D Timothy Bishop

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Geographical variation in the penetrance of CDKN2A mutations for melanoma
    D Timothy Bishop
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    J Natl Cancer Inst 94:894-903. 2002
  2. pmc Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
  3. pmc Patterns of expression of DNA repair genes and relapse from melanoma
    Rosalyn Jewell
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 16:5211-21. 2010
  4. pmc The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James s Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Cancer Causes Control 22:1471-82. 2011
  5. pmc A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL)
    Mark Harland
    Division of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Cancer Centre at Leeds, St James s University Hospital, Leeds, UK
    Eur J Cancer 44:1269-74. 2008
  6. ncbi request reprint No Evidence for BRAF as a melanoma/nevus susceptibility gene
    Sharon Jackson
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:913-8. 2005
  7. pmc Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma
    Caroline Conway
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 49:425-38. 2010
  8. pmc DNA repair gene XRCC1 polymorphisms and bladder cancer risk
    Sei Chung Sak
    Molecular Radiobiology Group, Section of Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    BMC Genet 8:13. 2007
  9. ncbi request reprint Prevalence of 9p21 deletions in UK melanoma families
    Sushila H Mistry
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre in Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Genes Chromosomes Cancer 44:292-300. 2005
  10. pmc Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Pigment Cell Melanoma Res 25:384-94. 2012

