P J McKiernan

Summary

Affiliation: Birmingham Heartlands Hospital
Country: UK

Publications

  1. ncbi request reprint A prospective study of endoscopic esophageal variceal ligation using a multiband ligator
    Patrick J McKiernan
    Liver Unit, Birmingham Children s Hospital National Health Service Trust, Birmingham, United Kingdom
    J Pediatr Gastroenterol Nutr 34:207-11. 2002
  2. ncbi request reprint The frequency and outcome of biliary atresia in the UK and Ireland
    P J McKiernan
    Liver Unit, Birmingham Children s Hospital NHS Trust, UK
    Lancet 355:25-9. 2000
  3. ncbi request reprint Treatment of variceal bleeding
    P J McKiernan
    Liver Unit, Children s Hospital NHS Trust, Birmingham, United Kingdom
    Gastrointest Endosc Clin N Am 11:789-812, viii. 2001
  4. ncbi request reprint Neonatal cholestasis
    P J McKiernan
    Liver Unit, Children s Hospital NHS Trust, Birmingham B4 6NH, UK
    Semin Neonatol 7:153-65. 2002
  5. ncbi request reprint Combined liver-kidney transplantation for primary hyperoxaluria type 1 in young children
    S R Ellis
    The Liver Unit, Birmingham Children's Hospital NHS Trust, Birmingham, UK
    Nephrol Dial Transplant 16:348-54. 2001
  6. doi request reprint British paediatric surveillance unit study of biliary atresia: outcome at 13 years
    P J McKiernan
    Liver Unit, The Children s Hospital NHS Trust, Birmingham, UK
    J Pediatr Gastroenterol Nutr 48:78-81. 2009
  7. pmc Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy
    W S Lee
    Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK
    Arch Dis Child 85:38-42. 2001
  8. doi request reprint Successful isolated liver transplantation in a child with atypical hemolytic uremic syndrome and a mutation in complement factor H
    W Haller
    Liver Unit, Birmingham Children s Hospital NHS Foundation Trust, Birmingham, UK
    Am J Transplant 10:2142-7. 2010
  9. ncbi request reprint Is serum gentamicin level a good predictor of graft injury in intestinal transplantation?
    K S Haghighi
    Liver Unit, Birmingham Children s Hospital, Steelhouse Lane, Birmingham B4 6NH, United Kingdom
    Transplant Proc 38:1733-4. 2006
  10. ncbi request reprint Induction therapy for small bowel transplant recipients: early experience in Birmingham, UK
    Sue V Beath
    Liver Unit at Birmingham Children s Hospital, Birmingham, West Midlands B4 6NH, United Kingdom
    Transplant Proc 34:1892-3. 2002

