Anthony Barnett

Summary

Affiliation: Birmingham Heartlands Hospital
Country: UK

Publications

  1. doi request reprint The efficacy of self-monitoring of blood glucose in the management of patients with type 2 diabetes treated with a gliclazide modified release-based regimen. A multicentre, randomized, parallel-group, 6-month evaluation (DINAMIC 1 study)
    A H Barnett
    Department of Medicine, University of Birmingham, Birmingham Heartlands Hospital, Birmingham, UK
    Diabetes Obes Metab 10:1239-47. 2008
  2. doi request reprint Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: a randomised, double-blind, placebo-controlled trial
    Anthony H Barnett
    Diabetes Centre, Heart of England NHS Foundation Trust, Birmingham, UK University of Birmingham, Birmingham, UK Electronic address
    Lancet 382:1413-23. 2013
  3. ncbi request reprint Complementing insulin therapy to achieve glycemic control
    Anthony H Barnett
    Diabetes Centre, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Adv Ther 30:557-76. 2013
  4. doi request reprint Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    Anthony H Barnett
    University of Birmingham and BioMedical Research Centre, Heart of England National Health Service Foundation Trust, Birmingham, UK
    Curr Med Res Opin 28:513-23. 2012
  5. pmc The role of GLP-1 mimetics and basal insulin analogues in type 2 diabetes mellitus: guidance from studies of liraglutide
    A H Barnett
    Biomedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, UK
    Diabetes Obes Metab 14:304-14. 2012
  6. pmc The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population
    Simon D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 10:83. 2009
  7. pmc Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population
    Simon D Rees
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 9:8. 2008
  8. pmc Securing recruitment and obtaining informed consent in minority ethnic groups in the UK
    Cathy E Lloyd
    Faculty of Health and Social Care, The Open University, Milton Keynes, UK
    BMC Health Serv Res 8:68. 2008
  9. ncbi request reprint Dosing of insulin glargine in the treatment of type 2 diabetes
    Anthony Barnett
    Undergraduate Centre, Heart of England National Health Service Foundation Trust, Birmingham, United Kingdom
    Clin Ther 29:987-99. 2007
  10. ncbi request reprint Minimising metabolic and cardiovascular risk in schizophrenia: diabetes, obesity and dyslipidaemia
    A H Barnett
    Birmingham Heartlands Hospital, Birmingham, UK
    J Psychopharmacol 21:357-73. 2007

Detail Information

Publications98

  1. doi request reprint The efficacy of self-monitoring of blood glucose in the management of patients with type 2 diabetes treated with a gliclazide modified release-based regimen. A multicentre, randomized, parallel-group, 6-month evaluation (DINAMIC 1 study)
    A H Barnett
    Department of Medicine, University of Birmingham, Birmingham Heartlands Hospital, Birmingham, UK
    Diabetes Obes Metab 10:1239-47. 2008
    ....
  2. doi request reprint Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: a randomised, double-blind, placebo-controlled trial
    Anthony H Barnett
    Diabetes Centre, Heart of England NHS Foundation Trust, Birmingham, UK University of Birmingham, Birmingham, UK Electronic address
    Lancet 382:1413-23. 2013
    ..We aimed to assess the effectiveness of linagliptin, a dipeptidyl peptidase-4 inhibitor, in elderly patients with type 2 diabetes...
  3. ncbi request reprint Complementing insulin therapy to achieve glycemic control
    Anthony H Barnett
    Diabetes Centre, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Adv Ther 30:557-76. 2013
    ....
  4. doi request reprint Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    Anthony H Barnett
    University of Birmingham and BioMedical Research Centre, Heart of England National Health Service Foundation Trust, Birmingham, UK
    Curr Med Res Opin 28:513-23. 2012
    ..To evaluate efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes (T2D) with inadequate glycemic control on insulin alone or combined with metformin...
  5. pmc The role of GLP-1 mimetics and basal insulin analogues in type 2 diabetes mellitus: guidance from studies of liraglutide
    A H Barnett
    Biomedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, UK
    Diabetes Obes Metab 14:304-14. 2012
    ..Evidence also suggests a future role for GLP-1 mimetics in combination with basal insulin...
  6. pmc The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population
    Simon D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 10:83. 2009
    ..We therefore aimed to investigate the association between common variants of the PCK1 gene and T2D in a UK-resident South Asian population of Punjabi ancestry, originating predominantly from the Mirpur area of Azad Kashmir, Pakistan...
  7. pmc Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population
    Simon D Rees
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 9:8. 2008
    ..The aim of this study was to determine whether variants of this gene are also risk factors for type 2 diabetes development in a UK-resident South Asian cohort of Punjabi ancestry...
