Research Topics
Genomes and Genes
| Ralf H AdamsSummaryAffiliation: Cancer Research UK Country: UK Publications
| Collaborators
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Detail Information
Publications
Molecular regulation of angiogenesis and lymphangiogenesisRalf H Adams
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Nat Rev Mol Cell Biol 8:464-78. 2007..The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell-cell communication...- Vascular patterning by Eph receptor tyrosine kinases and ephrinsRalf H Adams
Vascular Development Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Semin Cell Dev Biol 13:55-60. 2002.... - Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularizationNaoko Kogata
Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka, Japan
Circ Res 98:897-904. 2006.... 
Molecular control of arterial-venous blood vessel identityRalf H Adams
Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
J Anat 202:105-12. 2003..This review gives an up-to-date overview of differentially expressed genes and the regulatory processes leading to the differentiation of arteries and veins...
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesisYingdi Wang
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Nature 465:483-6. 2010..Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth...- Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contractionNaoko Kogata
Vascular Development Laboratory, UK London Research Institute, London WC2A 3PX, United Kingdom
Genes Dev 23:2278-83. 2009..Our findings identify ILK as a key component regulating vascular wall formation by negatively modulating VSMC contractility... - The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisRui Benedito
Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
Cell 137:1124-35. 2009.... - Regulation of angiogenesis by Eph-ephrin interactionsSanne Kuijper
Vascular Development Laboratory, Cancer Research UK, London Research Institute, London, UK
Trends Cardiovasc Med 17:145-51. 2007..Consequently, the expression, interactions, or signaling of Eph-ephrin molecules might be targets for future therapeutic approaches... - Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stabilitySabu Abraham
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
Circ Res 102:562-70. 2008..Similarly, mutant pericytes are poorly spread but present in larger numbers. Our analysis of this mutant model shows that integrin beta1-mediated cell-matrix adhesion is a major determinant of the mural cell phenotype... - Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assemblyShane S Foo
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Cell 124:161-73. 2006..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions... - Regulation of vascular morphogenesis by Notch signalingCristina Roca
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
Genes Dev 21:2511-24. 2007..Recent findings highlight the Notch ligand Delta-like 4 as a key regulator of tumor angiogenesis and suggest that this protein might be a promising target for cancer therapy... - Expression and function of junctional adhesion molecule-C in myelinated peripheral nervesChristoph Scheiermann
National Heart and Lung Institute, Imperial College London, London, UK
Science 318:1472-5. 2007..These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves... - ERK activation causes epilepsy by stimulating NMDA receptor activityAbdolrahman S Nateri
Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
EMBO J 26:4891-901. 2007..Therefore, our study identifies a mechanism of epileptogenesis that links MAP kinase to Eph/Ephrin and NMDA receptor signalling... - Control of skeletal patterning by ephrinB1-EphB interactionsAmelia Compagni
Cancer Research UK London Research Institute, Vascular Development Laboratory, WC2A 3PX, London, United Kingdom
Dev Cell 5:217-30. 2003..Our findings suggest that differential cell adhesion and sorting might be relevant for an unusual class of X-linked human genetic disorders, in which heterozygous females show more severe phenotypes than hemizygous males... - Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-CGeorgia Gliki
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Nature 431:320-4. 2004..We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex... - Investigation of the angiogenic programme with tissue-specific and inducible genetic approaches in miceRalf H Adams
Vascular Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Novartis Found Symp 283:165-71; discussion 171-3, 238-41. 2007..Here, I will discuss the characterization of these lines and present examples of their application in the analysis of vascular development... - Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epitheliumLauren L Daniele
F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 505:166-76. 2007..The nonclassical distribution of Jam-C in the apical membranes of Müller cells and RPE suggests that Jam-C has a novel function in the retina... - Hippocampal plasticity requires postsynaptic ephrinBsIlona C Grunwald
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
Nat Neurosci 7:33-40. 2004..This work raises the intriguing possibility that depending on the type of synapse, Eph/ephrins can be involved in activity-dependent plasticity in converse ways, with ephrinBs on the pre- or the postsynaptic side... - Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasisDiana M E Otto
Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
Mol Cell Biol 23:6103-16. 2003.... - PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculatureTaija Makinen
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
Genes Dev 19:397-410. 2005..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions...