Douglas G Altman

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. pmc LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
  2. pmc Decision tools in health care: focus on the problem, not the solution
    Joseph Liu
    Cancer Research UK NHS Centre for Statistics in Medicine, Oxford University, UK
    BMC Med Inform Decis Mak 6:4. 2006
  3. pmc Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol
    Diana Eccles
    Somers Cancer Sciences Building Mail Point 824, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YA, UK
    BMC Cancer 7:160. 2007
  4. pmc Endorsement of the CONSORT statement by high impact medical journals: survey of instructions for authors
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD
    BMJ 330:1056-7. 2005
  5. pmc Standard deviations and standard errors
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD
    BMJ 331:903. 2005
  6. ncbi Why we need confidence intervals
    Douglas G Altman
    NHS Cancer Research UK Centre for Statistics in Medicine, Old Road Campus, Headington, Oxford OX3 7LF, UK
    World J Surg 29:554-6. 2005
  7. ncbi Improving design and analysis of research: lessons from clinical research
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford OX3 7LF, UK
    Altern Lab Anim 32:31-9. 2004
  8. ncbi [Randomization and comparison of final quality in clinical studies]
    Douglas G Altman
    Medical Statistics Laboratory, Imperial Cancer Research Fund, London
    Z Arztl Fortbild Qualitatssich 99:629-34. 2005
  9. pmc Interaction revisited: the difference between two estimates
    Douglas G Altman
    Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Institute for Health Sciences, Oxford OX3 7LF
    BMJ 326:219. 2003
  10. ncbi [Developing guidelines for reporting healthcare research: scientific rationale and procedures]
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College, Oxford, Reino Unido
    Med Clin (Barc) 125:8-13. 2005

Detail Information

Publications106 found, 100 shown here

  1. pmc LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
    ..The secondary objectives are to describe, for published RCTs, (1) the reporting of loss to follow-up information, (2) the analytic methods used for handling loss to follow-up information, and (3) the extent of reported loss to follow-up...
  2. pmc Decision tools in health care: focus on the problem, not the solution
    Joseph Liu
    Cancer Research UK NHS Centre for Statistics in Medicine, Oxford University, UK
    BMC Med Inform Decis Mak 6:4. 2006
    ..The generic term, 'decision tool' (DT), is therefore suggested to demonstrate that these aids, which seem different technically, are conceptually the same from a clinical viewpoint...
  3. pmc Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol
    Diana Eccles
    Somers Cancer Sciences Building Mail Point 824, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YA, UK
    BMC Cancer 7:160. 2007
    ..The primary aim of the POSH study is to establish whether genetic status influences the prognosis of primary breast cancer independently of known prognostic factors...
  4. pmc Endorsement of the CONSORT statement by high impact medical journals: survey of instructions for authors
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD
    BMJ 330:1056-7. 2005
  5. pmc Standard deviations and standard errors
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD
    BMJ 331:903. 2005
  6. ncbi Why we need confidence intervals
    Douglas G Altman
    NHS Cancer Research UK Centre for Statistics in Medicine, Old Road Campus, Headington, Oxford OX3 7LF, UK
    World J Surg 29:554-6. 2005
    ..They are especially useful for avoiding misinterpretation of nonsignificant results of small studies. CIs should be provided routinely for the main results of trials and observational studies...
  7. ncbi Improving design and analysis of research: lessons from clinical research
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford OX3 7LF, UK
    Altern Lab Anim 32:31-9. 2004
    ..Published reviews of the quality of design and analysis in clinical studies are used to see what lessons can be drawn in respect of animal research. The need for clear and full reporting of research is discussed...
  8. ncbi [Randomization and comparison of final quality in clinical studies]
    Douglas G Altman
    Medical Statistics Laboratory, Imperial Cancer Research Fund, London
    Z Arztl Fortbild Qualitatssich 99:629-34. 2005
  9. pmc Interaction revisited: the difference between two estimates
    Douglas G Altman
    Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Institute for Health Sciences, Oxford OX3 7LF
    BMJ 326:219. 2003
  10. ncbi [Developing guidelines for reporting healthcare research: scientific rationale and procedures]
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College, Oxford, Reino Unido
    Med Clin (Barc) 125:8-13. 2005
    ..We describe recommended processes to produce guidelines that have evolved over several years during the preparation of a sequence of reporting guidelines including CONSORT, QUOROM, STARD and STROBE...
  11. ncbi Commentary: Systematic reviewers face challenges from varied study designs
    Douglas G Altman
    Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Institute of Health Sciences, Oxford OX3 7LF
    BMJ 325:461. 2002
  12. ncbi [Diagnostic (STARD) and prognostic (REMARK) studies]
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College, Oxford, Reino Unido
    Med Clin (Barc) 125:49-55. 2005
    ..We describe initiatives to develop reporting guidelines for diagnostic accuracy studies (STARD) and tumour marker prognostic studies (REMARK)...
  13. pmc Treatment allocation by minimisation
    Douglas G Altman
    Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Oxford OX3 7LF
    BMJ 330:843. 2005
  14. pmc Meta-analysis, Simpson's paradox, and the number needed to treat
    Douglas G Altman
    Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford, UK
    BMC Med Res Methodol 2:3. 2002
    ..There is debate concerning methods for calculating numbers needed to treat (NNT) from results of systematic reviews...
  15. pmc Missing data
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Oxford OX2 6UD
    BMJ 334:424. 2007
  16. ncbi Poor-quality medical research: what can journals do?
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, England
    JAMA 287:2765-7. 2002
    ..In 1994 I observed that research papers commonly contain methodological errors, report results selectively, and draw unjustified conclusions. Here I revisit the topic and suggest how journal editors can help...
  17. ncbi How statistical expertise is used in medical research
    Douglas G Altman
    Centre for Statistics in Medicine, Cancer Research UK NHS, Institute of Health Sciences, Old Rd, Headington, Oxford OX3 7LF, England
    JAMA 287:2817-20. 2002
    ..Investigation of the nature and frequency of statistician involvement in medical research and its relation to the final editorial decision...
  18. ncbi Primer: an evidence-based approach to prognostic markers
    Douglas G Altman
    Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Wolfson College, Oxford, UK
    Nat Clin Pract Oncol 2:466-72. 2005
    ..Prospectively planned pooled analyses of high-quality studies, along with general availability of individual patient data and adherence to reporting guidelines, would help alleviate many of these problems...
  19. pmc The cost of dichotomising continuous variables
    Douglas G Altman
    Cancer Research UK NHS Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD
    BMJ 332:1080. 2006
  20. ncbi Polyp measurement and size categorisation by CT colonography: effect of observer experience in a multi-centre setting
    David Burling
    Intestinal Imaging Centre, St Marks Hospital, London, UK
    Eur Radiol 16:1737-44. 2006
    ..e. large polyps misclassified as medium). Caution should be exercised for polyps whose colonographic diameter is below but close to the 1-cm boundary threshold in order to avoid potential miscategorisation of advanced adenomas...
  21. pmc Reporting on covariate adjustment in randomised controlled trials before and after revision of the 2001 CONSORT statement: a literature review
    Ly Mee Yu
    Centre for Statistics in Medicine, University of Oxford, Wolfson College Annexe, Oxford, UK
    Trials 11:59. 2010
    ..To evaluate the use and reporting of adjusted analysis in randomised controlled trials (RCTs) and compare the quality of reporting before and after the revision of the CONSORT Statement in 2001...
  22. pmc Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR Network
    Iveta Simera
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    BMC Med 8:24. 2010
    ..This paper outlines EQUATOR's goals and activities and offers suggestions for organizations and individuals involved in health research on how to strengthen research reporting...
  23. doi The EQUATOR Network and reporting guidelines: Helping to achieve high standards in reporting health research studies
    Iveta Simera
    Centre for Statistics in Medicine, Oxford, UK
    Maturitas 63:4-6. 2009
    ....
  24. pmc Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration
    Douglas G Altman
    Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
    PLoS Med 9:e1001216. 2012
    ..The paper provides a comprehensive overview to educate on good reporting and provide a valuable reference of issues to consider when designing, conducting, and analyzing tumor marker studies and prognostic studies in medicine in general...
  25. pmc Comparison of techniques for handling missing covariate data within prognostic modelling studies: a simulation study
    Andrea Marshall
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    BMC Med Res Methodol 10:7. 2010
    ..Therefore a simulation study was performed to assess the effects of different missing data techniques on the performance of a prognostic model...