  8. pmc Securing recruitment and obtaining informed consent in minority ethnic groups in the UK
    Cathy E Lloyd
    Faculty of Health and Social Care, The Open University, Milton Keynes, UK
    BMC Health Serv Res 8:68. 2008
    ....
  9. ncbi request reprint Dosing of insulin glargine in the treatment of type 2 diabetes
    Anthony Barnett
    Undergraduate Centre, Heart of England National Health Service Foundation Trust, Birmingham, United Kingdom
    Clin Ther 29:987-99. 2007
    ..5 mmol/L [<100 mg/dL] to achieve glycosylated hemoglobin [HbA1c] <7%)...
  10. ncbi request reprint Minimising metabolic and cardiovascular risk in schizophrenia: diabetes, obesity and dyslipidaemia
    A H Barnett
    Birmingham Heartlands Hospital, Birmingham, UK
    J Psychopharmacol 21:357-73. 2007
    ..This review recommends a framework for the assessment, monitoring and management of patients with schizophrenia in the UK clinical setting...
  11. ncbi request reprint A review of the effects of antihyperglycaemic agents on body weight: the potential of incretin targeted therapies
    Anthony Barnett
    Department of Medicine, University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Curr Med Res Opin 23:1493-507. 2007
    ..This article reviews the effect on body weight of current treatments for type 2 diabetes and discusses the potential impact of weight gain in this patient group...
  12. pmc Insulin glargine in the treatment of type 1 and type 2 diabetes
    Anthony H Barnett
    Birmingham Heartlands Hospital, Undergraduate Centre, Birmingham, West Midlands, England, UK
    Vasc Health Risk Manag 2:59-67. 2006
    ..This review appraises the evidence for the view that insulin glargine represents an advance in basal insulin therapy for both type 1 and type 2 diabetes patients...
  13. ncbi request reprint Long-term tolerability of inhaled human insulin (Exubera) in patients with poorly controlled type 2 diabetes
    A H Barnett
    University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Int J Clin Pract 61:1614-25. 2007
    ..Inhaled human insulin (Exubera; EXU) has shown encouraging tolerability in short-term trials. We evaluated the safety profile of EXU after long-term exposure...
  14. ncbi request reprint DPP-4 inhibitors and their potential role in the management of type 2 diabetes
    A Barnett
    Department of Medicine, University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Int J Clin Pract 60:1454-70. 2006
    ....
  15. doi request reprint Translating science into clinical practice: focus on vildagliptin in combination with metformin
    A H Barnett
    Department of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Diabetes Obes Metab 11:18-26. 2009
    ..The combination of vildagliptin and metformin poses numerous advantages in the treatment of T2DM...
  16. ncbi request reprint An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin
    Anthony H Barnett
    University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, UK
    Diabetes Care 29:1818-25. 2006
    ..To compare the efficacy and safety profile of adding inhaled human insulin (INH) (Exubera) or glibenclamide to metformin monotherapy in patients with poorly controlled type 2 diabetes...
  17. ncbi request reprint Type 2 diabetes and cardiovascular risk in the UK south Asian community
    A H Barnett
    University of Birmingham, Birmingham, UK
    Diabetologia 49:2234-46. 2006
    ..Finally, we describe a UK community-based programme that attempts to reduce the morbidity and mortality from type 2 diabetes and cardiovascular disease in south Asians through a new approach to management...
  18. ncbi request reprint How well do rapid-acting insulins work in obese individuals?
    A H Barnett
    University of Birmingham and Birmingham Heartlands and Solihull NHS Trust Teaching, Birmingham, UK
    Diabetes Obes Metab 8:388-95. 2006
    ..This review focuses on the potential impact of obesity on RAIs and presents an overview of investigations in this area...
  19. ncbi request reprint An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea
    Anthony H Barnett
    University of Birmingham and Heart of England NHS Foundation Trust Teaching, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK
    Diabetes Care 29:1282-7. 2006
    ..To compare the efficacy and safety profile of adding inhaled human insulin (INH; Exubera) or metformin to sulfonylurea monotherapy in patients with poorly controlled type 2 diabetes...
  20. ncbi request reprint Preventing renal complications in type 2 diabetes: results of the diabetics exposed to telmisartan and enalapril trial
    Anthony Barnett
    Undergraduate Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    J Am Soc Nephrol 17:S132-5. 2006
    ..During the 5-yr study period, no patient developed a serum creatinine >200 micromol/L, and none required dialysis. There were only six deaths in each treatment group during the study, with half being due to cardiovascular events...
