J Cuzick

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 369:1711-23. 2007
  2. ncbi Role of HPV testing in clinical practice
    Jack Cuzick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, 61 Lincoln s Inn Fields, London, UK
    Virus Res 89:263-9. 2002
  3. pmc Bone versus breast density
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Breast Cancer Res 8:104. 2006
  4. ncbi Chapter 10: New dimensions in cervical cancer screening
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, United Kingdom
    Vaccine 24:S3/90-7. 2006
  5. pmc Long-term outcome among men with conservatively treated localised prostate cancer
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, St Bartholomew s Medical School, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 95:1186-94. 2006
  6. pmc Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view
    Stephen W Duffy
    Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast Cancer Res 10:R64. 2008
  7. pmc Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study
    Rahul Roychoudhuri
    King s College London, Thames Cancer Registry, 1st Floor Capital House, 42 Weston Street, London SE1 3QD, UK
    BMC Cancer 7:9. 2007
  8. ncbi Treatment of DCIS--results from clinical trials
    Jack Cuzick
    Department of Epidemiology, Mathematics and Statistics, Cancer Research UK, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, EC1M 6BQ, UK
    Surg Oncol 12:213-9. 2003
  9. ncbi Overview of the main outcomes in breast-cancer prevention trials
    J Cuzick
    Cancer Research UK, London, UK
    Lancet 361:296-300. 2003
  10. ncbi Chemoprevention of breast cancer
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Womens Health (Lond Engl) 2:853-61. 2006

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 369:1711-23. 2007
    ..Several trials have been done to assess treatment of premenopausal breast cancer with luteinising-hormone-releasing hormone (LHRH) agonists, but results have been inconclusive, especially for patients with hormone-receptor-positive cancer...
  2. ncbi Role of HPV testing in clinical practice
    Jack Cuzick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, 61 Lincoln s Inn Fields, London, UK
    Virus Res 89:263-9. 2002
  3. pmc Bone versus breast density
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Breast Cancer Res 8:104. 2006
    ..Overall, the relationship is very weak, if it exists at all. Other factors such as weight-bearing exercise, which have opposing impacts on these variables, may have a more dominant effect...
  4. ncbi Chapter 10: New dimensions in cervical cancer screening
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, United Kingdom
    Vaccine 24:S3/90-7. 2006
    ..The fact that HPV is a sexually transmitted infection may lead to anxiety and concerns about sexual relationships and these issues are also discussed. Ongoing HPV studies are identified and briefly reviewed...
  5. pmc Long-term outcome among men with conservatively treated localised prostate cancer
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, St Bartholomew s Medical School, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 95:1186-94. 2006
    ..This classification is a substantial improvement on previous ones using only Gleason score, but better markers are needed to predict survival more accurately in the intermediate group of patients...
  6. pmc Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view
    Stephen W Duffy
    Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast Cancer Res 10:R64. 2008
    ..A particularly strong association with risk has been observed when density is measured using interactive threshold software. This, however, is a labour-intensive process for large-scale studies...
  7. pmc Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study
    Rahul Roychoudhuri
    King s College London, Thames Cancer Registry, 1st Floor Capital House, 42 Weston Street, London SE1 3QD, UK
    BMC Cancer 7:9. 2007
    ..It has been proposed that this difference might result in greater cardiovascular mortality following irradiation of the left breast when compared with the right...
  8. ncbi Treatment of DCIS--results from clinical trials
    Jack Cuzick
    Department of Epidemiology, Mathematics and Statistics, Cancer Research UK, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, EC1M 6BQ, UK
    Surg Oncol 12:213-9. 2003
  9. ncbi Overview of the main outcomes in breast-cancer prevention trials
    J Cuzick
    Cancer Research UK, London, UK
    Lancet 361:296-300. 2003
    ..Early findings on the use of tamoxifen or raloxifene as prophylaxis against breast cancer have been mixed; we update available data and overview the combined results...
  10. ncbi Chemoprevention of breast cancer
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Womens Health (Lond Engl) 2:853-61. 2006
    ..New agents are needed for receptor-negative breast cancer and several possibilities are currently under investigation...