Collaborators

Detail Information

Publications38

  1. ncbi request reprint A prospective study of endoscopic esophageal variceal ligation using a multiband ligator
    Patrick J McKiernan
    Liver Unit, Birmingham Children s Hospital National Health Service Trust, Birmingham, United Kingdom
    J Pediatr Gastroenterol Nutr 34:207-11. 2002
    ..The Saeed multiband ligator allows ligation of multiple varices during a single insertion. The multibander has not been used previously in children...
  2. ncbi request reprint The frequency and outcome of biliary atresia in the UK and Ireland
    P J McKiernan
    Liver Unit, Birmingham Children s Hospital NHS Trust, UK
    Lancet 355:25-9. 2000
    ..The outcome of a 2-year cohort of children with biliary atresia in the UK and Ireland was assessed to find the current frequency, the factors influencing outcome, and the medium-term need for liver transplantation...
  3. ncbi request reprint Treatment of variceal bleeding
    P J McKiernan
    Liver Unit, Children s Hospital NHS Trust, Birmingham, United Kingdom
    Gastrointest Endosc Clin N Am 11:789-812, viii. 2001
    ..All children surviving variceal hemorrhage should undergo secondary prophylaxis with band ligation. No evidence supports the routine use of primary prophylaxis in children with esophageal varices...
  4. ncbi request reprint Neonatal cholestasis
    P J McKiernan
    Liver Unit, Children s Hospital NHS Trust, Birmingham B4 6NH, UK
    Semin Neonatol 7:153-65. 2002
    ..Outcome is dependent on aetiology. In idiopathic neonatal hepatitis more than 90% make a complete biochemical and d clinical recovery...
  5. ncbi request reprint Combined liver-kidney transplantation for primary hyperoxaluria type 1 in young children
    S R Ellis
    The Liver Unit, Birmingham Children's Hospital NHS Trust, Birmingham, UK
    Nephrol Dial Transplant 16:348-54. 2001
    ..We feel that earlier LKT, or pre-emptive liver transplantation, may be a better therapeutic strategy to improve the outlook for these patients...
  6. doi request reprint British paediatric surveillance unit study of biliary atresia: outcome at 13 years
    P J McKiernan
    Liver Unit, The Children s Hospital NHS Trust, Birmingham, UK
    J Pediatr Gastroenterol Nutr 48:78-81. 2009
    ..Little information is available on contemporary, prospectively collected data on the long-term outcome of national cohorts of children with biliary atresia...
  7. pmc Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy
    W S Lee
    Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK
    Arch Dis Child 85:38-42. 2001
    ....
  8. doi request reprint Successful isolated liver transplantation in a child with atypical hemolytic uremic syndrome and a mutation in complement factor H
    W Haller
    Liver Unit, Birmingham Children s Hospital NHS Foundation Trust, Birmingham, UK
    Am J Transplant 10:2142-7. 2010
    ..Preemptive liver transplantation prior to the development of end stage renal disease is a valuable option in the management of aHUS associated with CFH mutations...
  9. ncbi request reprint Is serum gentamicin level a good predictor of graft injury in intestinal transplantation?
    K S Haghighi
    Liver Unit, Birmingham Children s Hospital, Steelhouse Lane, Birmingham B4 6NH, United Kingdom
    Transplant Proc 38:1733-4. 2006
    ..Oral gentamycin (2.5 mg/kg) was used for selective decontamination of the digestive system. Our hypothesis was that gentamycin might be absorbed in the presence of graft dysfunction...
  10. ncbi request reprint Induction therapy for small bowel transplant recipients: early experience in Birmingham, UK
    Sue V Beath
    Liver Unit at Birmingham Children s Hospital, Birmingham, West Midlands B4 6NH, United Kingdom
    Transplant Proc 34:1892-3. 2002
  11. doi request reprint Renal tubular function in children with tyrosinaemia type I treated with nitisinone
    S Santra
    Liver Unit, Birmingham Children s Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK
    J Inherit Metab Dis 31:399-402. 2008
    ..Nitisinone has revolutionized the management of TTI but its effect on renal tubular dysfunction has not been described in a large cohort of patients...
  12. ncbi request reprint Neonatal liver transplantation for fulminant hepatitis caused by herpes simplex virus type 2
    W S Lee
    Liver Units, Birmingham Children s Hospital, Birmingham, United Kingdom
    J Pediatr Gastroenterol Nutr 35:220-3. 2002
  13. ncbi request reprint Endoscopic ultrasound is a useful diagnostic test for superior mesenteric artery syndrome in children
    P Sundaram
    Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    J Pediatr Gastroenterol Nutr 45:474-6. 2007
  14. ncbi request reprint Peripheral lymphocyte subsets in the management of PTLD
    G L Gupte
    Liver Unit, Birmingham Children s Hospital, Steelhouse Lane, Birmingham B4 6NH, UK
    Transplant Proc 34:1782-3. 2002
  15. ncbi request reprint Successful treatment of refractory ascites in a child with transjugular intrahepatic portosystemic shunt
    W S Lee
    Liver Unit, Birmingham Children s Hospital, UK
    Acta Paediatr 90:1352-5. 2001
    ..At 24 mo following TIPS there has been no re-accumulation of ascites...
  16. pmc The usefulness of bone marrow aspiration in the diagnosis of Niemann-Pick disease type C in infantile liver disease
    A F Rodrigues
    Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    Arch Dis Child 91:841-4. 2006
    ..Typically in patients with NPC, macrophages with abnormal cholesterol storage, so called foam cells, can be detected in the bone marrow...
  17. ncbi request reprint Cardiomyopathy in tyrosinaemia type I is common but usually benign
    N Arora
    Liver Unit, Department of Cardiology, Children s Hospital NHS Trust, Birmingham, UK
    J Inherit Metab Dis 29:54-7. 2006
    ..Tyrosinaemia type I (TTI) is an inherited multisystemic disorder of tyrosine metabolism. In addition to hepatic and renal involvement, cardiomyopathy is an important clinical manifestation...
  18. pmc Paracetamol induced hepatotoxicity
    S B K Mahadevan
    The Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    Arch Dis Child 91:598-603. 2006
    ..To identify the clinical and biochemical risk factors associated with outcome of paracetamol induced significant hepatotoxicity in children...
  19. doi request reprint Rejection is less common in children undergoing liver transplantation for hepatoblastoma
    N D Ruth
    Liver and Small bowel transplant Unit, Birmingham Children s Hospital NHS Foundation Trust, Birmingham, UK
    Pediatr Transplant 18:52-7. 2014
    ..Renal function was noted to be reduced one yr post-transplant in both groups, as previously reported. A modified immunosuppression regimen could be considered in children with hepatoblastoma undergoing liver transplantation. ..
  20. ncbi request reprint Concomitant basiliximab with low-dose calcineurin inhibitors in children post-liver transplantation
    N Arora
    Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    Pediatr Transplant 6:214-8. 2002
    ..Further studies to evaluate the appropriate levels of CNI immunosuppression with Bx are required...
  21. ncbi request reprint Duodenal capillary hemangiomatous polyps: a novel manifestation of extrahepatic portal hypertension?
    D Devadason
    Birmingham Children s Hospital, Birmingham, UK
    J Pediatr Gastroenterol Nutr 45:114-6. 2007
  22. ncbi request reprint Metabolic stroke in methylmalonic acidemia five years after liver transplantation
    Anupam Chakrapani
    Liver Unit, Birmingham Children s Hospital, United Kingdom
    J Pediatr 140:261-3. 2002
    ..We report a case of methylmalonic acidemia in which successful liver transplantation in infancy failed to prevent neurologic damage caused by a metabolic stroke...
  23. ncbi request reprint Hyperinsulinism in tyrosinaemia type I
    U Baumann
    The Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    J Inherit Metab Dis 28:131-5. 2005
    ..In patients with persistent hypoglycaemia, C-peptide should always be measured. Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong...
  24. ncbi request reprint Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis
    Bryan Lo
    Department of Paediatrics, Division of Clinical and Metabolic Genetics, Programme in Cell Biology, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada
    Blood 106:4159-66. 2005
    ..We conclude that like other Sec1/Munc18 proteins, VPS33B is involved in intracellular vesicle trafficking, being essential for the development of platelet alpha-granules but not for granule secretion...
  25. ncbi request reprint Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation
    Dominic Dell Olio
    The Liver Unit, Birmingham Children s Hospital BCH, Birmingham, UK
    Pediatr Transplant 10:677-81. 2006
    ..Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD)...
