Ralf H Adams

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
  2. ncbi Vascular patterning by Eph receptor tyrosine kinases and ephrins
    Ralf H Adams
    Vascular Development Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Semin Cell Dev Biol 13:55-60. 2002
  3. ncbi Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization
    Naoko Kogata
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka, Japan
    Circ Res 98:897-904. 2006
  4. pmc Molecular control of arterial-venous blood vessel identity
    Ralf H Adams
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    J Anat 202:105-12. 2003
  5. ncbi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
  6. pmc Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction
    Naoko Kogata
    Vascular Development Laboratory, UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 23:2278-83. 2009
  7. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
  8. ncbi Regulation of angiogenesis by Eph-ephrin interactions
    Sanne Kuijper
    Vascular Development Laboratory, Cancer Research UK, London Research Institute, London, UK
    Trends Cardiovasc Med 17:145-51. 2007
  9. doi Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability
    Sabu Abraham
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Circ Res 102:562-70. 2008
  10. ncbi Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly
    Shane S Foo
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Cell 124:161-73. 2006

Collaborators

  • Reinhard Fassler
  • Taija Makinen
  • Achim Gossler
  • Michael Way
  • Sussan Nourshargh
  • Mara E Pitulescu
  • Rui Benedito
  • Thomas E Salt
  • Kari Alitalo
  • Michel Aurrand-Lions
  • Rudiger Klein
  • Malcolm Logan
  • George A Wilkinson
  • Cheryll Tickle
  • Naoko Kogata
  • Amelia Compagni
  • Yingdi Wang
  • Sabu Abraham
  • Susanne Adams
  • Sanne Kuijper
  • Lauren L Daniele
  • Abdolrahman S Nateri
  • Cristina Roca
  • Christoph Scheiermann
  • Christopher J Turner
  • Shane S Foo
  • Beat A Imhof
  • Georgia Gliki
  • Ilona C Grunwald
  • Diana M E Otto
  • Catherine D Nobes
  • Alcide Barberis
  • Masanori Nakayama
  • Urs Lüthi
  • Tim S Schmidt
  • Akira Sakakibara
  • Laura E Benjamin
  • Urban Deutsch
  • Alice Davy
  • Magdalena L Bochenek
  • Rachel M Tribe
  • Praveen Anand
  • Alexander Lobrinus
  • Edward N Pugh
  • Peter Coffey
  • Paolo Meda
  • Owain Howell
  • Christine Gebhardt
  • Martin Vreugdenhil
  • Rime Madani
  • Axel Behrens
  • Richard Reynolds
  • Yiangos Yiangou
  • Diane E Durante
  • Dominique Ducrest-Gay
  • Alan S L Yu
  • Gennadij Raivich
  • Dorothee Caille
  • Nancy J Philp
  • Oliver Kann
  • Sebastian Brandner
  • Clive Da Costa
  • John G R Jefferys
  • Milan Makwana
  • Heike Naumann
  • Minetaro Ogawa
  • Per Lindblom
  • James T Pearson
  • Masato Okada
  • Yoshikazu Nakaoka
  • Satoshi Somekawa
  • Kazuaki Hashimoto
  • Naoki Mochizuki
  • Kyoko Hidaka
  • Deborah Aubyn
  • Yuji Arai
  • Tatsuya Koyama
  • Daniel Zicha
  • Moshe Shani
  • Tobias Bonhoeffer
  • Klaus Ebnet
  • Giselind Adelmann
  • Martin Korte
  • Klas Kullander
  • Michael Frotscher
  • Anne Plueck
  • Dianne Carrie
  • Colin J Henderson
  • Thomas E Gundersen
  • Megan Davey

