOSE cells... - Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancerCharles Swanton
Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute, London, UK
Breast Cancer Res 10:214. 2008.... - Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in miceSurbhi Gupta
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Cell 129:957-68. 2007..Most importantly, they are highly resistant to endogenous Ras oncogene-induced tumorigenesis. The interaction of Ras with p110alpha is thus required in vivo for certain normal growth factor signaling and for Ras-driven tumor formation... - The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1Helene Plun-Favreau
Signal Transduction, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Cell Biol 9:1243-52. 2007..We suggest that PINK1-dependent phosphorylation of HtrA2 might modulate its proteolytic activity, thereby contributing to an increased resistance of cells to mitochondrial stress... - Intramolecular and intermolecular interactions of protein kinase B define its activation in vivoVéronique Calleja
Cell Biophysics Laboratory, Lincoln s Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom
PLoS Biol 5:e95. 2007..This has important implications not only in extending our understanding of this oncogenic protein kinase but also in opening up distinct opportunities for therapeutic intervention... - Chromosomal instability determines taxane responseCharles Swanton
Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
Proc Natl Acad Sci U S A 106:8671-6. 2009..Thus, pretherapeutic assessment of CIN may optimize treatment stratification and clinical trial design using these agents... - CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasivenessPatrick Michl
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Cancer Cell 7:521-32. 2005..This suggests that CUTL1 plays a central role in coordinating a gene expression program associated with cell motility and tumor progression... - PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBPThomas Porstmann
Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Oncogene 24:6465-81. 2005..Our data indicate that activation of SREBP by Akt leads to the induction of key enzymes of the cholesterol and fatty acid biosynthesis pathways, and thus membrane lipid biosynthesis... - Assessing cell size and cell cycle regulation in cells with altered TOR activityMegan Cully
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
Methods Mol Biol 821:227-37. 2012..Since it regulates growth at the cellular level, cell size can be used as an indirect readout of TOR activity. Here, we describe methods used to analyze cell size in cell culture and in the Drosophila wing... - A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1Megan Cully
Signal Transduction, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
Mol Cell Biol 30:481-95. 2010..These data suggest that p38 is an important positive regulator of TORC1 in both mammalian and Drosophila systems in response to certain stresses and growth factors... - Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugsCharles Swanton
Signal Transduction, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Cancer Cell 11:498-512. 2007..COL4A3BP expression is increased in drug-resistant cell lines and in residual tumor following paclitaxel treatment of ovarian cancer, suggesting that it could be a target for chemotherapy-resistant cancers... - Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosisSubham Basu
Signal Transduction, Cancer Research UK London Research Institue, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Mol Cell 11:11-23. 2003..Akt phosphorylation of YAP may thus suppress the induction of the proapoptotic gene expression response following cellular damage... - RNA interference libraries prove their worth in hunt for tumor suppressor genesJulian Downward
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom
Cell 121:813-5. 2005..REST is a transcriptional repressor that silences neuron-specific gene expression, and PITX1 is a homeodomain transcription factor that promotes the expression of a negative regulator of Ras... - FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2Olivier E Pardo
Lung Cancer Biology Group, Cancer Research UK, Imperial College London, Hammersmith Hospitals Campus, Du Cane Road, London, UK
EMBO J 25:3078-88. 2006..However, increased S6K1 kinase activity has no such effect. Thus, S6K2 but not S6K1 mediates prosurvival/chemoresistance signalling... - PI 3-kinase, Akt and cell survivalJulian Downward
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Semin Cell Dev Biol 15:177-82. 2004..In addition, novel connections between the metabolic effects of Akt and its control of survival have recently been made... - Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopyVéronique Calleja
Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, Lincoln s Inn Fields Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, U K
Biochem J 372:33-40. 2003..This novel approach of monitoring the in situ conformational changes has broad application for other members of the AGC kinase superfamily and other proteins... - The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancerMadhu S Kumar
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
Cell 149:642-55. 2012..Discovery of the nononcogene addiction of KRAS mutant lung cancers to GATA2 presents a network of druggable pathways for therapeutic exploitation... - Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in miceL Miguel Martins
Signal Transduction Laboratory, Cancer Research UK London Research Institute, United Kingdom
Mol Cell Biol 24:9848-62. 2004.... - Ras and phosphoinositide 3-kinase: partners in development and tumorigenesisAntoine R Ramjaun
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
Cell Cycle 6:2902-5. 2007..Many questions still remain: in this Perspective, we explore the remaining uncertainties surrounding the role of this signalling mechanism, as well as the future directions that will likely shed further light on its role within cells... - Translational responses to growth factors and stressMegan Cully
Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Biochem Soc Trans 37:284-8. 2009..In the present paper, we review mTOR-dependent and -independent translational responses, and discuss their regulation by stress... - Chromosomal instability, colorectal cancer and taxane resistanceCharles Swanton
Royal Marsden Hospital, Department of Medicine, London, UK
Cell Cycle 5:818-23. 2006..A phase II trial of taxanes in patients with metastatic CIN negative CRC may be indicated... - Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasetsCharles Swanton
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
Genome Med 2:53. 2010.... - Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancerRebecca Roylance
Cancer Research UK, London Research Institute, London, United Kingdom
Cancer Epidemiol Biomarkers Prev 20:2183-94. 2011.... - RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy?Charles Swanton
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
Lancet Oncol 5:653-4. 2004 - Use of RNA interference libraries to investigate oncogenic signalling in mammalian cellsJulian Downward
Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Oncogene 23:8376-83. 2004..RNA interference library technology holds great promise for enabling somatic cell genetics in tissue culture systems. Whether it can provide significant new insights into cancer will be its greatest challenge... - RNA interference-based functional genomics in cancer research--an introductionJulian Downward
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
Oncogene 23:8334-5. 2004 - SnapShot: Ras SignalingMegan Cully
Cancer Research UK London Research Institute, UK
Cell 133:1292-1292.e1. 2008 - The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine componentAlmut Schulze
Gene Expression Analysis, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
Mol Biol Cell 15:3450-63. 2004..The use of transcriptional profiling in this way allows detailed analysis of the architecture of signaling pathways to be undertaken... - Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrestFrancisco J Nicolás
Developmental Signalling Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
J Biol Chem 278:3251-6. 2003..Regulation of apoptosis is not affected by Smad3 levels. These data attribute to Smad3 a critical role in the control of cell proliferation by TGF-beta, which is lost following an epithelial to mesenchymal transition... - Genomic Determinants of PI3K Pathway Inhibitor Response in CancerBritta Weigelt
Signal Transduction Laboratory, Cancer Research UK London Research Institute London, UK
Front Oncol 2:109. 2012.... - Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/OmiL Miguel Martins
Signal Transduction and Protein Isolation and Cloning Laboratories, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom
J Biol Chem 278:49417-27. 2003..This, together with the ability of HtrA2/Omi to degrade IAPs, may limit the overall cellular protection that can be provided by these proteins... - RNA interferenceJulian Downward
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX
BMJ 328:1245-8. 2004 - Role of RAS in the regulation of PI 3-kinaseEsther Castellano
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, WC2A 3PX, UK
Curr Top Microbiol Immunol 346:143-69. 2010..In this chapter, we summarize current knowledge about how RAS regulates one of its best-known effectors, phosphoinositide 3-kinase (PI3K)... - RAS Interaction with PI3K: More Than Just Another Effector PathwayEsther Castellano
Signal Transduction Laboratory, Cancer Research UK London Research Institute, London, UK
Genes Cancer 2:261-74. 2011..In this review, we will summarize current knowledge about how RAS regulates one of its best-known effectors, PI3K... - Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cellsAlmut Schulze
Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK
Mol Cell 44:846-8. 2011..In this issue of Molecular Cell, Hitosugi et al. (2011) show that the switch from oxidative phosphorylation to glycolysis in cancer cells is regulated by tyrosine phosphorylation of PDHK1... - Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-RasSoon Young Shin
Division of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan, Korea
EMBO J 25:1093-103. 2006..Our findings suggest a novel signaling mechanism by which prolonged activation of oncogenic H-Ras can trigger the loss of tumor suppressor Egr-1 through the PI3K pathway in NIH3T3 fibroblast model cell lines... - Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathwaysNatacha Edme
, Institut Curie Section de Recherche, Centre Universitaire Paris-Sud, 91405 Orsay, France
J Cell Sci 115:2591-601. 2002..Finally, coexpression of active Rac1 and active MEK1 induced the motility of NBT-II cells, suggesting that Ras mediates NBT-II cell scattering through the coordinate activation of Rac and the Raf/MAPK pathway... - Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathwayElzbieta Janda
Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Oncogene 21:5148-59. 2002..Our data thus indicate that Ras-dependent signaling through the PI3K- and MAPK pathways fulfil distinct, but complementary functions during carcinogenesis... - Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastomaAngelo Agathanggelou
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, United Kingdom
Cancer Res 63:5344-51. 2003..The identified targets are involved in diverse cellular processes; this should help toward understanding mechanisms that contribute to RASSF1A biological activity... - Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosisOlivier E Pardo
Cancer Research United Kingdom Lung Cancer Biology Group and the Medical Research Council Clinical Sciences Centre, Hammersmith Campus of Imperial College, DuCane Road, London W12 0NN, United Kingdom
