Research Topics
| Graham C BurdgeSummaryCountry: UK Publications
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Publications
Epigenetics: are there implications for personalised nutrition?Graham C Burdge
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, UK
Curr Opin Clin Nutr Metab Care 15:442-7. 2012..Findings from animal models and human cohorts are discussed in the context of whether or not epigenetics may be an important factor in the progress towards the goal of personalised nutrition...
Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transitionGraham C Burdge
Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
PLoS ONE 6:e28282. 2011..The transgenerational effects on phenotype were associated with altered DNA methylation of specific genes in a manner consistent with induction de novo of epigenetic marks in each generation...- Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?Graham C Burdge
Institute of Human Nutrition, Southampton General Hospital, Tremona Road, Southampton, UK
Br J Nutr 101:619-30. 2009..However, the induction of specific disease risk is dependent upon the nature of the environmental challenge and interactions between the susceptibility set by the altered epigenome and the environment throughout the life course... - Bridging the gap between epigenetics research and nutritional public health interventionsGraham C Burdge
Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building MP887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Genome Med 2:80. 2010..Despite the early stage of knowledge in this field and the intellectual, technological and financial challenges, epigenetic research has substantial potential for public health benefits... - Nutrition, epigenetics, and developmental plasticity: implications for understanding human diseaseGraham C Burdge
Institute of Human Nutrition, University of Southampton School of Medicine, Southampton, SO16 6YD, United Kingdom
Annu Rev Nutr 30:315-39. 2010..The purpose of this review is to discuss recent advances in understanding the mechanism that underlies the early life origins of disease and to place these studies in a broader life-course context... - Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50-65 yearsGraham C Burdge
Institute of Human Nutrition, Southampton General Hospital, University of Southampton, Developmental Sciences Building, Mail point 887, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 102:160-5. 2009..Increased consumption of fish oil induces acute changes in the VLDL, but not in the LDL or HDL, metabolism... - Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutritionGraham C Burdge
Institute of Human Nutrition
J Nutr 139:1054-60. 2009..This may represent a period of plasticity when specific nutrient intakes may alter the phenotype of the offspring through epigenetic changes in specific genes... - Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male ratsKaren A Lillycrop
Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
Br J Nutr 103:1711-9. 2010..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy... - The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumptionGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
Br J Nutr 99:540-9. 2008..Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth... - Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and Karen A Lillycrop
Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 97:1064-73. 2007..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression... 
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspringKaren A Lillycrop
Development and Cell Biology, University of Southampton, UK
J Nutr 135:1382-6. 2005..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...- Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generationsGraham C Burdge
Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
Br J Nutr 97:435-9. 2007..This may represent a mechanism for the transmission of induced phenotypes between generations.. - Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's diseaseTimothy M Trebble
School of Medicine, Institute of Human Nutrition, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Clin Nutr 23:647-55. 2004..CONCLUSIONS: CD is associated with a greater availability, and not a deficiency, of n-3 PUFA in PBMC, but lower concentrations of AA, and lower rates of production of PGE2 and IFN-gamma, compared to healthy controls... - Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementationTimothy M Trebble
Institute of Human Nutrition, School of Medicine, University of Southampton, United Kingdom
Am J Clin Nutr 78:376-82. 2003..The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants... - Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspringKaren A Lillycrop
Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 100:278-82. 2008..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults... - Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual dietsGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX, UK
Br J Nutr 96:489-500. 2006..These results suggest that differences in meal fatty acid composition exert little or no effect on postprandial changes in plasma lipids, glucose and insulin concentrations... - Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heartJoanne L Slater-Jefferies
Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Prostaglandins Leukot Essent Fatty Acids 83:219-23. 2010..These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease... - Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspringSamuel P Hoile
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
PLoS ONE 6:e21668. 2011..Such variation may reflect differences between generations in the signals received by the fetus from the mother as a consequence of changes in the interaction between her phenotype and the environment... - Polyunsaturated fatty acid concentrations in young men and women consuming their habitual dietsLucy Bakewell
Institute of Human Nutrition, Developmental Origins of Health and Disease Division, University of Southampton, Southampton SO16 7PX, UK
Br J Nutr 96:93-9. 2006..Overall, the present data support the suggestion that greater DHA synthesis in women than men results in a higher DHA concentration in plasma lipids... - Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?Graham C Burdge
DOHaD Research Division, University of Southampton, Bassett Cresent East, Southampton, UK
Br J Nutr 97:1036-46. 2007..The demonstration of altered epigenetic regulation of genes in phenotype induction suggests the possibility of interventions to modify long-term disease risk associated with unbalanced nutrition in early life... - The polyunsaturated fatty acid composition of hepatic and plasma lipids differ by both sex and dietary fat intake in ratsCaroline E Childs
Institute of Human Nutrition and Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
J Nutr 140:245-50. 2010..Together, these findings show that sex is an important determinant of the effect of variations in fat and fatty acid intake on LCPUFA status, which may have implications for recommendations for fat and fatty acid intake in humans... - Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acidsGraham C Burdge
Institute of Human Nutrition, Biomedical Sciences Building, University of Southhampton, Bassett Crescent East, Southhampton, S016 7PX, UK
Br J Nutr 94:237-43. 2005..001) and PBMC (84 %; P = 0.004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids... - Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in ratsSamuel P Hoile
Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
