Claude Chelala

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets
    Claude Chelala
    Centre for Molecular Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London School of Medicine QMUL, Charterhouse Square London EC1M 6BQ, UK
    BMC Genomics 8:439. 2007
  2. doi A web-based platform for mining pancreatic expression datasets
    Claude Chelala
    Centre for Molecular Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London School of Medicine QMUL, London, UK
    Pancreatology 9:340-3. 2009
  3. pmc SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms
    Claude Chelala
    Centre for Molecular Oncology and Imaging, Institute of Cancer and CR UK Clinical Centre, Barts and The London School of Medicine QMUL, Charterhouse Square, London EC1M 6BQ, UK
    Bioinformatics 25:655-61. 2009
  4. ncbi The pancreatic expression database: recent extensions and updates
    Abu Z Dayem Ullah
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK and Molecular GI Onkologie MGO, University of Bochum, Germany
    Nucleic Acids Res 42:D944-9. 2014
  5. pmc O-miner: an integrative platform for automated analysis and mining of -omics data
    Rosalind J Cutts
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nucleic Acids Res 40:W560-8. 2012
  6. pmc Using BioMart as a framework to manage and query pancreatic cancer data
    Rosalind J Cutts
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Database (Oxford) 2011:bar024. 2011
  7. ncbi Identification of ZDHHC14 as a novel human tumour suppressor gene
    Marc Yeste-Velasco
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
    J Pathol 232:566-77. 2014
  8. pmc A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws
    Emanuela Gadaleta
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK
    Nucleic Acids Res 39:7900-7. 2011
  9. doi Genome-wide analysis of pancreatic cancer using microarray-based techniques
    Tomohiko Harada
    Centre for Molecular Oncology, Cancer Research UK, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Pancreatology 9:13-24. 2009
  10. pmc The Pancreatic Expression database: 2011 update
    Rosalind J Cutts
    Centre for Molecular Oncology and Imaging, Institute of Cancer and CR UK Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nucleic Acids Res 39:D1023-8. 2011