J Biol Chem 277:12040-6. 2002..Thus, MEK/extracellularly regulated kinase signaling is critical in the coordinate modulation of both pro- and anti-apoptotic Bcl-2 family members by FGF-2... - Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cellsOlivier E Pardo
Lung Cancer Biology Group, Cancer Research UK, London SW3, United Kingdom
Mol Cell Biol 23:7600-10. 2003.... - Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathwaysElzbieta Janda
Institute of Molecular Pathology, A-1030 Vienna, Austria
J Cell Biol 156:299-313. 2002..Thus, EMT seems to be a close in vitro correlate of metastasis, both requiring synergism between TGFbeta-R and Raf/MAPK signaling... - The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell deathShairaz Baksh
Cancer Biology Program, Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 1038 NRB, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Mol Cell 18:637-50. 2005..Our findings identify RASSF1A and MAP-1 as important components between death receptors and the apoptotic machinery and reveal a potential link between tumor suppression and death receptor signaling... - Cancer biology: signatures guide drug choiceJulian Downward
Nature 439:274-5. 2006 - Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/AktAnna L Jansson
Department of Medical Biosciences/Pathology, , S-901 87, Ume, Sweden
Cell Microbiol 8:815-22. 2006..In conclusion, we suggest that Ras proteins are an important cellular target for the P. aeruginosa toxin ExoS, which induces cell death during pathogenesis as a means of defending the bacterium against eukaryotic phagocytosis... - The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxelAhmed Ashour Ahmed
Functional Genomics of Drug Resistance Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Cancer Cell 12:514-27. 2007..These data show that ECM can mediate taxane sensitivity by modulating microtubule stability... - Role of Bim in the survival pathway induced by Raf in epithelial cellsMichela Marani
Cancer Research UK Molecular Oncology Unit, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Oncogene 23:2431-41. 2004..This represents an important route to protect epithelial cells from the proapoptotic effect of Bim... - Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activationKazunori Inabe
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
J Exp Med 195:189-200. 2002..Hence, our results suggest a role for Vav3 in regulating the B cell responses by promoting the sustained production of PIP3 and thereby calcium flux... - Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathwaysLucinda F Reynolds
National Institute for Medical Research, London NW7 1AA, United Kingdom
J Exp Med 195:1103-14. 2002..We show that this latter function is independent of PI3K... - Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosisMichela Marani
Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
Mol Cell Biol 22:3577-89. 2002..Furthermore, we have shown that the interaction of the BimS and BimAD isoforms with Bax leads to a conformational change in this protein analogous to that triggered by the BH3-only protein Bid... - Roles of cortactin in tumor pathogenesisLaszlo Buday
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Street, 1088 Budapest, Hungary
Biochim Biophys Acta 1775:263-73. 2007..This review aims to focus on cortactin-mediated signaling pathways, with emphasis on its contribution to tumor progression and metastasis formation... - Minimizing the risk of reporting false positives in large-scale RNAi screensChristophe J Echeverri
Cenix BioScience GmbH, Tatzberg 47, Dresden, 10307, Germany
Nat Methods 3:777-9. 2006.... - CUTL1: a key mediator of TGFbeta-induced tumor invasionPatrick Michl
Abteilung Innere Medizin I, , Ulm, Germany
Cell Cycle 5:132-4. 2006..Therefore we postulate that CUTL1 might be a key mediator of the tumor-promoting effects of TGFbeta in advanced cancers... - Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's diseaseKarsten M Strauss
Center of Neurology and Hertie Institute for Clinical Brain Research, Leicester, UK
Hum Mol Genet 14:2099-111. 2005..On the basis of functional genomics, our results provide a novel link between mitochondrial dysfunction and neurodegeneration in PD... - Involvement of survival motor neuron (SMN) protein in cell deathSheela Vyas
INSERM U497, 46 rue d Ulm, Paris 75005, France
Hum Mol Genet 11:2751-64. 2002..Thus, our results show that the C-terminal region is critical in suppression of apoptosis by SMN... - Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for RacPeter Tamas
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Street, 1088 Budapest, Hungary
J Biol Chem 278:5163-71. 2003..These results suggest that EGF regulates Vav2 activity basically through phosphatidylinositol 3-kinase activation, whereas tyrosine phosphorylation of Vav2 may rather be necessary for mediating protein-protein interactions... - RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamicsAshraf Dallol
Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham, United Kingdom
Cancer Res 64:4112-6. 2004..Our data identify a role for RASSF1A in the regulation of microtubules and cell cycle dynamics that could be part of the mechanism(s) by which RASSF1A exerts its growth inhibition on cancer cells... - Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor geneSarah L Fenton
Section of Medical and Molecular Genetics, Department of Reproductive and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham, United Kingdom
Cancer Res 64:102-7. 2004..As p120(E4F) has been reported previously to interact with p14ARF, retinoblastoma, and p53, these findings provide an important link between the function of RASSF1A and other major human tumor suppressor genes... - PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsAlison Wood-Kaczmar
Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom
PLoS ONE 3:e2455. 2008..The phenotypic effects of PINK1 loss-of-function described here in mammalian neurons provides mechanistic insight into the age-related degeneration of nigral dopaminergic neurons seen in PD...