Br J Nutr 108:852-7. 2012..Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis... - Antiretroviral therapy with or without protease inhibitors impairs postprandial TAG hydrolysis in HIV-infected menLisa J Ware
Institute of Human Nutrition, Southampton General Hospital, UK
Br J Nutr 102:1038-46. 2009..If dyslipidaemia is to be minimised in ART, the specific adverse effects of particular combinations during the fed state should be considered... - Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot studyGraham C Burdge
Institute of Human Nutrition, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
Reprod Nutr Dev 46:63-7. 2006..These data accord with the suggestion that the enrichment of alpha-LNA in TAG and of DHA in phospholipids reflects hepatic regulation of n-3 PUFA metabolism which potentially enhances the delivery of DHA to the placenta... - Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaningGraham C Burdge
Institute of Human Nutrition, Biomedical Sciences Building 62, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 90:345-52. 2003..These results suggest that restricted maternal protein intake during pregnancy results in persistent alterations to membrane fatty acid content... - Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementationTimothy Trebble
The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 90:405-12. 2003..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake... - The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseasesKaren A Lillycrop
Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
J Nutrigenet Nutrigenomics 4:248-60. 2011.... - Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesisChristopher J Kelsall
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
PLoS ONE 7:e34492. 2012.... - Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy menGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX UK
J Lipid Res 45:736-41. 2004..These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily... - Epigenetic gene promoter methylation at birth is associated with child's later adiposityKeith M Godfrey
Institute of Developmental Sciences, University of Southampton, Southampton, UK
Diabetes 60:1528-34. 2011..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans... - Epigenetic mechanisms linking early nutrition to long term healthKaren A Lillycrop
Centre for Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
Best Pract Res Clin Endocrinol Metab 26:667-76. 2012..This review will focus on how nutritional cues in early life can alter the epigenome, producing different phenotypes and altered disease susceptibilities... - Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older menGraham C Burdge
Institute of Human Nutrition, University of Southampton, UK
Br J Nutr 90:311-21. 2003..This suggests regulation of ALNA conversion may limit the influence of variations in dietary n-3 fatty acid intake on plasma lipid compositions... - Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanismsMark Hanson
DOHaD Centre, University of Southampton, Southampton SO166YD, United Kingdom
Prog Biophys Mol Biol 106:272-80. 2011..Elucidation of epigenetic processes may permit perinatal identification of individuals most at risk of later NCD and enable early intervention strategies to reduce such risk... - Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adultsGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, UK
Reprod Nutr Dev 45:581-97. 2005..Capacity to up-regulate alphaLNA conversion in women may be important for meeting the demands of the fetus and neonate for DHA... - Gender differences in the n-3 fatty acid content of tissuesCaroline E Childs
School of Medicine, University of Southampton, Southampton SO16 6YD, UK
Proc Nutr Soc 67:19-27. 2008..These findings suggest that sex hormones act to modify plasma and tissue n-3 PUFA content, possibly by altering the expression of desaturase and elongase enzymes in the liver, which is currently under investigation... - Epigenetic mechanisms and the mismatch concept of the developmental origins of health and diseaseKeith M Godfrey
Centre for Developmental Origins of Health and Disease, University of Southampton, UK
Pediatr Res 61:5R-10R. 2007..Future research into epigenetic processes may permit us to develop intervention strategies... - Homocysteine: a role in fetal programming?Graham C Burdge
Developmental Origins of Health and Disease Research Division, University of Southampton, Southampton
Br J Nutr 96:415-7. 2006 - Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester poolsRohan M Lewis
Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
Br J Nutr 106:463-7. 2011..The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues... - Selective changes to phosphatidylcholine and phosphatidylethanolamine molecular species in the developing fetal guinea pig liver and plasmaGraham C Burdge
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
Reprod Nutr Dev 44:571-82. 2004..Overall, these data suggest differential regulation of hepatic PC and PE molecular species composition during development which is essentially independent of the maternal fatty acid supply... - Non-imprinted epigenetics in fetal and postnatal development and growthKeith M Godfrey
MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
Nestle Nutr Inst Workshop Ser 71:57-63. 2013..Elucidation of epigenetic processes may enable early intervention strategies to improve early development and growth... - Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expressionKimberley D Bruce
Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
Hepatology 50:1796-808. 2009..CONCLUSION: Maternal fat intake contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepatic mitochondrial metabolism and up-regulated hepatic lipogenesis... - Folic acid supplementation in pregnancy: Are there devils in the detail?Graham C Burdge
Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences Building MP887, Southampton General Hospital, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 108:1924-30. 2012..Nevertheless, such effects should be investigated thoroughly in order to support firm conclusions about the risk of unanticipated long-term negative effects of maternal FA supplementation in humans... - Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?Graham C Burdge
Institute of Human Nutrition, Developmental Origins of Adult Health and Disease Division, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 93:3-9. 2005..Based on these results, we propose a model of a causal mechanism to explain how consumption of a fatty meal may impair vascular dysfunction... - Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young womenGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, UK
Br J Nutr 88:411-20. 2002..Differences in DHA status between women both in the non-pregnant state and in pregnancy may reflect variations in metabolic capacity for DHA synthesis... - Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brainGraham C Burdge
Institute of Human Nutrition, University of Southampton, Hants, UK
Br J Nutr 88:379-87. 2002..The present results suggest that lower maternal protein intakes reduce delivery of DHA from the mother to the fetus, which may impair development and function of the fetal brain... - Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*Graham C Burdge
Institute of Human Nutrition, Level C, West Wing, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Br J Nutr 88:355-63. 2002..Since the capacity of adult males to convert ALNA to DHA was either very low or absent, uptake of pre-formed DHA from the diet may be critical for maintaining adequate membrane DHA concentrations in these individuals...