Alice Brockington

Summary

Country: UK

Publications

  1. pmc Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit, University of Sheffield, E Floor, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    BMC Genomics 11:203. 2010
  2. pmc Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity
    Alice Brockington
    Academic Neurology Unit, Sheffield Institute for Translational Neuroscience SITRAN, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK
    Acta Neuropathol 125:95-109. 2013
  3. pmc Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit, University of Sheffield, E Floor, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    BMC Med Genet 8:23. 2007
  4. ncbi Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit and the Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, U K
    J Neuropathol Exp Neurol 65:26-36. 2006
  5. pmc Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
    Johnathan Cooper-Knock
    Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK
    Brain 135:751-64. 2012
  6. pmc Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
    Laura E Cox
    Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
    PLoS ONE 5:e9872. 2010
  7. ncbi Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosis
    Alice Brockington
    Neurogenetics 6:101-4. 2005
  8. ncbi Large-scale pathways-based association study in amyotrophic lateral sclerosis
    Dalia Kasperaviciute
    Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK
    Brain 130:2292-301. 2007

Collaborators

  • Paul G Ince
  • Janine Kirby
  • Michael Sendtner
  • Nicol√≥ Fusi
  • John Hardy
  • Emily F Goodall
  • Peter Carmeliet
  • Martin R Turner
  • Ammar Al-Chalabi
  • Pamela J Shaw
  • Johnathan Cooper-Knock
  • Stephen B Wharton
  • Laura E Cox
  • Judith Hartley
  • Karen E Morrison
  • Dalia Kasperaviciute
  • Lynne Baxter
  • Catherine Gelsthorpe
  • Joanne Martindale
  • Bryan J Traynor
  • Christopher J McDermott
  • Kin Mok
  • Joanna Bury
  • Theresa Walsh
  • Antonio Milano
  • Gillian Forster
  • Christopher Hewitt
  • J Robin Highley
  • Melanie Fox
  • Somai Man
  • Paul R Heath
  • Heather Mortiboys
  • Christine E Burness
  • Adrian Higginbottom
  • Andrew J Grierson
  • Judith A Hartley
  • Laura Ferraiuolo
  • Hannah C Hollinger
  • Richard W Orrell
  • Mike E Weale
  • David B Goldstein
  • Kevin V Shianna
  • Giampietro Schiavo
  • Claire L Simpson
  • Valerie K Hansen
  • Gareth T Banks
  • Nicholas W Wood
  • Hardev S Pall
  • Christopher E Shaw
  • Hannah Nixon
  • Elizabeth M C Fisher
  • Sibylle Jablonka
  • Marcus Beck

Detail Information

Publications8

  1. pmc Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit, University of Sheffield, E Floor, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    BMC Genomics 11:203. 2010
    ..Investigating the molecular pathways to neurodegeneration in the VEGFdelta/delta mouse model of ALS may improve understanding of the mechanisms of motor neurone death in the human disease...
  2. pmc Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity
    Alice Brockington
    Academic Neurology Unit, Sheffield Institute for Translational Neuroscience SITRAN, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK
    Acta Neuropathol 125:95-109. 2013
    ..The findings suggest that reduced susceptibility to excitotoxicity, mediated in part through enhanced GABAergic transmission, is an important determinant of the relative resistance of oculomotor neurons to degeneration in ALS...
  3. pmc Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit, University of Sheffield, E Floor, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    BMC Med Genet 8:23. 2007
    ..Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and expression of VEGFR2 is reduced in motor neurones and spinal cord of patients with ALS...
  4. ncbi Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit and the Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, U K
    J Neuropathol Exp Neurol 65:26-36. 2006
    ....
  5. pmc Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
    Johnathan Cooper-Knock
    Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK
    Brain 135:751-64. 2012
    ..0005) discriminated C9ORF72 cases strongly from the rest of the cohort. Inclusions in CA4 neurons were not present in non-C9ORF72 cases, indicating that this pathology predicts mutation status...
  6. pmc Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
    Laura E Cox
    Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
    PLoS ONE 5:e9872. 2010
    ..The initial aim of this study was to determine whether mutations in CHMP2B contribute more broadly to ALS pathogenesis...
  7. ncbi Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosis
    Alice Brockington
    Neurogenetics 6:101-4. 2005
  8. ncbi Large-scale pathways-based association study in amyotrophic lateral sclerosis
    Dalia Kasperaviciute
    Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK
    Brain 130:2292-301. 2007
    ..It is reliable for large scale genotyping studies of diseases such as ALS, where DNA sample collections are limited because of low disease prevalence and short survival time...