  21. ncbi request reprint Prevention of loss of renal function over time in patients with diabetic nephropathy
    Anthony Barnett
    Division of Medical Sciences, University of Birmingham and Birmingham Heartlands and Solihull National Health Service Trust, Birmingham, United Kingdom
    Am J Med 119:S40-7. 2006
    ..Inhibition of the RAAS should play a major part in management of patients with type 2 diabetes with nephropathy, for which both telmisartan and enalapril provide long-term renoprotection...
  22. ncbi request reprint Exenatide
    A Barnett
    Birmingham Heartlands Hospital, Undergraduate Centre, Bordesley Green East, Birmingham, B9 5SS, UK
    Expert Opin Pharmacother 8:2593-608. 2007
    ..Exenatide may enable patients with Type 2 diabetes to improve glycaemic control and reduce or eliminate the risk of hypoglycaemia and weight gain...
  23. ncbi request reprint Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial
    Anthony H Barnett
    Department of Diabetes, Obesity and Endocrinology, University of Birmingham and Birmingham Heartlands and Solihull NHS Trust, Bordesley Green East, Birmingham, United Kingdom
    Clin Ther 29:2333-48. 2007
    ..This study was conducted to compare the efficacy and safety profiles of exenatide and insulin glargine therapy in patients with type 2 diabetes who had not achieved glucose control with metformin or sulfonylurea monotherapy...
  24. doi request reprint Diabetes-science, serendipity and common sense
    A H Barnett
    Emeritus Professor of Medicine and Consultant Physician, University of Birmingham and BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, UK
    Diabet Med 28:1289-99. 2011
    ..Most importantly, a greater emphasis on prevention through public health measures and 'buy in' from the whole population is urgently required...
  25. doi request reprint Linagliptin: a novel dipeptidyl peptidase 4 inhibitor with a unique place in therapy
    Anthony H Barnett
    Heart of England National Health Service Foundation Trust Teaching, University of Birmingham and Biomedical Research Unit, UK
    Adv Ther 28:447-59. 2011
    ....
  26. doi request reprint New treatments for type 2 diabetes in the UK - an evolving landscape
    Anthony H Barnett
    Diabetes Centre, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham, B9 5SS, UK
    Prim Care Diabetes 5:1-7. 2011
    ....
  27. doi request reprint Premature cardiovascular events and mortality in south Asians with type 2 diabetes in the United Kingdom Asian Diabetes Study - effect of ethnicity on risk
    Srikanth Bellary
    Diabetes Centre, Heart of England NHS Foundation Trust, Birmingham, UK
    Curr Med Res Opin 26:1873-9. 2010
    ..We examined the effect of ethnicity on known risk factors and analysed the risk of cardiovascular events and mortality in UK south Asian and white Europeans patients with type 2 diabetes over a 2 year period...
  28. doi request reprint Avoiding hypoglycaemia while achieving good glycaemic control in type 2 diabetes through optimal use of oral agent therapy
    Anthony H Barnett
    University of Birmingham and Heart of England NHS Foundation Trust, Birmingham, UK
    Curr Med Res Opin 26:1333-42. 2010
    ..This article discusses the issues related specifically to hypoglycaemia associated with oral agent therapy and how these agents may be best employed to provide an optimal balance between hypoglycaemia and good glycaemic control...
  29. doi request reprint Key considerations around the risks and consequences of hypoglycaemia in people with type 2 diabetes
    A H Barnett
    Department of Medicine, University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Int J Clin Pract 64:1121-9. 2010
    ....
  30. pmc Redefining the role of thiazolidinediones in the management of type 2 diabetes
    Anthony H Barnett
    University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Vasc Health Risk Manag 5:141-51. 2009
    ..The place of thiazolidinediones in the management of type 2 diabetes is well established. The potential for additional benefits in reducing macrovascular risk encourages further long-term study of these agents...
  31. doi request reprint UK cost-consequence analysis of aripiprazole in schizophrenia: diabetes and coronary heart disease risk projections (STAR study)
    Anthony H Barnett
    Undergraduate Centre, Heart of England NHS Foundation Trust, Birmingham, B9 5SS, UK
    Eur Arch Psychiatry Clin Neurosci 259:239-47. 2009
    ..Compared with SOC, aripiprazole treatment may provide reductions in the health and economic burden to schizophrenia patients and health care services in the UK as a result of its favourable metabolic profile...
  32. pmc Insulin for type 2 diabetes: choosing a second-line insulin regimen
    A Barnett
    University of Birmingham and Heart of England NHS Foundation Trust, Birmingham, UK
    Int J Clin Pract 62:1647-53. 2008
    ....