  11. pmc Should aromatase inhibitors be used as initial adjuvant treatment or sequenced after tamoxifen?
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 94:460-4. 2006
    ..A mechanism explaining why greater efficacy might be so is proposed. Further results from ongoing trials will be needed to resolve this issue...
  12. pmc Early stopping of clinical trials
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, UK
    Breast Cancer Res 7:181-3. 2005
    ....
  13. ncbi Anastrozole
    Jack Cuzick
    Wolfson Institute of Preventive Medicine, St Bartholomew s Medical School, London, UK
    Drugs Today (Barc) 41:227-39. 2005
    ..Similarly, the use of anastrozole in the adjuvant setting has shown a significantly prolonged disease-free survival time and improved tolerability compared to tamoxifen in postmenopausal breast cancer survivors...
  14. ncbi Aromatase inhibitors for breast cancer prevention
    Jack Cuzick
    Centre of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 23:1636-43. 2005
  15. ncbi Epidemiology of breast cancer--selected highlights
    Jack Cuzick
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    Breast 12:405-11. 2003
    ..A computer programme for combining them to produce individualized risk profiles is described. The ongoing IBIS-II trial of chemoprevention for high risk postmenopausal women is presented as one approach to managing high risk women...
  16. ncbi Overview of the European and North American studies on HPV testing in primary cervical cancer screening
    Jack Cuzick
    Cancer Research UK, Wolfson Institute of Preventive Medicine, London
    Int J Cancer 119:1095-101. 2006
    ..These results support the use of HPV testing as the sole primary screening test, with cytology reserved for women who test HPV positive. Large demonstration projects are needed to fully evaluate this strategy...
  17. ncbi Management of women who test positive for high-risk types of human papillomavirus: the HART study
    J Cuzick
    Cancer Research UK, London, UK
    Lancet 362:1871-6. 2003
    ..We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women...
  18. ncbi Tamoxifen and breast density in women at increased risk of breast cancer
    Jack Cuzick
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary College, University of London, London, UK
    J Natl Cancer Inst 96:621-8. 2004
    ..We investigated mammographic breast density in healthy women with an increased risk of breast cancer at baseline and during 54 months of tamoxifen treatment...
  19. doi Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith study
    Jack Cuzick
    Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Int J Cancer 122:2294-300. 2008
    ..52, p = 0.001), whereas there was little difference according to initial cytology (HR = 1.64, p = 0.51)...
  20. ncbi IBIS II: a breast cancer prevention trial in postmenopausal women using the aromatase inhibitor anastrozole
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Rev Anticancer Ther 8:1377-85. 2008
    ..The primary end point is breast cancer incidence, but major efforts are also being directed at minimizing any fracture risk...
  21. doi Primary endpoints for randomised trials of cancer therapy
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London EC1M 6BQ, UK
    Lancet 371:2156-8. 2008
  22. ncbi Surrogate endpoints for cancer screening trials: general principles and an illustration using the UK Flexible Sigmoidoscopy Screening Trial
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Med Screen 14:178-85. 2007
    ..Surrogate endpoints should not replace a long-term analysis based directly on mortality, but can provide reliable early indicators which can be useful both for monitoring ongoing screening programmes and for making policy decisions...
  23. doi Aromatase inhibitors in early breast-cancer treatment: The story so far
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast 17:S2-8. 2008
    ..Further clinical trials are needed to ascertain the optimal length of treatment with an AI...
  24. ncbi Hormone replacement therapy and the risk of breast cancer
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London, UK
    Eur J Cancer 44:2344-9. 2008
    ..Recent sharp reductions in HRT use have been correlated with declines in breast cancer incidence in the USA, but not so clearly elsewhere...
  25. doi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
    ..These psychosocial aspects and the need for more information and educational programmes about HPV are also discussed in this article...
  26. ncbi Long-term results of tamoxifen prophylaxis for breast cancer--96-month follow-up of the randomized IBIS-I trial
    Jack Cuzick
    Centre for Epidemiology, Mathematics, and Statistics, Cancer Research UK, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Natl Cancer Inst 99:272-82. 2007
    ..We report an updated analysis of IBIS-I that focuses on the period after active treatment was completed, a time for which little evidence from other trials is available...
  27. ncbi Chemoprevention of breast cancer
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Breast Cancer 15:10-6. 2008
    ..3). New agents are needed, for receptor negative breast cancer and several possibilities are currently under investigation...
  28. ncbi The ATAC trial: the vanguard trial for use of aromatase inhibitors in early breast cancer
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Rev Anticancer Ther 7:1089-94. 2007
    ....
  29. pmc Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART study
    D Mesher
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Charterhouse Square, LondonEC1 M 6BQ, UK
    Br J Cancer 102:1405-10. 2010
    ..Several studies have shown that testing for high-risk human papillomavirus (HPV) types results in an improved sensitivity for CIN2+, compared with cytology, although with a somewhat lower specificity...
  30. pmc HPV testing in primary screening of older women
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 81:554-8. 1999
    ..A combined screening test offers the possibility of greater protection and/or longer screening intervals, which could reduce the overall cost of the screening programme...
  31. ncbi Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update ana
    M Baum
    University College London, London, United Kingdom
    Cancer 98:1802-10. 2003
    ..9 months)...
  32. pmc Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial
    M Dowsett
    CRC and UCL Cancer Trials Centre, University College London, Stephenson House, 158 160 N Gower Street, London, NW1 2ND, UK
    Br J Cancer 85:317-24. 2001
    ....
  33. pmc Future possibilities in the prevention of breast cancer: breast cancer prevention trials
    J Cuzick
    Department of Methematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Breast Cancer Res 2:258-63. 2000
    ..Continued follow up of these trials is crucial for resolving these issues...
  34. pmc Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London EC1 M 6BQ, UK
    Br J Cancer 106:1095-9. 2012
    ..A greater need is to predict outcome in patients diagnosed by needle biopsy...
  35. pmc Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 82:1348-52. 2000
    ..05), associated with HPV16-positive cervical cancers. Taking all cancers together, a marginally significant protective effect was found for DQB1*0501 (2P = 0.03) but no protective effect could be seen for DRB1*1301...
  36. pmc Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 69:167-71. 1994
    ..In particular, HPV testing appears to be helpful in determining which women with mildly abnormal smears have high-grade underlying lesions in need of immediate referral for colposcopy...
  37. ncbi Treatment-emergent endocrine symptoms and the risk of breast cancer recurrence: a retrospective analysis of the ATAC trial
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet Oncol 9:1143-8. 2008
    ..In this retrospective analysis, the relation between the reported incidence of vasomotor or joint symptoms and breast cancer recurrence in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial is assessed...
  38. pmc Long-term follow-up in cancer prevention trials (It ain't over 'til it's over)
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, United Kingdom
    Cancer Prev Res (Phila) 3:689-91. 2010
    ....
  39. ncbi Aromatase inhibitors in prevention--data from the ATAC (arimidex, tamoxifen alone or in combination) trial and the design of IBIS-II (the second International Breast Cancer Intervention Study)
    Jack Cuzick
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London ECIM 6BQ
    Recent Results Cancer Res 163:96-103; discussion 264-6. 2003
    ..A parallel trial will compare anastrozole against tamoxifen in 4,000 women with locally excised DCIS...
  40. pmc Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort
    G Fisher
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Br J Cancer 108:271-7. 2013
    ..Here, we present results in a more clinically relevant needle biopsy cohort...
  41. doi Does trauma or an intercurrent surgical intervention lead to a short-term increase in breast cancer recurrence rates?
    Z Allawi
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Ann Oncol 23:866-9. 2012
    ..To test this, we examined if accidental trauma or surgery, unrelated to the original cancer, might stimulate the growth of dormant micrometastases and be related to an increase in the recurrence rate in the period after the event...
  42. ncbi Pitfalls in the diagnosis of prostatic cancer: retrospective review of 1791 cases with clinical outcome
    D M Berney
    Department of Histopathology, St Bartholomew s Hospital, London, UK
    Histopathology 51:452-7. 2007
    ..To assess the possible reasons for error in the diagnosis of prostatic cancer with available follow-up data...