  26. pmc Guidelines for reporting health research: the EQUATOR network's survey of guideline authors
    Iveta Simera
    Centre for Statistics in Medicine, Oxford, United Kingdom
    PLoS Med 5:e139. 2008
  27. ncbi Computed tomographic colonography: assessment of radiologist performance with and without computer-aided detection
    Steve Halligan
    Department of Specialist Radiology, University College Hospital, London, England
    Gastroenterology 131:1690-9. 2006
    ..However, the unavoidable interaction between CAD and the reader has not been addressed...
  28. doi Identifying patients with undetected gastro-oesophageal cancer in primary care: External validation of QCancer® (Gastro-Oesophageal)
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Linton Road, Oxford, UK
    Eur J Cancer 49:1040-8. 2013
    ..To evaluate the performance of QCancer® (Gastro-Oesophageal) for predicting the risk of undiagnosed gastro-oesophageal cancer in an independent UK cohort of patients from general practice records...
  29. pmc Reporting methods in studies developing prognostic models in cancer: a review
    Susan Mallett
    Centre for Statistics in Medicine, University of Oxford, Linton Rd, Oxford, UK
    BMC Med 8:20. 2010
    ..The reliability of models depends on informed use of statistical methods, in combination with prior knowledge of disease. We reviewed published articles to assess reporting and methods used to develop new prognostic models in cancer...
  30. pmc Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines
    Andrea Marshall
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    BMC Med Res Methodol 9:57. 2009
    ..However, the normality assumption may not be appropriate for all the parameters of interest when analysing prognostic modelling studies, such as predicted survival probabilities and model performance measures...
  31. doi Improving the reporting of randomised trials: the CONSORT Statement and beyond
    Douglas G Altman
    Centre for Statistics in Medicine, University of Oxford, Wolfson College, Linton Road, Oxford, U K
    Stat Med 31:2985-97. 2012
    ..We detail the subsequent development and extension of CONSORT and consider related initiatives aimed at improving the reliability of the medical research literature...
  32. pmc Reporting of participant flow diagrams in published reports of randomized trials
    Sally Hopewell
    Centre for Statistics in Medicine, University of Oxford, Wolfson College, Linton Road, Oxford, UK
    Trials 12:253. 2011
    ..We assessed the type and completeness of information reported in CONSORT (Consolidated Standards of Reporting Trials) flow diagrams published in current reports of randomized trials...
  33. pmc Systematic reviews of diagnostic tests in cancer: review of methods and reporting
    Susan Mallett
    Centre for Statistics in Medicine, University of Oxford, Wolfson College, Oxford OX2 6UD
    BMJ 333:413. 2006
    ..To assess the methods and reporting of systematic reviews of diagnostic tests...
  34. pmc Comparison of imputation methods for handling missing covariate data when fitting a Cox proportional hazards model: a resampling study
    Andrea Marshall
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    BMC Med Res Methodol 10:112. 2010
    ..A resampling study was performed to investigate the effects of different missing data methods on the performance of a prognostic model...
  35. pmc Reporting characteristics of non-primary publications of results of randomized trials: a cross-sectional review
    Sally Hopewell
    Centre for Statistics in Medicine, University of Oxford, Botnar Recpsearch Building, Windmill Road, Oxford, UK
    Trials 14:240. 2013
    ..Other aspects of a randomized trial's findings (that is, non-primary results) are often reported in subsequent publications...
  36. doi Method for tracking eye gaze during interpretation of endoluminal 3D CT colonography: technical description and proposed metrics for analysis
    Peter Phillips
    Health and Medical Sciences Group, University of Cumbria, Bowerham Rd, Lancaster LA1 3DJ, England
    Radiology 267:924-31. 2013
    ..To develop an eye-tracking method applicable to three-dimensional (3D) images, where the abnormality is both moving and changing in size...
  37. pmc Are peer reviewers encouraged to use reporting guidelines? A survey of 116 health research journals
    Allison Hirst
    The EQUATOR Network, Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e35621. 2012
    ..We examined journals' instructions to peer reviewers to see if and how reviewers are encouraged to use them...
  38. doi Predicting the adverse risk of statin treatment: an independent and external validation of Qstatin risk scores in the UK
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Linton Road, Oxford OX2 6UD, UK
    Heart 98:1091-7. 2012
    ..To evaluate the performance of the QStatin scores for predicting the 5-year risk of developing acute renal failure, cataract, liver dysfunction and myopathy in men and women in England and Wales receiving statins...