  33. doi request reprint New treatments in type 2 diabetes: a focus on the incretin-based therapies
    Anthony H Barnett
    University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Clin Endocrinol (Oxf) 70:343-53. 2009
    ....
  34. doi request reprint The importance of treating cardiometabolic risk factors in patients with type 2 diabetes
    Anthony H Barnett
    Heart of England NHS Foundation Trust, Birmingham Heartlands Hospital, Birmingham, B9 5SS, UK
    Diab Vasc Dis Res 5:9-14. 2008
    ....
  35. pmc Inhaled human insulin (Exubera): clinical profile and patient considerations
    Anthony H Barnett
    University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Vasc Health Risk Manag 3:83-91. 2007
    ....
  36. ncbi request reprint Triple oral anti-diabetic therapy in type 2 diabetes
    A H Barnett
    Undergraduate Centre, Birmingham Heartlands Hospital, Birmingham, UK
    Diabet Med 20:14-6. 2003
  37. doi request reprint Pharmacotherapy for obesity in menopausal women
    Ashish Samat
    Department of Diabetes and Endocrinology, Birmingham Heartlands Hospital, Birmingham, UK
    Menopause Int 14:57-62. 2008
    ..The licensed drugs orlistat, sibutramine and rimonabant are discussed. Obesity increases the risk of type 2 diabetes. Thus, the effects of metformin and exenatide are examined...
  38. ncbi request reprint Rosiglitazone in Type 2 diabetes mellitus: an evaluation in British Indo-Asian patients
    A H Barnett
    Birmingham Heartlands Hospital and University of Birmingham, Birmingham, UK
    Diabet Med 20:387-93. 2003
    ..To evaluate the effectiveness of rosiglitazone in reducing hyperglycaemia in patients with Type 2 diabetes mellitus (DM) of Indo-Asian origin taking concurrent sulphonylurea therapy...
  39. doi request reprint Enhanced diabetes care to patients of south Asian ethnic origin (the United Kingdom Asian Diabetes Study): a cluster randomised controlled trial
    S Bellary
    Heart of England NHS Foundation Trust, Birmingham, UK
    Lancet 371:1769-76. 2008
    ..We investigated the effectiveness of a culturally sensitive, enhanced care package in UK general practices for improvement of cardiovascular risk factors in patients of south Asian origin with type 2 diabetes...
  40. ncbi request reprint Detection of impaired glucose tolerance and undiagnosed type 2 diabetes in UK South Asians: an effective screening strategy
    M W Hanif
    Department of Diabetes, University of Birmingham, Birmingham Heartlands Hospital NHS Trust, Birmingham, UK
    Diabetes Obes Metab 10:755-62. 2008
    ....
  41. ncbi request reprint A placebo-controlled crossover study comparing the effects of nateglinide and glibenclamide on postprandial hyperglycaemia and hyperinsulinaemia in patients with type 2 diabetes
    A H Barnett
    Department of Medicine, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, UK
    Diabetes Obes Metab 6:104-13. 2004
    ....
  42. pmc Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in South-Asians
    Hanif Wasim
    Queen Elizabeth Hospital, Birmingham University, Birmingham, UK
    Cardiovasc Diabetol 5:10. 2006
    ..This study aims to determine the relationship between body fat distribution and adipocytokine in South-Asian subjects by measuring serum adipocytokines, adiposity, insulinemia, and glucose tolerance levels...
  43. ncbi request reprint Characteristics of Type 1 diabetes of over 50 years duration (the Golden Years Cohort)
    S C Bain
    Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Diabet Med 20:808-11. 2003
    ..Type 1 diabetes mellitus is associated with high levels of premature morbidity and mortality. Prolonged survival is possible, however, and some patients appear to be protected from the long-term complications of this condition...
  44. ncbi request reprint Inhaled insulin: new technology, new possibilities
    S Bellary
    Department of Medicine, University of Birmingham and Heart of England NHS Foundation Trust, Birmingham, UK
    Int J Clin Pract 60:728-34. 2006
    ..In this article we review the efficacy and safety profile of Exubera and discuss its potential place in the management of diabetes...
  45. ncbi request reprint Exubera inhaled insulin: a review
    A H Barnett
    University of Birmingham and Birmingham Heartlands Hospital, Department of Medicine Undergraduate Centre, Birmingham, UK
    Int J Clin Pract 58:394-401. 2004
    ..This review summarises the studies available and discusses the potential implications to patients of needle-free insulin administration...
  46. ncbi request reprint Rationale and design of diabetics exposed to telmisartan and enalapril (DETAIL) study
    J Rippin
    Department of Medicine, University of Birmingham, Birmingham B9 5SS, UK
    J Diabetes Complications 16:195-200. 2002
    ..The planned date for the completion of the study is 2005...
  47. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus
    G Valsamakis
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 89:4755-61. 2004
    ..Inhibition of 11beta-HSD1 may therefore represent a therapeutic strategy in patients with type 2 diabetes mellitus and obesity...
  48. ncbi request reprint Management of lipids in patients with diabetes
    Anthony Barnett
    University of Birmingham, Birmingham Heartlands and Solihull NHS Trust, UK
    Diabetes Obes Metab 5:S3-9. 2003
  49. ncbi request reprint Ethnicity and cardiovascular disease prevention in the United Kingdom: a practical approach to management
    G Y H Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    J Hum Hypertens 21:183-211. 2007
    ....
  50. ncbi request reprint Rosiglitazone inhibits the insulin-mediated increase in PAI-1 secretion in human abdominal subcutaneous adipocytes
    A L Harte
    Division of Medical Sciences, Department of Medicine, University of Birmingham and Heartlands Hospital, Edgbaston, Birmingham, UK
    Diabetes Obes Metab 5:302-10. 2003
    ..Human tissue-type plasminogen activator (t-PA) was also measured to assess changes in overall thrombotic risk...
  51. ncbi request reprint HLA typing and immunological characterization of young-onset diabetes mellitus in a Hong Kong Chinese population
    M A Kelly
    Department of Medicine, University of Birmingham, UK
    Diabet Med 18:22-8. 2001
    ....
  52. ncbi request reprint A comparison of foetal and labour outcomes in Caucasian and Afro-Caribbean women with diabetes in pregnancy
    T Chaudhry
    Department of Medicine, University of Birmingham, Birmingham, UK
    Int J Clin Pract 58:932-6. 2004
    ..Variations in culture or access to health care may account for these differences. An awareness of the specific needs of ethnic minorities is essential to ensure that this encouraging trend continues...
  53. ncbi request reprint Differences in adiponectin protein expression: effect of fat depots and type 2 diabetic status
    F M Fisher
    Division of Medical Sciences, Medicine, University of Birmingham, Edgbaston, Birmingham, UK
    Horm Metab Res 34:650-4. 2002
    ..In conclusion, the adipose tissue depot-specific expression of adiponectin may influence the pattern of serum adiponectin concentrations and subsequent disease risk...
  54. ncbi request reprint Treating to goal: challenges of current management
    A H Barnett
    University of Birmingham and Birmingham Heartlands Hospital, Department of Medicine Undergraduate Centre, Bordesley Green East, Birmingham, B9 5SS, UK
    Eur J Endocrinol 151:T3-7; discussion T29-30. 2004
    ..These barriers to glycaemic control need to be overcome so that the established benefits of reducing glucose to normal or near-normal levels can be experienced by more people with type 2 diabetes...
  55. ncbi request reprint HRT in women with diabetes--review of the effects on glucose and lipid metabolism
    S L Palin
    Department of Diabetes and Endocrinology, Birmingham Heartlands and Solihull NHS Trust, Birmingham, UK
    Diabetes Res Clin Pract 54:67-77. 2001
    ..Current evidence is reassuring about the effects of HRT in women with diabetes, although as in all women, HRT should be prescribed on an individual basis with appropriate consideration given to advantages and disadvantages of therapy...
  56. ncbi request reprint Preventing renal complications in diabetic patients: the Diabetics Exposed to Telmisartan And enalaprIL (DETAIL) study
    A H Barnett
    Undergraduate Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, West Midlands, UK
    Acta Diabetol 42:S42-9. 2005
    ..The groundbreaking DETAIL study revealed that telmisartan conferred comparable renoprotection to enalapril and was associated with a low incidence of mortality...
  57. ncbi request reprint Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository
    K F Tait
    Department of Medicine, University of Birmingham, Birmingham, UK
    Diabet Med 21:358-62. 2004
    ..The aim of this study was to compare the prevalence of the common autoimmune diseases in the parents of siblings from the Type 1 diabetes Warren repository with the general population...
  58. ncbi request reprint Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol
    G Valsamakis
    Department of Diabetes and Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Birmingham, UK
    Diabetes Obes Metab 5:131-5. 2003
    ..Adiponectin is a 30-kDa protein secreted by adipose tissue. The aim of the present study was to compare serum adiponectin in male Indo-Asian and Caucasian subjects and examine its association with fat topography and metabolic parameters...
  59. ncbi request reprint Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity
    K F Tait
    Division of Medical Sciences, University of Birmingham, UK
    Diabet Med 21:267-70. 2004
    ..The aim of this study was to investigate whether the INS VNTR region is a Type 1 diabetes-specific locus or acting as a general autoimmunity gene...
  60. ncbi request reprint Assessment of the non-HLA-DR-DQ contribution to IDDM1 in British Caucasian families: analysis of LMP7 polymorphisms
    C L McTernan
    Department of Medicine, Birmingham University, UK
    Diabet Med 17:661-6. 2000
    ..The LMP7 (large multifunctional proteasome 7) gene is a potential candidate. The aim of this study was to assess whether LMP7 confers susceptibility to Type 1 diabetes independently of linkage disequilibrium with HLA-DRB1 and HLA-DQ...
  61. ncbi request reprint Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
    ..The severe obesity found in these congenitally leptin-deficient subjects provides the first genetic evidence that leptin is an important regulator of energy balance in humans...
  62. pmc Molecular aspects of type 1 diabetes
    M A Kelly
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Mol Pathol 56:1-10. 2003
    ..This review will focus on the mechanisms by which these genes might influence the risk of developing type 1 diabetes...
  63. ncbi request reprint Pigmentary retinal dystrophy and the syndrome of maternally inherited diabetes and deafness caused by the mitochondrial DNA 3243 tRNA(Leu) A to G mutation
    P R Smith
    Department of Medicine, University of Birmingham and Birmingham Heartlands Hospital, England
    Ophthalmology 106:1101-8. 1999
    ..To study the association of retinal disease and the syndrome of maternally inherited diabetes and deafness caused by an A to G mutation in the tRNA leucine gene at base pair 3243 (A3243G) of the mitochondrial genome...
  64. ncbi request reprint Association between stress and glycemic control in adults with type 1 (insulin-dependent) diabetes
    C E Lloyd
    Department of Public Health, University of Birmingham, UK
    Diabetes Care 22:1278-83. 1999
    ..To examine the relationship between stressful life events and alterations in glycemic control in adults with diabetes...
  65. ncbi request reprint The nucleotide sequence of a new DMB allele, DMB*0106
    C L McTernan
    Department of Medicine, Birmingham University, United Kingdom
    Tissue Antigens 55:470-2. 2000
    ..This was a previously unpublished combination of polymorphic sites, and was submitted to GenBank and assigned the accession number AF072680, and named HLA-DMB*0106...
  66. ncbi request reprint Genetics of type 1 diabetes
    M A Kelly
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, Edgbaston, B15 2TH, UK
    Best Pract Res Clin Endocrinol Metab 15:279-91. 2001
    ..The IDDM2 locus maps to a variable number of tandem repeats in the insulin gene region on chromosome 11. Further research is necessary to determine the precise location and identity of other diabetes susceptibility genes...
  67. ncbi request reprint Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue
    P G McTernan
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital and Birmingham Heartlands Hospital, Birmingham B15 2TH, UK
    Int J Obes Relat Metab Disord 24:875-81. 2000
    ..To investigate the hormonal regulation of P450 aromatase activity (responsible for the conversion of C19 androgens to C18 oestrogens) in human adipose tissue from men and pre- and post-menopausal women...
  68. ncbi request reprint The role of angiotensin II receptor antagonists in the management of diabetes
    A H Barnett
    Birmingham Heartlands Hospital, Department of Medicine, UK
    Blood Press Suppl 1:21-6. 2001
    ..The primary outcome is change in glomerular filtration rate over the 5 years of the study...
  69. doi request reprint Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes
    A C Britten
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Int J Immunogenet 36:47-57. 2009
    ..The functional relevance of our findings and their implications for the pathogenesis of autoimmunity remain to be determined...
  70. ncbi request reprint HLA-DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in Jamaica
    J M Heward
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Immunogenet 29:47-52. 2002
    ..Further support is provided for roles of the DQ genes and the DRB1 gene (or a gene in linkage disequilibrium with it) in determining susceptibility to type 1 diabetes...
  71. ncbi request reprint Hormone replacement therapy for postmenopausal women with diabetes
    S L Palin
    Department of Diabetes, University of Birmingham, Birmingham Heartlands Hospital NHS Trust, Birmingham, UK
    Diabetes Obes Metab 3:187-93. 2001
    ..Up to 80% of women experience menopausal symptoms, however, so it is expected that by using HRT many would gain benefit from symptom relief, in addition to benefiting from its effects in disease prophylaxis...
  72. ncbi request reprint Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines
    G Valsamakis
    Department of Diabetes and Endocrinology, Birmingham Heartlands Hospital, Birmingham, UK
    Metabolism 53:430-4. 2004
    ..Modest weight loss is also associated with potentially favourably changes in serum adipocytokines, particularly in a rise of serum adiponectin. Reduction of waist circumference is associated with a change in serum resistin...
  73. ncbi request reprint The TGF-beta 1 gene codon 10 polymorphism contributes to the genetic predisposition to nephropathy in Type 1 diabetes
    A Patel
    Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, UK
    Diabet Med 22:69-73. 2005
    ..Our aim was to examine three polymorphisms within the TGF-beta 1 gene, in codons 10, 25 and 263, for association with nephropathy in Type 1 diabetes...
  74. ncbi request reprint Nitric oxide synthase gene polymorphisms and diabetic nephropathy
    J D Rippin
    Division of Medicine, University of Birmingham and Birmingham Heartlands Hospital, Undergraduate Centre, Bordeley Green East, Birmingham B9 5SS, United Kingdom
    Diabetologia 46:426-8. 2003
    ..Recently positive associations have been reported. We examined polymorphisms within NOS3 and NOS2A, the genes encoding endothelial- and inducible nitric oxide synthase, for association with nephropathy...
  75. ncbi request reprint Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes
    A L Harte
    Division of Medical Sciences, Department of Medicine, University of Birmingham, Birmingham B15 2TH, UK
    Diabetes Obes Metab 5:462-7. 2003
    ..97 upward arrow ***; ***p < 0.001, n = 3). In conclusion, increasing insulin doses stimulates AGT production. In this study, protein analysis suggests that hyperinsulinaemia may be an important factor in obesity-related hypertension...
  76. ncbi request reprint Prevalence of microalbuminuria and hypertension in South Asians and white Europeans with type 2 diabetes: a report from the United Kingdom Asian Diabetes Study (UKADS)
    Anthony N Dixon
    Department of Medicine, University of Birmingham, Birmingham, UK
    Diab Vasc Dis Res 3:22-5. 2006
    ..In conclusion, thresholds and targets for treatment of cardiovascular risk factors in South Asians may need to be lower than those for white Europeans, and targeted intervention will be required to achieve this...
  77. ncbi request reprint Cross-cultural comparisons of anxiety and depression in adults with type 1 diabetes
    Cathy E Lloyd
    Birmingham Heartlands Hospital and University of Birmingham, Birmingham, UK
    Diabetes Metab Res Rev 19:401-7. 2003
    ..The aim of this study was to examine cross-cultural differences in prevalence and correlates of symptoms of anxiety and depression in two studies, one in the United Kingdom and one in the United States...
  78. ncbi request reprint Inhaled insulin (Exubera): Combining efficacy and convenience
    Srikanth Bellary
    Department of Medicine Undergraduate Centre, Heart of England NHS Foundation Trust, Birmingham, UK
    Diab Vasc Dis Res 3:179-85. 2006
    ..The potential benefits from improved adherence and better glycaemic control with this insulin are also significant...
  79. ncbi request reprint A review of basal insulins
    Anthony H Barnett
    University of Birmingham and Birmingham Heartlands Hospital, Department of Medicine Undergraduate Centre, Birmingham, UK
    Diabet Med 20:873-85. 2003
    ..Clinical evidence suggests efficacy and safety advantages for these analogues over NPH insulin (the most commonly used basal insulin), and may bring closer the goal of tight glycaemic control in patients with diabetes...
  80. ncbi request reprint Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes
    Philip G McTernan
    Department of Medicine, University of Birmingham and Heartlands Hospital, Edgbaston Birmingham, United Kingdom B15 2TH
    J Clin Endocrinol Metab 88:6098-106. 2003
    ..Our in vitro studies suggest a modest effect of resistin in reducing glucose uptake, and suppression of resistin expression may contribute to the insulin-sensitizing and glucose-lowering actions of the thiazolidinediones...
  81. ncbi request reprint Cost-effective strategies in the prevention of diabetic nephropathy
    Jonathan D Rippin
    Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham, UK
    Pharmacoeconomics 22:9-28. 2004
    ..The various costs associated with diabetic nephropathy are so great that even expensive interventions may have a favourable cost/benefit ratio, provided they are truly effective...
  82. ncbi request reprint Exenatide
    Anthony H Barnett
    University of Birmingham and Birmingham Heartlands and Solihull National Health Service Trust Teaching, UK anthony barnett heartofengland nhs uk
    Drugs Today (Barc) 41:563-78. 2005
    ..Exenatide may enable patients with type 2 diabetes to achieve glycemic control while reducing or eliminating the risk of hypoglycemia and weight gain. These would represent significant therapeutic gains...
