Spencer J Collis

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint The life and death of DNA-PK
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Oncogene 24:949-61. 2005
  2. ncbi request reprint Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors
    Spencer J Collis
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 63:1550-4. 2003
  3. ncbi request reprint Evasion of early cellular response mechanisms following low level radiation-induced DNA damage
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 279:49624-32. 2004
  4. ncbi request reprint Enhanced radiation response through directed molecular targeting approaches
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Metastasis Rev 23:277-92. 2004
  5. ncbi request reprint Novel therapeutic strategies in prostate cancer management using gene therapy in combination with radiation therapy
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    World J Urol 21:275-89. 2003
  6. ncbi request reprint Hematopoietic progenitor stem cell homing in mice lethally irradiated with ionizing radiation at differing dose rates
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Radiat Res 162:48-55. 2004
  7. ncbi request reprint Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha
    David Z Qian
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 66:8814-21. 2006
  8. ncbi request reprint HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
    Spencer J Collis
    DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms, EN6 3LD, UK
    Nat Cell Biol 9:391-401. 2007
  9. ncbi request reprint Emerging links between the biological clock and the DNA damage response
    Spencer J Collis
    DNA Damage Response Lab, Clare Hall Laboratories, Cancer Research UK, Blanch Lane, South Mimms, EN6 3LD, UK
    Chromosoma 116:331-9. 2007
  10. ncbi request reprint C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair
    Spencer J Collis
    DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK
    DNA Repair (Amst) 5:1398-406. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The life and death of DNA-PK
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Oncogene 24:949-61. 2005
    ..This review promotes the inhibition of DNA-PK as a valid approach to enhance the tumor-cell-killing effects of treatments such as IR...
  2. ncbi request reprint Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors
    Spencer J Collis
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 63:1550-4. 2003
    ..Together, these data provide strong evidence for the potential use of siRNA as a novel radiation/chemotherapy-sensitizing agent...
  3. ncbi request reprint Evasion of early cellular response mechanisms following low level radiation-induced DNA damage
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 279:49624-32. 2004
    ....
  4. ncbi request reprint Enhanced radiation response through directed molecular targeting approaches
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Metastasis Rev 23:277-92. 2004
    ..This review will summarize current and novel gene therapy strategies that are being developed aimed at enhancing the effects of radiotherapy through the use of directed molecular targeting approaches...
  5. ncbi request reprint Novel therapeutic strategies in prostate cancer management using gene therapy in combination with radiation therapy
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    World J Urol 21:275-89. 2003
  6. ncbi request reprint Hematopoietic progenitor stem cell homing in mice lethally irradiated with ionizing radiation at differing dose rates
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Radiat Res 162:48-55. 2004
    ..Further experiments will be needed to determine whether these homed cells are as capable of giving rise to long-term engraftment/repopulation of the marrow of secondary recipients as they are in irradiated recipients...
  7. ncbi request reprint Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha
    David Z Qian
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 66:8814-21. 2006
    ..Taken together, these results suggest that class II HDACs are associated with HIF-1 alpha stability and provide a rationale for targeting HIF-1 alpha with HDAC inhibitors against class II isozymes...
  8. ncbi request reprint HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
    Spencer J Collis
    DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms, EN6 3LD, UK
    Nat Cell Biol 9:391-401. 2007
    ..We conclude that HCLK2 promotes activation of the S-phase checkpoint and downstream repair responses by preventing unscheduled Chk1 degradation by the proteasome...
  9. ncbi request reprint Emerging links between the biological clock and the DNA damage response
    Spencer J Collis
    DNA Damage Response Lab, Clare Hall Laboratories, Cancer Research UK, Blanch Lane, South Mimms, EN6 3LD, UK
    Chromosoma 116:331-9. 2007
    ..This mini review will focus on these discoveries and emphasise how such BC proteins may be involved, through their interplay with cell cycle/DNA damage response pathways, in the development of human disease such as cancer...
  10. ncbi request reprint C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair
    Spencer J Collis
    DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK
    DNA Repair (Amst) 5:1398-406. 2006
    ....
  11. ncbi request reprint Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity
    Sarah A Krueger
    Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 69:1262-71. 2007
    ..The aim of this study was to define the roles of ataxia telangiectasia mutated (ATM) activity and the downstream ATM-dependent G(2)-phase cell cycle checkpoint in overcoming HRS and triggering radiation resistance...
  12. pmc DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair
    Jillian L Youds
    DNA Damage Response Laboratory, Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms EN6 3LD, United Kingdom
    Mol Cell Biol 28:1470-9. 2008
    ..The functional conservation between DOG-1 and FANCJ suggests a possible role for FANCJ in G/C tract maintenance in human cells...
  13. doi request reprint Low-dose hyper-radiosensitivity: past, present, and future
    Brian Marples
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 70:1310-8. 2008
    ..Finally, preclinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain...
  14. pmc RTEL1 maintains genomic stability by suppressing homologous recombination
    Louise J Barber
    DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
    Cell 135:261-71. 2008
    ..We propose that loss of HR control after deregulation of RTEL1 may be a critical event that drives genome instability and cancer...