  39. doi Reporting clinical research: guidance to encourage accurate and transparent research reporting
    Iveta Simera
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    Maturitas 72:84-7. 2012
    ..equator-network.org)...
  40. pmc Predicting risk of osteoporotic and hip fracture in the United Kingdom: prospective independent and external validation of QFractureScores
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Oxford OX2 6UD, UK
    BMJ 342:d3651. 2011
    ..To evaluate the performance of the QFractureScores for predicting the 10 year risk of osteoporotic and hip fractures in an independent UK cohort of patients from general practice records...
  41. ncbi Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles
    An Wen Chan
    Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford, England
    JAMA 291:2457-65. 2004
    ..Selective reporting of outcomes within published studies based on the nature or direction of their results has been widely suspected, but direct evidence of such bias is currently limited to case reports...
  42. doi Reviews assessing the quality or the reporting of randomized controlled trials are increasing over time but raised questions about how quality is assessed
    Agnes Dechartres
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    J Clin Epidemiol 64:136-44. 2011
    ..Many reviews specifically aimed to assess the quality of randomized controlled trials (RCTs). We evaluated the quality of reporting in such reviews...
  43. pmc An independent and external validation of QRISK2 cardiovascular disease risk score: a prospective open cohort study
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Oxford OX2 6UD
    BMJ 340:c2442. 2010
    ....
  44. pmc Reporting performance of prognostic models in cancer: a review
    Susan Mallett
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Linton Road, Oxford OX2 6UD, UK
    BMC Med 8:21. 2010
    ..We reviewed published articles to assess the methods and reporting used to develop and evaluate performance of prognostic indices and risk groups from prognostic models...
  45. pmc The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed
    Sally Hopewell
    Centre for Statistics in Medicine, University of Oxford, Linton Road, Oxford OX2 6UD
    BMJ 340:c723. 2010
    ....
  46. pmc Diagnostic tests 4: likelihood ratios
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 329:168-9. 2004
  47. ncbi Human papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 14:34-42. 2007
    ..To compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (HPV) types for the first time in a UK screening setting...
  48. pmc Predicting the 10 year risk of cardiovascular disease in the United Kingdom: independent and external validation of an updated version of QRISK2
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Oxford OX2 6UD, UK
    BMJ 344:e4181. 2012
    ....
  49. doi Systematic review: bias in imaging studies - the effect of manipulating clinical context, recall bias and reporting intensity
    Darren Boone
    Centre for Medical Imaging, University College London, London, UK
    Eur Radiol 22:495-505. 2012
    ..In particular, those which modify or conceal sample characteristics (e.g. disease prevalence or reporting intensity) or research setting ("laboratory" versus "field"). We also investigated recall bias...
  50. doi EQUATOR: reporting guidelines for health research
    Douglas G Altman
    Centre for Statistics in Medicine, University of Oxford, Oxford OX2 6UD, UK
    Lancet 371:1149-50. 2008
  51. ncbi CT colonography interpretation times: effect of reader experience, fatigue, and scan findings in a multi-centre setting
    David Burling
    Intestinal Imaging Centre, St Marks Hospital, London, UK
    Eur Radiol 16:1745-9. 2006
    ..Technicians who report more slowly are more accurate. All groups reported faster as the study period progressed...
  52. pmc Responsible reporting of health research studies: transparent, complete, accurate and timely
    Douglas G Altman
    Centre for Statistics in Medicine, University of Oxford, UK
    J Antimicrob Chemother 65:1-3. 2010
    ..equator-network.org). Poor reporting practices can be decreased only through close collaboration of all parties involved in research and its publication; EQUATOR can facilitate the process...
  53. doi Identifying patients with undetected renal tract cancer in primary care: an independent and external validation of QCancer® (Renal) prediction model
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Linton Road, Oxford OX2 6UD, UK
    Cancer Epidemiol 37:115-20. 2013
    ..To evaluate the performance of QCancer® (Renal) for predicting the absolute risk of renal tract cancer in a large independent UK cohort of patients from general practice records...
  54. pmc Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration
    Douglas G Altman
    Centre for Statistics in Medicine, University of Oxford, UK
    BMC Med 10:51. 2012
    ..In this paper we expand on the REMARK checklist to enhance its use and effectiveness through better understanding of the intent of each item and why the information is important to report...