Collaborators

Detail Information

Publications22

  1. pmc Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets
    Claude Chelala
    Centre for Molecular Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London School of Medicine QMUL, Charterhouse Square London EC1M 6BQ, UK
    BMC Genomics 8:439. 2007
    ....
  2. doi A web-based platform for mining pancreatic expression datasets
    Claude Chelala
    Centre for Molecular Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London School of Medicine QMUL, London, UK
    Pancreatology 9:340-3. 2009
    ....
  3. pmc SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms
    Claude Chelala
    Centre for Molecular Oncology and Imaging, Institute of Cancer and CR UK Clinical Centre, Barts and The London School of Medicine QMUL, Charterhouse Square, London EC1M 6BQ, UK
    Bioinformatics 25:655-61. 2009
    ....
  4. ncbi The pancreatic expression database: recent extensions and updates
    Abu Z Dayem Ullah
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK and Molecular GI Onkologie MGO, University of Bochum, Germany
    Nucleic Acids Res 42:D944-9. 2014
    ..Interoperability with biomart-compatible data sets was significantly improved to allow integrative queries with pancreatic cancer data. ..
  5. pmc O-miner: an integrative platform for automated analysis and mining of -omics data
    Rosalind J Cutts
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nucleic Acids Res 40:W560-8. 2012
    ..Here we describe the analytical workflows currently available using O-miner and present examples of use. O-miner is freely available at www.o-miner.org...
  6. pmc Using BioMart as a framework to manage and query pancreatic cancer data
    Rosalind J Cutts
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Database (Oxford) 2011:bar024. 2011
    ..This article is intended to give an overview of PED, describe its data content and work through examples of how to successfully mine and integrate pancreatic cancer data sets and other BioMart resources...
  7. ncbi Identification of ZDHHC14 as a novel human tumour suppressor gene
    Marc Yeste-Velasco
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
    J Pathol 232:566-77. 2014
    ....
  8. pmc A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws
    Emanuela Gadaleta
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK
    Nucleic Acids Res 39:7900-7. 2011
    ..It stresses the importance of a global-systems approach to assess and maximise findings from expression profiling of malignant and non-malignant diseases...
  9. doi Genome-wide analysis of pancreatic cancer using microarray-based techniques
    Tomohiko Harada
    Centre for Molecular Oncology, Cancer Research UK, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Pancreatology 9:13-24. 2009
    ..Recent advances in bioinformatics tools enable us to perform a robust and highly sensitive analysis of array CGH data and facilitate the discovery of novel cancer-related genes...
  10. pmc The Pancreatic Expression database: 2011 update
    Rosalind J Cutts
    Centre for Molecular Oncology and Imaging, Institute of Cancer and CR UK Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nucleic Acids Res 39:D1023-8. 2011
    ..We also focus on the importance of data sharing and interoperability in the cancer field, and the integration of PED into the International Cancer Genome Consortium (ICGC) data portal...
  11. doi Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia
    Manu Gupta
    Cancer Genomics Unit, Medical Oncology Centre, Barts and the London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Genes Chromosomes Cancer 47:729-39. 2008
    ..This study demonstrates aUPD is a frequent and significant finding in AML and pinpoints regions that may contain novel mutational targets...
  12. doi S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells
    Sayka Barry
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Clin Exp Metastasis 30:251-64. 2013
    ..Thus S100P facilitates cancer cell intravasation/extravasation, critical steps in the hematogenous dissemination of pancreatic cancer cells...
  13. doi A practical guide for the functional annotation of genetic variations using SNPnexus
    Abu Z Dayem Ullah
    Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK
    Brief Bioinform 14:437-47. 2013
    ..We focus on the SNPnexus query system, its annotation categories and the biological interpretation of results. ..
  14. pmc SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update)
    Abu Z Dayem Ullah
    Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK
    Nucleic Acids Res 40:W65-70. 2012
    ..SNPnexus is freely available at http://www.snp-nexus.org...
  15. doi Online resources of cancer data: barriers, benefits and lessons
    Emanuela Gadaleta
    Barts and the London School of Medicine, QMUL, London, UK
    Brief Bioinform 12:52-63. 2011
    ..Some of the considerations to be addressed when building interoperable, sustainable cancer resources will be discussed with case studies-hoping this will prove useful for researchers designing their own cancer databases...
  16. pmc CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells
    Yaohe Wang
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    J Clin Invest 119:1604-15. 2009
    ....
  17. pmc p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker
    Magdalena B Flak
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine, Queen Mary University of London, London EC1 M 6BQ, UK
    Mol Cancer 9:175. 2010
    ..These results highlight that host cell factors beyond simple infectivity can influence the efficacy of oncolytic adenoviruses. p21 expression may be an important biomarker of response in clinical trials...
  18. doi Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia
    Manoj Raghavan
    Medical Oncology Unit, Centre for Molecular Oncology, Institute of Cancer, Barts and the London School of Medicine and Dentistry, London, UK
    Blood 112:814-21. 2008
    ..We conclude that acquisition of segmental UPD and the resulting homozygous mutation is a common event associated with relapse of AML...
  19. ncbi S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    Patrick C Mahon
    Centre for Molecular Oncology, Institute of Cancer and the Cancer Research UK Clinical Centre, Barts and the London School of Medicine, London, United Kingdom
    Cancer Res 67:6786-95. 2007
    ..These findings provide evidence that supports a novel role for S100A4 as a prosurvival factor in pancreatic cancer...
  20. ncbi PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits
    Claude Chelala
    Genetics of Infectious and Autoimmune Diseases, INSERM U730, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris 15, France
    Diabetes 56:522-6. 2007
    ....
  21. ncbi Sex-linked recombination variation and distribution of disease-related genes
    Claude Chelala
    Genexpress, Functional Genomics and Systems Biology for Health, CNRS UMR 7091 7, rue Guy Moquet, BP8, 94801 Villejuif Cedex, France
    Gene 346:29-39. 2005
    ....
  22. pmc Integrative annotation of 21,037 human genes validated by full-length cDNA clones
    Tadashi Imanishi
    Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
    PLoS Biol 2:e162. 2004
    ..The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology...