Peter Hewitson

Summary

Affiliation: Brunel University
Country: UK

Publications

  1. doi request reprint Intermittent counter-current extraction-Equilibrium cell model, scaling and an improved bobbin design
    Peter Hewitson
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
    J Chromatogr A 1303:18-27. 2013
  2. doi request reprint Intermittent counter-current extraction--effect of the key operating parameters on selectivity and throughput
    Peter Hewitson
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB83PH, UK
    J Chromatogr A 1218:6072-8. 2011
  3. doi request reprint Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine
    Peter Hewitson
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge, UK
    J Chromatogr A 1216:4187-92. 2009
  4. doi request reprint Scalable technology for the extraction of pharmaceutics: outcomes from a 3 year collaborative industry/academia research programme
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
    J Chromatogr A 1282:84-94. 2013
  5. doi request reprint Scale-up of counter-current chromatography: demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex UB83PH, UK
    J Chromatogr A 1216:8787-92. 2009
  6. doi request reprint Evaluation of dual flow counter-current chromatography and intermittent counter-current extraction
    Svetlana Ignatova
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge UB83PH, UK
    J Chromatogr A 1218:6102-6. 2011
  7. doi request reprint A new non-synchronous preparative counter-current centrifuge-the next generation of dynamic extraction/chromatography devices with independent mixing and settling control, which offer a step change in efficiency
    Svetlana Ignatova
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
    J Chromatogr A 1217:34-9. 2010
  8. pmc Toroidal coil chromatography: the effect of scale-up and "g" field on stage efficiency
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge, Middlesex UB83PH, UK
    J Chromatogr A 1218:6144-7. 2011
  9. doi request reprint New 18-l process-scale counter-current chromatography centrifuge
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK
    J Chromatogr A 1216:4201-5. 2009
  10. doi request reprint Scalable Technology for the Extraction of Pharmaceutics (STEP): the transition from academic knowhow to industrial reality
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge UB83PH, UK
    J Chromatogr A 1218:6114-21. 2011

Detail Information

Publications11

  1. doi request reprint Intermittent counter-current extraction-Equilibrium cell model, scaling and an improved bobbin design
    Peter Hewitson
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
    J Chromatogr A 1303:18-27. 2013
    ....
  2. doi request reprint Intermittent counter-current extraction--effect of the key operating parameters on selectivity and throughput
    Peter Hewitson
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB83PH, UK
    J Chromatogr A 1218:6072-8. 2011
    ....
  3. doi request reprint Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine
    Peter Hewitson
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge, UK
    J Chromatogr A 1216:4187-92. 2009
    ..188mg of triptolide at greater than 98% purity was separated from 9.2g of crude extract, using 10l of solvent in a 3-h separation...
  4. doi request reprint Scalable technology for the extraction of pharmaceutics: outcomes from a 3 year collaborative industry/academia research programme
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
    J Chromatogr A 1282:84-94. 2013
    ....
  5. doi request reprint Scale-up of counter-current chromatography: demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex UB83PH, UK
    J Chromatogr A 1216:8787-92. 2009
    ....
  6. doi request reprint Evaluation of dual flow counter-current chromatography and intermittent counter-current extraction
    Svetlana Ignatova
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge UB83PH, UK
    J Chromatogr A 1218:6102-6. 2011
    ..While similar throughputs of 7.8 g/h and 6.9 g/h were achieved for the ICcE and DFCCC methods respectively, ICcE was demonstrated to have a number of advantages over DFCCC...
  7. doi request reprint A new non-synchronous preparative counter-current centrifuge-the next generation of dynamic extraction/chromatography devices with independent mixing and settling control, which offer a step change in efficiency
    Svetlana Ignatova
    Advanced Bioprocessing Centre, Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK
    J Chromatogr A 1217:34-9. 2010
    ..A step change of up to 30% in resolution and 90% in plate efficiency is demonstrated...
  8. pmc Toroidal coil chromatography: the effect of scale-up and "g" field on stage efficiency
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge, Middlesex UB83PH, UK
    J Chromatogr A 1218:6144-7. 2011
    ..The results show that stage mixing efficiencies have increased from 1.1% in 1998 to greater than 25% in the latest scaled-up version of a Toroidal coil chromatography (TCC) instrument working at 240 g...
  9. doi request reprint New 18-l process-scale counter-current chromatography centrifuge
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK
    J Chromatogr A 1216:4201-5. 2009
    ..They also show that predictable scale-up from simple test tube tests is feasible with knowledge of the stationary phase retention for the planned process scale run...
  10. doi request reprint Scalable Technology for the Extraction of Pharmaceutics (STEP): the transition from academic knowhow to industrial reality
    Ian Sutherland
    Brunel Institute for Bioengineering, Brunel University, Uxbridge UB83PH, UK
    J Chromatogr A 1218:6114-21. 2011
    ..The future challenge for the CCC community will be to address these development needs urgently if CCC is to become the platform technology it deserves to be...
  11. doi request reprint Scale-up of protein purifications using aqueous two-phase systems: comparing multilayer toroidal coil chromatography with centrifugal partition chromatography
    Ian Sutherland
    Advanced Bioprocessing Centre, sBrunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK
    J Chromatogr A 1218:5527-30. 2011
    ..While CPC has already demonstrated that it can be scaled to pilot scale, MTCC has still to achieve this goal...