  55. pmc Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS)
    Simon P L Travis
    Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    Gut 61:535-42. 2012
    ..Variability in endoscopic assessment necessitates rigorous investigation of descriptors for scoring severity of ulcerative colitis (UC)...
  56. ncbi Developing a prognostic model in the presence of missing data: an ovarian cancer case study
    Taane G Clark
    Centre for Statistics in Medicine, Institute of Health Sciences, University of Oxford, Old Road, Oxford OX3 7LF, United Kingdom
    J Clin Epidemiol 56:28-37. 2003
    ..This will increase the power of an analysis and may produce models that are more statistically reliable and applicable within clinical practice...
  57. doi Ensuring trial validity by data quality assurance and diversification of monitoring methods
    Colin Baigent
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF
    Clin Trials 5:49-55. 2008
    ....
  58. doi No surgical innovation without evaluation: the IDEAL recommendations
    Peter McCulloch
    Nuffield Department of Surgery, University of Oxford, Oxford, UK
    Lancet 374:1105-12. 2009
    ..Achievement of improved design, conduct, and reporting of surgical research will need concerted action by editors, funders of health care and research, regulatory bodies, and professional societies...
  59. ncbi The design of simulation studies in medical statistics
    Andrea Burton
    Cancer Research UK NHS Centre for Statistics in Medicine, Oxford, UK
    Stat Med 25:4279-92. 2006
    ..A checklist highlighting the important considerations when designing a simulation study is provided. A small review of the literature identifies the current practices within published simulation studies...
  60. pmc Identifying patients with undetected pancreatic cancer in primary care: an independent and external validation of QCancer(®) (Pancreas)
    Gary S Collins
    Centre for Statistics in Medicine, Oxford, UK
    Br J Gen Pract 63:636-42. 2013
    ..Despite its rarity, the prognosis of pancreatic cancer is very poor and it is a major cause of cancer mortality; being ranked fourth in the world, it has one of the worst survival rates of any cancer...
  61. doi Agreed statistics: measurement method comparison
    J Martin Bland
    Department of Health Sciences, University of York, Heslington, York, United Kingdom
    Anesthesiology 116:182-5. 2012
    ..The use of correlation is misleading. An alternative approach, based on graphical techniques and simple calculations, is described, together with the relation between this analysis and the assessment of repeatability...
  62. pmc An independent external validation and evaluation of QRISK cardiovascular risk prediction: a prospective open cohort study
    Gary S Collins
    Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Oxford OX2 6UD
    BMJ 339:b2584. 2009
    ..To independently evaluate the performance of the QRISK score for predicting 10 year risk of cardiovascular disease in an independent UK cohort of patients from general practice and compare the performance with Framingham equations...
  63. ncbi CT colonography in the detection of colorectal polyps and cancer: systematic review, meta-analysis, and proposed minimum data set for study level reporting
    Steve Halligan
    Department of Specialist Radiology, University College Hospital, Euston Rd, London, NW1 2BU, England
    Radiology 237:893-904. 2005
    ..To assess the methodologic quality of available data in published reports of computed tomographic (CT) colonography by performing systematic review and meta-analysis...
  64. doi Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes
    Isabelle Boutron
    Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
    JAMA 303:2058-64. 2010
    ..Previous studies indicate that the interpretation of trial results can be distorted by authors of published reports...
  65. ncbi The Oxford Conception Study design and recruitment experience
    Cecilia Pyper
    National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
    Paediatr Perinat Epidemiol 20:51-9. 2006
    ..In addition to presenting the study design, we review the recruitment experience for the Oxford Conception Study. We have achieved sustained and effective recruitment over time by primary use of recruiting via the Internet...
  66. ncbi Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls
    Stuart J Pocock
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Lancet 359:1686-9. 2002
    ....
  67. ncbi Improving the completeness and transparency of reports of randomized trials in oral health: the CONSORT statement
    Ian Needleman
    International Centre for Evidence Based Oral Health, Unit of Periodontology, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Am J Dent 21:7-12. 2008
    ..A systematic review has shown that the quality of reporting of trials improves in journals that have adopted this guidance, although with significant variation, most likely due to differing levels of editorial adherence to it...
  68. ncbi The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, CH 3012 Bern, Switzerland
    Prev Med 45:247-51. 2007
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  69. ncbi Reporting recommendations for tumor marker prognostic studies (REMARK)
    Lisa M McShane
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, 6130 Executive Blvd, Bethesda, MD 20892 7434, USA
    J Natl Cancer Inst 97:1180-4. 2005
    ....
