Deborah E Barnes

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint DNA damage: air-breaks?
    Deborah E Barnes
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Curr Biol 12:R262-4. 2002
  2. pmc C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases
    Qian An
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK
    EMBO J 24:2205-13. 2005
  3. ncbi request reprint Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors
    Yali Xie
    Department of Microbiology, Immunology, and Molecular Genetics and The Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
    Cancer Res 64:3096-102. 2004
  4. ncbi request reprint Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    Deborah E Barnes
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Annu Rev Genet 38:445-76. 2004
  5. ncbi request reprint 5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity
    Qian An
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, UK
    Cancer Res 67:940-5. 2007
  6. doi request reprint Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease
    Tomas Lindahl
    Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Herts, UK
    Biochem Soc Trans 37:535-8. 2009
  7. pmc Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
    Masashi Morita
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Mol Cell Biol 24:6719-27. 2004
  8. ncbi request reprint Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    Yun gui Yang
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Cell 131:873-86. 2007
  9. ncbi request reprint Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
    Hilde Nilsen
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Oncogene 22:5381-6. 2003
  10. ncbi request reprint Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    Cristina Rada
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Curr Biol 12:1748-55. 2002

Collaborators

  • Tomas Lindahl
  • Hilde Nilsen
  • Hans E Krokan
  • Masashi Morita
  • Han G Brunner
  • Patricia J Gearhart
  • Jeffrey Miller
  • Xianmin Zeng
  • M S Neuberger
  • Richard Fishel
  • Qian An
  • Peter Robins
  • Yun gui Yang
  • Yanick J Crow
  • Maria Teresa Russo
  • Yali Xie
  • Hanjing Yang
  • David B Winter
  • Cristina Rada
  • John H Livingston
  • Jean Francois Meritet
  • Bruce E Hayward
  • Peter C Corry
  • Deborah N Black
  • Frances M Cowan
  • Rekha Parmar
  • Gerard Ponsot
  • Roger F Massey
  • Andrew P Jackson
  • Sally Ann Lynch
  • Suzanne G Frints
  • David T Bonthron
  • Andrea Leitch
  • Pierre Lebon
  • Manir Ali
  • Thomas Voit
  • Jacques L Michaud
  • Hans van Bokhoven
  • Ben C Hamel
  • Joerg Klepper
  • Cristina Cunanan
  • Darryl Shibata
  • Margherita Bignami
  • Paolo Degan
  • Janet Pan
  • Kimberly Okamoto
  • Michael McIlhatton
  • Eugenia Dogliotti
  • Eleonora Parlanti
  • Gabriele De Luca
  • Erling Seeberg
  • Quy H Phung
  • Gareth T Williams

Detail Information

Publications13

  1. ncbi request reprint DNA damage: air-breaks?
    Deborah E Barnes
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Curr Biol 12:R262-4. 2002
    ..Modulating the level of molecular oxygen and its reactive metabolites demonstrates that oxygen metabolism is a major source of genomic instability...
  2. pmc C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases
    Qian An
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK
    EMBO J 24:2205-13. 2005
    ..Such cells are also hypersensitive to ionizing radiation, and reveal a role of Smug1 in the repair of lesions generated by oxidation of cytosine...
  3. ncbi request reprint Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors
    Yali Xie
    Department of Microbiology, Immunology, and Molecular Genetics and The Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
    Cancer Res 64:3096-102. 2004
    ..The mice described here provide a valuable model for studying the mechanisms of oxidative DNA damage in tumorigenesis and investigating preventive or therapeutic approaches...
  4. ncbi request reprint Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    Deborah E Barnes
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Annu Rev Genet 38:445-76. 2004
    ..The genetic instability characteristic of cancer cells may be due, in part, to mutations in genes whose products normally function to ensure DNA integrity...
  5. ncbi request reprint 5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity
    Qian An
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, UK
    Cancer Res 67:940-5. 2007
    ..The data provides a clearer understanding of the action of FU, suggesting predictive biomarkers of drug response and a mechanism for acquired resistance in tumors...
  6. doi request reprint Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease
    Tomas Lindahl
    Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Herts, UK
    Biochem Soc Trans 37:535-8. 2009
    ....
  7. pmc Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
    Masashi Morita
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Mol Cell Biol 24:6719-27. 2004
    ..Unexpectedly, Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure...
  8. ncbi request reprint Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    Yun gui Yang
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Cell 131:873-86. 2007
    ..Our data indicate that Trex1 acts on a single-stranded DNA polynucleotide species generated from processing of aberrant replication intermediates to attenuate DNA damage checkpoint signaling and prevent pathological immune activation...
  9. ncbi request reprint Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
    Hilde Nilsen
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Oncogene 22:5381-6. 2003
    ..Furthermore, they support a specific role for Ung in the immune system, with lymphomagenesis being related to perturbed processing of antibody genes in germinal centre B cells...
  10. ncbi request reprint Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    Cristina Rada
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Curr Biol 12:1748-55. 2002
    ..A major resolution mode involves excising the uracil, an activity that at least four different enzymes can accomplish in the mouse...
  11. ncbi request reprint Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases
    Maria Teresa Russo
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Rome, Italy
    Cancer Res 64:4411-4. 2004
    ..Because there is an increased incidence of lung and small intestine cancer in Myh(-/-)/Ogg1(-/-) mice, these findings support a causal role for unrepaired oxidized DNA bases in cancer development...
  12. ncbi request reprint Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase
    David B Winter
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 170:5558-62. 2003
    ..These findings show that hypermutation is unaffected in the absence of Ogg1 activity and indicate that 8-hydroxyguanine lesions most likely do not cause V gene mutations...
  13. ncbi request reprint Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus
    Yanick J Crow
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Nat Genet 38:917-20. 2006
    ..Our findings suggest an unanticipated role for TREX1 in processing or clearing anomalous DNA structures, failure of which results in the triggering of an abnormal innate immune response...