  43. pmc Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study
    D M Berney
    The Orchid Tissue Laboratory, Centre for Molecular Oncology, Barts and the London School of Medicine and Dentistry, London, UK
    Br J Cancer 100:888-93. 2009
    ..As it is already in widespread use in routine pathology, it is confirmed as the most promising biomarker to be applied into routine practice...
  44. pmc The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions
    G Terry
    Department of Epidemiology, Mathematics and Statistics, Cancer Research UK, Queen Mary University of London, Wolfson Institute, Charterhouse Square, London ECIM 6BQ, UK
    Br J Cancer 96:110-7. 2007
    ....
  45. pmc A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusions
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 83:561-5. 2000
    ..A range of issues including the age to start and stop screening, the appropriate screening interval, the role of self-sampling for HPV testing and the choice of primary test (HPV and/or cytology) require further evaluation...
  46. pmc Predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20-29 in the UK
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK
    Br J Cancer 102:933-9. 2010
    ..In the UK, vaccination for girls aged 12-13 with catch-up for girls up to age 18 was introduced in 2008, using the bivalent GSK vaccine (Cervarix)...
  47. ncbi Screening for cancer: future potential
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, U K
    Eur J Cancer 35:1925-32. 1999
    ..Less certainty exists about screening for other major cancers such as lung, prostate and ovary, but a range of potential approaches merit investigation...
  48. ncbi Electropotential measurements as a new diagnostic modality for breast cancer
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Lancet 352:359-63. 1998
    ..Diagnostic information might be obtained from a non-imaging and non-invasive test based on skin-surface electropotentials...
  49. ncbi Breast density and breast cancer risk factors in a high-risk population
    J Warwick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK
    Breast 12:10-6. 2003
    ....
  50. ncbi Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    Lancet Oncol 9:866-72. 2008
    ..The aim of this study was to assess the relative importance of different risk factors for treatment-emergent joint symptoms in patients assigned to anastrozole or tamoxifen as adjuvant treatment for postmenopausal breast cancer...
  51. pmc Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK
    Br J Cancer 108:2582-9. 2013
    ..We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate...
  52. pmc Comparing the performance of six human papillomavirus tests in a screening population
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 108:908-13. 2013
    ..Several new assays have been developed for high-risk HPV testing of cervical samples; we compare six HPV tests in a screening population...
  53. doi Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial
    Ivana Sestak
    Cancer Research UK UK, Queen Mary University of London, London, United Kingdom
    J Clin Oncol 28:3411-5. 2010
    ..As aromatase inhibitors work by inhibiting the conversion of androgens to estrogens in adipose tissue, we hypothesized that anastrozole may be more effective in women with a high body mass index (BMI)...
  54. ncbi Human papillomavirus DNA detection in the management of women with twice mildly abnormal cytological smears
    Linda Ho
    Department of Molecular Pathology, University College London, London, United Kingdom
    J Med Virol 69:118-21. 2003
    ..The utility of high-risk HPV detection in the management of women presenting with mild cytological abnormalities is discussed...
  55. pmc Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer
    N Vasiljevic
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Prostate Cancer Prostatic Dis 16:35-40. 2013
    ..To gain insight into the mechanism regulating its expression, we tested the hypothesis that differential methylation of CpG islands within HSPB1 controls transcription and subsequent translation of the gene...
  56. ncbi Screening for cancer: future potential
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, U K
    Eur J Cancer 35:685-92. 1999
    ..Less certainty exists about screening for other major cancers such as lung, prostate and ovary, but a range of potential approaches merit investigation...
  57. pmc The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
    G Terry
    Department of Epidemiology, Mathematics and Statistics, CRUK, Wolfson Institute, Queen Mary and Westfield University, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 91:2056-62. 2004
    ..Abnormal fragile histidine triad gene expression was more frequent in cervical intraepithelial neoplasia grade 1 lesions with increased risk of disease progression...
  58. pmc Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 339:b2968. 2009
    ..To study the effect of cervical screening on incidence of cervical cancer as a function of age with particular focus on women screened under the age of 25...