Detail Information

Publications31

  1. ncbi request reprint Geographical variation in the penetrance of CDKN2A mutations for melanoma
    D Timothy Bishop
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    J Natl Cancer Inst 94:894-903. 2002
    ..We examined the penetrance of such mutations using data from eight groups from Europe, Australia and the United States that are part of The Melanoma Genetics Consortium...
  2. pmc Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
    ..6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series...
  3. pmc Patterns of expression of DNA repair genes and relapse from melanoma
    Rosalyn Jewell
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 16:5211-21. 2010
    ..To use gene expression profiling of formalin-fixed primary melanoma samples to detect expression patterns that are predictive of relapse and response to chemotherapy...
  4. pmc The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James s Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Cancer Causes Control 22:1471-82. 2011
    ..We report the determinants of serum levels of vitamin D in a U.K. melanoma case-control study benefitting from detailed exposure and genotyping data...
  5. pmc A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL)
    Mark Harland
    Division of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Cancer Centre at Leeds, St James s University Hospital, Leeds, UK
    Eur J Cancer 44:1269-74. 2008
    ..The relatively low rate of CDKN2A mutation detection is not due to failure to detect mutations and implies the existence of other high penetrance melanoma susceptibility genes...
  6. ncbi request reprint No Evidence for BRAF as a melanoma/nevus susceptibility gene
    Sharon Jackson
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:913-8. 2005
    ..In addition, we found that there was no association between the BRAF genotype and mean total number of banal or atypical nevi in either the cases or controls...
  7. pmc Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma
    Caroline Conway
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 49:425-38. 2010
    ..There was no association between reduced gene dosage at 9p21.3 and subtype or site of tumor. This study presents supportive evidence that CDKN2B, P14ARF, and CDKN2A may all play a tumor suppressor role in melanoma progression...
  8. pmc DNA repair gene XRCC1 polymorphisms and bladder cancer risk
    Sei Chung Sak
    Molecular Radiobiology Group, Section of Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    BMC Genet 8:13. 2007
    ..To clarify the situation, we conducted a comprehensive analysis of 14 XRCC1 polymorphisms in a case-control study involving more than 1100 subjects...
  9. ncbi request reprint Prevalence of 9p21 deletions in UK melanoma families
    Sushila H Mistry
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre in Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Genes Chromosomes Cancer 44:292-300. 2005
    ..Deletions at 9p21 are rare and explain only a small proportion of melanoma susceptibility. This study is the first to comprehensively exclude deletions in melanoma-prone families with no previously identified CDKN2A mutations...
  10. pmc Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Pigment Cell Melanoma Res 25:384-94. 2012
    ..78; 95% CI, 0.65-0.94) with some support from the nine smaller data sets considered together (HR, 0.83; 95% CI, 0.67-1.04). The data are suggestive of a survival benefit for inherited MC1R variants in melanoma patients...
  11. pmc Analysis of variants in DNA damage signalling genes in bladder cancer
    Ananya Choudhury
    Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, Leeds, LS9 7TF, UK
    BMC Med Genet 9:69. 2008
    ..We hypothesized that SNPs in DSB signalling genes may modulate predisposition to bladder cancer and influence the effects of environmental exposures...
  12. pmc Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls
    Yu Mei Chang
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, UK
    Int J Epidemiol 38:814-30. 2009
    ..Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude...
  13. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
    ..Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk...
  14. pmc Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Cancer 47:732-41. 2011
    ..A melanoma case-control study was conducted to elucidate the complex relationship between sun exposure and risk...
  15. ncbi request reprint A mutation hotspot at the p14ARF splice site
    Mark Harland
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Beckett Street, Leeds LS9 7TF, England
    Oncogene 24:4604-8. 2005
    ..Further investigation into the spectrum of mutations observed in this gene may help clarify the exact role of p14ARF in melanoma predisposition...
  16. ncbi request reprint An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype
    Chandra Gooptu Bertram
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Leeds, UK
    J Invest Dermatol 122:429-32. 2004
    ..The previous association between XRCC3 and melanoma may be a result of the choice of control group and we emphasize the need for appropriate choice of controls...
  17. ncbi request reprint Sun-protective behaviors in families at increased risk of melanoma
    Julia A Newton Bishop
    Genetic Epidemiology Division, Cancer Research UK, St James s University Hospital, Leeds, UK
    J Invest Dermatol 127:1343-50. 2007
    ....
  18. ncbi request reprint Management of familial melanoma
    Julia Newton Bishop
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Lancet Oncol 8:46-54. 2007
    ..Prevention advice to families relates to moderation of sun exposure and self-examination of naevi, although there are few supportive data...
  19. ncbi request reprint Comprehensive analysis of 22 XPC polymorphisms and bladder cancer risk
    Sei Chung Sak
    Molecular Radiobiology Group, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:2537-41. 2006
    ..05-2.59), 1.82 (1.12-2.97), and 1.82 (1.12-2.96), respectively]. The associations were somewhat stronger for smokers and those occupationally exposed to chemicals, although tests for gene-environment interactions were not significant...
  20. pmc A variant in FTO shows association with melanoma risk not due to BMI
    Mark M Iles
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 45:428-32, 432e1. 2013
    ..This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity...
  21. pmc Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival
    Caroline Conway
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 15:6939-46. 2009
    ..The purpose of this study was to evaluate the Illumina DASL Array Human Cancer Panel for gene expression studies in formalin-fixed melanoma primary tumors and to identify prognostic biomarkers...
  22. pmc Strategies for selecting subsets of single-nucleotide polymorphisms to genotype in association studies
    Joe M Butler
    Cancer Research UK Genetic Epidemiology Division, University of Leeds, Cancer Genetics Building, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    BMC Genet 6:S72. 2005
    ..An initial sample size of 50 individuals is sufficient in most situations investigated, which involved selection from a set of 7 SNPs, although to select a larger number of SNPs, a larger initial sample size may be required...
  23. pmc Environmental risk factors for relapse of melanoma
    Samantha Beswick
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, United Kingdom
    Eur J Cancer 44:1717-25. 2008
    ..To identify lifestyle factors affecting risk of relapse...
  24. ncbi request reprint The genetics of susceptibility to cutaneous melanoma
    Julia A Newton Bishop
    Division of Genetic Epidemiology, Cancer Research UK, St James s Hospital, Leeds, UK
    Drugs Today (Barc) 41:193-203. 2005
    ..There is evidence of one at 1p22. The Melanoma Genetics Consortium (www.genomel.org) continues to explore this and the genetic epidemiology of the CDKN2A locus...
  25. ncbi request reprint The effect of sun exposure in determining nevus density in UK adolescent twins
    Rachel C Wachsmuth
    Genetic Epidemiology Division, Cancer Research UK, St James s University Hospital, Leeds, UK
    J Invest Dermatol 124:56-62. 2005
    ..Of the 25% of variation attributable to environmental influences, one-third is estimated to be because of sun exposure on hot holidays...
  26. ncbi request reprint Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer
    Faye Turner
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Int J Cancer 112:259-64. 2004
    ..06), GSTP1 (p=0.16, with p=0.02 after adjustment for potential confounders) and NQO1 predicted phenotype (p=0.01). Because of the multiple hypotheses tested in our study, these findings require independent confirmation...
  27. ncbi request reprint Genome-wide linkage screen for testicular germ cell tumour susceptibility loci
    Gillian P Crockford
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Hum Mol Genet 15:443-51. 2006
    ..Overall, the results indicate that no single major locus can account for the majority of the familial aggregation of TGCT, and suggests that multiple susceptibility loci with weak effects contribute to the disease...
  28. ncbi request reprint An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele
    Chandra G Bertram
    Division of Genetic Epidemiology, Cancer Research UK Clinical Center in Leeds, St James s University Hospital, Leeds, U K
    J Invest Dermatol 119:961-5. 2002
    ..5 nevi in those without, p = 0.02). After allowing for potential confounders this was not evident in the population-based sample...
  29. ncbi request reprint Intronic sequence variants of the CDKN2A gene in melanoma pedigrees
    Mark Harland
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, England
    Genes Chromosomes Cancer 43:128-36. 2005
    ..IVS1 + 1104 was shown to result in the aberrant splicing of both p16(INK4a) and p14(ARF) mRNA. Overall, however, the proportion of English melanoma families with these variants is small...
  30. doi request reprint Design considerations for genetic linkage and association studies
    Jeremie Nsengimana
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, Leeds, UK
    Methods Mol Biol 850:237-62. 2012
    ..Differential bias could be a more serious threat and must be minimised by strictly controlling all the aspects of DNA acquisition, storage, and processing...
  31. ncbi request reprint Enhanced linkage of a locus on chromosome 2 to premature coronary artery disease in the absence of hypercholesterolemia
    Jeremie Nsengimana
    Genetic Epidemiology Division, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Hum Genet 15:313-9. 2007
    ..Candidate genes include the interleukin 1 cluster and two potential regulators of high-density lipoprotein cholesterol level, PLA2R1 and OSBPL6...