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Genomes and Genes | Spencer J CollisSummaryAffiliation: Cancer Research UK Country: UK Publications
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Publications
The life and death of DNA-PKSpencer J Collis
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
Oncogene 24:949-61. 2005..This review promotes the inhibition of DNA-PK as a valid approach to enhance the tumor-cell-killing effects of treatments such as IR...- Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factorsSpencer J Collis
Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 63:1550-4. 2003..Together, these data provide strong evidence for the potential use of siRNA as a novel radiation/chemotherapy-sensitizing agent... - Evasion of early cellular response mechanisms following low level radiation-induced DNA damageSpencer J Collis
Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Biol Chem 279:49624-32. 2004.... - Enhanced radiation response through directed molecular targeting approachesSpencer J Collis
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Metastasis Rev 23:277-92. 2004..This review will summarize current and novel gene therapy strategies that are being developed aimed at enhancing the effects of radiotherapy through the use of directed molecular targeting approaches... - Novel therapeutic strategies in prostate cancer management using gene therapy in combination with radiation therapySpencer J Collis
Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
World J Urol 21:275-89. 2003 - Hematopoietic progenitor stem cell homing in mice lethally irradiated with ionizing radiation at differing dose ratesSpencer J Collis
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Radiat Res 162:48-55. 2004..Further experiments will be needed to determine whether these homed cells are as capable of giving rise to long-term engraftment/repopulation of the marrow of secondary recipients as they are in irradiated recipients... - Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alphaDavid Z Qian
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Cancer Res 66:8814-21. 2006..Taken together, these results suggest that class II HDACs are associated with HIF-1 alpha stability and provide a rationale for targeting HIF-1 alpha with HDAC inhibitors against class II isozymes... - HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stabilitySpencer J Collis
DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms, EN6 3LD, UK
Nat Cell Biol 9:391-401. 2007..We conclude that HCLK2 promotes activation of the S-phase checkpoint and downstream repair responses by preventing unscheduled Chk1 degradation by the proteasome... - Emerging links between the biological clock and the DNA damage responseSpencer J Collis
DNA Damage Response Lab, Clare Hall Laboratories, Cancer Research UK, Blanch Lane, South Mimms, EN6 3LD, UK
Chromosoma 116:331-9. 2007..This mini review will focus on these discoveries and emphasise how such BC proteins may be involved, through their interplay with cell cycle/DNA damage response pathways, in the development of human disease such as cancer... - C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repairSpencer J Collis
DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK
DNA Repair (Amst) 5:1398-406. 2006.... - Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activitySarah A Krueger
Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
Int J Radiat Oncol Biol Phys 69:1262-71. 2007..The aim of this study was to define the roles of ataxia telangiectasia mutated (ATM) activity and the downstream ATM-dependent G(2)-phase cell cycle checkpoint in overcoming HRS and triggering radiation resistance... 
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repairJillian L Youds
DNA Damage Response Laboratory, Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms EN6 3LD, United Kingdom
Mol Cell Biol 28:1470-9. 2008..The functional conservation between DOG-1 and FANCJ suggests a possible role for FANCJ in G/C tract maintenance in human cells...
Low-dose hyper-radiosensitivity: past, present, and futureBrian Marples
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
Int J Radiat Oncol Biol Phys 70:1310-8. 2008..Finally, preclinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain...- RTEL1 maintains genomic stability by suppressing homologous recombinationLouise J Barber
DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Cell 135:261-71. 2008..We propose that loss of HR control after deregulation of RTEL1 may be a critical event that drives genome instability and cancer...