  59. ncbi Screening and adenocarcinoma of the cervix
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    Int J Cancer 125:525-9. 2009
    ..The impact of screening on adenosquamous carcinoma is similar to its impact on squamous carcinoma...
  60. ncbi Controversies in design and interpretation of adjuvant clinical trials
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, UK
    Cancer Invest 28:28-34. 2010
    ..Distant metastasis is an excellent surrogate for breast cancer death and is available a few years earlier. These changes should lead to more rapid and reliable introduction of improved therapeutic strategies...
  61. pmc Benefit of cervical screening at different ages: evidence from the UK audit of screening histories
    P Sasieni
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 89:88-93. 2003
    ..British Journal of Cancer (2003) 89, 88-93. doi:10.1038/sj.bjc.6600974 www.bjcancer.com..
  62. ncbi A brief review of the current breast cancer prevention trials and proposals for future trials
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Eur J Cancer 36:1298-302. 2000
    ..Continued follow-up of these trials is crucial for resolving these issues...
  63. ncbi Influence of hormone replacement therapy on tamoxifen-induced vasomotor symptoms
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    J Clin Oncol 24:3991-6. 2006
    ..Vasomotor symptoms were evaluated according to follow-up time, severity, and use of hormone replacement therapy (HRT) in a retrospective analysis...
  64. ncbi Inherited and acquired risk factors for venous thromboembolic disease among women taking tamoxifen to prevent breast cancer
    Catherine Duggan
    Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 21:3588-93. 2003
    ..We investigate the association between acquired and inherited risk factors for VTE in the International Breast Cancer Intervention Study (IBIS-I) trial of tamoxifen prophylaxis for women at increased risk of breast cancer...
  65. pmc Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial
    I Sestak
    Centre for Cancer Prevention, Queen Mary University of London, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 107:230-3. 2012
    ..Other studies have suggested that menopausal symptoms may be a predictive factor to tamoxifen response...
  66. ncbi Neuroendocrine differentiation does not have independent prognostic value in conservatively treated prostate cancer
    S S Jeetle
    Department of Molecular Oncology, Barts Cancer Institute, Charterhouse Square, London, EC1M 6BQ, UK
    Virchows Arch 461:103-7. 2012
    ..083). Determination of neuroendocrine differentiation does not appear to have any bearing on the outcome of prostatic carcinoma and does not add to the established prognostic model...
  67. ncbi Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
    Wendy S Atkin
    Department of Surgery and Cancer, Imperial College London, London, UK
    Lancet 375:1624-33. 2010
    ..We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality...
  68. pmc A case-control study of cervix cancer in Singapore
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 60:238-43. 1989
    ..Biopsies were available for HPV DNA analysis in 38 cases and 37% were positive, mostly for HPV type 16. All these factors gave similar risks in invasive and preinvasive disease...
  69. ncbi Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: a case-control study
    V Bataille
    Genetic Epidemiology and Twin Research Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Eur J Cancer 40:429-35. 2004
    ..However, it is possible that the mean lag time of 7 years between exposure to sunbed and melanoma in this study may have led to an under-estimation of the long-term melanoma risk...
  70. doi Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008
    ..This study compared the sensitivity and specificity of several adjunctive tests for the detection of high-grade CIN in a population referred to colposcopy because of abnormal cytology...
  71. ncbi Wide variation in adenoma detection rates at screening flexible sigmoidoscopy
    Wendy Atkin
    Colorectal Unit, Cancer Research UK, St Mark s Hospital, Northwick Park, Harrow, Middlesex HA1 3UJ, England, UK
    Gastroenterology 126:1247-56. 2004
    ....
  72. ncbi Performance of the Abbott RealTime high-risk HPV test in women with abnormal cervical cytology smears
    Jack Cuzick
    Wolfson Institute of Preventive Medicine, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary University of London, London, United Kingdom
    J Med Virol 82:1186-91. 2010
    ..Differences between these tests appeared to be related mostly to the choice of cutoff level. An added feature of the Abbott test was the provision of type specific results for HPV 16 and 18...
  73. ncbi A breast cancer prediction model incorporating familial and personal risk factors
    Jonathan Tyrer
    Department of Epidemiology, Mathematics and Statistics, Cancer Research UK
    Stat Med 23:1111-30. 2004
    ..This risk was further refined based on the woman's personal history. The model has been incorporated into a computer program that gives a personalised risk estimate...
  74. ncbi Aromatase inhibitor-induced carpal tunnel syndrome: results from the ATAC trial
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    J Clin Oncol 27:4961-5. 2009
    ..Aromatase inhibitors lead to profound estrogen suppression and may be expected to increase the risk of CTS in postmenopausal women receiving adjuvant therapy for early breast cancer...
  75. ncbi A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe
    Veronique Bataille
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, London, UK
    Eur J Cancer 41:2141-9. 2005
    ..Sunbed exposure has become increasingly prevalent over the last 20 years, especially in Northern Europe but the full impact of this exposure on skin cancers may not become apparent for many years...
  76. pmc Human papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 14:34-42. 2007
    ..To compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (HPV) types for the first time in a UK screening setting...
  77. ncbi Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    Mitch Dowsett
    Academic Department of Biochemistry, Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 28:509-18. 2010
    ..To conduct meta-analyses of randomized trials of aromatase inhibitors (AIs) compared with tamoxifen either as initial monotherapy (cohort 1) or after 2 to 3 years of tamoxifen (cohort 2)...
  78. ncbi A brief review of the International Breast Cancer Intervention Study (IBIS), the other current breast cancer prevention trials, and proposals for future trials
    J Cuzick
    Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, London, United Kingdom
    Ann N Y Acad Sci 949:123-33. 2001
    ..Continued follow-up of these trials is crucial for resolving these issues...
  79. ncbi Once-only sigmoidoscopy
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Ann Oncol 10:65-9. 1999
    ..The rationale for infrequent screening for colorectal cancers by sigmoidoscopy of the general population around age 60 is reviewed. A progress report for a trial to evaluate this approach is also presented...
  80. ncbi The effect of stopping smoking on cervical Langerhans' cells and lymphocytes
    A Szarewski
    Margaret Pyke Centre, London, UK
    BJOG 108:295-303. 2001
    ....
  81. pmc The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia
    V Bataille
    Imperial Cancer Research Fund Skin Tumour Laboratory, London, UK
    Br J Cancer 77:505-10. 1998
    ....
  82. pmc Estimating the efficacy of screening by auditing smear histories of women with and without cervical cancer. The National Co-ordinating Network for Cervical Screening Working Group
    P D Sasieni
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 73:1001-5. 1996
    ..These data suggest that full adherence to current guidelines could perhaps have prevented another 1250 cases, but additional steps would have been required to prevent some of the 2300 remaining cases in women under the age of 70...
  83. pmc Significant differences in UK and US female bone density reference ranges
    E Noon
    Osteoporosis Research Unit, Division of Imaging Sciences, King s College London, London, UK
    Osteoporos Int 21:1871-80. 2010
    ..6 standard deviation higher than their US counterparts...
  84. pmc The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer
    L Shan
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Prostate Cancer Prostatic Dis 13:117-25. 2010
    ..0628). The potential role of this translocation in the development of human prostate cancer is discussed...
  85. pmc Multiple myeloma--a case-control study
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 57:516-20. 1988
    ..001), but most of the excess cases occurred within 10 years of diagnosis, suggesting this was a preclinical manifestation of disease rather than a cause of it...
  86. ncbi Psychosocial influences on older adults' interest in participating in bowel cancer screening
    J Wardle
    ICRF Health Behaviour Unit, Department of Epidemiology and Public Health, University College, London, United Kingdom
    Prev Med 31:323-34. 2000
    ..As part of a multicenter, randomized controlled trial of the efficacy of flexible sigmoidoscopy for the prevention of bowel cancer, an investigation of the predictors of screening interest was carried out in a subsample of older adults...