  83. ncbi request reprint Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease?
    Colin A Hutchison
    Queen Elizabeth Hospital, Department of Renal Medicine, QEMC, Birmingham, B15 2TH, UK
    Expert Opin Ther Targets 12:667-76. 2008
    ..Free light chains (FLCs) are bi-products of normal immunoglobulin synthesis and are predominately removed from the circulation by the kidneys. This study assessed polyclonal FLCs as a novel biomarker of early diabetic kidney disease...
  84. doi request reprint Treatment intensification in patients with type 2 diabetes
    Anthony H Barnett
    Department of Diabetes and Endocrinology, Heart of England NHS Foundation Trust and University of Birmingham, Birmingham Heartlands Hospital, Undergraduate Centre, Birmingham, UK
    Diabetes Obes Metab 10:iii. 2008
  85. ncbi request reprint Cardiovascular risk factors and their management in 1282 adult people with type 1 diabetes
    Ateeq Syed
    University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Curr Med Res Opin 23:2921-7. 2007
    ..Strict control of CVD risk factors, for which guidelines now exist, reduces morbidity and mortality. The objective of this study was to determine if these guidelines are being achieved...
  86. ncbi request reprint Selection and education of patients for inhaled insulin
    Srikanth Bellary
    Undergraduate Centre, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham, UK
    Curr Diab Rep 7:363-8. 2007
    ..But, careful selection of patients, education, and continued support from health professionals is vital to ensure success with this new technology...
  87. ncbi request reprint Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
    Anthony H Barnett
    Division of Medical Sciences, University of Birmingham and Birmingham Heartlands and Solihull National Health Service Trust Teaching, Birmingham, United Kingdom
    N Engl J Med 351:1952-61. 2004
    ..Few studies have directly compared the renoprotective effects of angiotensin II-receptor blockers and angiotensin-converting-enzyme (ACE) inhibitors in persons with type 2 diabetes...
  88. ncbi request reprint A burning mouth associated with the use of hormone replacement therapy
    Suzanne L Palin
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    J Br Menopause Soc 11:38. 2005
  89. ncbi request reprint The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
    Kathleen M Gillespie
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Lancet 364:1699-700. 2004
    ..003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect...
  90. doi request reprint Physical activity and risk of diabetes
    Cathy E Lloyd
    Faculty of Health and Social Care, Open University, Milton Keynes, Buckinghamshire, UK
    Lancet 371:5-7. 2008
  91. ncbi request reprint Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus
    Michelle L Rayner
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, United Kingdom
    Hum Immunol 63:413-7. 2002
    ..This contrasts with findings for the DRbeta, DQalpha and DQbeta peptide chains, where the identity of the amino acid at particular sites has been found to correlate with predisposition to type I diabetes...
  92. ncbi request reprint Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham and Heartlands Hospital, Edgbaston, Birmingham, UK
    Diabetes 51:1493-8. 2002
    ..These data, therefore, may explain in part why hyperinsulinemia coexists with increased circulating nonesterified free fatty acids and increased adiposity in obese and/or type 2 diabetic patients...
  93. ncbi request reprint Increased resistin gene and protein expression in human abdominal adipose tissue
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham, Birmingham, B15 2TH, UK
    J Clin Endocrinol Metab 87:2407. 2002
    ..In conclusion, this study confirms the expression of resistin in human adipose tissue and increased expression in abdominal fat, this suggests a potential role in linking central obesity to type 2 diabetes and/or cardiovascular disease...
  94. ncbi request reprint Dyslipidaemia in diabetes--a GP guide
    Anthony H Barnett
    University of Birmingham
    Practitioner 246:120-3. 2002
  95. ncbi request reprint Latent autoimmune diabetes in adults in a South Asian population of the U.K
    Abigail C Britten
    Department of Medicine, University of Birmingham, Birmingham, UK
    Diabetes Care 30:3088-90. 2007
  96. ncbi request reprint Glucose tolerance testing for all?
    Anthony H Barnett
    Int J Clin Pract 61:541-3. 2007
  97. doi request reprint Value of glycaemic control in diabetes
    Clifford J Bailey
    Lancet 371:116. 2008
  98. ncbi request reprint Polymorphisms of interleukin 4 receptor gene and interleukin 10 gene are not associated with Graves' disease in the UK
    Karen F Tait
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Autoimmunity 37:189-94. 2004
    ..We conclude these polymorphisms of IL-10 and IL-4R previously associated with other immune mediated diseases, do not confer susceptibility to GD in white Caucasians in the United Kingdom...