Detail Information

Publications20

  1. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
    ..The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell-cell communication...
  2. ncbi Vascular patterning by Eph receptor tyrosine kinases and ephrins
    Ralf H Adams
    Vascular Development Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Semin Cell Dev Biol 13:55-60. 2002
    ....
  3. ncbi Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization
    Naoko Kogata
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka, Japan
    Circ Res 98:897-904. 2006
    ....
  4. pmc Molecular control of arterial-venous blood vessel identity
    Ralf H Adams
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    J Anat 202:105-12. 2003
    ..This review gives an up-to-date overview of differentially expressed genes and the regulatory processes leading to the differentiation of arteries and veins...
  5. ncbi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
    ..Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth...
  6. pmc Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction
    Naoko Kogata
    Vascular Development Laboratory, UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 23:2278-83. 2009
    ..Our findings identify ILK as a key component regulating vascular wall formation by negatively modulating VSMC contractility...
  7. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ....
  8. ncbi Regulation of angiogenesis by Eph-ephrin interactions
    Sanne Kuijper
    Vascular Development Laboratory, Cancer Research UK, London Research Institute, London, UK
    Trends Cardiovasc Med 17:145-51. 2007
    ..Consequently, the expression, interactions, or signaling of Eph-ephrin molecules might be targets for future therapeutic approaches...
  9. doi Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability
    Sabu Abraham
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Circ Res 102:562-70. 2008
    ..Similarly, mutant pericytes are poorly spread but present in larger numbers. Our analysis of this mutant model shows that integrin beta1-mediated cell-matrix adhesion is a major determinant of the mural cell phenotype...
  10. ncbi Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly
    Shane S Foo
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Cell 124:161-73. 2006
    ..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions...
  11. ncbi Regulation of vascular morphogenesis by Notch signaling
    Cristina Roca
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 21:2511-24. 2007
    ..Recent findings highlight the Notch ligand Delta-like 4 as a key regulator of tumor angiogenesis and suggest that this protein might be a promising target for cancer therapy...
  12. pmc Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves
    Christoph Scheiermann
    National Heart and Lung Institute, Imperial College London, London, UK
    Science 318:1472-5. 2007
    ..These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves...
  13. pmc ERK activation causes epilepsy by stimulating NMDA receptor activity
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    EMBO J 26:4891-901. 2007
    ..Therefore, our study identifies a mechanism of epileptogenesis that links MAP kinase to Eph/Ephrin and NMDA receptor signalling...
  14. ncbi Control of skeletal patterning by ephrinB1-EphB interactions
    Amelia Compagni
    Cancer Research UK London Research Institute, Vascular Development Laboratory, WC2A 3PX, London, United Kingdom
    Dev Cell 5:217-30. 2003
    ..Our findings suggest that differential cell adhesion and sorting might be relevant for an unusual class of X-linked human genetic disorders, in which heterozygous females show more severe phenotypes than hemizygous males...
  15. ncbi Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C
    Georgia Gliki
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 431:320-4. 2004
    ..We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex...
  16. ncbi Investigation of the angiogenic programme with tissue-specific and inducible genetic approaches in mice
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Novartis Found Symp 283:165-71; discussion 171-3, 238-41. 2007
    ..Here, I will discuss the characterization of these lines and present examples of their application in the analysis of vascular development...
  17. pmc Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium
    Lauren L Daniele
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Comp Neurol 505:166-76. 2007
    ..The nonclassical distribution of Jam-C in the apical membranes of Müller cells and RPE suggests that Jam-C has a novel function in the retina...
  18. ncbi Hippocampal plasticity requires postsynaptic ephrinBs
    Ilona C Grunwald
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Nat Neurosci 7:33-40. 2004
    ..This work raises the intriguing possibility that depending on the type of synapse, Eph/ephrins can be involved in activity-dependent plasticity in converse ways, with ephrinBs on the pre- or the postsynaptic side...
  19. pmc Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis
    Diana M E Otto
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 23:6103-16. 2003
    ....
  20. pmc PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    Taija Makinen
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Genes Dev 19:397-410. 2005
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions...