Research Topics
| Peter HewitsonSummaryAffiliation: Brunel University Country: UK Publications
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Detail Information
Publications
Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicinePeter Hewitson
Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge, UK
J Chromatogr A 1216:4187-92. 2009..188mg of triptolide at greater than 98% purity was separated from 9.2g of crude extract, using 10l of solvent in a 3-h separation...- Intermittent counter-current extraction--effect of the key operating parameters on selectivity and throughputPeter Hewitson
Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB83PH, UK
J Chromatogr A 1218:6072-8. 2011.... - Scale-up of counter-current chromatography: demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scaleIan Sutherland
Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex UB83PH, UK
J Chromatogr A 1216:8787-92. 2009.... - Evaluation of dual flow counter-current chromatography and intermittent counter-current extractionSvetlana Ignatova
Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge UB83PH, UK
J Chromatogr A 1218:6102-6. 2011..While similar throughputs of 7.8 g/h and 6.9 g/h were achieved for the ICcE and DFCCC methods respectively, ICcE was demonstrated to have a number of advantages over DFCCC... - New 18-l process-scale counter-current chromatography centrifugeIan Sutherland
Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK
J Chromatogr A 1216:4201-5. 2009..They also show that predictable scale-up from simple test tube tests is feasible with knowledge of the stationary phase retention for the planned process scale run... - A new non-synchronous preparative counter-current centrifuge-the next generation of dynamic extraction/chromatography devices with independent mixing and settling control, which offer a step change in efficiencySvetlana Ignatova
Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
J Chromatogr A 1217:34-9. 2010..A step change of up to 30% in resolution and 90% in plate efficiency is demonstrated... 
Toroidal coil chromatography: the effect of scale-up and "g" field on stage efficiencyIan Sutherland
Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge, Middlesex UB83PH, UK
J Chromatogr A 1218:6144-7. 2011..The results show that stage mixing efficiencies have increased from 1.1% in 1998 to greater than 25% in the latest scaled-up version of a Toroidal coil chromatography (TCC) instrument working at 240 g...- Scalable Technology for the Extraction of Pharmaceutics (STEP): the transition from academic knowhow to industrial realityIan Sutherland
Brunel Institute for Bioengineering, Brunel University, Uxbridge UB83PH, UK
J Chromatogr A 1218:6114-21. 2011..The future challenge for the CCC community will be to address these development needs urgently if CCC is to become the platform technology it deserves to be... - Scale-up of protein purifications using aqueous two-phase systems: comparing multilayer toroidal coil chromatography with centrifugal partition chromatographyIan Sutherland
Advanced Bioprocessing Centre, sBrunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK
J Chromatogr A 1218:5527-30. 2011..While CPC has already demonstrated that it can be scaled to pilot scale, MTCC has still to achieve this goal...