  70. ncbi REporting recommendations for tumour MARKer prognostic studies (REMARK)
    Lisa M McShane
    National Cancer Institute, Biometric Research Branch, DCTD, Room 8126, Executive Plaza North, MSC 7434, 6130 Executive Boulevard, Bethesda, MD 20892 7434, USA
    Eur J Cancer 41:1690-6. 2005
    ....
  71. ncbi Identification of clinically useful cancer prognostic factors: what are we missing?
    Lisa M McShane
    J Natl Cancer Inst 97:1023-5. 2005
  72. ncbi Better reporting of harms in randomized trials: an extension of the CONSORT statement
    John P A Ioannidis
    University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Ann Intern Med 141:781-8. 2004
    ..Better reporting will help readers critically appraise and interpret trial results. Journals can support this goal by revising Instructions to Authors so that they refer authors to this document...
  73. pmc Opportunities and challenges for improving the quality of reporting clinical research: CONSORT and beyond
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    CMAJ 171:349-50. 2004
  74. ncbi Analysis and reporting of factorial trials: a systematic review
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    JAMA 289:2545-53. 2003
    ....
  75. ncbi The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, University of Ottawa, Ottawa, Ontario, Canada
    Clin Oral Investig 7:2-7. 2003
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  76. pmc Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses
    Fujian Song
    Department of Public Health and Epidemiology, University of Birmingham, Birmingham B15 2TT
    BMJ 326:472. 2003
    ..To determine the validity of adjusted indirect comparisons by using data from published meta-analyses of randomised trials...
  77. ncbi Meta-analysis combining parallel and cross-over clinical trials. III: The issue of carry-over
    Francois Curtin
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, UK
    Stat Med 21:2161-73. 2002
    ....
  78. ncbi Meta-analysis combining parallel and cross-over clinical trials. II: Binary outcomes
    Francois Curtin
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, UK
    Stat Med 21:2145-59. 2002
    ..As its computation is similar in cross-over and parallel trials, it is the method of choice to pool results from parallel and cross-over trials in a combined design meta-analysis...
  79. ncbi Meta-analysis combining parallel and cross-over clinical trials. I: Continuous outcomes
    Francois Curtin
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, UK
    Stat Med 21:2131-44. 2002
    ..Differences in the weight estimation between WMD and SWMD can also accentuate the relative weight of cross-over trials, which must be considered a case of design-specific bias...
  80. ncbi Statistical methods for assessing the influence of study characteristics on treatment effects in 'meta-epidemiological' research
    Jonathan A C Sterne
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
    Stat Med 21:1513-24. 2002
    ..We show that both within- and between meta-analysis heterogeneity may be of importance in the analysis of meta-epidemiological studies, and that confounding exists between the effects of publication status and trial quality...
  81. ncbi Quantification of the completeness of follow-up
    Taane G Clark
    Lancet 359:1309-10. 2002
    ..Our measure is easy to calculate, can be illustrated pictorially, and can be used to identify subgroups with especially poor follow-up...
  82. ncbi Meta-analyses involving cross-over trials: methodological issues
    Diana R Elbourne
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 31:140-9. 2002
    ..This paper concentrates on RCTs of a different design-two-period, two-treatment cross-over trials...
  83. ncbi [Selective reporting of positive outcomes in randomised trials--secondary publication.. A comparison of protocols with published reports]
    Asbjørn Hróbjartsson
    H S Rigshopitalet, Det Nordiske Cochrane Center, University Health Network Toronto, Department of Medicine
    Ugeskr Laeger 167:3189-91. 2005
    ..Selective reporting of positive outcomes is associated with bias...
  84. ncbi Bayesian random effects meta-analysis of trials with binary outcomes: methods for the absolute risk difference and relative risk scales
    Keith O'Rourke
    Stat Med 24:2733-42; author reply 2743. 2005
    ..Conflating what Bayes actually offers to meta-analysts-a means of converting likelihood functions to credibility intervals-with the use of likelihood functions themselves to summarize, contrast and combine studies is at best misleading...
  85. ncbi Agreement between methods of measurement with multiple observations per individual
    J Martin Bland
    Department of Health Sciences, University of York, York, UK
    J Biopharm Stat 17:571-82. 2007
    ..In this paper we describe methods for analysing such clustered observations, both when the underlying quantity is assumed to be changing and when it is not...
  86. ncbi Evidence-based practice in radiology: steps 3 and 4--appraise and apply systematic reviews and meta-analyses
    Steve Halligan
    Department of Specialist Radiology, University College Hospital, Podium Level 2, 235 Euston Rd, London NW1 2BU, England
    Radiology 243:13-27. 2007
    ..They also explain how systematic review can help guide methodologic development for future research...
  87. pmc Epidemiology and reporting characteristics of systematic reviews
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    PLoS Med 4:e78. 2007
    ..We set out to capture a representative cross-sectional sample of published SRs and examine them in terms of a broad range of epidemiological, descriptive, and reporting characteristics, including emerging aspects not previously examined...
  88. ncbi REporting recommendations for tumor MARKer prognostic studies (REMARK)
    Lisa M McShane
    Biometric Research Branch, DCTD, National Cancer Institute, Room 8126, Executive Plaza North, 6130 Executive Boulevard, Bethesda, MD 20892 7434, USA
    Breast Cancer Res Treat 100:229-35. 2006
    ....
  89. ncbi Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement
    Gilda Piaggio
    Statistics and Informatics Services Group, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    JAMA 295:1152-60. 2006
    ..The intent is to improve reporting of noninferiority and equivalence trials, enabling readers to assess the validity of their results and conclusions...
  90. ncbi REporting recommendations for tumor MARKer prognostic studies (REMARK)
    Lisa M McShane
    National Cancer Institute, Biometric Research Branch, Bethesda, MD 20892 7434, USA
    Nat Clin Pract Urol 2:416-22. 2005
    ....
  91. ncbi Reporting on statistical methods to adjust for confounding: a cross-sectional survey
    Marcus Mullner
    Universitätsklinik für Notfallmedizin, Allgemeines Krankenhaus Wien, Währinger Gürtel 18 20 6D, A 1090 Vienna, Austria
    Ann Intern Med 136:122-6. 2002
    ..The use of complex statistical models to adjust for confounding is common in medical research...
  92. ncbi REporting recommendations for tumor MARKer prognostic studies (REMARK)
    Lisa M McShane
    National Cancer Institute, Biometric Research Branch, DCTD, Room 8126, Executive Plaza North, MSC 7434, 6130 Executive Boulevard, Bethesda, MD 20892 7434, USA
    Nat Clin Pract Oncol 2:416-22. 2005
    ....
  93. ncbi Reporting recommendations for tumor marker prognostic studies
    Lisa M McShane
    Biometric Research Branch, National Cancer Institute, Bethesda, MD, USA
    J Clin Oncol 23:9067-72. 2005
  94. ncbi Dichotomizing continuous predictors in multiple regression: a bad idea
    Patrick Royston
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Stat Med 25:127-41. 2006
    ..Dichotomization of continuous data is unnecessary for statistical analysis and in particular should not be applied to explanatory variables in regression models...
  95. pmc Unjustified restrictions on letters to the editor
    Douglas G Altman
    PLoS Med 2:e126; discussion e152. 2005
  96. ncbi The landscape and lexicon of blinding in randomized trials
    Kenneth F Schulz
    Family Health International, Box 13950, Research Triangle Park, NC 27709, USA
    Ann Intern Med 136:254-9. 2002
  97. ncbi Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:W60-6. 2008
    ..The conduct of randomized, controlled trials of nonpharmacologic treatments presents specific challenges that are not adequately addressed in trial reports...
  98. ncbi Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:295-309. 2008
    ..This extension, in conjunction with the main CONSORT Statement and other CONSORT extensions, should help to improve the reporting of RCTs performed in this field...
  99. pmc Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research
    An Wen Chan
    Randomized Controlled Trials Unit, Canadian Institutes of Health Research, Ottawa, Ont
    CMAJ 171:735-40. 2004
    ..We sought to determine whether outcome reporting bias would be present in a cohort of government-funded trials subjected to rigorous peer review...
  100. ncbi Prognosis research: toward evidence-based results and a Cochrane methods group
    Richard D Riley
    J Clin Epidemiol 60:863-5; author reply 865-6. 2007
  101. ncbi [The CONSORT statenent: Revised Recommendations For Improving the Quality of Reports of Parallel-Group Randomized Trials]
    David Moher
    Zhongguo Zhong Xi Yi Jie He Za Zhi 25:658-61. 2005