  26. ncbi request reprint Visual loss and idiopathic intracranial hypertension in children with Alagille syndrome
    Priya Narula
    Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    J Pediatr Gastroenterol Nutr 43:348-52. 2006
    ..Although visual problems are recognised, the severity of visual loss and its link with idiopathic intracranial hypertension (IIH) has not been reported...
  27. ncbi request reprint Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome
    Paul Gissen
    Section of Medical and Molecular Genetics, University of Birmingham, and Liver Unit, Birmingham Children s Hospital, UK
    Nat Genet 36:400-4. 2004
    ..VPS33B encodes a homolog of the class C yeast vacuolar protein sorting gene, Vps33, that contains a Sec1-like domain important in the regulation of vesicle-to-target SNARE complex formation and subsequent membrane fusion...
  28. ncbi request reprint Difficult management choices for infants with short bowel syndrome and liver failure
    Kamal O Hassan
    The Liver Unit, Birmingham Childrens Hospital NHS Trust, United Kingdom
    J Pediatr Gastroenterol Nutr 35:216-9. 2002
  29. ncbi request reprint Safety and efficacy of octreotide in the immediate control of oesophageal variceal bleeding
    Patrick J McKiernan
    J Pediatr Gastroenterol Nutr 39:437-8; author reply 438. 2004
  30. ncbi request reprint Clinical and molecular genetic features of ARC syndrome
    Paul Gissen
    Section of Medical and Molecular Genetics, Norton Court, Birmingham Women s Hospital, University of Birmingham, B15 2TG, Edgbaston, Birmingham, UK
    Hum Genet 120:396-409. 2006
    ..In conclusion we state that molecular diagnosis is possible for most children in whom ARC syndrome is suspected and VPS33B mutation analysis should replace organ biopsy as a first line diagnostic test for ARC syndrome...
  31. ncbi request reprint The trouble with biopsies
    Ulrich Baumann
    J Pediatr Gastroenterol Nutr 43:122. 2006
  32. ncbi request reprint Histiocytic sarcoma with interdigitating dendritic cell differentiation
    David W Porter
    Liver Unit, Birmingham Children s Hospital, Steelhouse Lane, Birmingham B4 6NH, UK
    J Pediatr Hematol Oncol 26:827-30. 2004
    ..A repeat liver biopsy coupled with splenic biopsy is recommended in young children with unexplained hepatosplenomegaly and thrombocytopenia...
  33. ncbi request reprint 6-Thioguanine-related chronic hepatotoxicity and variceal haemorrhage in children treated for acute lymphoblastic leukaemia--a dual-centre experience
    Madhur Ravikumara
    Department of Hepatology, Birmingham Children s Hospital, Birmingham, UK
    J Pediatr Gastroenterol Nutr 42:535-8. 2006
    ..We describe our experience from 2 UK centres of chronic hepatotoxicity in children receiving maintenance 6-thioguanine for ALL in the national leukaemia protocol ALL 97/99...
  34. ncbi request reprint Nitisinone in the treatment of hereditary tyrosinaemia type 1
    Patrick J McKiernan
    Liver Unit, Children s Hospital NHS Trust, Birmingham, UK
    Drugs 66:743-50. 2006
    ..Nitisinone is indicated for all children with HT-1, and liver transplantation is only indicated where nitisinone fails, or where the development of HCC is likely or suspected...
  35. pmc Improved outcome of referrals for intestinal transplantation in the UK
    Girish L Gupte
    Liver Unit, Birmingham Children s Hospital, Birmingham, UK
    Arch Dis Child 92:147-52. 2007
    ..Subjects and..
  36. ncbi request reprint Progressive histological damage in liver allografts following pediatric liver transplantation
    Helen M Evans
    Liver Unit, Birmingham Children s Hospital, Birmingham, United Kingdom
    Hepatology 43:1109-17. 2006
    ..The cause of chronic hepatitis in transplanted allografts is uncertain but may be immune mediated, representing a hepatitic form of chronic rejection...
  37. ncbi request reprint Mycophenolate mofetil for renal dysfunction after pediatric liver transplantation
    Helen M Evans
    The Liver Unit, Birmingham Children s Hospital, Birmingham B4 6NH, UK
    Transplantation 79:1575-80. 2005
    ..Mycophenolate mofetil (MMF) is a newer immunosuppressant that does not affect renal function. Its long-term use in children with renal dysfunction after OLT has not yet been fully evaluated...
  38. ncbi request reprint Portal vein cavernoma associated with goldenhar syndrome
    Mark D Stringer
    Children s Liver and GI Unit, St James s University Hospital, Leeds, United Kingdom
    J Pediatr Gastroenterol Nutr 41:368-70. 2005