  87. ncbi Development of a protocol for evaluation of mammographic surveillance services in women under 50 with a family history of breast cancer
    J Mackay
    North East Thames Regional Genetics Service, Institute of Child Health, London, UK
    J Epidemiol Biostat 6:365-9; discussion 371-5. 2001
    ..Incremental cost-effectiveness ratios of implementing the standardised mammography strategy compared with no screening will be presented in terms of the additional cost per cancer detected, per life saved and per life-year saved...
  88. ncbi Avoidance of premature death: a new definition for the proportion cured
    P D Sasieni
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London
    J Cancer Epidemiol Prev 7:165-71. 2002
    ..Interpretation of differences between countries or over time is complicated and requires consideration of incidence and mortality data...
  89. ncbi Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
    Lancet Oncol 10:501-7. 2009
    ..The main side-effect of aspirin is peptic ulcers; therefore coadministration of aspirin with a proton-pump inhibitor is an attractive option and is under investigation in the AspECT trial...
  90. ncbi International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate: a meta-analysis of 1446 patients
    Greg L Shaw
    St Bartholemew s Hospital, London, UK, and University of Western Australia, Perth, Australia
    BJU Int 99:1056-65. 2007
    ....
  91. doi A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis
    Gavin Giovannoni
    Queen Mary University London, the Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    N Engl J Med 362:416-26. 2010
    ..Cladribine provides immunomodulation through selective targeting of lymphocyte subtypes. We report the results of a 96-week phase 3 trial of a short-course oral tablet therapy in patients with relapsing-remitting multiple sclerosis...
  92. pmc Measurements of cancer extent in a conservatively treated prostate cancer biopsy cohort
    Ramzi Rajab
    Centre for Molecular Oncology and Imaging, Queen Mary University of London, UK
    Virchows Arch 457:547-53. 2010
    ..The percentage of positive cores appeared the strongest predictor and was stronger than percentage length of cancer in the cores...
  93. ncbi HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
    Elzbieta Stankiewicz
    Centre for Molecular Oncology and Imaging, Barts and the London School of Medicine and Dentistry, London, UK
    Mod Pathol 22:1160-8. 2009
    ....
  94. ncbi Cervical screening by visual inspection, HPV testing, liquid-based and conventional cytology in Amazonian Peru
    Maribel Almonte
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Int J Cancer 121:796-802. 2007
    ..VIA gives immediate results, but will require investment in regular training and supervision. Further work is needed to determine whether screened-positive women should all be treated or triaged with a more specific test...
  95. ncbi Major shifts in the treatment and prognosis of prostate cancer due to changes in pathological diagnosis and grading
    Daniel M Berney
    Department of Histopathology, St Bartholomew s Hospital, Queen Mary University of London, London, UK
    BJU Int 100:1240-4. 2007
    ..To examine data on the changes in the accuracy of the diagnosis of prostate cancer and of Gleason grading in the modern era...
  96. ncbi Anastrozole as an adjuvant endocrine treatment for postmenopausal patients with breast cancer: emerging data
    Aman U Buzdar
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:1037s-1048s. 2006
    ..These data suggest that long-term safety profiles may differ between aromatase inhibitors, although comprehensive comparative data for letrozole and exemestane versus tamoxifen are lacking...
  97. ncbi Quality of life of postmenopausal women in the ATAC ("Arimidex", tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer
    David Cella
    Feinberg School of Medicine, Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    Breast Cancer Res Treat 100:273-84. 2006
    ....
  98. ncbi Systemic adjuvant therapies for early breast cancer: 15-year results for recurrence and survival
    John F Forbes
    Med J Aust 183:447-8. 2005
  99. ncbi Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: an hypothesis-generating study
    Mitch Dowsett
    Royal Marsden Hospital London, SW3 6JJ United Kingdom
    J Clin Oncol 23:7512-7. 2005
    ..We retrospectively tested the hypothesis that this benefit might differ according to PgR status...
  100. ncbi Quality of life of postmenopausal women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial
    Lesley Fallowfield
    Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9QG, UK
    J Clin Oncol 22:4261-71. 2004
    ..To determine the quality of life (QoL) of women participating in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial during the first 2 years of treatment...